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VAV2 (vav guanine nucleotide exchange factor 2)

Identity

Alias_namesvav 2 oncogene
vav 2 guanine nucleotide exchange factor
Other aliasVAV-2
HGNC (Hugo) VAV2
LocusID (NCBI) 7410
Atlas_Id 42781
Location 9q34.2  [Link to chromosome band 9q34]
Location_base_pair Starts at 133761894 and ends at 133992324 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
KIAA0895L (16q22.1) / VAV2 (9q34.2)MAPKAP1 (9q33.3) / VAV2 (9q34.2)MEGF6 (1p36.32) / VAV2 (9q34.2)
VAV2 (9q34.2) / CCDC67 (11q21)VAV2 (9q34.2) / COL27A1 (9q32)VAV2 (9q34.2) / EFNB1 (Xq13.1)
VAV2 (9q34.2) / NOTCH1 (9q34.3)VAV2 (9q34.2) / QSOX2 (9q34.3)VAV2 (9q34.2) / TRUB2 (9q34.11)
VAV2 (9q34.2) / TSPO (22q13.2)VAV2 (9q34.2) / VAV2 (9q34.2)MAPKAP1 9q33.3 / VAV2 9q34.2
VAV2 9q34.2 / COL27A1 9q32

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  del(9)(q34q34) VAV2/QSOX2
t(9;9)(q32;q34) VAV2/COL27A1
t(9;9)(q33;q34) MAPKAP1/VAV2
VAV2/NOTCH1 (9q34)


External links

Nomenclature
HGNC (Hugo)VAV2   12658
Cards
Entrez_Gene (NCBI)VAV2  7410  vav guanine nucleotide exchange factor 2
AliasesVAV-2
GeneCards (Weizmann)VAV2
Ensembl hg19 (Hinxton)ENSG00000160293 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160293 [Gene_View]  ENSG00000160293 [Sequence]  chr9:133761894-133992324 [Contig_View]  VAV2 [Vega]
ICGC DataPortalENSG00000160293
TCGA cBioPortalVAV2
AceView (NCBI)VAV2
Genatlas (Paris)VAV2
WikiGenes7410
SOURCE (Princeton)VAV2
Genetics Home Reference (NIH)VAV2
Genomic and cartography
GoldenPath hg38 (UCSC)VAV2  -     chr9:133761894-133992324 -  9q34.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)VAV2  -     9q34.2   [Description]    (hg19-Feb_2009)
EnsemblVAV2 - 9q34.2 [CytoView hg19]  VAV2 - 9q34.2 [CytoView hg38]
Mapping of homologs : NCBIVAV2 [Mapview hg19]  VAV2 [Mapview hg38]
OMIM600428   
Gene and transcription
Genbank (Entrez)AJ420448 AK091622 AK123314 AK124271 AK130575
RefSeq transcript (Entrez)NM_001134398 NM_003371
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)VAV2
Cluster EST : UnigeneHs.689325 [ NCBI ]
CGAP (NCI)Hs.689325
Alternative Splicing GalleryENSG00000160293
Gene ExpressionVAV2 [ NCBI-GEO ]   VAV2 [ EBI - ARRAY_EXPRESS ]   VAV2 [ SEEK ]   VAV2 [ MEM ]
Gene Expression Viewer (FireBrowse)VAV2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7410
GTEX Portal (Tissue expression)VAV2
Human Protein AtlasENSG00000160293-VAV2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52735   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52735  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52735
Splice isoforms : SwissVarP52735
PhosPhoSitePlusP52735
Domaine pattern : Prosite (Expaxy)CH (PS50021)    DH_1 (PS00741)    DH_2 (PS50010)    PH_DOMAIN (PS50003)    SH2 (PS50001)    SH3 (PS50002)    ZF_DAG_PE_1 (PS00479)    ZF_DAG_PE_2 (PS50081)   
Domains : Interpro (EBI)CAMSAP_CH    CH-domain    CH_dom_sf    DBL_dom_sf    DH-domain    GDS_CDC24_CS    PE/DAG-bd    PH-like_dom_sf    PH_domain    PH_Vav    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    VAV2_SH2    VAV2_SH3_1    VAV2_SH3_2   
Domain families : Pfam (Sanger)C1_1 (PF00130)    CAMSAP_CH (PF11971)    PH (PF00169)    RhoGEF (PF00621)    SH2 (PF00017)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00130    pfam11971    pfam00169    pfam00621    pfam00017    pfam07653   
Domain families : Smart (EMBL)C1 (SM00109)  CH (SM00033)  PH (SM00233)  RhoGEF (SM00325)  SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)VAV2
DMDM Disease mutations7410
Blocks (Seattle)VAV2
PDB (SRS)2DLZ    2DM1    2LNW    2LNX    4ROJ   
PDB (PDBSum)2DLZ    2DM1    2LNW    2LNX    4ROJ   
PDB (IMB)2DLZ    2DM1    2LNW    2LNX    4ROJ   
PDB (RSDB)2DLZ    2DM1    2LNW    2LNX    4ROJ   
Structural Biology KnowledgeBase2DLZ    2DM1    2LNW    2LNX    4ROJ   
SCOP (Structural Classification of Proteins)2DLZ    2DM1    2LNW    2LNX    4ROJ   
CATH (Classification of proteins structures)2DLZ    2DM1    2LNW    2LNX    4ROJ   
SuperfamilyP52735
Human Protein Atlas [tissue]ENSG00000160293-VAV2 [tissue]
Peptide AtlasP52735
HPRD02694
IPIIPI00472451   IPI00872160   IPI00004977   IPI00935955   IPI00983340   
Protein Interaction databases
DIP (DOE-UCLA)P52735
IntAct (EBI)P52735
FunCoupENSG00000160293
BioGRIDVAV2
STRING (EMBL)VAV2
ZODIACVAV2
Ontologies - Pathways
QuickGOP52735
Ontology : AmiGOangiogenesis  phosphotyrosine residue binding  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  protein binding  cytosol  plasma membrane  signal transduction  G-protein coupled receptor signaling pathway  small GTPase mediated signal transduction  regulation of cell size  regulation of cell size  cell migration  lamellipodium assembly  platelet activation  regulation of Rho protein signal transduction  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of apoptotic process  regulation of GTPase activity  positive regulation of phosphatidylinositol 3-kinase activity  metal ion binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  regulation of small GTPase mediated signal transduction  
Ontology : EGO-EBIangiogenesis  phosphotyrosine residue binding  guanyl-nucleotide exchange factor activity  guanyl-nucleotide exchange factor activity  Rho guanyl-nucleotide exchange factor activity  epidermal growth factor receptor binding  protein binding  cytosol  plasma membrane  signal transduction  G-protein coupled receptor signaling pathway  small GTPase mediated signal transduction  regulation of cell size  regulation of cell size  cell migration  lamellipodium assembly  platelet activation  regulation of Rho protein signal transduction  Fc-epsilon receptor signaling pathway  Fc-gamma receptor signaling pathway involved in phagocytosis  positive regulation of apoptotic process  regulation of GTPase activity  positive regulation of phosphatidylinositol 3-kinase activity  metal ion binding  vascular endothelial growth factor receptor signaling pathway  ephrin receptor signaling pathway  regulation of small GTPase mediated signal transduction  
Pathways : KEGG   
NDEx NetworkVAV2
Atlas of Cancer Signalling NetworkVAV2
Wikipedia pathwaysVAV2
Orthology - Evolution
OrthoDB7410
GeneTree (enSembl)ENSG00000160293
Phylogenetic Trees/Animal Genes : TreeFamVAV2
HOVERGENP52735
HOGENOMP52735
Homologs : HomoloGeneVAV2
Homology/Alignments : Family Browser (UCSC)VAV2
Gene fusions - Rearrangements
Fusion : MitelmanMAPKAP1/VAV2 [9q33.3/9q34.2]  [t(9;9)(q33;q34)]  
Fusion : MitelmanVAV2/CCDC67 [9q34.2/11q21]  [t(9;11)(q34;q21)]  
Fusion : MitelmanVAV2/COL27A1 [9q34.2/9q32]  [t(9;9)(q32;q34)]  
Fusion : MitelmanVAV2/NOTCH1 [9q34.2/9q34.3]  [t(9;9)(q34;q34)]  
Fusion : MitelmanVAV2/QSOX2 [9q34.2/9q34.3]  [del(9)(q34q34)]  
Fusion PortalMAPKAP1 9q33.3 VAV2 9q34.2 BRCA
Fusion PortalVAV2 9q34.2 COL27A1 9q32 PRAD
Fusion : QuiverVAV2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerVAV2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)VAV2
dbVarVAV2
ClinVarVAV2
1000_GenomesVAV2 
Exome Variant ServerVAV2
ExAC (Exome Aggregation Consortium)ENSG00000160293
GNOMAD BrowserENSG00000160293
Varsome BrowserVAV2
Genetic variants : HAPMAP7410
Genomic Variants (DGV)VAV2 [DGVbeta]
DECIPHERVAV2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisVAV2 
Mutations
ICGC Data PortalVAV2 
TCGA Data PortalVAV2 
Broad Tumor PortalVAV2
OASIS PortalVAV2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICVAV2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDVAV2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch VAV2
DgiDB (Drug Gene Interaction Database)VAV2
DoCM (Curated mutations)VAV2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)VAV2 (select a term)
intoGenVAV2
Cancer3DVAV2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600428   
Orphanet
DisGeNETVAV2
MedgenVAV2
Genetic Testing Registry VAV2
NextProtP52735 [Medical]
TSGene7410
GENETestsVAV2
Target ValidationVAV2
Huge Navigator VAV2 [HugePedia]
snp3D : Map Gene to Disease7410
BioCentury BCIQVAV2
ClinGenVAV2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7410
Chemical/Pharm GKB GenePA37281
Clinical trialVAV2
Miscellaneous
canSAR (ICR)VAV2 (select the gene name)
Probes
Litterature
PubMed105 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineVAV2
EVEXVAV2
GoPubMedVAV2
iHOPVAV2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Aug 27 12:01:16 CEST 2018

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