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XRCC1 (X-ray repair complementing defective repair in Chinese hamster cells 1)

Identity

Other namesRCC
HGNC (Hugo) XRCC1
LocusID (NCBI) 7515
Atlas_Id 42847
Location 19q13.31
Location_base_pair Starts at 44047464 and ends at 44079730 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CEP295 (11q21) / XRCC1 (19q13.31)LLGL2 (17q25.1) / XRCC1 (19q13.31)URI1 (19q12) / XRCC1 (19q13.31)
XRCC1 (19q13.31) / MAL (2q11.1)C19orf2 XRCC1 19q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)XRCC1   12828
Cards
Entrez_Gene (NCBI)XRCC1  7515  X-ray repair complementing defective repair in Chinese hamster cells 1
GeneCards (Weizmann)XRCC1
Ensembl hg19 (Hinxton)ENSG00000073050 [Gene_View]  chr19:44047464-44079730 [Contig_View]  XRCC1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000073050 [Gene_View]  chr19:44047464-44079730 [Contig_View]  XRCC1 [Vega]
ICGC DataPortalENSG00000073050
TCGA cBioPortalXRCC1
AceView (NCBI)XRCC1
Genatlas (Paris)XRCC1
WikiGenes7515
SOURCE (Princeton)XRCC1
Genomic and cartography
GoldenPath hg19 (UCSC)XRCC1  -     chr19:44047464-44079730 -  19q13.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)XRCC1  -     19q13.31   [Description]    (hg38-Dec_2013)
EnsemblXRCC1 - 19q13.31 [CytoView hg19]  XRCC1 - 19q13.31 [CytoView hg38]
Mapping of homologs : NCBIXRCC1 [Mapview hg19]  XRCC1 [Mapview hg38]
OMIM194360   
Gene and transcription
Genbank (Entrez)AB208781 AK293542 AK300163 AK315332 BC023593
RefSeq transcript (Entrez)NM_006297
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_033799 NT_011109 NW_004929415
Consensus coding sequences : CCDS (NCBI)XRCC1
Cluster EST : UnigeneHs.98493 [ NCBI ]
CGAP (NCI)Hs.98493
Alternative Splicing : Fast-db (Paris)GSHG0015880
Alternative Splicing GalleryENSG00000073050
Gene ExpressionXRCC1 [ NCBI-GEO ]   XRCC1 [ EBI - ARRAY_EXPRESS ]   XRCC1 [ SEEK ]   XRCC1 [ MEM ]
Gene Expression Viewer (FireBrowse)XRCC1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)7515
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18887 (Uniprot)
NextProtP18887  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP18887
Splice isoforms : SwissVarP18887 (Swissvar)
PhosPhoSitePlusP18887
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)   
Domains : Interpro (EBI)BRCT_dom    Galactose-bd-like    Xrcc1_N   
Domain families : Pfam (Sanger)BRCT (PF00533)    BRCT_2 (PF16589)    XRCC1_N (PF01834)   
Domain families : Pfam (NCBI)pfam00533    pfam16589    pfam01834   
Domain families : Smart (EMBL)BRCT (SM00292)  
DMDM Disease mutations7515
Blocks (Seattle)XRCC1
PDB (SRS)1CDZ    1XNA    1XNT    2D8M    2W3O    3K75    3K77    3LQC    5E6Q   
PDB (PDBSum)1CDZ    1XNA    1XNT    2D8M    2W3O    3K75    3K77    3LQC    5E6Q   
PDB (IMB)1CDZ    1XNA    1XNT    2D8M    2W3O    3K75    3K77    3LQC    5E6Q   
PDB (RSDB)1CDZ    1XNA    1XNT    2D8M    2W3O    3K75    3K77    3LQC    5E6Q   
Structural Biology KnowledgeBase1CDZ    1XNA    1XNT    2D8M    2W3O    3K75    3K77    3LQC    5E6Q   
SCOP (Structural Classification of Proteins)1CDZ    1XNA    1XNT    2D8M    2W3O    3K75    3K77    3LQC    5E6Q   
CATH (Classification of proteins structures)1CDZ    1XNA    1XNT    2D8M    2W3O    3K75    3K77    3LQC    5E6Q   
SuperfamilyP18887
Human Protein AtlasENSG00000073050
Peptide AtlasP18887
HPRD01909
IPIIPI00002564   IPI01010850   IPI00911037   IPI01010437   
Protein Interaction databases
DIP (DOE-UCLA)P18887
IntAct (EBI)P18887
FunCoupENSG00000073050
BioGRIDXRCC1
STRING (EMBL)XRCC1
ZODIACXRCC1
Ontologies - Pathways
QuickGOP18887
Ontology : AmiGOsingle strand break repair  double-strand break repair via homologous recombination  response to hypoxia  damaged DNA binding  DNA ligase activity  protein binding  nucleus  nucleoplasm  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair, DNA ligation  nucleotide-excision repair, DNA gap filling  response to organic substance  enzyme binding  response to drug  
Ontology : EGO-EBIsingle strand break repair  double-strand break repair via homologous recombination  response to hypoxia  damaged DNA binding  DNA ligase activity  protein binding  nucleus  nucleoplasm  transcription-coupled nucleotide-excision repair  base-excision repair  base-excision repair, DNA ligation  nucleotide-excision repair, DNA gap filling  response to organic substance  enzyme binding  response to drug  
Pathways : KEGGBase excision repair   
NDEx Network
Atlas of Cancer Signalling NetworkXRCC1
Wikipedia pathwaysXRCC1
Orthology - Evolution
OrthoDB7515
GeneTree (enSembl)ENSG00000073050
Phylogenetic Trees/Animal Genes : TreeFamXRCC1
Homologs : HomoloGeneXRCC1
Homology/Alignments : Family Browser (UCSC)XRCC1
Gene fusions - Rearrangements
Fusion: TCGAC19orf2 XRCC1 19q13.31 OV
Polymorphisms : SNP, variants
NCBI Variation ViewerXRCC1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)XRCC1
dbVarXRCC1
ClinVarXRCC1
1000_GenomesXRCC1 
Exome Variant ServerXRCC1
ExAC (Exome Aggregation Consortium)XRCC1 (select the gene name)
SNP (GeneSNP Utah)XRCC1
SNP : HGBaseXRCC1
Genetic variants : HAPMAPXRCC1
Genomic Variants (DGV)XRCC1 [DGVbeta]
Mutations
ICGC Data PortalXRCC1 
TCGA Data PortalXRCC1 
Broad Tumor PortalXRCC1
OASIS PortalXRCC1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICXRCC1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch XRCC1
DgiDB (Drug Gene Interaction Database)XRCC1
DoCM (Curated mutations)XRCC1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)XRCC1 (select a term)
intoGenXRCC1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:44047464-44079730
CONAN: Copy Number AnalysisXRCC1 
Mutations and Diseases : HGMDXRCC1
OMIM194360   
MedgenXRCC1
Genetic Testing Registry XRCC1
NextProtP18887 [Medical]
TSGene7515
GENETestsXRCC1
Huge Navigator XRCC1 [HugePedia]  XRCC1 [HugeCancerGEM]
snp3D : Map Gene to Disease7515
BioCentury BCIQXRCC1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7515
Chemical/Pharm GKB GenePA369
Clinical trialXRCC1
Miscellaneous
canSAR (ICR)XRCC1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineXRCC1
GoPubMedXRCC1
iHOPXRCC1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Sat Apr 16 18:10:14 CEST 2016

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