Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

XDH (xanthine dehydrogenase)

Identity

Alias_namesxanthene dehydrogenase
Alias_symbol (synonym)XOR
XO
HGNC (Hugo) XDH
LocusID (NCBI) 7498
Atlas_Id 50157
Location 2p23.1  [Link to chromosome band 2p23]
Location_base_pair Starts at 31557188 and ends at 31637611 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
XDH (2p23.1) / LOC146880 (17q24.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)XDH   12805
Cards
Entrez_Gene (NCBI)XDH  7498  xanthine dehydrogenase
AliasesXO; XOR
GeneCards (Weizmann)XDH
Ensembl hg19 (Hinxton)ENSG00000158125 [Gene_View]  chr2:31557188-31637611 [Contig_View]  XDH [Vega]
Ensembl hg38 (Hinxton)ENSG00000158125 [Gene_View]  chr2:31557188-31637611 [Contig_View]  XDH [Vega]
ICGC DataPortalENSG00000158125
TCGA cBioPortalXDH
AceView (NCBI)XDH
Genatlas (Paris)XDH
WikiGenes7498
SOURCE (Princeton)XDH
Genetics Home Reference (NIH)XDH
Genomic and cartography
GoldenPath hg19 (UCSC)XDH  -     chr2:31557188-31637611 -  2p23.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)XDH  -     2p23.1   [Description]    (hg38-Dec_2013)
EnsemblXDH - 2p23.1 [CytoView hg19]  XDH - 2p23.1 [CytoView hg38]
Mapping of homologs : NCBIXDH [Mapview hg19]  XDH [Mapview hg38]
OMIM278300   607633   
Gene and transcription
Genbank (Entrez)AK130114 BC166696 CV574002 D11456 U06117
RefSeq transcript (Entrez)NM_000379
RefSeq genomic (Entrez)NC_000002 NC_018913 NG_008871 NT_022184 NW_004929300
Consensus coding sequences : CCDS (NCBI)XDH
Cluster EST : UnigeneHs.250 [ NCBI ]
CGAP (NCI)Hs.250
Alternative Splicing GalleryENSG00000158125
Gene ExpressionXDH [ NCBI-GEO ]   XDH [ EBI - ARRAY_EXPRESS ]   XDH [ SEEK ]   XDH [ MEM ]
Gene Expression Viewer (FireBrowse)XDH [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7498
GTEX Portal (Tissue expression)XDH
Protein : pattern, domain, 3D structure
UniProt/SwissProtP47989   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP47989  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP47989
Splice isoforms : SwissVarP47989
Catalytic activity : Enzyme1.17.1.4 [ Enzyme-Expasy ]   1.17.1.41.17.1.4 [ IntEnz-EBI ]   1.17.1.4 [ BRENDA ]   1.17.1.4 [ KEGG ]   
PhosPhoSitePlusP47989
Domaine pattern : Prosite (Expaxy)2FE2S_FER_1 (PS00197)    2FE2S_FER_2 (PS51085)    FAD_PCMH (PS51387)    MOLYBDOPTERIN_EUK (PS00559)   
Domains : Interpro (EBI)2Fe-2S-bd    2Fe-2S_ferredoxin-type    2Fe2S_fd_BS    Ald_Oxase/Xan_DH_a/b    Ald_Oxase/xanthine_DH    AldOxase/xan_DH_Mopterin-bd    Beta-grasp_dom    CO_DH_flav_C    CO_DH_flavot_FAD-bd_sub2    FAD-bd_2    FAD-bd_2_sub1    Mopterin_DH_FAD-bd    OxRdtase_Mopterin_BS    Xanthine_DH_ssu   
Domain families : Pfam (Sanger)Ald_Xan_dh_C (PF01315)    Ald_Xan_dh_C2 (PF02738)    CO_deh_flav_C (PF03450)    FAD_binding_5 (PF00941)    Fer2 (PF00111)    Fer2_2 (PF01799)   
Domain families : Pfam (NCBI)pfam01315    pfam02738    pfam03450    pfam00941    pfam00111    pfam01799   
Domain families : Smart (EMBL)Ald_Xan_dh_C (SM01008)  CO_deh_flav_C (SM01092)  
Conserved Domain (NCBI)XDH
DMDM Disease mutations7498
Blocks (Seattle)XDH
PDB (SRS)2CKJ    2E1Q   
PDB (PDBSum)2CKJ    2E1Q   
PDB (IMB)2CKJ    2E1Q   
PDB (RSDB)2CKJ    2E1Q   
Structural Biology KnowledgeBase2CKJ    2E1Q   
SCOP (Structural Classification of Proteins)2CKJ    2E1Q   
CATH (Classification of proteins structures)2CKJ    2E1Q   
SuperfamilyP47989
Human Protein AtlasENSG00000158125
Peptide AtlasP47989
HPRD06363
IPIIPI00244391   IPI00921526   
Protein Interaction databases
DIP (DOE-UCLA)P47989
IntAct (EBI)P47989
FunCoupENSG00000158125
BioGRIDXDH
STRING (EMBL)XDH
ZODIACXDH
Ontologies - Pathways
QuickGOP47989
Ontology : AmiGOnegative regulation of protein phosphorylation  negative regulation of endothelial cell proliferation  xanthine dehydrogenase activity  xanthine oxidase activity  xanthine oxidase activity  iron ion binding  extracellular space  peroxisome  cytosol  cytosol  purine nucleotide catabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  lactation  electron carrier activity  xanthine catabolic process  negative regulation of gene expression  sarcoplasmic reticulum  oxidoreductase activity, acting on CH-OH group of donors  oxidoreductase activity, acting on the aldehyde or oxo group of donors  protein homodimerization activity  molybdopterin cofactor binding  negative regulation of endothelial cell differentiation  flavin adenine dinucleotide binding  2 iron, 2 sulfur cluster binding  negative regulation of protein kinase B signaling  oxidation-reduction process  positive regulation of p38MAPK cascade  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of reactive oxygen species metabolic process  negative regulation of vasculogenesis  
Ontology : EGO-EBInegative regulation of protein phosphorylation  negative regulation of endothelial cell proliferation  xanthine dehydrogenase activity  xanthine oxidase activity  xanthine oxidase activity  iron ion binding  extracellular space  peroxisome  cytosol  cytosol  purine nucleotide catabolic process  activation of cysteine-type endopeptidase activity involved in apoptotic process  lactation  electron carrier activity  xanthine catabolic process  negative regulation of gene expression  sarcoplasmic reticulum  oxidoreductase activity, acting on CH-OH group of donors  oxidoreductase activity, acting on the aldehyde or oxo group of donors  protein homodimerization activity  molybdopterin cofactor binding  negative regulation of endothelial cell differentiation  flavin adenine dinucleotide binding  2 iron, 2 sulfur cluster binding  negative regulation of protein kinase B signaling  oxidation-reduction process  positive regulation of p38MAPK cascade  negative regulation of vascular endothelial growth factor signaling pathway  positive regulation of reactive oxygen species metabolic process  negative regulation of vasculogenesis  
Pathways : BIOCARTAFree Radical Induced Apoptosis [Genes]   
Pathways : KEGGPurine metabolism    Caffeine metabolism    Drug metabolism - other enzymes    Peroxisome   
NDEx NetworkXDH
Atlas of Cancer Signalling NetworkXDH
Wikipedia pathwaysXDH
Orthology - Evolution
OrthoDB7498
GeneTree (enSembl)ENSG00000158125
Phylogenetic Trees/Animal Genes : TreeFamXDH
HOVERGENP47989
HOGENOMP47989
Homologs : HomoloGeneXDH
Homology/Alignments : Family Browser (UCSC)XDH
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerXDH [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)XDH
dbVarXDH
ClinVarXDH
1000_GenomesXDH 
Exome Variant ServerXDH
ExAC (Exome Aggregation Consortium)XDH (select the gene name)
Genetic variants : HAPMAP7498
Genomic Variants (DGV)XDH [DGVbeta]
DECIPHER (Syndromes)2:31557188-31637611  ENSG00000158125
CONAN: Copy Number AnalysisXDH 
Mutations
ICGC Data PortalXDH 
TCGA Data PortalXDH 
Broad Tumor PortalXDH
OASIS PortalXDH [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICXDH  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDXDH
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch XDH
DgiDB (Drug Gene Interaction Database)XDH
DoCM (Curated mutations)XDH (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)XDH (select a term)
intoGenXDH
Cancer3DXDH(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM278300    607633   
Orphanet12434   
MedgenXDH
Genetic Testing Registry XDH
NextProtP47989 [Medical]
TSGene7498
GENETestsXDH
Huge Navigator XDH [HugePedia]
snp3D : Map Gene to Disease7498
BioCentury BCIQXDH
ClinGenXDH
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7498
Chemical/Pharm GKB GenePA37404
Clinical trialXDH
Miscellaneous
canSAR (ICR)XDH (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineXDH
EVEXXDH
GoPubMedXDH
iHOPXDH
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:55:56 CET 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.