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YES1 (YES proto-oncogene 1, Src family tyrosine kinase)

Identity

Alias (NCBI)HsT441
P61-YES
Yes
c-yes
HGNC (Hugo) YES1
HGNC Alias symbYes
c-yes
HsT441
HGNC Previous namev-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
LocusID (NCBI) 7525
Atlas_Id 42856
Location 18p11.32  [Link to chromosome band 18p11]
Location_base_pair Starts at 721588 and ends at 812242 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
YES1 (18p11.32)::DAGLB (7p22.1)YES1 (18p11.32)::ENOSF1 (18p11.32)YES1 (18p11.32)::SETD3 (14q32.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dup(18)(p11p11) YES1::ENOSF1

External links

 

Nomenclature
HGNC (Hugo)YES1   12841
Cards
Entrez_Gene (NCBI)YES1    YES proto-oncogene 1, Src family tyrosine kinase
AliasesHsT441; P61-YES; Yes; c-yes
GeneCards (Weizmann)YES1
Ensembl hg19 (Hinxton)ENSG00000176105 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000176105 [Gene_View]  ENSG00000176105 [Sequence]  chr18:721588-812242 [Contig_View]  YES1 [Vega]
ICGC DataPortalENSG00000176105
TCGA cBioPortalYES1
AceView (NCBI)YES1
Genatlas (Paris)YES1
SOURCE (Princeton)YES1
Genetics Home Reference (NIH)YES1
Genomic and cartography
GoldenPath hg38 (UCSC)YES1  -     chr18:721588-812242 -  18p11.32   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)YES1  -     18p11.32   [Description]    (hg19-Feb_2009)
GoldenPathYES1 - 18p11.32 [CytoView hg19]  YES1 - 18p11.32 [CytoView hg38]
ImmunoBaseENSG00000176105
Genome Data Viewer NCBIYES1 [Mapview hg19]  
OMIM164880   
Gene and transcription
Genbank (Entrez)AK314063 AU123956 BC031080 BC048960 BM969640
RefSeq transcript (Entrez)NM_005433
Consensus coding sequences : CCDS (NCBI)YES1
Gene ExpressionYES1 [ NCBI-GEO ]   YES1 [ EBI - ARRAY_EXPRESS ]   YES1 [ SEEK ]   YES1 [ MEM ]
Gene Expression Viewer (FireBrowse)YES1 [ Firebrowse - Broad ]
GenevisibleExpression of YES1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7525
GTEX Portal (Tissue expression)YES1
Human Protein AtlasENSG00000176105-YES1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP07947   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP07947  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP07947
Catalytic activity : Enzyme2.7.10.2 [ Enzyme-Expasy ]   2.7.10.22.7.10.2 [ IntEnz-EBI ]   2.7.10.2 [ BRENDA ]   2.7.10.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP07947
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_TYR (PS00109)    SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    SH2    SH2_dom_sf    SH3-like_dom_sf    SH3_domain    Tyr_kinase_AS    Tyr_kinase_cat_dom    Yes_SH3   
Domain families : Pfam (Sanger)PK_Tyr_Ser-Thr (PF07714)    SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam07714    pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)YES1
PDB (RSDB)2HDA   
PDB Europe2HDA   
PDB (PDBSum)2HDA   
PDB (IMB)2HDA   
Structural Biology KnowledgeBase2HDA   
SCOP (Structural Classification of Proteins)2HDA   
CATH (Classification of proteins structures)2HDA   
SuperfamilyP07947
AlphaFold pdb e-kbP07947   
Human Protein Atlas [tissue]ENSG00000176105-YES1 [tissue]
HPRD01285
Protein Interaction databases
DIP (DOE-UCLA)P07947
IntAct (EBI)P07947
BioGRIDYES1
STRING (EMBL)YES1
ZODIACYES1
Ontologies - Pathways
QuickGOP07947
Ontology : AmiGOphosphotyrosine residue binding  negative regulation of inflammatory response to antigenic stimulus  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  Golgi apparatus  microtubule organizing center  cytosol  cytosol  actin filament  plasma membrane  focal adhesion  cellular protein modification process  transmembrane receptor protein tyrosine kinase signaling pathway  regulation of glucose transmembrane transport  peptidyl-tyrosine phosphorylation  enzyme binding  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  cellular response to platelet-derived growth factor stimulus  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of vascular permeability  transmembrane transporter binding  innate immune response  positive regulation of transcription by RNA polymerase II  ephrin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  extracellular exosome  cellular response to retinoic acid  cellular response to transforming growth factor beta stimulus  
Ontology : EGO-EBIphosphotyrosine residue binding  negative regulation of inflammatory response to antigenic stimulus  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  non-membrane spanning protein tyrosine kinase activity  signaling receptor binding  protein binding  ATP binding  Golgi apparatus  microtubule organizing center  cytosol  cytosol  actin filament  plasma membrane  focal adhesion  cellular protein modification process  transmembrane receptor protein tyrosine kinase signaling pathway  regulation of glucose transmembrane transport  peptidyl-tyrosine phosphorylation  enzyme binding  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  cellular response to platelet-derived growth factor stimulus  Fc-gamma receptor signaling pathway involved in phagocytosis  regulation of vascular permeability  transmembrane transporter binding  innate immune response  positive regulation of transcription by RNA polymerase II  ephrin receptor signaling pathway  positive regulation of peptidyl-tyrosine phosphorylation  leukocyte migration  extracellular exosome  cellular response to retinoic acid  cellular response to transforming growth factor beta stimulus  
Pathways : KEGGKEGG_ADHERENS_JUNCTION    KEGG_TIGHT_JUNCTION   
NDEx NetworkYES1
Atlas of Cancer Signalling NetworkYES1
Wikipedia pathwaysYES1
Orthology - Evolution
OrthoDB7525
GeneTree (enSembl)ENSG00000176105
Phylogenetic Trees/Animal Genes : TreeFamYES1
Homologs : HomoloGeneYES1
Homology/Alignments : Family Browser (UCSC)YES1
Gene fusions - Rearrangements
Fusion : MitelmanYES1::ENOSF1 [18p11.32/18p11.32]  
Fusion : QuiverYES1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerYES1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)YES1
dbVarYES1
ClinVarYES1
MonarchYES1
1000_GenomesYES1 
Exome Variant ServerYES1
GNOMAD BrowserENSG00000176105
Varsome BrowserYES1
ACMGYES1 variants
VarityP07947
Genomic Variants (DGV)YES1 [DGVbeta]
DECIPHERYES1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisYES1 
Mutations
ICGC Data PortalYES1 
TCGA Data PortalYES1 
Broad Tumor PortalYES1
OASIS PortalYES1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICYES1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DYES1
Mutations and Diseases : HGMDYES1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaYES1
DgiDB (Drug Gene Interaction Database)YES1
DoCM (Curated mutations)YES1
CIViC (Clinical Interpretations of Variants in Cancer)YES1
Cancer3DYES1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM164880   
Orphanet
DisGeNETYES1
MedgenYES1
Genetic Testing Registry YES1
NextProtP07947 [Medical]
GENETestsYES1
Target ValidationYES1
Huge Navigator YES1 [HugePedia]
ClinGenYES1
Clinical trials, drugs, therapy
MyCancerGenomeYES1
Protein Interactions : CTDYES1
Pharm GKB GenePA37432
PharosP07947
Clinical trialYES1
Miscellaneous
canSAR (ICR)YES1
HarmonizomeYES1
ARCHS4YES1
DataMed IndexYES1
Probes
Litterature
PubMed193 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXYES1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 13:06:51 CET 2022
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