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VAV2 (vav 2 guanine nucleotide exchange factor)

Identity

Other names-
HGNC (Hugo) VAV2
Location 9q34.1
Location_base_pair Starts at 135616838 and ends at 135847267 bp from pter ( according to hg18-March_2006)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)VAV2   12658
Entrez_Gene (NCBI)VAV2  7410  vav 2 guanine nucleotide exchange factor
Cards
GeneCards (Weizmann)VAV2
Ensembl (Hinxton)ENSG00000160293 [Gene_View]  VAV2 [Vega]
AceView (NCBI)VAV2
Genatlas (Paris)VAV2
euGene (Indiana)7410
SOURCE (Stanford)NM_001134398 NM_003371
Genomic and cartography
GoldenPath (UCSC)VAV2  -  9q34.1   chr9:135616838-135847267 -  9q34.2   [Description]    (hg18-March_2006)
EnsemblVAV2 - 9q34.2 [CytoView]
Mapping of homologs : NCBIVAV2 [Mapview]
OMIM600428   
Gene and transcription
Gene : Genbank (Entrez)AJ420448 AK091622 AK123314 AK124271 AK130575
Reference sequence (RefSeq transcript) :SRSNM_001134398 NM_003371
Reference transcript : EntrezNM_001134398 NM_003371
RefSeq genomic : SRSAC_000052 AC_000141 NC_000009 NT_035014 NW_001839242 NW_924573
RefSeq genomic : EntrezAC_000052 AC_000141 NC_000009 NT_035014 NW_001839242 NW_924573
Consensus coding sequences : CCDS NCBIVAV2
Cluster EST : UnigeneHs.689325 [ SRS ] Hs.689325 [ NCBI ]
Alternative Splicing : Fast-db (Paris)16432
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP52735 (SRS) P52735 (Expasy) P52735 (Uniprot)
With graphics : InterProP52735
Splice isoforms : VarSplice FASTAP52735(VarSplice FASTA)
Domaine pattern : Prosite (SRS)CH (PS50021)    DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    SH2 (PS50001)    SH3 (PS50002)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domain pattern : Prosite (Expaxy)CH (PS50021)    DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    SH2 (PS50001)    SH3 (PS50002)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (SRS)Calponin-homology    Calponin_act_bd    DAG_PE_bd    DH-domain    GDS_CDC24_CS    PH    SH2    SH3    SH3_2   
Domains : Interpro (EBI)Calponin-homology    Calponin_act_bd    DAG_PE_bd    DH-domain    GDS_CDC24_CS    PH    SH2    SH3    SH3_2   
Related proteins : CluSTrP52735
Domain families : Pfam SRSC1_1 (PF00130)    CH (PF00307)    PH (PF00169)    RhoGEF (PF00621)    SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam SangerC1_1 (PF00130)    CH (PF00307)    PH (PF00169)    RhoGEF (PF00621)    SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam NCBIpfam00130    pfam00307    pfam00169    pfam00621    pfam00017    pfam00018    pfam07653   
Domain families : Smart EMBLC1 (SM00109)CH (SM00033)PH (SM00233)RhoGEF (SM00325)SH2 (SM00252)SH3 (SM00326)
Domain structure : Prodom (Prabi Lyon)SH2 (PD000093)    (PD000093)   
Blocks (Seattle)P52735
Crystal structure of protein : PDB SRS2DLZ    2DM1   
Crystal structure of protein : PDBSum2DLZ    2DM1   
Crystal structure of protein : IMB2DLZ    2DM1   
Crystal structure of protein : PDB RSDB2DLZ    2DM1   
HPRD02694
Protein Interaction databases
DIP (DOE-UCLA)P52735
IntAct (EBI)P52735
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIVAV2
SNP : GeneSNP UtahVAV2
SNP : HGBaseVAV2
Genetic variants : HAPMAPVAV2
Somatic Mutations in Cancer : COSMICVAV2 
Mutations and Diseases : HGMDVAV2
Hereditary diseases : OMIM600428   
Hereditary diseases : GENETests600428   
Diseases : Genetic AssociationVAV2
General knowledge
Homologs : HomoloGeneVAV2
Homology/Alignments : Family Browser UCSCVAV2
Phylogenetic Trees/Animal Genes : TreeFamVAV2
Chemical/Protein Interactions : CTD7410
Keywords Ontology : AmiGOguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  intracellular  intracellular signaling cascade  zinc ion binding  diacylglycerol binding  regulation of Rho protein signal transduction  metal ion binding  
Keywords Ontology : EGO-EBIguanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  protein binding  intracellular  intracellular signaling cascade  zinc ion binding  diacylglycerol binding  regulation of Rho protein signal transduction  metal ion binding  
Pathways : BIOCARTAPhosphoinositides and their downstream targets. [Genes]   
Pathways : KEGGFocal adhesionNatural killer cell mediated cytotoxicityT cell receptor signaling pathwayB cell receptor signaling pathwayFc epsilon RI signaling pathwayLeukocyte transendothelial migrationRegulation of actin cytoskeleton
Other databases
Probes
Probes : ImagenesVAV2 Related clones (RZPD - Berlin)
Literature
PubMed31 Pubmed reference(s) in Entrez
PubGeneVAV2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated03-2009Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jun 27 16:33:50 CEST 2009
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