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UGT1A6 (UDP glucuronosyltransferase family 1 member A6)

Identity

Alias_namesUDP glycosyltransferase 1 family
Alias_symbol (synonym)HLUGP
GNT1
UGT1F
Other aliasHLUGP1
UDPGT
UDPGT 1-6
UGT1
UGT1A6S
HGNC (Hugo) UGT1A6
LocusID (NCBI) 54578
Atlas_Id 46238
Location 2q37.1  [Link to chromosome band 2q37]
Location_base_pair Starts at 233691675 and ends at 233773299 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)UGT1A6   12538
Cards
Entrez_Gene (NCBI)UGT1A6  54578  UDP glucuronosyltransferase family 1 member A6
AliasesGNT1; HLUGP; HLUGP1; UDPGT; 
UDPGT; UGT1; UGT1A6S; UGT1F
GeneCards (Weizmann)UGT1A6
Ensembl hg19 (Hinxton)ENSG00000167165 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167165 [Gene_View]  ENSG00000167165 [Sequence]  chr2:233691675-233773299 [Contig_View]  UGT1A6 [Vega]
ICGC DataPortalENSG00000167165
TCGA cBioPortalUGT1A6
AceView (NCBI)UGT1A6
Genatlas (Paris)UGT1A6
WikiGenes54578
SOURCE (Princeton)UGT1A6
Genetics Home Reference (NIH)UGT1A6
Genomic and cartography
GoldenPath hg38 (UCSC)UGT1A6  -     chr2:233691675-233773299 +  2q37.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)UGT1A6  -     2q37.1   [Description]    (hg19-Feb_2009)
EnsemblUGT1A6 - 2q37.1 [CytoView hg19]  UGT1A6 - 2q37.1 [CytoView hg38]
Mapping of homologs : NCBIUGT1A6 [Mapview hg19]  UGT1A6 [Mapview hg38]
OMIM606431   
Gene and transcription
Genbank (Entrez)AY435141 BC011409 BC019861 BE463503 BM688740
RefSeq transcript (Entrez)NM_001072 NM_205862
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)UGT1A6
Cluster EST : UnigeneHs.554822 [ NCBI ]
CGAP (NCI)Hs.554822
Alternative Splicing GalleryENSG00000167165
Gene ExpressionUGT1A6 [ NCBI-GEO ]   UGT1A6 [ EBI - ARRAY_EXPRESS ]   UGT1A6 [ SEEK ]   UGT1A6 [ MEM ]
Gene Expression Viewer (FireBrowse)UGT1A6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)54578
GTEX Portal (Tissue expression)UGT1A6
Human Protein AtlasENSG00000167165-UGT1A6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP19224   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP19224  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP19224
Splice isoforms : SwissVarP19224
Catalytic activity : Enzyme2.4.1.17 [ Enzyme-Expasy ]   2.4.1.172.4.1.17 [ IntEnz-EBI ]   2.4.1.17 [ BRENDA ]   2.4.1.17 [ KEGG ]   
PhosPhoSitePlusP19224
Domaine pattern : Prosite (Expaxy)UDPGT (PS00375)   
Domains : Interpro (EBI)UDP_glucos_trans    UDP_glycos_trans_CS   
Domain families : Pfam (Sanger)UDPGT (PF00201)   
Domain families : Pfam (NCBI)pfam00201   
Conserved Domain (NCBI)UGT1A6
DMDM Disease mutations54578
Blocks (Seattle)UGT1A6
SuperfamilyP19224
Human Protein Atlas [tissue]ENSG00000167165-UGT1A6 [tissue]
Peptide AtlasP19224
HPRD07071
IPIIPI00451965   IPI00410366   IPI00760952   IPI00892843   IPI00946165   
Protein Interaction databases
DIP (DOE-UCLA)P19224
IntAct (EBI)P19224
FunCoupENSG00000167165
BioGRIDUGT1A6
STRING (EMBL)UGT1A6
ZODIACUGT1A6
Ontologies - Pathways
QuickGOP19224
Ontology : AmiGOretinoic acid binding  endoplasmic reticulum  endoplasmic reticulum membrane  xenobiotic metabolic process  UDP-glycosyltransferase activity  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  protein homodimerization activity  intracellular membrane-bounded organelle  protein heterodimerization activity  cellular glucuronidation  cellular glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  
Ontology : EGO-EBIretinoic acid binding  endoplasmic reticulum  endoplasmic reticulum membrane  xenobiotic metabolic process  UDP-glycosyltransferase activity  glucuronosyltransferase activity  glucuronosyltransferase activity  integral component of membrane  protein homodimerization activity  intracellular membrane-bounded organelle  protein heterodimerization activity  cellular glucuronidation  cellular glucuronidation  flavonoid glucuronidation  xenobiotic glucuronidation  
Pathways : KEGG   
NDEx NetworkUGT1A6
Atlas of Cancer Signalling NetworkUGT1A6
Wikipedia pathwaysUGT1A6
Orthology - Evolution
OrthoDB54578
GeneTree (enSembl)ENSG00000167165
Phylogenetic Trees/Animal Genes : TreeFamUGT1A6
HOVERGENP19224
HOGENOMP19224
Homologs : HomoloGeneUGT1A6
Homology/Alignments : Family Browser (UCSC)UGT1A6
Gene fusions - Rearrangements
Fusion : QuiverUGT1A6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUGT1A6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)UGT1A6
dbVarUGT1A6
ClinVarUGT1A6
1000_GenomesUGT1A6 
Exome Variant ServerUGT1A6
ExAC (Exome Aggregation Consortium)ENSG00000167165
GNOMAD BrowserENSG00000167165
Varsome BrowserUGT1A6
Genetic variants : HAPMAP54578
Genomic Variants (DGV)UGT1A6 [DGVbeta]
DECIPHERUGT1A6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUGT1A6 
Mutations
ICGC Data PortalUGT1A6 
TCGA Data PortalUGT1A6 
Broad Tumor PortalUGT1A6
OASIS PortalUGT1A6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUGT1A6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUGT1A6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch UGT1A6
DgiDB (Drug Gene Interaction Database)UGT1A6
DoCM (Curated mutations)UGT1A6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)UGT1A6 (select a term)
intoGenUGT1A6
Cancer3DUGT1A6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606431   
Orphanet
DisGeNETUGT1A6
MedgenUGT1A6
Genetic Testing Registry UGT1A6
NextProtP19224 [Medical]
TSGene54578
GENETestsUGT1A6
Target ValidationUGT1A6
Huge Navigator UGT1A6 [HugePedia]
snp3D : Map Gene to Disease54578
BioCentury BCIQUGT1A6
ClinGenUGT1A6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD54578
Chemical/Pharm GKB GenePA37181
Clinical trialUGT1A6
Miscellaneous
canSAR (ICR)UGT1A6 (select the gene name)
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUGT1A6
EVEXUGT1A6
GoPubMedUGT1A6
iHOPUGT1A6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 12:00:29 CEST 2018

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