TRRAP (transformation/transcription domain associated protein)

2003-02-01  

Identity

HGNC
TRRAP
LOCATION
7q22.1
LOCUSID
8295
ALIAS
DEDDFA,DFNA75,PAF350/400,PAF400,STAF40,TR-AP,Tra1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8295
MIM: 603015
HGNC: 12347
Ensembl: ENSG00000196367

Variants:

dbSNP: 8295
ClinVar: 8295
TCGA: ENSG00000196367
COSMIC: TRRAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196367ENST00000355540Q9Y4A5
ENSG00000196367ENST00000359863Q9Y4A5
ENSG00000196367ENST00000360902A0A2R8YFJ4
ENSG00000196367ENST00000417523C9K0N1
ENSG00000196367ENST00000446306F2Z2U4
ENSG00000196367ENST00000456197H0Y4W2
ENSG00000196367ENST00000628380F2Z2U4

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Formation of the beta-catenin:TCF transactivating complexREACTOMER-HSA-201722
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
351516932022Interaction of transcription factor FoxO3 with histone acetyltransferase complex subunit TRRAP modulates gene expression and apoptosis.0
351516932022Interaction of transcription factor FoxO3 with histone acetyltransferase complex subunit TRRAP modulates gene expression and apoptosis.0
341561462021Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism.4
348303242021Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription.9
341561462021Lipid droplet screen in human hepatocytes identifies TRRAP as a regulator of cellular triglyceride metabolism.4
348303242021Beyond HAT Adaptor: TRRAP Liaisons with Sp1-Mediated Transcription.9
311884952020Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes.31
311884952020Depletion of TRRAP Induces p53-Independent Senescence in Liver Cancer by Down-Regulating Mitotic Genes.31
308274962019Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability.20
308274962019Missense Variants in the Histone Acetyltransferase Complex Component Gene TRRAP Cause Autism and Syndromic Intellectual Disability.20
295883762018TRRAP is a central regulator of human multiciliated cell formation.9
296539642018TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.19
299369292018TRRAP stimulates the tumorigenic potential of ovarian cancer stem cells.8
295883762018TRRAP is a central regulator of human multiciliated cell formation.9
296539642018TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.19

Citation

Dessen P

TRRAP (transformation/transcription domain associated protein)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42710/trrap-(transformation-transcription-domain-associated-protein)