XDH (xanthine dehydrogenase)

Identity

Other names	XO
	XOR
HGNC	XDH
Location	2p23.1
Location_base_pair	Starts at 31410692 and ends at 31491115 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

External links

	Nomenclature
HGNC	XDH   12805
Entrez_Gene	XDH  7498  xanthine dehydrogenase
	Cards
GeneCards	XDH
Ensembl	ENSG00000158125 [Gene_View]  XDH [Vega]
Genatlas	XDH
	Genomic and cartography
GoldenPath	XDH  -  2p23.1   chr2:31410692-31491115 -  2p23.1   [Description]    (hg18-March_2006)
Ensembl	XDH - 2p23.1 [CytoView]
NCBI	Mapview
OMIM	278300 Disease map [OMIM]
OMIM	607633 Disease map [OMIM]
HomoloGene	XDH
	Gene and transcription
Genbank	AK130114 [ ENTREZ ]
Genbank	BC166696 [ ENTREZ ]
Genbank	CR614711 [ ENTREZ ]
Genbank	CV574002 [ ENTREZ ]
Genbank	D11456 [ ENTREZ ]
RefSeq	NM_000379 [ SRS ]    NM_000379 [ ENTREZ ]
RefSeq	AC_000045 [ SRS ]    AC_000045 [ ENTREZ ]
RefSeq	AC_000134 [ SRS ]    AC_000134 [ ENTREZ ]
RefSeq	NC_000002 [ SRS ]    NC_000002 [ ENTREZ ]
RefSeq	NT_022184 [ SRS ]    NT_022184 [ ENTREZ ]
RefSeq	NW_001838769 [ SRS ]    NW_001838769 [ ENTREZ ]
RefSeq	NW_927719 [ SRS ]    NW_927719 [ ENTREZ ]
CCDS	XDH CCDS - NCBI
AceView	XDH AceView - NCBI
Unigene	Hs.250 [ SRS ]    Hs.250 [ NCBI ]
	Protein : pattern, domain, 3D structure
SwissProt	P47989 [ SRS]    P47989 [ EXPASY ]     P47989 [ INTERPRO ]     P47989 [ UNIPROT ] P47989 [ VarSplice FASTA ]
Prosite	PS00197 2FE2S_FER_1 [ SRS ]    PS00197 2FE2S_FER_1 [ Expasy ]
Prosite	PS51085 2FE2S_FER_2 [ SRS ]    PS51085 2FE2S_FER_2 [ Expasy ]
Prosite	PS51387 FAD_PCMH [ SRS ]    PS51387 FAD_PCMH [ Expasy ]
Prosite	PS00559 MOLYBDOPTERIN_EUK [ SRS ]    PS00559 MOLYBDOPTERIN_EUK [ Expasy ]
Interpro	IPR002888 2Fe-2S_bd [ SRS ]    IPR002888 2Fe-2S_bd [ EBI ]
Interpro	IPR006058 2Fe2S_fd_BS [ SRS ]    IPR006058 2Fe2S_fd_BS [ EBI ]
Interpro	IPR000674 Ald_Oxase/Xan_DHase_a/b [ SRS ]    IPR000674 Ald_Oxase/Xan_DHase_a/b [ EBI ]
Interpro	IPR016208 Ald_Oxase/xanthine_DHase [ SRS ]    IPR016208 Ald_Oxase/xanthine_DHase [ EBI ]
Interpro	IPR008274 AldOxase/xan_DHase_Mopterin-bd [ SRS ]    IPR008274 AldOxase/xan_DHase_Mopterin-bd [ EBI ]
Interpro	IPR012675 b-grasp_ferredoxin-like [ SRS ]    IPR012675 b-grasp_ferredoxin-like [ EBI ]
Interpro	IPR005107 CO_DHase_flav_C [ SRS ]    IPR005107 CO_DHase_flav_C [ EBI ]
Interpro	IPR016169 CO_DHase_flavot_FAD-bd_sub2 [ SRS ]    IPR016169 CO_DHase_flavot_FAD-bd_sub2 [ EBI ]
Interpro	IPR016167 FAD-bd_2_sub1 [ SRS ]    IPR016167 FAD-bd_2_sub1 [ EBI ]
Interpro	IPR001041 Ferredoxin [ SRS ]    IPR001041 Ferredoxin [ EBI ]
Interpro	IPR002346 Mopterin_DHase_FAD-bd [ SRS ]    IPR002346 Mopterin_DHase_FAD-bd [ EBI ]
Interpro	IPR000572 OxRdtase_Mopterin-bd [ SRS ]    IPR000572 OxRdtase_Mopterin-bd [ EBI ]
Interpro	IPR014309 Xanthine_DHase_Mopterin-bd_su [ SRS ]    IPR014309 Xanthine_DHase_Mopterin-bd_su [ EBI ]
Interpro	IPR014307 Xanthine_DHase_ssu [ SRS ]    IPR014307 Xanthine_DHase_ssu [ EBI ]
CluSTr	P47989
Pfam	PF01315 Ald_Xan_dh_C [ SRS ]    PF01315 Ald_Xan_dh_C [ Sanger ]    pfam01315 [ NCBI-CDD ]
Pfam	PF02738 Ald_Xan_dh_C2 [ SRS ]    PF02738 Ald_Xan_dh_C2 [ Sanger ]    pfam02738 [ NCBI-CDD ]
Pfam	PF03450 CO_deh_flav_C [ SRS ]    PF03450 CO_deh_flav_C [ Sanger ]    pfam03450 [ NCBI-CDD ]
Pfam	PF00941 FAD_binding_5 [ SRS ]    PF00941 FAD_binding_5 [ Sanger ]    pfam00941 [ NCBI-CDD ]
Pfam	PF00111 Fer2 [ SRS ]    PF00111 Fer2 [ Sanger ]    pfam00111 [ NCBI-CDD ]
Pfam	PF01799 Fer2_2 [ SRS ]    PF01799 Fer2_2 [ Sanger ]    pfam01799 [ NCBI-CDD ]
Prodom	PD186071 2Fe-2S_bind[INRA-Toulouse]
Prodom	P47989 XDH_HUMAN [ Domain structure ]   P47989 XDH_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P47989
PDB	2CKJ [ SRS ]    2CKJ [ PdbSum ],   2CKJ [ IMB ]   2CKJ [ RSDB ]
PDB	2E1Q [ SRS ]    2E1Q [ PdbSum ],   2E1Q [ IMB ]   2E1Q [ RSDB ]
HPRD	06363
	Protein Interaction databases
DIP	P47989
IntAct	P47989
	Polymorphism : SNP, mutations, diseases
OMIM	278300    [ map ]
OMIM	607633    [ map ]
GENETests	278300
GENETests	607633
SNP	XDH [dbSNP-NCBI]
SNP	NM_000379 [SNP-NCI]
SNP	XDH [GeneSNPs - Utah]  XDH] [HGBASE - SRS]
HAPMAP	XDH [HAPMAP]
HGMD	XDH
Genetic Association	XDH
CDC HuGE	XDH
	General knowledge
Family Browser	XDH [UCSC Family Browser]
SOURCE	NM_000379
SMD	Hs.250
SAGE	Hs.250
Enzyme	1.17.1.4 [ Enzyme-Expasy ]   1.17.1.4 [ Enzyme-SRS ]   1.17.1.4 [ IntEnz-EBI ]   1.17.1.4 [ BRENDA ]   1.17.1.4 [ KEGG ]
GO	xanthine dehydrogenase activity [Amigo]  xanthine dehydrogenase activity
GO	xanthine oxidase activity [Amigo]  xanthine oxidase activity
GO	xanthine oxidase activity [Amigo]  xanthine oxidase activity
GO	iron ion binding [Amigo]  iron ion binding
GO	peroxisome [Amigo]  peroxisome
GO	cytosol [Amigo]  cytosol
GO	lactation [Amigo]  lactation
GO	electron carrier activity [Amigo]  electron carrier activity
GO	oxidoreductase activity [Amigo]  oxidoreductase activity
GO	molybdenum ion binding [Amigo]  molybdenum ion binding
GO	regulation of epithelial cell differentiation [Amigo]  regulation of epithelial cell differentiation
GO	metal ion binding [Amigo]  metal ion binding
GO	FAD binding [Amigo]  FAD binding
GO	2 iron, 2 sulfur cluster binding [Amigo]  2 iron, 2 sulfur cluster binding
GO	oxidation reduction [Amigo]  oxidation reduction
BIOCARTA	Free Radical Induced Apoptosis    [Genes]
KEGG	Purine metabolism
PubGene	XDH
TreeFam	XDH
CTD	7498 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	XDH Related clones (RZPD - Berlin)
	PubMed
PubMed	33 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:19:31 2008