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ZMPSTE24 (zinc metallopeptidase STE24)

Identity

Other namesFACE-1
FACE1
HGPS
PRO1
STE24
Ste24p
HGNC (Hugo) ZMPSTE24
LocusID (NCBI) 10269
Atlas_Id 42868
Location 1p34.2
Location_base_pair Starts at 40723722 and ends at 40759856 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas)
  Lung: Translocations in Small Cell Carcinoma

External links

Nomenclature
HGNC (Hugo)ZMPSTE24   12877
Cards
Entrez_Gene (NCBI)ZMPSTE24  10269  zinc metallopeptidase STE24
GeneCards (Weizmann)ZMPSTE24
Ensembl hg19 (Hinxton)ENSG00000084073 [Gene_View]  chr1:40723722-40759856 [Contig_View]  ZMPSTE24 [Vega]
Ensembl hg38 (Hinxton)ENSG00000084073 [Gene_View]  chr1:40723722-40759856 [Contig_View]  ZMPSTE24 [Vega]
ICGC DataPortalENSG00000084073
TCGA cBioPortalZMPSTE24
AceView (NCBI)ZMPSTE24
Genatlas (Paris)ZMPSTE24
WikiGenes10269
SOURCE (Princeton)ZMPSTE24
Genomic and cartography
GoldenPath hg19 (UCSC)ZMPSTE24  -     chr1:40723722-40759856 +  1p34.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZMPSTE24  -     1p34.2   [Description]    (hg38-Dec_2013)
EnsemblZMPSTE24 - 1p34.2 [CytoView hg19]  ZMPSTE24 - 1p34.2 [CytoView hg38]
Mapping of homologs : NCBIZMPSTE24 [Mapview hg19]  ZMPSTE24 [Mapview hg38]
OMIM275210   606480   608612   
Gene and transcription
Genbank (Entrez)AA436253 AB016068 AF064867 AI003768 AK027874
RefSeq transcript (Entrez)NM_005857
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_008695 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)ZMPSTE24
Cluster EST : UnigeneHs.721062 [ NCBI ]
CGAP (NCI)Hs.721062
Alternative Splicing : Fast-db (Paris)GSHG0000414
Alternative Splicing GalleryENSG00000084073
Gene ExpressionZMPSTE24 [ NCBI-GEO ]     ZMPSTE24 [ SEEK ]   ZMPSTE24 [ MEM ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)10269
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75844 (Uniprot)
NextProtO75844  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75844
Splice isoforms : SwissVarO75844 (Swissvar)
Catalytic activity : Enzyme3.4.24.84 [ Enzyme-Expasy ]   3.4.24.84 [ Enzyme-SRS ]   3.4.24.84 [ IntEnz-EBI ]   3.4.24.84 [ PRIAM ]   3.4.24.84 [ BRENDA ]   3.4.24.84 [ KEGG ]   3.4.24.84 [ IUBMB ]
PhosPhoSitePlusO75844
Domains : Interpro (EBI)CAXX_Prtase_1    Peptidase_M48   
Domain families : Pfam (Sanger)Peptidase_M48 (PF01435)   
Domain families : Pfam (NCBI)pfam01435   
DMDM Disease mutations10269
Blocks (Seattle)ZMPSTE24
PDB (SRS)2YPT    4AW6   
PDB (PDBSum)2YPT    4AW6   
PDB (IMB)2YPT    4AW6   
PDB (RSDB)2YPT    4AW6   
Structural Biology KnowledgeBase2YPT    4AW6   
SCOP (Structural Classification of Proteins)2YPT    4AW6   
CATH (Classification of proteins structures)2YPT    4AW6   
Human Protein AtlasENSG00000084073
Peptide AtlasO75844
HPRD07349
IPIIPI00027180   
Protein Interaction databases
DIP (DOE-UCLA)O75844
IntAct (EBI)O75844
FunCoupENSG00000084073
BioGRIDZMPSTE24
IntegromeDBZMPSTE24
STRING (EMBL)ZMPSTE24
ZODIACZMPSTE24
Ontologies - Pathways
QuickGOO75844
Ontology : AmiGOmetalloendopeptidase activity  nuclear inner membrane  endoplasmic reticulum membrane  proteolysis  nuclear envelope organization  metalloexopeptidase activity  membrane  integral component of membrane  prenylated protein catabolic process  metal ion binding  extracellular exosome  CAAX-box protein processing  
Ontology : EGO-EBImetalloendopeptidase activity  nuclear inner membrane  endoplasmic reticulum membrane  proteolysis  nuclear envelope organization  metalloexopeptidase activity  membrane  integral component of membrane  prenylated protein catabolic process  metal ion binding  extracellular exosome  CAAX-box protein processing  
Pathways : KEGGTerpenoid backbone biosynthesis   
Protein Interaction DatabaseZMPSTE24
Atlas of Cancer Signalling NetworkZMPSTE24
Wikipedia pathwaysZMPSTE24
Orthology - Evolution
OrthoDB10269
GeneTree (enSembl)ENSG00000084073
Phylogenetic Trees/Animal Genes : TreeFamZMPSTE24
Homologs : HomoloGeneZMPSTE24
Homology/Alignments : Family Browser (UCSC)ZMPSTE24
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerZMPSTE24 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZMPSTE24
dbVarZMPSTE24
ClinVarZMPSTE24
1000_GenomesZMPSTE24 
Exome Variant ServerZMPSTE24
Exome Aggregation Consortium (ExAC)ENSG00000084073
SNP (GeneSNP Utah)ZMPSTE24
SNP : HGBaseZMPSTE24
Genetic variants : HAPMAPZMPSTE24
Genomic Variants (DGV)ZMPSTE24 [DGVbeta]
Mutations
ICGC Data PortalZMPSTE24 
TCGA Data PortalZMPSTE24 
Tumor PortalZMPSTE24
TCGA Copy Number PortalZMPSTE24
Somatic Mutations in Cancer : COSMICZMPSTE24 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)Leiden Muscular Dystrophy pages
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch ZMPSTE24
DgiDB (Drug Gene Interaction Database)ZMPSTE24
DoCM (Curated mutations)ZMPSTE24 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)ZMPSTE24 (select a term)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:40723722-40759856
CONAN: Copy Number AnalysisZMPSTE24 
Mutations and Diseases : HGMDZMPSTE24
OMIM275210    606480    608612   
MedgenZMPSTE24
NextProtO75844 [Medical]
TSGene10269
GENETestsZMPSTE24
Huge Navigator ZMPSTE24 [HugePedia]  ZMPSTE24 [HugeCancerGEM]
snp3D : Map Gene to Disease10269
BioCentury BCIQZMPSTE24
General knowledge
Chemical/Protein Interactions : CTD10269
Chemical/Pharm GKB GenePA37466
Clinical trialZMPSTE24
Other databases
Probes
Litterature
PubMed52 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineZMPSTE24
GoPubMedZMPSTE24
iHOPZMPSTE24
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jan 16 19:46:35 CET 2016

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