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ZFP36 (ZFP36 ring finger protein)

Identity

Alias (NCBI)G0S24
GOS24
NUP475
RNF162A
TIS11
TTP
zfp-36
HGNC (Hugo) ZFP36
HGNC Alias symbRNF162A
TIS11
G0S24
TTP
NUP475
HGNC Alias nametristetraprolin
HGNC Previous namezinc finger protein 36, C3H type, homolog (mouse)
LocusID (NCBI) 7538
Atlas_Id 45691
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 39406847 and ends at 39409407 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP1A1 (1p13.1) / ZFP36 (19q13.2)FUT5 (19p13.3) / ZFP36 (19q13.2)MYC (8q24.21) / ZFP36 (19q13.2)
PAK4 (19q13.2) / ZFP36 (19q13.2)PSMB7 (9q33.3) / ZFP36 (19q13.2)SLC12A8 (3q21.2) / ZFP36 (19q13.2)
ZFP36 (19q13.2) / FOSB (19q13.32)ZFP36 (19q13.2) / YY1AP1 (1q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)ZFP36   12862
Cards
Entrez_Gene (NCBI)ZFP36    ZFP36 ring finger protein
AliasesG0S24; GOS24; NUP475; RNF162A; 
TIS11; TTP; zfp-36
GeneCards (Weizmann)ZFP36
Ensembl hg19 (Hinxton)ENSG00000128016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000128016 [Gene_View]  ENSG00000128016 [Sequence]  chr19:39406847-39409407 [Contig_View]  ZFP36 [Vega]
ICGC DataPortalENSG00000128016
TCGA cBioPortalZFP36
AceView (NCBI)ZFP36
Genatlas (Paris)ZFP36
SOURCE (Princeton)ZFP36
Genetics Home Reference (NIH)ZFP36
Genomic and cartography
GoldenPath hg38 (UCSC)ZFP36  -     chr19:39406847-39409407 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)ZFP36  -     19q13.2   [Description]    (hg19-Feb_2009)
GoldenPathZFP36 - 19q13.2 [CytoView hg19]  ZFP36 - 19q13.2 [CytoView hg38]
ImmunoBaseENSG00000128016
Genome Data Viewer NCBIZFP36 [Mapview hg19]  
OMIM190700   
Gene and transcription
Genbank (Entrez)AJ227917 AK314042 BC009693 BM055332 M63625
RefSeq transcript (Entrez)NM_003407
Consensus coding sequences : CCDS (NCBI)ZFP36
Gene ExpressionZFP36 [ NCBI-GEO ]   ZFP36 [ EBI - ARRAY_EXPRESS ]   ZFP36 [ SEEK ]   ZFP36 [ MEM ]
Gene Expression Viewer (FireBrowse)ZFP36 [ Firebrowse - Broad ]
GenevisibleExpression of ZFP36 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7538
GTEX Portal (Tissue expression)ZFP36
Human Protein AtlasENSG00000128016-ZFP36 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP26651   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP26651  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP26651
PhosPhoSitePlusP26651
Domaine pattern : Prosite (Expaxy)ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Znf_CCCH    Znf_CCCH_sf   
Domain families : Pfam (Sanger)zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)ZFP36
PDB (RSDB)4J8S   
PDB Europe4J8S   
PDB (PDBSum)4J8S   
PDB (IMB)4J8S   
Structural Biology KnowledgeBase4J8S   
SCOP (Structural Classification of Proteins)4J8S   
CATH (Classification of proteins structures)4J8S   
SuperfamilyP26651
AlphaFold pdb e-kbP26651   
Human Protein Atlas [tissue]ENSG00000128016-ZFP36 [tissue]
HPRD01835
Protein Interaction databases
DIP (DOE-UCLA)P26651
IntAct (EBI)P26651
BioGRIDZFP36
STRING (EMBL)ZFP36
ZODIACZFP36
Ontologies - Pathways
QuickGOP26651
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  MAPK cascade  MAPK cascade  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  nuclear-transcribed mRNA poly(A) tail shortening  P-body  DNA binding  RNA binding  mRNA binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  mRNA catabolic process  mRNA catabolic process  response to wounding  response to wounding  cytoplasmic stress granule  regulation of keratinocyte proliferation  enzyme binding  protein kinase binding  C-C chemokine binding  heat shock protein binding  nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  regulation of tumor necrosis factor production  negative regulation of interleukin-2 production  negative regulation of viral transcription  miRNA mediated inhibition of translation  mRNA 3'-UTR AU-rich region binding  mRNA 3'-UTR AU-rich region binding  mRNA 3'-UTR AU-rich region binding  p38MAPK cascade  response to starvation  regulation of mRNA stability  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  protein-containing complex binding  positive regulation of fat cell differentiation  regulation of keratinocyte differentiation  negative regulation of erythrocyte differentiation  metal ion binding  negative regulation of inflammatory response  mRNA transport  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  RNA polymerase binding  3'-UTR-mediated mRNA stabilization  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  14-3-3 protein binding  cellular response to granulocyte macrophage colony-stimulating factor stimulus  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  regulation of keratinocyte apoptotic process  negative regulation of polynucleotide adenylyltransferase activity  positive regulation of intracellular mRNA localization  ribonucleoprotein complex  positive regulation of gene silencing by miRNA  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  MAPK cascade  MAPK cascade  nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  nuclear-transcribed mRNA poly(A) tail shortening  P-body  DNA binding  RNA binding  mRNA binding  protein binding  nucleus  cytoplasm  cytosol  cytosol  mRNA catabolic process  mRNA catabolic process  response to wounding  response to wounding  cytoplasmic stress granule  regulation of keratinocyte proliferation  enzyme binding  protein kinase binding  C-C chemokine binding  heat shock protein binding  nuclear-transcribed mRNA catabolic process, deadenylation-independent decay  regulation of tumor necrosis factor production  negative regulation of interleukin-2 production  negative regulation of viral transcription  miRNA mediated inhibition of translation  mRNA 3'-UTR AU-rich region binding  mRNA 3'-UTR AU-rich region binding  mRNA 3'-UTR AU-rich region binding  p38MAPK cascade  response to starvation  regulation of mRNA stability  regulation of mRNA stability  regulation of mRNA stability  cellular response to fibroblast growth factor stimulus  protein-containing complex binding  positive regulation of fat cell differentiation  regulation of keratinocyte differentiation  negative regulation of erythrocyte differentiation  metal ion binding  negative regulation of inflammatory response  mRNA transport  positive regulation of nuclear-transcribed mRNA poly(A) tail shortening  3'-UTR-mediated mRNA destabilization  3'-UTR-mediated mRNA destabilization  RNA polymerase binding  3'-UTR-mediated mRNA stabilization  cellular response to lipopolysaccharide  cellular response to lipopolysaccharide  cellular response to tumor necrosis factor  cellular response to epidermal growth factor stimulus  cellular response to glucocorticoid stimulus  14-3-3 protein binding  cellular response to granulocyte macrophage colony-stimulating factor stimulus  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA  regulation of keratinocyte apoptotic process  negative regulation of polynucleotide adenylyltransferase activity  positive regulation of intracellular mRNA localization  ribonucleoprotein complex  positive regulation of gene silencing by miRNA  
Pathways : KEGGHTLV-I infection   
NDEx NetworkZFP36
Atlas of Cancer Signalling NetworkZFP36
Wikipedia pathwaysZFP36
Orthology - Evolution
OrthoDB7538
GeneTree (enSembl)ENSG00000128016
Phylogenetic Trees/Animal Genes : TreeFamZFP36
Homologs : HomoloGeneZFP36
Homology/Alignments : Family Browser (UCSC)ZFP36
Gene fusions - Rearrangements
Fusion : MitelmanZFP36/FOSB [19q13.2/19q13.32]  
Fusion : QuiverZFP36
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerZFP36 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZFP36
dbVarZFP36
ClinVarZFP36
MonarchZFP36
1000_GenomesZFP36 
Exome Variant ServerZFP36
GNOMAD BrowserENSG00000128016
Varsome BrowserZFP36
ACMGZFP36 variants
VarityP26651
Genomic Variants (DGV)ZFP36 [DGVbeta]
DECIPHERZFP36 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisZFP36 
Mutations
ICGC Data PortalZFP36 
TCGA Data PortalZFP36 
Broad Tumor PortalZFP36
OASIS PortalZFP36 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICZFP36  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DZFP36
Mutations and Diseases : HGMDZFP36
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaZFP36
DgiDB (Drug Gene Interaction Database)ZFP36
DoCM (Curated mutations)ZFP36
CIViC (Clinical Interpretations of Variants in Cancer)ZFP36
Cancer3DZFP36
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM190700   
Orphanet
DisGeNETZFP36
MedgenZFP36
Genetic Testing Registry ZFP36
NextProtP26651 [Medical]
GENETestsZFP36
Target ValidationZFP36
Huge Navigator ZFP36 [HugePedia]
ClinGenZFP36
Clinical trials, drugs, therapy
MyCancerGenomeZFP36
Protein Interactions : CTDZFP36
Pharm GKB GenePA37451
PharosP26651
Clinical trialZFP36
Miscellaneous
canSAR (ICR)ZFP36
HarmonizomeZFP36
DataMed IndexZFP36
Probes
Litterature
PubMed214 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXZFP36
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:38:57 CEST 2021

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