Atlas of Genetics and Cytogenetics in Oncology and Haematology

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YES1 (YES proto-oncogene 1, Src family tyrosine kinase)

Identity

Alias_namesv-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
Alias_symbol (synonym)Yes
c-yes
HsT441
Other aliasP61-YES
HGNC (Hugo) YES1
LocusID (NCBI) 7525
Atlas_Id 42856
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 721592 and ends at 812326 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
YES1 (18p11.32) / DAGLB (7p22.1)YES1 (18p11.32) / ENOSF1 (18p11.32)YES1 (18p11.32) / SETD3 (14q32.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(18)(p11p11) YES1/ENOSF1

External links

Nomenclature
HGNC (Hugo)YES1   12841
Cards
Entrez_Gene (NCBI)YES1  7525  YES proto-oncogene 1, Src family tyrosine kinase
AliasesHsT441; P61-YES; Yes; c-yes
GeneCards (Weizmann)YES1
Ensembl hg19 (Hinxton)ENSG00000176105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176105 [Gene_View]  ENSG00000176105 [Sequence]  chr18:721592-812326 [Contig_View]  YES1 [Vega]
ICGC DataPortalENSG00000176105
TCGA cBioPortalYES1
AceView (NCBI)YES1
Genatlas (Paris)YES1
WikiGenes7525
SOURCE (Princeton)YES1
Genetics Home Reference (NIH)YES1
Genomic and cartography
GoldenPath hg38 (UCSC)YES1  -     chr18:721592-812326 -  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YES1  -     18p11.32   [Description]    (hg19-Feb_2009)
EnsemblYES1 - 18p11.32 [CytoView hg19]  YES1 - 18p11.32 [CytoView hg38]
Mapping of homologs : NCBIYES1 [Mapview hg19]  YES1 [Mapview hg38]
OMIM164880   
Gene and transcription
Genbank (Entrez)AK314063 AU123956 BC031080 BC048960 BM969640
RefSeq transcript (Entrez)NM_005433
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)YES1
Cluster EST : UnigeneHs.194148 [ NCBI ]
CGAP (NCI)Hs.194148
Alternative Splicing GalleryENSG00000176105
Gene ExpressionYES1 [ NCBI-GEO ]   YES1 [ EBI - ARRAY_EXPRESS ]   YES1 [ SEEK ]   YES1 [ MEM ]
Gene Expression Viewer (FireBrowse)YES1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7525
GTEX Portal (Tissue expression)YES1
Human Protein AtlasENSG00000176105-YES1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07947
Splice isoforms : SwissVarP07947
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   
PhosPhoSitePlusP07947
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom    Yes_SH3   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)YES1
DMDM Disease mutations7525
Blocks (Seattle)YES1
PDB (SRS)2HDA   
PDB (PDBSum)2HDA   
PDB (IMB)2HDA   
PDB (RSDB)2HDA   
Structural Biology KnowledgeBase2HDA   
SCOP (Structural Classification of Proteins)2HDA   
CATH (Classification of proteins structures)2HDA   
SuperfamilyP07947
Human Protein Atlas [tissue]ENSG00000176105-YES1 [tissue]
Peptide AtlasP07947
HPRD01285
IPIIPI00013981   
Protein Interaction databases
DIP (DOE-UCLA)P07947
IntAct (EBI)P07947
FunCoupENSG00000176105
BioGRIDYES1
STRING (EMBL)YES1
ZODIACYES1
Ontologies - Pathways
QuickGOP07947
Ontology : AmiGOphosphotyrosine residue binding  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  Golgi apparatus  microtubule organizing center  cytosol  cytosol  actin filament  plasma membrane  focal adhesion  cellular protein modification process  transmembrane receptor protein tyrosine kinase signaling pathway  regulation of glucose transmembrane transport  enzyme binding  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  cellular response to platelet-derived growth factor stimulus  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of vascular permeability  ion channel binding  positive regulation of transcription by RNA polymerase II  ephrin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  extracellular exosome  cellular response to retinoic acid  cellular response to transforming growth factor beta stimulus  glutamatergic synapse  postsynaptic specialization, intracellular component  
Ontology : EGO-EBIphosphotyrosine residue binding  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  epidermal growth factor receptor binding  protein binding  ATP binding  Golgi apparatus  microtubule organizing center  cytosol  cytosol  actin filament  plasma membrane  focal adhesion  cellular protein modification process  transmembrane receptor protein tyrosine kinase signaling pathway  regulation of glucose transmembrane transport  enzyme binding  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  cellular response to platelet-derived growth factor stimulus  peptidyl-tyrosine autophosphorylation  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of vascular permeability  ion channel binding  positive regulation of transcription by RNA polymerase II  ephrin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  extracellular exosome  cellular response to retinoic acid  cellular response to transforming growth factor beta stimulus  glutamatergic synapse  postsynaptic specialization, intracellular component  
Pathways : KEGGAdherens junction    Tight junction   
NDEx NetworkYES1
Atlas of Cancer Signalling NetworkYES1
Wikipedia pathwaysYES1
Orthology - Evolution
OrthoDB7525
GeneTree (enSembl)ENSG00000176105
Phylogenetic Trees/Animal Genes : TreeFamYES1
HOVERGENP07947
HOGENOMP07947
Homologs : HomoloGeneYES1
Homology/Alignments : Family Browser (UCSC)YES1
Gene fusions - Rearrangements
Fusion : MitelmanYES1/ENOSF1 [18p11.32/18p11.32]  
Fusion : QuiverYES1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYES1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YES1
dbVarYES1
ClinVarYES1
1000_GenomesYES1 
Exome Variant ServerYES1
ExAC (Exome Aggregation Consortium)ENSG00000176105
GNOMAD BrowserENSG00000176105
Varsome BrowserYES1
Genetic variants : HAPMAP7525
Genomic Variants (DGV)YES1 [DGVbeta]
DECIPHERYES1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYES1 
Mutations
ICGC Data PortalYES1 
TCGA Data PortalYES1 
Broad Tumor PortalYES1
OASIS PortalYES1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYES1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDYES1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch YES1
DgiDB (Drug Gene Interaction Database)YES1
DoCM (Curated mutations)YES1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)YES1 (select a term)
intoGenYES1
Cancer3DYES1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164880   
Orphanet
DisGeNETYES1
MedgenYES1
Genetic Testing Registry YES1
NextProtP07947 [Medical]
TSGene7525
GENETestsYES1
Target ValidationYES1
Huge Navigator YES1 [HugePedia]
snp3D : Map Gene to Disease7525
BioCentury BCIQYES1
ClinGenYES1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7525
Chemical/Pharm GKB GenePA37432
Clinical trialYES1
Miscellaneous
canSAR (ICR)YES1 (select the gene name)
Probes
Litterature
PubMed155 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineYES1
EVEXYES1
GoPubMedYES1
iHOPYES1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:50:31 CET 2018
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