ZBP1 (Z-DNA binding protein 1)

2009-10-01  

Identity

HGNC
LOCATION
20q13.31
LOCUSID
ALIAS
C20orf183,DAI,DLM-1,DLM1
FUSION GENES

Other Information

Locus ID:

NCBI: 81030
MIM: 606750
HGNC: 16176
Ensembl: ENSG00000124256

Variants:

dbSNP: 81030
ClinVar: 81030
TCGA: ENSG00000124256
COSMIC: ZBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124256ENST00000371173Q9H171
ENSG00000124256ENST00000395822Q9H171
ENSG00000124256ENST00000453793H0Y6D1
ENSG00000124256ENST00000541799Q9H171

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Cytosolic DNA-sensing pathwayKEGGko04623
Cytosolic DNA-sensing pathwayKEGGhsa04623
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
ZBP1(DAI) mediated induction of type I IFNsREACTOMER-HSA-1606322
IRF3 mediated activation of type 1 IFNREACTOMER-HSA-1606341
RIP-mediated NFkB activation via ZBP1REACTOMER-HSA-1810476
Regulation of innate immune responses to cytosolic DNAREACTOMER-HSA-3134975

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
198465112010Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.87
189412332008Receptor-interacting protein homotypic interaction motif-dependent control of NF-kappa B activation via the DNA-dependent activator of IFN regulatory factors.76
187715592008IFNbeta responses induced by intracellular bacteria or cytosolic DNA in different human cells do not require ZBP1 (DLM-1/DAI).36
190958002008The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
194610762009Blocking beta-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells.23
292366732018ZBP1: Innate Sensor Regulating Cell Death and Inflammation.20
221143172012The zipcode-binding protein ZBP1 influences the subcellular location of the Ro 60-kDa autoantigen and the noncoding Y3 RNA.19
295812562018PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors.19
232839622013DNA sensing-independent inhibition of herpes simplex virus 1 replication by DAI/ZBP1.18

Citation

Dessen P

ZBP1 (Z-DNA binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51169/zbp1