Atlas of Genetics and Cytogenetics in Oncology and Haematology


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XDH (xanthine dehydrogenase)

Identity

Other namesXO
XOR
HGNC (Hugo) XDH
LocusID (NCBI) 7498
Location 2p23.1
Location_base_pair Starts at 31557188 and ends at 31637611 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)XDH   12805
Cards
Entrez_Gene (NCBI)XDH  7498  xanthine dehydrogenase
GeneCards (Weizmann)XDH
Ensembl (Hinxton)ENSG00000158125 [Gene_View]  chr2:31557188-31637611 [Contig_View]  XDH [Vega]
ICGC DataPortalENSG00000158125
cBioPortalXDH
AceView (NCBI)XDH
Genatlas (Paris)XDH
WikiGenes7498
SOURCE (Princeton)NM_000379
Genomic and cartography
GoldenPath (UCSC)XDH  -  2p23.1   chr2:31557188-31637611 -  2p23.1   [Description]    (hg19-Feb_2009)
EnsemblXDH - 2p23.1 [CytoView]
Mapping of homologs : NCBIXDH [Mapview]
OMIM278300   607633   
Gene and transcription
Genbank (Entrez)AK130114 BC166696 CV574002 D11456 U06117
RefSeq transcript (Entrez)NM_000379
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NG_008871 NT_022184 NW_001838769 NW_004929300
Consensus coding sequences : CCDS (NCBI)XDH
Cluster EST : UnigeneHs.250 [ NCBI ]
CGAP (NCI)Hs.250
Alternative Splicing : Fast-db (Paris)GSHG0017529
Alternative Splicing GalleryENSG00000158125
Gene ExpressionXDH [ NCBI-GEO ]     XDH [ SEEK ]   XDH [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47989 (Uniprot)
NextProtP47989  [Medical]
With graphics : InterProP47989
Splice isoforms : SwissVarP47989 (Swissvar)
Catalytic activity : Enzyme1.17.1.4 [ Enzyme-Expasy ]   1.17.1.41.17.1.4 [ IntEnz-EBI ]   1.17.1.4 [ BRENDA ]   1.17.1.4 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)2FE2S_FER_1 (PS00197)    2FE2S_FER_2 (PS51085)    FAD_PCMH (PS51387)    MOLYBDOPTERIN_EUK (PS00559)   
Domains : Interpro (EBI)2Fe-2S-bd [organisation]   2Fe-2S_ferredoxin-type [organisation]   2Fe2S_fd_BS [organisation]   Ald_Oxase/Xan_DH_a/b [organisation]   Ald_Oxase/xanthine_DH [organisation]   AldOxase/xan_DH_Mopterin-bd [organisation]   Beta-grasp_dom [organisation]   CO_DH_flav_C [organisation]   CO_DH_flavot_FAD-bd_sub2 [organisation]   FAD-bd_2 [organisation]   FAD-bd_2_sub1 [organisation]   Mopterin_DH_FAD-bd [organisation]   OxRdtase_Mopterin_BS [organisation]   Xanthine_DH_ssu [organisation]  
Related proteins : CluSTrP47989
Domain families : Pfam (Sanger)Ald_Xan_dh_C (PF01315)    Ald_Xan_dh_C2 (PF02738)    CO_deh_flav_C (PF03450)    FAD_binding_5 (PF00941)    Fer2 (PF00111)    Fer2_2 (PF01799)   
Domain families : Pfam (NCBI)pfam01315    pfam02738    pfam03450    pfam00941    pfam00111    pfam01799   
Domain families : Smart (EMBL)Ald_Xan_dh_C (SM01008)  CO_deh_flav_C (SM01092)  
DMDM Disease mutations7498
Blocks (Seattle)P47989
PDB (SRS)2CKJ    2E1Q   
PDB (PDBSum)2CKJ    2E1Q   
PDB (IMB)2CKJ    2E1Q   
PDB (RSDB)2CKJ    2E1Q   
Human Protein AtlasENSG00000158125 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP47989
HPRD06363
IPIIPI00244391   IPI00921526   
Protein Interaction databases
DIP (DOE-UCLA)P47989
IntAct (EBI)P47989
FunCoupENSG00000158125
BioGRIDXDH
InParanoidP47989
Interologous Interaction database P47989
IntegromeDBXDH
STRING (EMBL)XDH
Ontologies - Pathways
Ontology : AmiGOnegative regulation of protein phosphorylation  negative regulation of endothelial cell proliferation  xanthine dehydrogenase activity  xanthine oxidase activity  xanthine oxidase activity  iron ion binding  extracellular space  peroxisome  cytosol  purine nucleobase metabolic process  purine nucleotide catabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  lactation  UDP-N-acetylmuramate dehydrogenase activity  electron carrier activity  xanthine catabolic process  negative regulation of gene expression  protein homodimerization activity  molybdopterin cofactor binding  small molecule metabolic process  negative regulation of endothelial cell differentiation  flavin adenine dinucleotide binding  2 iron, 2 sulfur cluster binding  negative regulation of protein kinase B signaling  nucleobase-containing small molecule metabolic process  oxidation-reduction process  positive regulation of p38MAPK cascade  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of reactive oxygen species metabolic process  negative regulation of vasculogenesis  
Ontology : EGO-EBInegative regulation of protein phosphorylation  negative regulation of endothelial cell proliferation  xanthine dehydrogenase activity  xanthine oxidase activity  xanthine oxidase activity  iron ion binding  extracellular space  peroxisome  cytosol  purine nucleobase metabolic process  purine nucleotide catabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  lactation  UDP-N-acetylmuramate dehydrogenase activity  electron carrier activity  xanthine catabolic process  negative regulation of gene expression  protein homodimerization activity  molybdopterin cofactor binding  small molecule metabolic process  negative regulation of endothelial cell differentiation  flavin adenine dinucleotide binding  2 iron, 2 sulfur cluster binding  negative regulation of protein kinase B signaling  nucleobase-containing small molecule metabolic process  oxidation-reduction process  positive regulation of p38MAPK cascade  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of reactive oxygen species metabolic process  negative regulation of vasculogenesis  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]   
Pathways : KEGGPurine metabolism    Caffeine metabolism    Drug metabolism - other enzymes    Peroxisome   
Protein Interaction DatabaseXDH
Wikipedia pathwaysXDH
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)XDH
snp3D : Map Gene to Disease7498
SNP (GeneSNP Utah)XDH
SNP : HGBaseXDH
Genetic variants : HAPMAPXDH
Exome VariantXDH
1000_GenomesXDH 
ICGC programENSG00000158125 
Somatic Mutations in Cancer : COSMICXDH 
CONAN: Copy Number AnalysisXDH 
Mutations and Diseases : HGMDXDH
Genomic VariantsXDH  XDH [DGVbeta]
dbVarXDH
ClinVarXDH
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM278300    607633   
MedgenXDH
GENETestsXDH
Disease Genetic AssociationXDH
Huge Navigator XDH [HugePedia]  XDH [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneXDH
Homology/Alignments : Family Browser (UCSC)XDH
Phylogenetic Trees/Animal Genes : TreeFamXDH
Chemical/Protein Interactions : CTD7498
Chemical/Pharm GKB GenePA37404
Clinical trialXDH
Cancer Resource (Charite)ENSG00000158125
Other databases
Probes
Litterature
PubMed87 Pubmed reference(s) in Entrez
CoreMineXDH
iHOPXDH
OncoSearchXDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 30 14:21:34 CEST 2014

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