Atlas of Genetics and Cytogenetics in Oncology and Haematology

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XDH (xanthine dehydrogenase)

Identity

Other namesXO
XOR
HGNC (Hugo) XDH
LocusID (NCBI) 7498
Location 2p23.1
Location_base_pair Starts at 31557188 and ends at 31637611 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)XDH   12805
Entrez_Gene (NCBI)XDH  7498  xanthine dehydrogenase
Cards
GeneCards (Weizmann)XDH
Ensembl (Hinxton)ENSG00000158125 [Gene_View]  chr2:31557188-31637611 [Contig_View]  XDH [Vega]
AceView (NCBI)XDH
Genatlas (Paris)XDH
SOURCE (Stanford)NM_000379
Genomic and cartography
GoldenPath (UCSC)XDH  -  2p23.1   chr2:31557188-31637611 -  2p23.1   [Description]    (hg19-Feb_2009)
EnsemblXDH - 2p23.1 [CytoView]
Mapping of homologs : NCBIXDH [Mapview]
OMIM278300   607633   
Gene and transcription
Genbank (Entrez)AK130114 BC166696 CV574002 D11456 U06117
RefSeq transcript (SRS)NM_000379
RefSeq transcript (Entrez)NM_000379
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NG_008871 NT_022184 NW_001838769 NW_004078005
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008871 NT_022184 NW_001838769 NW_004078005
Consensus coding sequences : CCDS (NCBI)XDH
Cluster EST : UnigeneHs.250 [ SRS ] Hs.250 [ NCBI ]
CGAP (NCI)Hs.250
Alternative Splicing : Fast-db (Paris)GSHG0017529
Alternative Splicing GalleryENSG00000158125
Gene ExpressionXDH [ NCBI-GEO ]   XDH [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47989 (SRS) P47989 (Uniprot)
NextProtP47989
With graphics : InterProP47989
Splice isoforms : SwissVarP47989(Swissvar)
Domaine pattern : Prosite (SRS)2FE2S_FER_1 (PS00197)    2FE2S_FER_2 (PS51085)    FAD_PCMH (PS51387)    MOLYBDOPTERIN_EUK (PS00559)   
Domaine pattern : Prosite (Expaxy)2FE2S_FER_1 (PS00197)    2FE2S_FER_2 (PS51085)    FAD_PCMH (PS51387)    MOLYBDOPTERIN_EUK (PS00559)   
Domains : Interpro (SRS)2Fe-2S-bd    2Fe-2S_ferredoxin-type    2Fe2S_fd_BS    Ald_Oxase/Xan_DH_a/b    Ald_Oxase/xanthine_DH    AldOxase/xan_DH_Mopterin-bd    Beta-grasp_dom    CO_DH_flav_C    CO_DH_flavot_FAD-bd_sub2    FAD-bd_2    FAD-bd_2_sub1    Mopterin_DH_FAD-bd    OxRdtase_Mopterin_BS    Xanthine_DH_ssu   
Domains : Interpro (EBI)2Fe-2S-bd    2Fe-2S_ferredoxin-type    2Fe2S_fd_BS    Ald_Oxase/Xan_DH_a/b    Ald_Oxase/xanthine_DH    AldOxase/xan_DH_Mopterin-bd    Beta-grasp_dom    CO_DH_flav_C    CO_DH_flavot_FAD-bd_sub2    FAD-bd_2    FAD-bd_2_sub1    Mopterin_DH_FAD-bd    OxRdtase_Mopterin_BS    Xanthine_DH_ssu   
Related proteins : CluSTrP47989
Domain families : Pfam (SRS)Ald_Xan_dh_C (PF01315)    Ald_Xan_dh_C2 (PF02738)    CO_deh_flav_C (PF03450)    FAD_binding_5 (PF00941)    Fer2 (PF00111)    Fer2_2 (PF01799)   
Domain families : Pfam (Sanger)Ald_Xan_dh_C (PF01315)    Ald_Xan_dh_C2 (PF02738)    CO_deh_flav_C (PF03450)    FAD_binding_5 (PF00941)    Fer2 (PF00111)    Fer2_2 (PF01799)   
Domain families : Pfam (NCBI)pfam01315    pfam02738    pfam03450    pfam00941    pfam00111    pfam01799   
Domain families : Smart (EMBL)Ald_Xan_dh_C (SM01008)  CO_deh_flav_C (SM01092)  
DMDM7498
Blocks (Seattle)P47989
PDB (SRS)2CKJ    2E1Q   
PDB (PDBSum)2CKJ    2E1Q   
PDB (IMB)2CKJ    2E1Q   
PDB (RSDB)2CKJ    2E1Q   
Human Protein AtlasENSG00000158125
HPRD06363
IPIIPI00244391   IPI00921526   
Protein Interaction databases
DIP (DOE-UCLA)P47989
IntAct (EBI)P47989
FunCoupENSG00000158125
REACTOMEXDH
Protein Interaction Database7498
BioGRIDXDH
InParanoidP47989
Interologous Interaction database P47989
IntegromeDBXDH
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)XDH
SNP (GeneSNP Utah)XDH
SNP : HGBaseXDH
Genetic variants : HAPMAPXDH
Somatic Mutations in Cancer : COSMICXDH 
CONAN: Copy Number AnalysisXDH 
Mutations and Diseases : HGMDXDH
OMIM278300    607633   
GENETests278300    607633   
Disease Genetic AssociationXDH
Huge Navigator XDH [HugePedia]  XDH [HugeCancerGEM]
Genomic VariantsXDH  XDH [DGVbeta]
snp3D : Map Gene to Disease7498
General knowledge
Homologs : HomoloGeneXDH
Homology/Alignments : Family Browser (UCSC)XDH
Phylogenetic Trees/Animal Genes : TreeFamXDH
Catalytic activity : Enzyme1.17.1.4 [ Enzyme-Expasy ]   1.17.1.4 [ Enzyme-SRS ]   1.17.1.4 [ IntEnz-EBI ]   1.17.1.4 [ BRENDA ]   1.17.1.4 [ KEGG ]   
Chemical/Protein Interactions : CTD7498
Chemical/Pharm GKB GenePA37404
Clinical trialXDH
Cancer Resource (Charite)ENSG00000158125
Ontology : AmiGOnegative regulation of protein phosphorylation  negative regulation of endothelial cell proliferation  xanthine dehydrogenase activity  xanthine oxidase activity  xanthine oxidase activity  iron ion binding  extracellular region  peroxisome  cytosol  purine nucleobase metabolic process  purine nucleotide catabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  lactation  UDP-N-acetylmuramate dehydrogenase activity  electron carrier activity  xanthine catabolic process  negative regulation of gene expression  protein homodimerization activity  molybdopterin cofactor binding  small molecule metabolic process  negative regulation of endothelial cell differentiation  flavin adenine dinucleotide binding  2 iron, 2 sulfur cluster binding  negative regulation of protein kinase B signaling cascade  nucleobase-containing small molecule metabolic process  positive regulation of p38MAPK cascade  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of reactive oxygen species metabolic process  negative regulation of vasculogenesis  
Ontology : EGO-EBInegative regulation of protein phosphorylation  negative regulation of endothelial cell proliferation  xanthine dehydrogenase activity  xanthine oxidase activity  xanthine oxidase activity  iron ion binding  extracellular region  peroxisome  cytosol  purine nucleobase metabolic process  purine nucleotide catabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  lactation  UDP-N-acetylmuramate dehydrogenase activity  electron carrier activity  xanthine catabolic process  negative regulation of gene expression  protein homodimerization activity  molybdopterin cofactor binding  small molecule metabolic process  negative regulation of endothelial cell differentiation  flavin adenine dinucleotide binding  2 iron, 2 sulfur cluster binding  negative regulation of protein kinase B signaling cascade  nucleobase-containing small molecule metabolic process  positive regulation of p38MAPK cascade  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of reactive oxygen species metabolic process  negative regulation of vasculogenesis  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]   
Pathways : KEGGPurine metabolism
Other databases
Probes
Litterature
PubMed75 Pubmed reference(s) in Entrez
PubGeneXDH
iHOPXDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:34:16 CEST 2013
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