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KAT5 (HIV-1 Tat interacting protein, 60kDa)

Written2007-10Lise Mattera
Dr Trouche Team, LBCMCP, UMR 5088 CNRS, 118 route de Narbonne, 31062 Toulouse cedex 9, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesHTATIP
HIV-1 Tat interactive protein, 60kDa
K(lysine) acetyltransferase 5
Alias_symbol (synonym)TIP60
PLIP
cPLA2
HTATIP1
ESA1
ZC2HC5
Other aliasHTATIP (HIV-1 Tat interacting protein, 60kDa)
Tip60
Tip
60kDa Tat interacting protein
HIV-1 Tat interacting protein
cPLA(2) interacting protein
iTip60
PLIP/Tip60b
Tip60a
Esa1
Hs.6364
HGNC (Hugo) KAT5
LocusID (NCBI) 10524
Atlas_Id 40893
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 65712002 and ends at 65719606 bp from pter ( according to hg19-Feb_2009)  [Mapping KAT5.png]
Fusion genes
(updated 2016)
KAT5 (11q13.1) / KAT5 (11q13.1)KAT5 (11q13.1) / RASIP1 (19q13.33)

DNA/RNA

 
Description The HTATIP gene consists of 14 exons. 7,586 bases.
Transcription The predominant mRNA transcribed from this gene is 2,229 bp long. This is actually the isoform 2 of HTATIP.
Two others isoforms generated by alternative splicing have been described:
  • Isoform 1 retains the alternatively spliced intron 1.
  • Isoform 3 lacks exon 5.
  • Pseudogene No pseudogene is currently known.

    Protein

     
    Description The Tip60 protein (isoform 2) is 513 amino acids long and its molecular weight is about 60 kDa. It was cloned and characterized in 1996 thanks to its interaction with the HIV-1 transactivator Tat protein.
    Isoform 1 produces a 546 amino acids long protein.
    Isoform 3 produces a 461 amino acids long protein.
    A novel isoform, Tip55, encodes a novel splicing variant corresponding to 103 amino acids of the C-terminus.
    The domain architectures of human TIP60 is similar to yeast Esa1 protein and consist of a chromodomain and a MYST domain harboring a zinc finger and an Acetyl-CoA binding site.
    Expression Tip60 is ubiquitously expressed.
    In mouse adult tissues Tip60 is expressed in the following decreasing order of intensity: testis, heart, brain, kidney, liver, lung, with little to no expression in spleen and skeletal muscle .
    In human, Tip60 (Isoform 2) and PLIP (Isoform 3) are expressed in human heart, kidney and brain tissue.
    With a half-life of approximately 30 minutes, Tip60 is very unstable. In normal conditions, the proteasome pathway permits to maintain low protein levels. Tip60 is ubiquitinated and targeted to proteasome-mediated degradation by Mdm2 but also by p300-associated E4 ubiquitin ligase. Tip60 is stabilized after DNA damage, and accumulates in cells. Moreover, Tip60 is the target of several post-translational modifications such as phosphorylation on serine 86 and 90 by cdc2 but also acetylation by p300/CBP acetyltransferases. Acetylation by p300/CBP occurs in the zinc finger of Tip60 but consequences of this modification are currently not known. Finally, a recent report shows that Tip60 is sumoylated at lysines 430 and 451 via Ubc9.
    No data are available about regulation of the Tip60 promoter.
    Localisation Tip60 (Isoform 2) is nuclear. PLIP (Isoform 3) is nuclear but also cytoplasmic.
    Function Tip60 is a Histone Acetyltransferase (HAT), which belongs to the MYST family. It participates in a multimolecular complex: The Tip60 complex, which contains proteins such as p400, Tip49a and Tip49b . Within this complex, Tip60 exerts its HAT activity on nucleosomal histone H4. Tip60 is involved in various cellular mechanisms:
  • In transcription: Tip60 acts as a coactivator. Indeed, Tip60 is able to interact with transcription factors, such as E2F-1 or c-Myc. Tip60 can be recruited to Myc and E2F-1 target promoters and enhances Myc transactivation. It also acetylates histone H4 on several E2F responsive genes. Moreover Tip60 was found to be involved in nuclear receptor (NR) signaling and to be a NR-coregulator.
  • In apoptosis and cell cycle arrest: Tip60 can interact with and acetylate the tumor suppressor p53. It enhances p53 binding to pro-apoptotic target genes like PUMA, Bax or Fas. Moreover, Tip60 is also required for cell growth arrest via the p21-dependent pathway.
  • In DNA repair: Tip60 is involved in double strand breaks (DSB) repair. Interacting and acetylating ATM, Tip60 participates in DNA damage signaling. But, Tip60 is also involved directly in DSB repair since it is recruited, with TRRAP, to the DSB site. Tip60 interacts with the chromatin surrounding sites of DSBs and this recruitment is responsible for hyperacetylation of histone H4.
  • Homology Tip60 CHROMO domain has been identified by sequence homology with the Heterochromatin-associated protein 1 (HP1) chromodomain, which recognizes methylated lysines. It also harbors the MYST domain, which is highly conserved from yeast to human.
    Homologs in other species:
  • S. Cerevisae: Esa1
  • D. Melanogaster: DmeI/Tip60
  • M. musculus: Htatip
  • R. norvegicus: Htatip
    Predicted:
  • P.troglodytes: HTATIP
  • M.mulatta: HTATIP
  • Mutations

    Note No mutation in Tip60 protein has been currently described.

    Implicated in

    Note
      
    Entity Acquired Immunodeficiency Syndrome (AIDS)
    Disease Tip60 interacts with the HIV-1 transactivator Tat and this interaction inhibits Tip60 HAT activity. Moreover, in Jurkat cells, Tat enhances Tip60 turnover since it uses the p300/CBP-associated E4-type ubiquitin-ligase activity to induce polyubiquitynation and degradation of Tip60. This targeting by Tat induces an impairment of Tip60-dependent apoptosis after DNA damage.
      
      
    Entity Neurodegenerative diseases
      
      
    Entity Alzheimer' disease
    Disease In the nucleus of human H4 neuroglioma cells, TIP60 can interact with a free carboxyl-terminal intracellular fragment, APP-CT, which is generated by the cleavage of the Amyloid precursor protein APP by a gamma-secretase. This fragment induces apoptosis of neuroglioma and this cell death is enhanced when a wild type form of Tip60 is transfected. Thus Tip60 might play a role in Alzheimer's disease neurodegeneration.
      
      
    Entity Spinocerebellar ataxia type-1
    Disease TIP60 participates in a complex with ATXN1 and ROR-alpha in a conditional transgenic mouse model of Spinocerebellar ataxia type-1 (SCA1), one of the nine inherited polyglutamine neurodegenerative diseases.
      
      
    Entity Cancers
      
      
    Entity Prostate cancer
    Disease Immunohistochemistry experiments have shown that Tip60 accumulates in the nucleus of hormone-refractory prostate cancer compared to prostate hyperplasia and primary prostate cancer.
      
      
    Entity Lung cancer and colon cancer
    Disease Real time RT-PCR experiments have shown that Tip60 mRNA is under expressed in colon and lung carcinomas.
      
      
    Entity Skin cancer
    Disease The expression levels of TIP60 protein, analyzed by western blot, were found to be greater in skin tumors as compared to adjacent non-tumor-bearing skin in a skin cancer mouse model (K6/ODC mouse). Additionally, the interaction between Tip60 and E2F1 is enhanced in these tumors.
      
      
    Entity HTLV-1 induced leukemogenesis
    Disease Enhancement of c-Myc transforming activity by HTLV-1 p30II oncoprotein in HeLa cells requires TIP60 HAT activity.
      

    Bibliography

    A human T-cell lymphotropic virus type 1 enhancer of Myc transforming potential stabilizes Myc-TIP60 transcriptional interactions.
    Awasthi S, Sharma A, Wong K, Zhang J, Matlock EF, Rogers L, Motloch P, Takemoto S, Taguchi H, Cole MD, Lüscher B, Dittrich O, Tagami H, Nakatani Y, McGee M, Girard AM, Gaughan L, Robson CN, Monnat RJ Jr, Harrod R
    Molecular and cellular biology. 2005 ; 25 (14) : 6178-6198.
    PMID 15988028
     
    A large-scale RNAi screen in human cells identifies new components of the p53 pathway.
    Berns K, Hijmans EM, Mullenders J, Brummelkamp TR, Velds A, Heimerikx M, Kerkhoven RM, Madiredjo M, Nijkamp W, Weigelt B, Agami R, Ge W, Cavet G, Linsley PS, Beijersbergen RL, Bernards R
    Nature. 2004 ; 428 (6981) : 431-437.
    PMID 15042092
     
    Tip60 is a nuclear hormone receptor coactivator.
    Brady ME, Ozanne DM, Gaughan L, Waite I, Cook S, Neal DE, Robson CN
    The Journal of biological chemistry. 1999 ; 274 (25) : 17599-17604.
    PMID 10364196
     
    Functional characterization of TIP60 sumoylation in UV-irradiated DNA damage response.
    Cheng Z, Ke Y, Ding X, Wang F, Wang H, Ahmed K, Liu Z, Xu Y, Aikhionbare F, Yan H, Liu J, Xue Y, Powell M, Liang S, Reddy SE, Hu R, Huang H, Jin C, Yao X
    Oncogene. 2008 ; 27 (7) : 931-941.
    PMID 17704809
     
    HIV-1 Tat targets Tip60 to impair the apoptotic cell response to genotoxic stresses.
    Col E, Caron C, Chable-Bessia C, Legube G, Gazzeri S, Komatsu Y, Yoshida M, Benkirane M, Trouche D, Khochbin S
    The EMBO journal. 2005 ; 24 (14) : 2634-2645.
    PMID 16001085
     
    Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat.
    Creaven M, Hans F, Mutskov V, Col E, Caron C, Dimitrov S, Khochbin S
    Biochemistry. 1999 ; 38 (27) : 8826-8830.
    PMID 10393559
     
    MYC recruits the TIP60 histone acetyltransferase complex to chromatin.
    Frank SR, Parisi T, Taubert S, Fernandez P, Fuchs M, Chan HM, Livingston DM, Amati B
    EMBO reports. 2003 ; 4 (6) : 575-580.
    PMID 12776177
     
    Tip60 is a co-activator specific for class I nuclear hormone receptors.
    Gaughan L, Brady ME, Cook S, Neal DE, Robson CN
    The Journal of biological chemistry. 2001 ; 276 (50) : 46841-46848.
    PMID 11591700
     
    Tip60 and histone deacetylase 1 regulate androgen receptor activity through changes to the acetylation status of the receptor.
    Gaughan L, Logan IR, Cook S, Neal DE, Robson CN
    The Journal of biological chemistry. 2002 ; 277 (29) : 25904-25913.
    PMID 11994312
     
    Expression of Tip60, an androgen receptor coactivator, and its role in prostate cancer development.
    Halkidou K, Gnanapragasam VJ, Mehta PB, Logan IR, Brady ME, Cook S, Leung HY, Neal DE, Robson CN
    Oncogene. 2003 ; 22 (16) : 2466-2477.
    PMID 12717424
     
    Tip60 protein isoforms and altered function in skin and tumors that overexpress ornithine decarboxylase.
    Hobbs CA, Wei G, DeFeo K, Paul B, Hayes CS, Gilmour SK
    Cancer research. 2006 ; 66 (16) : 8116-8122.
    PMID 16912189
     
    Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis.
    Ikura T, Ogryzko VV, Grigoriev M, Groisman R, Wang J, Horikoshi M, Scully R, Qin J, Nakatani Y
    Cell. 2000 ; 102 (4) : 463-473.
    PMID 10966108
     
    Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator.
    Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G
    Virology. 1996 ; 216 (2) : 357-366.
    PMID 8607265
     
    Co-activation of atrial natriuretic factor promoter by Tip60 and serum response factor.
    Kim MS, Merlo X, Wilson C, Lough J
    The Journal of biological chemistry. 2006 ; 281 (22) : 15082-15089.
    PMID 16597624
     
    The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells.
    Kinoshita A, Whelan CM, Berezovska O, Hyman BT
    The Journal of biological chemistry. 2002 ; 277 (32) : 28530-28536.
    PMID 12032152
     
    New p53 related genes in human tumors: significant downregulation in colon and lung carcinomas.
    LLeonart ME, Vidal F, Gallardo D, Diaz-Fuertes M, Rojo F, Cuatrecasas M, López-Vicente L, Kondoh H, Blanco C, Carnero A, Ramón y Cajal S
    Oncology reports. 2006 ; 16 (3) : 603-608.
    PMID 16865262
     
    Role of the histone acetyl transferase Tip60 in the p53 pathway.
    Legube G, Linares LK, Tyteca S, Caron C, Scheffner M, Chevillard-Briet M, Trouche D
    The Journal of biological chemistry. 2004 ; 279 (43) : 44825-44833.
    PMID 15310756
     
    Identification of a larger form of the histone acetyl transferase Tip60.
    Legube G, Trouche D
    Gene. 2003 ; 310 : 161-168.
    PMID 12801643
     
    Tip60 acetyltransferase activity is controlled by phosphorylation.
    Lemercier C, Legube G, Caron C, Louwagie M, Garin J, Trouche D, Khochbin S
    The Journal of biological chemistry. 2003 ; 278 (7) : 4713-4718.
    PMID 12468530
     
    Characterization and expression of the mouse tat interactive protein 60 kD (TIP60) gene.
    McAllister D, Merlo X, Lough J
    Gene. 2002 ; 289 (1-2) : 169-176.
    PMID 12036595
     
    Histone acetylation by Trrap-Tip60 modulates loading of repair proteins and repair of DNA double-strand breaks.
    Murr R, Loizou JI, Yang YG, Cuenin C, Li H, Wang ZQ, Herceg Z
    Nature cell biology. 2006 ; 8 (1) : 91-99.
    PMID 16341205
     
    Identification of an alternatively spliced form of the Tat interactive protein (Tip60), Tip60(beta).
    Ran Q, Pereira-Smith OM
    Gene. 2000 ; 258 (1-2) : 141-146.
    PMID 11111051
     
    RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice.
    Serra HG, Duvick L, Zu T, Carlson K, Stevens S, Jorgensen N, Lysholm A, Burright E, Zoghbi HY, Clark HB, Andresen JM, Orr HT
    Cell. 2006 ; 127 (4) : 697-708.
    PMID 17110330
     
    PLIP, a novel splice variant of Tip60, interacts with group IV cytosolic phospholipase A(2), induces apoptosis, and potentiates prostaglandin production.
    Sheridan AM, Force T, Yoon HJ, O'Leary E, Choukroun G, Taheri MR, Bonventre JV
    Molecular and cellular biology. 2001 ; 21 (14) : 4470-4481.
    PMID 11416127
     
    A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.
    Sun Y, Jiang X, Chen S, Fernandes N, Price BD
    Proceedings of the National Academy of Sciences of the United States of America. 2005 ; 102 (37) : 13182-13187.
    PMID 16141325
     
    Acetylation of the p53 DNA-binding domain regulates apoptosis induction.
    Sykes SM, Mellert HS, Holbert MA, Li K, Marmorstein R, Lane WS, McMahon SB
    Molecular cell. 2006 ; 24 (6) : 841-851.
    PMID 17189187
     
    Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis.
    Tang Y, Luo J, Zhang W, Gu W
    Molecular cell. 2006 ; 24 (6) : 827-839.
    PMID 17189186
     
    E2F-dependent histone acetylation and recruitment of the Tip60 acetyltransferase complex to chromatin in late G1.
    Taubert S, Gorrini C, Frank SR, Parisi T, Fuchs M, Chan HM, Livingston DM, Amati B
    Molecular and cellular biology. 2004 ; 24 (10) : 4546-4556.
    PMID 15121871
     
    Tip60 and p400 are both required for UV-induced apoptosis but play antagonistic roles in cell cycle progression.
    Tyteca S, Vandromme M, Legube G, Chevillard-Briet M, Trouche D
    The EMBO journal. 2006 ; 25 (8) : 1680-1689.
    PMID 16601686
     

    Citation

    This paper should be referenced as such :
    Mattera, L
    HTATIP (HIV-1 Tat interacting protein, 60kDa)
    Atlas Genet Cytogenet Oncol Haematol. 2008;12(3):213-216.
    Free journal version : [ pdf ]   [ DOI ]
    On line version : http://AtlasGeneticsOncology.org/Genes/HTATIPID40893ch11q13.html


    External links

    Nomenclature
    HGNC (Hugo)KAT5   5275
    Cards
    AtlasHTATIPID40893ch11q13
    Entrez_Gene (NCBI)KAT5  10524  lysine acetyltransferase 5
    AliasesESA1; HTATIP; HTATIP1; PLIP; 
    TIP; TIP60; ZC2HC5; cPLA2
    GeneCards (Weizmann)KAT5
    Ensembl hg19 (Hinxton)ENSG00000172977 [Gene_View]
    Ensembl hg38 (Hinxton)ENSG00000172977 [Gene_View]  chr11:65712002-65719606 [Contig_View]  KAT5 [Vega]
    ICGC DataPortalENSG00000172977
    TCGA cBioPortalKAT5
    AceView (NCBI)KAT5
    Genatlas (Paris)KAT5
    WikiGenes10524
    SOURCE (Princeton)KAT5
    Genetics Home Reference (NIH)KAT5
    Genomic and cartography
    GoldenPath hg38 (UCSC)KAT5  -     chr11:65712002-65719606 +  11q13.1   [Description]    (hg38-Dec_2013)
    GoldenPath hg19 (UCSC)KAT5  -     11q13.1   [Description]    (hg19-Feb_2009)
    EnsemblKAT5 - 11q13.1 [CytoView hg19]  KAT5 - 11q13.1 [CytoView hg38]
    Mapping of homologs : NCBIKAT5 [Mapview hg19]  KAT5 [Mapview hg38]
    OMIM601409   
    Gene and transcription
    Genbank (Entrez)AB209813 AK130717 AK225100 AK226002 AK304664
    RefSeq transcript (Entrez)NM_001206833 NM_006388 NM_182709 NM_182710
    RefSeq genomic (Entrez)
    Consensus coding sequences : CCDS (NCBI)KAT5
    Cluster EST : UnigeneHs.397010 [ NCBI ]
    CGAP (NCI)Hs.397010
    Alternative Splicing GalleryENSG00000172977
    Gene ExpressionKAT5 [ NCBI-GEO ]   KAT5 [ EBI - ARRAY_EXPRESS ]   KAT5 [ SEEK ]   KAT5 [ MEM ]
    Gene Expression Viewer (FireBrowse)KAT5 [ Firebrowse - Broad ]
    SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
    GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
    BioGPS (Tissue expression)10524
    GTEX Portal (Tissue expression)KAT5
    Protein : pattern, domain, 3D structure
    UniProt/SwissProtQ92993   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
    NextProtQ92993  [Sequence]  [Exons]  [Medical]  [Publications]
    With graphics : InterProQ92993
    Splice isoforms : SwissVarQ92993
    PhosPhoSitePlusQ92993
    Domaine pattern : Prosite (Expaxy)MYST_HAT (PS51726)   
    Domains : Interpro (EBI)Acyl_CoA_acyltransferase    Chromo/chromo_shadow_dom    Chromodomain-like    HAT_MYST-type    Tudor-knot   
    Domain families : Pfam (Sanger)MOZ_SAS (PF01853)    Tudor-knot (PF11717)   
    Domain families : Pfam (NCBI)pfam01853    pfam11717   
    Domain families : Smart (EMBL)CHROMO (SM00298)  
    Conserved Domain (NCBI)KAT5
    DMDM Disease mutations10524
    Blocks (Seattle)KAT5
    PDB (SRS)2EKO    2OU2    4QQG   
    PDB (PDBSum)2EKO    2OU2    4QQG   
    PDB (IMB)2EKO    2OU2    4QQG   
    PDB (RSDB)2EKO    2OU2    4QQG   
    Structural Biology KnowledgeBase2EKO    2OU2    4QQG   
    SCOP (Structural Classification of Proteins)2EKO    2OU2    4QQG   
    CATH (Classification of proteins structures)2EKO    2OU2    4QQG   
    SuperfamilyQ92993
    Human Protein AtlasENSG00000172977
    Peptide AtlasQ92993
    HPRD03245
    IPIIPI00290020   IPI00165536   IPI00394657   IPI00953051   IPI00981546   IPI00983518   IPI00985491   IPI00984196   IPI00984830   IPI00980876   IPI00982194   IPI00982836   
    Protein Interaction databases
    DIP (DOE-UCLA)Q92993
    IntAct (EBI)Q92993
    FunCoupENSG00000172977
    BioGRIDKAT5
    STRING (EMBL)KAT5
    ZODIACKAT5
    Ontologies - Pathways
    QuickGOQ92993
    Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  DNA double-strand break processing  DNA synthesis involved in DNA repair  strand displacement  Swr1 complex  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  nucleolus  DNA replication  double-strand break repair  double-strand break repair via nonhomologous end joining  transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  response to ionizing radiation  viral process  acetyltransferase activity  histone acetylation  androgen receptor signaling pathway  negative regulation of interleukin-2 production  Piccolo NuA4 histone acetyltransferase complex  NuA4 histone acetyltransferase complex  regulation of growth  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  perinuclear region of cytoplasm  androgen receptor binding  repressing transcription factor binding  cellular response to estradiol stimulus  regulation of signal transduction by p53 class mediator  positive regulation of protein acetylation  beta-catenin-TCF complex assembly  
    Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  DNA double-strand break processing  DNA synthesis involved in DNA repair  strand displacement  Swr1 complex  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  histone acetyltransferase activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription factor complex  nucleolus  DNA replication  double-strand break repair  double-strand break repair via nonhomologous end joining  transcription, DNA-templated  DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator  response to ionizing radiation  viral process  acetyltransferase activity  histone acetylation  androgen receptor signaling pathway  negative regulation of interleukin-2 production  Piccolo NuA4 histone acetyltransferase complex  NuA4 histone acetyltransferase complex  regulation of growth  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  perinuclear region of cytoplasm  androgen receptor binding  repressing transcription factor binding  cellular response to estradiol stimulus  regulation of signal transduction by p53 class mediator  positive regulation of protein acetylation  beta-catenin-TCF complex assembly  
    Pathways : BIOCARTAMulti-step Regulation of Transcription by Pitx2 [Genes]   
    Pathways : KEGGHTLV-I infection   
    REACTOMEQ92993 [protein]
    REACTOME PathwaysR-HSA-69473 [pathway]   
    NDEx NetworkKAT5
    Atlas of Cancer Signalling NetworkKAT5
    Wikipedia pathwaysKAT5
    Orthology - Evolution
    OrthoDB10524
    GeneTree (enSembl)ENSG00000172977
    Phylogenetic Trees/Animal Genes : TreeFamKAT5
    HOVERGENQ92993
    HOGENOMQ92993
    Homologs : HomoloGeneKAT5
    Homology/Alignments : Family Browser (UCSC)KAT5
    Gene fusions - Rearrangements
    Polymorphisms : SNP and Copy number variants
    NCBI Variation ViewerKAT5 [hg38]
    dbSNP Single Nucleotide Polymorphism (NCBI)KAT5
    dbVarKAT5
    ClinVarKAT5
    1000_GenomesKAT5 
    Exome Variant ServerKAT5
    ExAC (Exome Aggregation Consortium)KAT5 (select the gene name)
    Genetic variants : HAPMAP10524
    Genomic Variants (DGV)KAT5 [DGVbeta]
    DECIPHERKAT5 [patients]   [syndromes]   [variants]   [genes]  
    CONAN: Copy Number AnalysisKAT5 
    Mutations
    ICGC Data PortalKAT5 
    TCGA Data PortalKAT5 
    Broad Tumor PortalKAT5
    OASIS PortalKAT5 [ Somatic mutations - Copy number]
    Somatic Mutations in Cancer : COSMICKAT5  [overview]  [genome browser]  [tissue]  [distribution]  
    Mutations and Diseases : HGMDKAT5
    LOVD (Leiden Open Variation Database)Whole genome datasets
    LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
    LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
    BioMutasearch KAT5
    DgiDB (Drug Gene Interaction Database)KAT5
    DoCM (Curated mutations)KAT5 (select the gene name)
    CIViC (Clinical Interpretations of Variants in Cancer)KAT5 (select a term)
    intoGenKAT5
    NCG5 (London)KAT5
    Cancer3DKAT5(select the gene name)
    Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
    Diseases
    OMIM601409   
    Orphanet
    MedgenKAT5
    Genetic Testing Registry KAT5
    NextProtQ92993 [Medical]
    TSGene10524
    GENETestsKAT5
    Target ValidationKAT5
    Huge Navigator KAT5 [HugePedia]
    snp3D : Map Gene to Disease10524
    BioCentury BCIQKAT5
    ClinGenKAT5
    Clinical trials, drugs, therapy
    Chemical/Protein Interactions : CTD10524
    Chemical/Pharm GKB GenePA162392746
    Clinical trialKAT5
    Miscellaneous
    canSAR (ICR)KAT5 (select the gene name)
    Probes
    Litterature
    PubMed233 Pubmed reference(s) in Entrez
    GeneRIFsGene References Into Functions (Entrez)
    CoreMineKAT5
    EVEXKAT5
    GoPubMedKAT5
    iHOPKAT5
    REVIEW articlesautomatic search in PubMed
    Last year publicationsautomatic search in PubMed

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    indexed on : Mon Sep 18 17:05:06 CEST 2017

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