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GMPS (guanine monphosphate synthetase)

Written2000-02Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Alias_namesguanine monophosphate synthetase
Other aliasGMPS-PEN
LocusID (NCBI) 8833
Atlas_Id 229
Location 3q25.31  [Link to chromosome band 3q25]
Location_base_pair Starts at 155870536 and ends at 155937731 bp from pter ( according to hg19-Feb_2009)  [Mapping GMPS.png]
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CCDC141 (2q31.2) / GMPS (3q25.31)GMPS (3q25.31) / KMT2A (11q23.3)GMPS (3q25.31) / PQLC2L (3q25.32)
GMPS (3q25.31) / SYNPR (3p14.2)KMT2A (11q23.3) / GMPS (3q25.31)KPNA1 (3q21.1) / GMPS (3q25.31)


Transcription 2212 bp mRNA; ORF: 2081 bp


Description 693 amino acids; 76 kDa;there are two variant forms of human GMP synthetase; homodimerization; GMP synthetase contains two functional domains: a glutamine amidotransferase (glutaminase domain, with a conserved Cys-His-Glu triad), responsible for glutamine hydrolysis, and a synthetase domain; responsible for ATP hydrolysis and GMP formation
Expression higher in proliferating, transformed cells than in nontransformed cells; in normal cells, higher expression in fibroblasts, followed by bone marrow, leukocytes, erythrocytes, placenta, and liver
Localisation cytoplasmic
Function enzyme of the de novo synthesis of guanine nucleotides: amidotransferase that catalyzes the amination of xanthosine 5 prime monophosphate to form GMP in the presence of ATP and glutamine; GTP is also involved in many enzymatic reactions important for cell division.

Implicated in

Entity t(3;11)(q25;q23)
Disease treatment related acute non lymphoblastic leukemia (M4 AML)
Hybrid/Mutated Gene fusion of MLL to GMPS


Assignment and ordering of twenty-three unique NotI-linking clones containing expressed genes including the guanosine 5'-monophosphate synthetase gene to human chromosome 3.
Fedorova L, Kost-Alimova M, Gizatullin RZ, Alimov A, Zabarovska VI, Szeles A, Protopopov AI, Vorobieva NV, Kashuba VI, Klein G, Zelenin AV, Sheer D, Zabarovsky ER
European journal of human genetics : EJHG. 1997 ; 5 (2) : 110-116.
PMID 9195163
Human GMP synthetase. Protein purification, cloning, and functional expression of cDNA.
Hirst M, Haliday E, Nakamura J, Lou L
The Journal of biological chemistry. 1994 ; 269 (38) : 23830-23837.
PMID 8089153
High-level production from a baculovirus expression system and biochemical characterization of human GMP synthetase.
Lou L, Nakamura J, Tsing S, Nguyen B, Chow J, Straub K, Chan H, Barnett J
Protein expression and purification. 1995 ; 6 (4) : 487-495.
PMID 8527935
The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine.
Nakamura J, Straub K, Wu J, Lou L
The Journal of biological chemistry. 1995 ; 270 (40) : 23450-23455.
PMID 7559506
Human GMP synthetase.
Page T, Bakay B, Nyhan WL
The International journal of biochemistry. 1984 ; 16 (1) : 117-120.
PMID 6698284
t(3;11)(q25;q23) fuses MLL with the GMPS (guanosine 5'-monophosphate synthetase) gene in treatment-related acute myeloid leukemia (AML).
Pegram LD, Megonigal MD, Lange BJ, Nowell PC, Rappaport EF, Felix CA
Blood. 1999 ; 94 (numero Suppl 1).
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families.
Tesmer JJ, Klem TJ, Deras ML, Davisson VJ, Smith JL
Nature structural biology. 1996 ; 3 (1) : 74-86.
PMID 8548458


This paper should be referenced as such :
Huret, JL
GMPS (guanine monphosphate synthetase)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(1):11-12.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  11q23 rearrangements (KMT2A) in leukaemia
t(3;11)(q25;q23) KMT2A/GMPS

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  Lung: Translocations in Squamous Cell Carcinoma
t(3;3)(p14;q25) GMPS/SYNPR
t(3;3)(q21;q25) KPNA1/GMPS
t(3;3)(q25;q25) GMPS/PQLC2L
t(3;3)(q25;q25) GMPS/C3orf55

External links

HGNC (Hugo)GMPS   4378
Entrez_Gene (NCBI)GMPS  8833  guanine monophosphate synthase
GeneCards (Weizmann)GMPS
Ensembl hg19 (Hinxton)ENSG00000163655 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000163655 [Gene_View]  chr3:155870536-155937731 [Contig_View]  GMPS [Vega]
ICGC DataPortalENSG00000163655
Genatlas (Paris)GMPS
SOURCE (Princeton)GMPS
Genetics Home Reference (NIH)GMPS
Genomic and cartography
GoldenPath hg38 (UCSC)GMPS  -     chr3:155870536-155937731 +  3q25.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GMPS  -     3q25.31   [Description]    (hg19-Feb_2009)
EnsemblGMPS - 3q25.31 [CytoView hg19]  GMPS - 3q25.31 [CytoView hg38]
Mapping of homologs : NCBIGMPS [Mapview hg19]  GMPS [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK223399 AK291504 AK300787 AK302148 AK315832
RefSeq transcript (Entrez)NM_003875
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GMPS
Cluster EST : UnigeneHs.591314 [ NCBI ]
CGAP (NCI)Hs.591314
Alternative Splicing GalleryENSG00000163655
Gene ExpressionGMPS [ NCBI-GEO ]   GMPS [ EBI - ARRAY_EXPRESS ]   GMPS [ SEEK ]   GMPS [ MEM ]
Gene Expression Viewer (FireBrowse)GMPS [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8833
GTEX Portal (Tissue expression)GMPS
Human Protein AtlasENSG00000163655-GMPS [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP49915   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP49915  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP49915
Splice isoforms : SwissVarP49915
Catalytic activity : Enzyme6.3.5.2 [ Enzyme-Expasy ] [ IntEnz-EBI ] [ BRENDA ] [ KEGG ]   
Domaine pattern : Prosite (Expaxy)GATASE_TYPE_1 (PS51273)    GMPS_ATP_PPASE (PS51553)   
Domains : Interpro (EBI)Class_I_gatase-like    GATASE    GMP_synth_C    GMP_synth_GATase    GMPS_ATP_PPase_dom    NAD/GMP_synthase    Rossmann-like_a/b/a_fold   
Domain families : Pfam (Sanger)GATase (PF00117)    GMP_synt_C (PF00958)    NAD_synthase (PF02540)   
Domain families : Pfam (NCBI)pfam00117    pfam00958    pfam02540   
Conserved Domain (NCBI)GMPS
DMDM Disease mutations8833
Blocks (Seattle)GMPS
PDB (SRS)2VPI    2VXO   
PDB (PDBSum)2VPI    2VXO   
PDB (IMB)2VPI    2VXO   
Structural Biology KnowledgeBase2VPI    2VXO   
SCOP (Structural Classification of Proteins)2VPI    2VXO   
CATH (Classification of proteins structures)2VPI    2VXO   
Human Protein Atlas [tissue]ENSG00000163655-GMPS [tissue]
Peptide AtlasP49915
IPIIPI00029079   IPI01013391   IPI00945620   
Protein Interaction databases
IntAct (EBI)P49915
Ontologies - Pathways
Ontology : AmiGOGMP synthase activity  GMP synthase activity  GMP synthase (glutamine-hydrolyzing) activity  ATP binding  cytosol  cytosol  GMP biosynthetic process  GMP biosynthetic process  glutamine metabolic process  purine nucleobase biosynthetic process  purine ribonucleoside monophosphate biosynthetic process  pyrophosphatase activity  
Ontology : EGO-EBIGMP synthase activity  GMP synthase activity  GMP synthase (glutamine-hydrolyzing) activity  ATP binding  cytosol  cytosol  GMP biosynthetic process  GMP biosynthetic process  glutamine metabolic process  purine nucleobase biosynthetic process  purine ribonucleoside monophosphate biosynthetic process  pyrophosphatase activity  
Pathways : KEGGPurine metabolism    Glutamate metabolism   
REACTOMEP49915 [protein]
REACTOME PathwaysR-HSA-73817 [pathway]   
NDEx NetworkGMPS
Atlas of Cancer Signalling NetworkGMPS
Wikipedia pathwaysGMPS
Orthology - Evolution
GeneTree (enSembl)ENSG00000163655
Phylogenetic Trees/Animal Genes : TreeFamGMPS
Homologs : HomoloGeneGMPS
Homology/Alignments : Family Browser (UCSC)GMPS
Gene fusions - Rearrangements
Fusion : MitelmanGMPS/PQLC2L [3q25.31/3q25.32]  
Fusion : MitelmanKPNA1/GMPS [3q21.1/3q25.31]  [t(3;3)(q21;q25)]  
Fusion : COSMICKMT2A [11q23.3]  -  GMPS [3q25.31]  [fusion_1841]  
Fusion: TCGA_MDACCGMPS 3q25.31 C3orf55 LUSC
Fusion: TCGA_MDACCKPNA1 3q21.1 GMPS 3q25.31 LUAD
Fusion PortalGMPS 3q25.31 C3orf55 LUSC
Fusion PortalKPNA1 3q21.1 GMPS 3q25.31 LUAD
Fusion : TICdbKMT2A [11q23.3]  -  GMPS [3q25.31]
Fusion : QuiverGMPS
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGMPS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GMPS
Exome Variant ServerGMPS
ExAC (Exome Aggregation Consortium)ENSG00000163655
GNOMAD BrowserENSG00000163655
Genetic variants : HAPMAP8833
Genomic Variants (DGV)GMPS [DGVbeta]
DECIPHERGMPS [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGMPS 
ICGC Data PortalGMPS 
TCGA Data PortalGMPS 
Broad Tumor PortalGMPS
OASIS PortalGMPS [ Somatic mutations - Copy number]
Cancer Gene: CensusGMPS 
Somatic Mutations in Cancer : COSMICGMPS  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGMPS
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GMPS
DgiDB (Drug Gene Interaction Database)GMPS
DoCM (Curated mutations)GMPS (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GMPS (select a term)
NCG5 (London)GMPS
Cancer3DGMPS(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry GMPS
NextProtP49915 [Medical]
Target ValidationGMPS
Huge Navigator GMPS [HugePedia]
snp3D : Map Gene to Disease8833
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8833
Chemical/Pharm GKB GenePA28763
Clinical trialGMPS
canSAR (ICR)GMPS (select the gene name)
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Feb 28 13:54:53 CET 2018

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