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USP2 (ubiquitin specific peptidase 2)

Identity

Alias_namesubiquitin specific protease 2
Alias_symbol (synonym)UBP41
Other aliasUSP9
HGNC (Hugo) USP2
LocusID (NCBI) 9099
Atlas_Id 46243
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 119355215 and ends at 119364182 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KMT2A (11q23.3) / USP2 (11q23.3)RGS12 (4p16.3) / USP2 (11q23.3)USP2 (11q23.3) / CEP63 (3q22.2)
USP2 (11q23.3) / KCNK9 (8q24.3)RGS12 4p16.3 / USP2 11q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(11;11)(q23;q23) KMT2A/USP2

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(4;11)(p16;q23) RGS12/USP2

External links

Nomenclature
HGNC (Hugo)USP2   12618
Cards
Entrez_Gene (NCBI)USP2  9099  ubiquitin specific peptidase 2
AliasesUBP41; USP9
GeneCards (Weizmann)USP2
Ensembl hg19 (Hinxton)ENSG00000036672 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000036672 [Gene_View]  ENSG00000036672 [Sequence]  chr11:119355215-119364182 [Contig_View]  USP2 [Vega]
ICGC DataPortalENSG00000036672
TCGA cBioPortalUSP2
AceView (NCBI)USP2
Genatlas (Paris)USP2
WikiGenes9099
SOURCE (Princeton)USP2
Genetics Home Reference (NIH)USP2
Genomic and cartography
GoldenPath hg38 (UCSC)USP2  -     chr11:119355215-119364182 -  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)USP2  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblUSP2 - 11q23.3 [CytoView hg19]  USP2 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIUSP2 [Mapview hg19]  USP2 [Mapview hg38]
OMIM604725   
Gene and transcription
Genbank (Entrez)AF079564 AF440755 AI806430 AK057225 AK292255
RefSeq transcript (Entrez)NM_001243759 NM_004205 NM_171997
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)USP2
Cluster EST : UnigeneHs.524085 [ NCBI ]
CGAP (NCI)Hs.524085
Alternative Splicing GalleryENSG00000036672
Gene ExpressionUSP2 [ NCBI-GEO ]   USP2 [ EBI - ARRAY_EXPRESS ]   USP2 [ SEEK ]   USP2 [ MEM ]
Gene Expression Viewer (FireBrowse)USP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9099
GTEX Portal (Tissue expression)USP2
Human Protein AtlasENSG00000036672-USP2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75604   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75604  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75604
Splice isoforms : SwissVarO75604
Catalytic activity : Enzyme3.4.19.12 [ Enzyme-Expasy ]   3.4.19.123.4.19.12 [ IntEnz-EBI ]   3.4.19.12 [ BRENDA ]   3.4.19.12 [ KEGG ]   
PhosPhoSitePlusO75604
Domaine pattern : Prosite (Expaxy)USP_1 (PS00972)    USP_2 (PS00973)    USP_3 (PS50235)   
Domains : Interpro (EBI)Peptidase_C19_UCH    USP_CS    USP_dom   
Domain families : Pfam (Sanger)UCH (PF00443)   
Domain families : Pfam (NCBI)pfam00443   
Conserved Domain (NCBI)USP2
DMDM Disease mutations9099
Blocks (Seattle)USP2
PDB (SRS)2HD5    2IBI    3NHE    3V6C    3V6E    5XU8    5XVE   
PDB (PDBSum)2HD5    2IBI    3NHE    3V6C    3V6E    5XU8    5XVE   
PDB (IMB)2HD5    2IBI    3NHE    3V6C    3V6E    5XU8    5XVE   
PDB (RSDB)2HD5    2IBI    3NHE    3V6C    3V6E    5XU8    5XVE   
Structural Biology KnowledgeBase2HD5    2IBI    3NHE    3V6C    3V6E    5XU8    5XVE   
SCOP (Structural Classification of Proteins)2HD5    2IBI    3NHE    3V6C    3V6E    5XU8    5XVE   
CATH (Classification of proteins structures)2HD5    2IBI    3NHE    3V6C    3V6E    5XU8    5XVE   
SuperfamilyO75604
Human Protein Atlas [tissue]ENSG00000036672-USP2 [tissue]
Peptide AtlasO75604
HPRD05287
IPIIPI00298910   IPI00216783   IPI00969474   IPI00969446   IPI01009002   IPI00979043   IPI00979746   IPI00980247   
Protein Interaction databases
DIP (DOE-UCLA)O75604
IntAct (EBI)O75604
FunCoupENSG00000036672
BioGRIDUSP2
STRING (EMBL)USP2
ZODIACUSP2
Ontologies - Pathways
QuickGOO75604
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  cytoplasm  centrosome  ubiquitin-dependent protein catabolic process  cell cycle  muscle organ development  membrane  protein deubiquitination  protein deubiquitination  cyclin binding  ubiquitin protein ligase binding  circadian regulation of gene expression  thiol-dependent ubiquitinyl hydrolase activity  identical protein binding  entrainment of circadian clock by photoperiod  locomotor rhythm  positive regulation of mitotic cell cycle  metal ion binding  perinuclear region of cytoplasm  circadian behavior  protein stabilization  protein stabilization  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  cysteine-type endopeptidase activity  thiol-dependent ubiquitin-specific protease activity  thiol-dependent ubiquitin-specific protease activity  protein binding  nucleoplasm  cytoplasm  centrosome  ubiquitin-dependent protein catabolic process  cell cycle  muscle organ development  membrane  protein deubiquitination  protein deubiquitination  cyclin binding  ubiquitin protein ligase binding  circadian regulation of gene expression  thiol-dependent ubiquitinyl hydrolase activity  identical protein binding  entrainment of circadian clock by photoperiod  locomotor rhythm  positive regulation of mitotic cell cycle  metal ion binding  perinuclear region of cytoplasm  circadian behavior  protein stabilization  protein stabilization  
NDEx NetworkUSP2
Atlas of Cancer Signalling NetworkUSP2
Wikipedia pathwaysUSP2
Orthology - Evolution
OrthoDB9099
GeneTree (enSembl)ENSG00000036672
Phylogenetic Trees/Animal Genes : TreeFamUSP2
HOVERGENO75604
HOGENOMO75604
Homologs : HomoloGeneUSP2
Homology/Alignments : Family Browser (UCSC)USP2
Gene fusions - Rearrangements
Fusion : MitelmanRGS12/USP2 [4p16.3/11q23.3]  [t(4;11)(p16;q23)]  
Fusion PortalRGS12 4p16.3 USP2 11q23.3 BRCA
Fusion : QuiverUSP2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerUSP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)USP2
dbVarUSP2
ClinVarUSP2
1000_GenomesUSP2 
Exome Variant ServerUSP2
ExAC (Exome Aggregation Consortium)ENSG00000036672
GNOMAD BrowserENSG00000036672
Varsome BrowserUSP2
Genetic variants : HAPMAP9099
Genomic Variants (DGV)USP2 [DGVbeta]
DECIPHERUSP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisUSP2 
Mutations
ICGC Data PortalUSP2 
TCGA Data PortalUSP2 
Broad Tumor PortalUSP2
OASIS PortalUSP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICUSP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDUSP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch USP2
DgiDB (Drug Gene Interaction Database)USP2
DoCM (Curated mutations)USP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)USP2 (select a term)
intoGenUSP2
Cancer3DUSP2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604725   
Orphanet
DisGeNETUSP2
MedgenUSP2
Genetic Testing Registry USP2
NextProtO75604 [Medical]
TSGene9099
GENETestsUSP2
Target ValidationUSP2
Huge Navigator USP2 [HugePedia]
snp3D : Map Gene to Disease9099
BioCentury BCIQUSP2
ClinGenUSP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9099
Chemical/Pharm GKB GenePA37244
Clinical trialUSP2
Miscellaneous
canSAR (ICR)USP2 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineUSP2
EVEXUSP2
GoPubMedUSP2
iHOPUSP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:49:01 CET 2018
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