Atlas of Genetics and Cytogenetics in Oncology and Haematology

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ZFP36 (ZFP36 ring finger protein)

Identity

Alias_nameszinc finger protein 36
Alias_symbol (synonym)RNF162A
TIS11
G0S24
TTP
NUP475
Other aliasGOS24
zfp-36
HGNC (Hugo) ZFP36
LocusID (NCBI) 7538
Atlas_Id 45691
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39406847 and ends at 39409412 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP1A1 (1p13.1) / ZFP36 (19q13.2)FUT5 (19p13.3) / ZFP36 (19q13.2)MYC (8q24.21) / ZFP36 (19q13.2)
PAK4 (19q13.2) / ZFP36 (19q13.2)PSMB7 (9q33.3) / ZFP36 (19q13.2)SLC12A8 (3q21.2) / ZFP36 (19q13.2)
ZFP36 (19q13.2) / FOSB (19q13.32)ZFP36 (19q13.2) / YY1AP1 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Bone: Vascular Tumors

External links

Nomenclature
HGNC (Hugo)ZFP36   12862
Cards
Entrez_Gene (NCBI)ZFP36  7538  ZFP36 ring finger protein
AliasesG0S24; GOS24; NUP475; RNF162A; 
TIS11; TTP; zfp-36
GeneCards (Weizmann)ZFP36
Ensembl hg19 (Hinxton)ENSG00000128016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128016 [Gene_View]  ENSG00000128016 [Sequence]  chr19:39406847-39409412 [Contig_View]  ZFP36 [Vega]
ICGC DataPortalENSG00000128016
TCGA cBioPortalZFP36
AceView (NCBI)ZFP36
Genatlas (Paris)ZFP36
WikiGenes7538
SOURCE (Princeton)ZFP36
Genetics Home Reference (NIH)ZFP36
Genomic and cartography
GoldenPath hg38 (UCSC)ZFP36  -     chr19:39406847-39409412 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFP36  -     19q13.2   [Description]    (hg19-Feb_2009)
GoldenPathZFP36 - 19q13.2 [CytoView hg19]  ZFP36 - 19q13.2 [CytoView hg38]
ImmunoBaseENSG00000128016
Mapping of homologs : NCBIZFP36 [Mapview hg19]  ZFP36 [Mapview hg38]
OMIM190700   
Gene and transcription
Genbank (Entrez)AJ227917 AK314042 BC009693 BM055332 M63625
RefSeq transcript (Entrez)NM_003407
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)ZFP36
Cluster EST : UnigeneHs.534052 [ NCBI ]
CGAP (NCI)Hs.534052
Alternative Splicing GalleryENSG00000128016
Gene ExpressionZFP36 [ NCBI-GEO ]   ZFP36 [ EBI - ARRAY_EXPRESS ]   ZFP36 [ SEEK ]   ZFP36 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFP36 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7538
GTEX Portal (Tissue expression)ZFP36
Human Protein AtlasENSG00000128016-ZFP36 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26651   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26651  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26651
Splice isoforms : SwissVarP26651
PhosPhoSitePlusP26651
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)ZFP36
DMDM Disease mutations7538
Blocks (Seattle)ZFP36
PDB (RSDB)4J8S   
PDB Europe4J8S   
PDB (PDBSum)4J8S   
PDB (IMB)4J8S   
Structural Biology KnowledgeBase4J8S   
SCOP (Structural Classification of Proteins)4J8S   
CATH (Classification of proteins structures)4J8S   
SuperfamilyP26651
Human Protein Atlas [tissue]ENSG00000128016-ZFP36 [tissue]
Peptide AtlasP26651
HPRD01835
IPIIPI00000893   IPI00976735   
Protein Interaction databases
DIP (DOE-UCLA)P26651
IntAct (EBI)P26651
FunCoupENSG00000128016
BioGRIDZFP36
STRING (EMBL)ZFP36
ZODIACZFP36
Ontologies - Pathways
QuickGOP26651
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  MAPK cascade  MAPK cascade  exosome (RNase complex)  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  nuclear-transcribed mRNA poly(A) tail shortening  P-body  DNA binding  RNA binding  single-stranded RNA binding  mRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  cytosol  mRNA catabolic process  response to wounding  response to wounding  cytoplasmic stress granule  regulation of keratinocyte proliferation  AU-rich element binding  AU-rich element binding  enzyme binding  protein kinase binding  C-C chemokine binding  CCR4-NOT complex  heat shock protein binding  nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  regulation of tumor necrosis factor production  negative regulation of viral transcription  miRNA mediated inhibition of translation  mRNA 3'-UTR AU-rich region binding  p38MAPK cascade  response to starvation  regulation of mRNA stability  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  negative regulation of interleukin-2 biosynthetic process  positive regulation of fat cell differentiation  regulation of keratinocyte differentiation  negative regulation of erythrocyte differentiation  metal ion binding  mRNA transport  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  RNA polymerase binding  RISC-loading complex  3'-UTR-mediated mRNA stabilization  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  14-3-3 protein binding  cellular response to granulocyte macrophage colony-stimulating factor stimulus  Dcp1-Dcp2 complex  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  regulation of keratinocyte apoptotic process  negative regulation of polynucleotide adenylyltransferase activity  positive regulation of intracellular mRNA localization  ribonucleoprotein complex  positive regulation of gene silencing by miRNA  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  MAPK cascade  MAPK cascade  exosome (RNase complex)  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  nuclear-transcribed mRNA poly(A) tail shortening  P-body  DNA binding  RNA binding  single-stranded RNA binding  mRNA binding  mRNA 3'-UTR binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  cytosol  mRNA catabolic process  response to wounding  response to wounding  cytoplasmic stress granule  regulation of keratinocyte proliferation  AU-rich element binding  AU-rich element binding  enzyme binding  protein kinase binding  C-C chemokine binding  CCR4-NOT complex  heat shock protein binding  nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  regulation of tumor necrosis factor production  negative regulation of viral transcription  miRNA mediated inhibition of translation  mRNA 3'-UTR AU-rich region binding  p38MAPK cascade  response to starvation  regulation of mRNA stability  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  negative regulation of interleukin-2 biosynthetic process  positive regulation of fat cell differentiation  regulation of keratinocyte differentiation  negative regulation of erythrocyte differentiation  metal ion binding  mRNA transport  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  RNA polymerase binding  RISC-loading complex  3'-UTR-mediated mRNA stabilization  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  14-3-3 protein binding  cellular response to granulocyte macrophage colony-stimulating factor stimulus  Dcp1-Dcp2 complex  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  regulation of keratinocyte apoptotic process  negative regulation of polynucleotide adenylyltransferase activity  positive regulation of intracellular mRNA localization  ribonucleoprotein complex  positive regulation of gene silencing by miRNA  
Pathways : KEGGHTLV-I infection   
NDEx NetworkZFP36
Atlas of Cancer Signalling NetworkZFP36
Wikipedia pathwaysZFP36
Orthology - Evolution
OrthoDB7538
GeneTree (enSembl)ENSG00000128016
Phylogenetic Trees/Animal Genes : TreeFamZFP36
HOGENOMP26651
Homologs : HomoloGeneZFP36
Homology/Alignments : Family Browser (UCSC)ZFP36
Gene fusions - Rearrangements
Fusion : MitelmanZFP36/FOSB [19q13.2/19q13.32]  
Fusion : QuiverZFP36
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFP36 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFP36
dbVarZFP36
ClinVarZFP36
1000_GenomesZFP36 
Exome Variant ServerZFP36
ExAC (Exome Aggregation Consortium)ENSG00000128016
GNOMAD BrowserENSG00000128016
Varsome BrowserZFP36
Genetic variants : HAPMAP7538
Genomic Variants (DGV)ZFP36 [DGVbeta]
DECIPHERZFP36 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFP36 
Mutations
ICGC Data PortalZFP36 
TCGA Data PortalZFP36 
Broad Tumor PortalZFP36
OASIS PortalZFP36 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFP36  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDZFP36
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZFP36
DgiDB (Drug Gene Interaction Database)ZFP36
DoCM (Curated mutations)ZFP36 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZFP36 (select a term)
intoGenZFP36
Cancer3DZFP36(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190700   
Orphanet
DisGeNETZFP36
MedgenZFP36
Genetic Testing Registry ZFP36
NextProtP26651 [Medical]
TSGene7538
GENETestsZFP36
Target ValidationZFP36
Huge Navigator ZFP36 [HugePedia]
snp3D : Map Gene to Disease7538
BioCentury BCIQZFP36
ClinGenZFP36
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7538
Chemical/Pharm GKB GenePA37451
Clinical trialZFP36
Miscellaneous
canSAR (ICR)ZFP36 (select the gene name)
DataMed IndexZFP36
Probes
Litterature
PubMed184 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZFP36
EVEXZFP36
GoPubMedZFP36
iHOPZFP36
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 7 18:22:21 CEST 2019
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