Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 7515
MIM: 194360
HGNC: 12828
Ensembl: ENSG00000073050
Variants:
dbSNP: 7515
ClinVar: 7515
TCGA: ENSG00000073050
COSMIC: XRCC1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA128406956 | fluorouracil | Chemical | ClinicalAnnotation | associated | PD | 23314736 | |
| PA164713176 | Platinum compounds | Chemical | ClinicalAnnotation | associated | PD | 16875718, 19362955, 19786980, 21057378, 22026922, 22188361, 22821704, 24224851, 24446315, 27636246, 29662106 | |
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 22188361, 22821704, 24446315, 29662106 | |
| PA443685 | Uterine Cervical Neoplasms | Disease | ClinicalAnnotation | associated | PD | 23314736 | |
| PA443756 | Colonic Neoplasms | Disease | ClinicalAnnotation | associated | PD | 23314736 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PD | 16875718, 19362955, 19786980, 21057378, 22026922, 22188361, 23314736, 24224851, 24446315, 27636246, 29662106 | |
| PA445204 | Ovarian Neoplasms | Disease | ClinicalAnnotation | associated | PD | 19786980, 22188361 | |
| PA445503 | Rectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 23314736 | |
| PA446108 | Colorectal Neoplasms | Disease | ClinicalAnnotation | associated | PD | 23314736 | |
| PA449165 | cyclophosphamide | Chemical | ClinicalAnnotation | associated | PD | 19786980, 22188361 | |
| PA449412 | doxorubicin | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38135179 | 2024 | Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway. | 1 |
| 38217545 | 2024 | XRCC1: a potential prognostic and immunological biomarker in LGG based on systematic pan-cancer analysis. | 0 |
| 38337001 | 2024 | Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer. | 0 |
| 38898405 | 2024 | Association of XRCC1 p. Arg194Trp gene polymorphism with the risk of hepatocellular carcinoma in HCV Egyptian population: A pilot case-control study. | 0 |
| 38135179 | 2024 | Impact of polβ/XRCC1 Interaction Variants on the Efficiency of Nick Sealing by DNA Ligase IIIα in the Base Excision Repair Pathway. | 1 |
| 38217545 | 2024 | XRCC1: a potential prognostic and immunological biomarker in LGG based on systematic pan-cancer analysis. | 0 |
| 38337001 | 2024 | Correlations of SDF-1ɑ and XRCC1 gene polymorphisms with the risk of renal cancer development and bioinformatics studies of SDF-1α and XRCC1 and the prognosis of renal cancer. | 0 |
| 38898405 | 2024 | Association of XRCC1 p. Arg194Trp gene polymorphism with the risk of hepatocellular carcinoma in HCV Egyptian population: A pilot case-control study. | 0 |
| 36195778 | 2023 | Elucidation of Increased Cervical Cancer Risk Due to Polymorphisms in XRCC1 (R399Q and R194W), ERCC5 (D1104H), and NQO1 (P187S). | 2 |
| 36573562 | 2023 | The XRCC1 Arg194Trp polymorphism was associated with the risk of head and neck squamous cell carcinoma development: Results from a systematic review and meta-analysis. | 1 |
| 36853312 | 2023 | The Relationship between Gene Polymorphisms od the XRCC1 and TP53 with the Gender of Children with Acute Leukemia. | 1 |
| 37247289 | 2023 | Effect of XRCC1 Arg399Gln Gene Polymorphism on Survival in Lymphoblastic Leukemia. | 1 |
| 37522793 | 2023 | Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with Risk of Breast Cancer. | 0 |
| 37678329 | 2023 | Association Between the XRCC1, GSTM1, and GSTT1 Polymorphisms in Model of Thyroid Cancer: A Meta-Analysis. | 1 |
| 37774058 | 2023 | Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study. | 2 |
Citation
Dessen P
XRCC1 (X-ray repair cross complementing 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/42847/xrcc1
