Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZBTB2 (zinc finger and BTB domain containing 2)

Identity

Alias_symbol (synonym)KIAA1483
ZNF437
bA351K16.2
Other alias
HGNC (Hugo) ZBTB2
LocusID (NCBI) 57621
Atlas_Id 51184
Location 6q25.1  [Link to chromosome band 6q25]
Location_base_pair Starts at 151364115 and ends at 151391700 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ZBTB2 (6q25.1) / CBFA2T2 (20q11.21)ZBTB2 (6q25.1) / SYNE1 (6q25.1)ZBTB2 6q25.1 / SYNE1 6q25.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ZBTB2/SYNE1 (6q25)


External links

Nomenclature
HGNC (Hugo)ZBTB2   20868
Cards
Entrez_Gene (NCBI)ZBTB2  57621  zinc finger and BTB domain containing 2
AliasesZNF437
GeneCards (Weizmann)ZBTB2
Ensembl hg19 (Hinxton)ENSG00000181472 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000181472 [Gene_View]  ENSG00000181472 [Sequence]  chr6:151364115-151391700 [Contig_View]  ZBTB2 [Vega]
ICGC DataPortalENSG00000181472
TCGA cBioPortalZBTB2
AceView (NCBI)ZBTB2
Genatlas (Paris)ZBTB2
WikiGenes57621
SOURCE (Princeton)ZBTB2
Genetics Home Reference (NIH)ZBTB2
Genomic and cartography
GoldenPath hg38 (UCSC)ZBTB2  -     chr6:151364115-151391700 -  6q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZBTB2  -     6q25.1   [Description]    (hg19-Feb_2009)
EnsemblZBTB2 - 6q25.1 [CytoView hg19]  ZBTB2 - 6q25.1 [CytoView hg38]
Mapping of homologs : NCBIZBTB2 [Mapview hg19]  ZBTB2 [Mapview hg38]
OMIM616595   
Gene and transcription
Genbank (Entrez)AB040916 AJ420526 AK092886 AK291942 AL832957
RefSeq transcript (Entrez)NM_020861
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZBTB2
Cluster EST : UnigeneHs.520073 [ NCBI ]
CGAP (NCI)Hs.520073
Alternative Splicing GalleryENSG00000181472
Gene ExpressionZBTB2 [ NCBI-GEO ]   ZBTB2 [ EBI - ARRAY_EXPRESS ]   ZBTB2 [ SEEK ]   ZBTB2 [ MEM ]
Gene Expression Viewer (FireBrowse)ZBTB2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57621
GTEX Portal (Tissue expression)ZBTB2
Human Protein AtlasENSG00000181472-ZBTB2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8N680   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8N680  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8N680
Splice isoforms : SwissVarQ8N680
PhosPhoSitePlusQ8N680
Domaine pattern : Prosite (Expaxy)BTB (PS50097)    ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)BTB/POZ_dom    SKP1/BTB/POZ_sf    Znf_C2H2_sf    Znf_C2H2_type   
Domain families : Pfam (Sanger)BTB (PF00651)   
Domain families : Pfam (NCBI)pfam00651   
Domain families : Smart (EMBL)BTB (SM00225)  ZnF_C2H2 (SM00355)  
Conserved Domain (NCBI)ZBTB2
DMDM Disease mutations57621
Blocks (Seattle)ZBTB2
SuperfamilyQ8N680
Human Protein Atlas [tissue]ENSG00000181472-ZBTB2 [tissue]
Peptide AtlasQ8N680
HPRD10314
IPIIPI00166957   
Protein Interaction databases
DIP (DOE-UCLA)Q8N680
IntAct (EBI)Q8N680
FunCoupENSG00000181472
BioGRIDZBTB2
STRING (EMBL)ZBTB2
ZODIACZBTB2
Ontologies - Pathways
QuickGOQ8N680
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific  protein binding  nucleus  metal ion binding  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  RNA polymerase II proximal promoter sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific  protein binding  nucleus  metal ion binding  
NDEx NetworkZBTB2
Atlas of Cancer Signalling NetworkZBTB2
Wikipedia pathwaysZBTB2
Orthology - Evolution
OrthoDB57621
GeneTree (enSembl)ENSG00000181472
Phylogenetic Trees/Animal Genes : TreeFamZBTB2
HOVERGENQ8N680
HOGENOMQ8N680
Homologs : HomoloGeneZBTB2
Homology/Alignments : Family Browser (UCSC)ZBTB2
Gene fusions - Rearrangements
Fusion : MitelmanZBTB2/SYNE1 [6q25.1/6q25.1]  
Fusion PortalZBTB2 6q25.1 SYNE1 6q25.1 BRCA
Fusion : QuiverZBTB2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZBTB2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZBTB2
dbVarZBTB2
ClinVarZBTB2
1000_GenomesZBTB2 
Exome Variant ServerZBTB2
ExAC (Exome Aggregation Consortium)ENSG00000181472
GNOMAD BrowserENSG00000181472
Varsome BrowserZBTB2
Genetic variants : HAPMAP57621
Genomic Variants (DGV)ZBTB2 [DGVbeta]
DECIPHERZBTB2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZBTB2 
Mutations
ICGC Data PortalZBTB2 
TCGA Data PortalZBTB2 
Broad Tumor PortalZBTB2
OASIS PortalZBTB2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZBTB2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZBTB2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZBTB2
DgiDB (Drug Gene Interaction Database)ZBTB2
DoCM (Curated mutations)ZBTB2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZBTB2 (select a term)
intoGenZBTB2
Cancer3DZBTB2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616595   
Orphanet
DisGeNETZBTB2
MedgenZBTB2
Genetic Testing Registry ZBTB2
NextProtQ8N680 [Medical]
TSGene57621
GENETestsZBTB2
Target ValidationZBTB2
Huge Navigator ZBTB2 [HugePedia]
snp3D : Map Gene to Disease57621
BioCentury BCIQZBTB2
ClinGenZBTB2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57621
Chemical/Pharm GKB GenePA134949885
Clinical trialZBTB2
Miscellaneous
canSAR (ICR)ZBTB2 (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZBTB2
EVEXZBTB2
GoPubMedZBTB2
iHOPZBTB2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:50:42 CET 2018

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