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JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))

Written2003-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)c-jun
Activator Protein-1
HGNC (Hugo) JUN
HGNC Alias symbc-Jun
AP-1
HGNC Previous namev-jun avian sarcoma virus 17 oncogene homolog
 jun oncogene
LocusID (NCBI) 3725
Atlas_Id 151
Location 1p32.1  [Link to chromosome band 1p32]
Location_base_pair Starts at 58780791 and ends at 58784047 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping JUN.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY1 (7p12.3)::JUN (1p32.1)JUN (1p32.1)::GMPR2 (14q12)JUN (1p32.1)::LARP4B (10p15.3)
JUN (1p32.1)::MPV17 (2p23.3)JUN (1p32.1)::SLC25A1 (22q11.21)MAGI1 (3p14.1)::JUN (1p32.1)
PIGY (4q22.1)::JUN (1p32.1)SLC25A1 (22q11.21)::JUN (1p32.1)

DNA/RNA

Description The Jun gene maps on chromosome 1p32-p31 spanning 333799bp. The study by Hattori et al suggested that the Jun gene has no introns.
Transcription Due to 5' and 3' heterogeneities, several transcripts of Jun mRNA has been identified. The predicted molecular weight of JUN protein is 41.9 kD.

Protein

 
Description The JUN protein was originally identified as an oncoprotein encoded by a cellular insert in the genome of avian sarcoma virus 17. Following studies demonstrated that JUN is a critical component of AP-1 transcription factor that recognizes the palindromic DNA sequence TGAC/GTCA, the so-called TPA response element (TRE), in the promoter or intron region of a number of genes. JUN can stably associate with itself or Fos protein to form AP-1 complex. JUN can also interact with some activating transcription factor (ATF) members, such as ATF2, ATF3 and ATF4, to form heterodimers that bind to the cAMP-responsive element (CRE) DNA sequence, TGACGTCA. All JUN proteins from different species contain a N-terminal JNK docking domain (delta domain) adjacent to the JNK phosphorylating site Ser63/73. In the C-terminal, there is a basic domain for DNA binding, followed by a nuclear localization signal (NLS) and a leucine zipper motif for dimerization with partner proteins.
Expression Ubiquitously expressed.
Localisation Nuclear and mitochondria.
Function JUN is the most important component of AP-1 transcription factors, and its transcriptional activity is possibly attenuated by JUNB or JUND. It has been well accepted that JUN regulates cell proliferation, apoptosis and transformation. JUN promotes cell cycle transition from G1 phase to S phase by up-regulating cyclin D1 expression and antagonizing the function of p53and p21. The JUN protein is involved in both the induction and prevention of apoptosis, possibly dependent on the types and development stages of cells. JUN-dependent induction of pro-apoptotic protein FasL and Bim has been demonstrated in several experimental systems. However, evidence indicating an anti-apoptotic activity of JUN has also been provided by the fact that deficiency of Jun gene causes massive hepatocyte apoptosis. The potential oncogenic transformation of JUN has been revealed by overexpression experiments. This effect of JUN may partially through the induction of certain JUN targeting genes, such as heparin-bind epidermal growth factor-like growth factor (HB-EGF), proliferin and Jun-activated gene in chicken embryo fibroblasts (JAC).

Implicated in

Note
  
Entity Inflammation
  
  
Entity cancer
Oncogenesis Overexpression of JUN has been observed in certain human cancer. However, no mutation, rearrangement or amplification of Jun gene has been reported.
  

Bibliography

Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Hattori K, Angel P, Le Beau MM, Karin M
Proceedings of the National Academy of Sciences of the United States of America. 1988 ; 85 (23) : 9148-9152.
PMID 3194415
 
AP-1 as a regulator of cell life and death.
Shaulian E, Karin M
Nature cell biology. 2002 ; 4 (5) : E131-E136.
PMID 11988758
 
Fortuitous convergences: the beginnings of JUN.
Vogt PK
Nature reviews. Cancer. 2002 ; 2 (6) : 465-469.
PMID 12189388
 

Citation

This paper should be referenced as such :
Chen, F
JUN (v-Jun sarcoma virus 17 oncogene homolog (avian))
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):98-99.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(1;5)(p32;q31) without TAL1 rearrangement
t(2;11)(p21;q24) MIR125B1::?
t(5;7)(q35;q21) TLX3::CDK6
t(9;13)(p12;q21) PAX5::DACH1
t(10;16)(q22;p13) KAT6B::CREBBP


External links

 

Nomenclature
HGNC (Hugo)JUN   6204
Cards
AtlasJUNID151
Atlas Explorer : (Salamanque)JUN
Entrez_Gene (NCBI)JUN    Jun proto-oncogene, AP-1 transcription factor subunit
AliasesAP-1; AP1; c-Jun; cJUN; 
p39
GeneCards (Weizmann)JUN
Ensembl hg19 (Hinxton)ENSG00000177606 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177606 [Gene_View]  ENSG00000177606 [Sequence]  chr1:58780791-58784047 [Contig_View]  JUN [Vega]
ICGC DataPortalENSG00000177606
TCGA cBioPortalJUN
AceView (NCBI)JUN
Genatlas (Paris)JUN
SOURCE (Princeton)JUN
Genetics Home Reference (NIH)JUN
Genomic and cartography
GoldenPath hg38 (UCSC)JUN  -     chr1:58780791-58784047 -  1p32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)JUN  -     1p32.1   [Description]    (hg19-Feb_2009)
GoldenPathJUN - 1p32.1 [CytoView hg19]  JUN - 1p32.1 [CytoView hg38]
ImmunoBaseENSG00000177606
Genome Data Viewer NCBIJUN [Mapview hg19]  
OMIM165160   
Gene and transcription
Genbank (Entrez)AK307137 BC002646 BC006175 BC009874 BC068522
RefSeq transcript (Entrez)NM_002228
Consensus coding sequences : CCDS (NCBI)JUN
Gene ExpressionJUN [ NCBI-GEO ]   JUN [ EBI - ARRAY_EXPRESS ]   JUN [ SEEK ]   JUN [ MEM ]
Gene Expression Viewer (FireBrowse)JUN [ Firebrowse - Broad ]
GenevisibleExpression of JUN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3725
GTEX Portal (Tissue expression)JUN
Human Protein AtlasENSG00000177606-JUN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05412   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05412  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05412
PhosPhoSitePlusP05412
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    C_Jun/v-Jun    JNK    Leuzip_Jun    TF_DNA-bd_sf   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    Jun (PF03957)   
Domain families : Pfam (NCBI)pfam00170    pfam03957   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)JUN
PDB (RSDB)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
PDB Europe1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
PDB (PDBSum)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
PDB (IMB)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
Structural Biology KnowledgeBase1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
SCOP (Structural Classification of Proteins)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
CATH (Classification of proteins structures)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
SuperfamilyP05412
AlphaFold pdb e-kbP05412   
Human Protein Atlas [tissue]ENSG00000177606-JUN [tissue]
HPRD01302
Protein Interaction databases
DIP (DOE-UCLA)P05412
IntAct (EBI)P05412
Complex Portal (EBI)P05412 CPX-480 AP-1 transcription factor complex FOS-JUN-NFATC2
P05412 CPX-490 AP-1 transcription factor complex JUN dimer
P05412 CPX-490 AP-1 transcription factor complex JUN dimer
P05412 CPX-486 AP-1 transcription factor complex FOS-JUN
BioGRIDJUN
STRING (EMBL)JUN
ZODIACJUN
Ontologies - Pathways
QuickGOP05412
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromosome  chromatin  euchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  microglial cell activation  liver development  positive regulation of endothelial cell proliferation  outflow tract morphogenesis  DNA binding  chromatin binding  DNA-binding transcription factor activity  RNA binding  GTPase activator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  plasma membrane  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  transforming growth factor beta receptor signaling pathway  Ras protein signal transduction  transcription factor binding  negative regulation of cell population proliferation  response to xenobiotic stimulus  positive regulation of epithelial cell migration  transcription repressor complex  enzyme binding  monocyte differentiation  axon regeneration  ubiquitin protein ligase binding  negative regulation of protein autophosphorylation  cellular response to reactive oxygen species  leading edge cell differentiation  cAMP response element binding  transcription factor AP-1 complex  transcription factor AP-1 complex  transcription factor AP-1 complex  response to muscle stretch  regulation of cell population proliferation  identical protein binding  positive regulation of apoptotic process  negative regulation of DNA binding  negative regulation of neuron apoptotic process  negative regulation by host of viral transcription  positive regulation by host of viral transcription  ubiquitin-like protein ligase binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of fibroblast proliferation  regulation of catalytic activity  regulation of cell cycle  SMAD protein signal transduction  eyelid development in camera-type eye  RNA polymerase II-specific DNA-binding transcription factor binding  positive regulation of ERK1 and ERK2 cascade  R-SMAD binding  cellular response to cadmium ion  cellular response to calcium ion  cellular response to anisomycin  RNA polymerase II transcription regulator complex  general transcription initiation factor binding  positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  positive regulation of miRNA transcription  positive regulation of miRNA transcription  positive regulation of vascular associated smooth muscle cell proliferation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  sequence-specific double-stranded DNA binding  positive regulation of DNA-templated transcription, initiation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromosome  chromatin  euchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  microglial cell activation  liver development  positive regulation of endothelial cell proliferation  outflow tract morphogenesis  DNA binding  chromatin binding  DNA-binding transcription factor activity  RNA binding  GTPase activator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  plasma membrane  regulation of transcription by RNA polymerase II  regulation of transcription by RNA polymerase II  transforming growth factor beta receptor signaling pathway  Ras protein signal transduction  transcription factor binding  negative regulation of cell population proliferation  response to xenobiotic stimulus  positive regulation of epithelial cell migration  transcription repressor complex  enzyme binding  monocyte differentiation  axon regeneration  ubiquitin protein ligase binding  negative regulation of protein autophosphorylation  cellular response to reactive oxygen species  leading edge cell differentiation  cAMP response element binding  transcription factor AP-1 complex  transcription factor AP-1 complex  transcription factor AP-1 complex  response to muscle stretch  regulation of cell population proliferation  identical protein binding  positive regulation of apoptotic process  negative regulation of DNA binding  negative regulation of neuron apoptotic process  negative regulation by host of viral transcription  positive regulation by host of viral transcription  ubiquitin-like protein ligase binding  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  positive regulation of fibroblast proliferation  regulation of catalytic activity  regulation of cell cycle  SMAD protein signal transduction  eyelid development in camera-type eye  RNA polymerase II-specific DNA-binding transcription factor binding  positive regulation of ERK1 and ERK2 cascade  R-SMAD binding  cellular response to cadmium ion  cellular response to calcium ion  cellular response to anisomycin  RNA polymerase II transcription regulator complex  general transcription initiation factor binding  positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus  positive regulation of miRNA transcription  positive regulation of miRNA transcription  positive regulation of vascular associated smooth muscle cell proliferation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  sequence-specific double-stranded DNA binding  positive regulation of DNA-templated transcription, initiation  
Pathways : BIOCARTABIOCARTA_PCAFPATHWAY    BIOCARTA_TSP1PATHWAY    BIOCARTA_AGRPATHWAY    BIOCARTA_AT1RPATHWAY    BIOCARTA_ATMPATHWAY    BIOCARTA_BCRPATHWAY    BIOCARTA_CDMACPATHWAY    BIOCARTA_D4GDIPATHWAY    BIOCARTA_EGFPATHWAY    BIOCARTA_EPOPATHWAY    BIOCARTA_FASPATHWAY    BIOCARTA_FCER1PATHWAY    BIOCARTA_HIFPATHWAY    BIOCARTA_IGF1PATHWAY    BIOCARTA_IL2PATHWAY    BIOCARTA_IL6PATHWAY    BIOCARTA_IL12PATHWAY    BIOCARTA_GLEEVECPATHWAY    BIOCARTA_INSULINPATHWAY    BIOCARTA_INTEGRINPATHWAY    BIOCARTA_KERATINOCYTEPATHWAY    BIOCARTA_PYK2PATHWAY    BIOCARTA_MAPKPATHWAY    BIOCARTA_PPARAPATHWAY    BIOCARTA_ETSPATHWAY    BIOCARTA_NGFPATHWAY    BIOCARTA_ARENRF2PATHWAY    BIOCARTA_PDGFPATHWAY    BIOCARTA_CCR5PATHWAY    BIOCARTA_DREAMPATHWAY    BIOCARTA_CARDIACEGFPATHWAY    BIOCARTA_IL1RPATHWAY    BIOCARTA_METPATHWAY    BIOCARTA_GPCRPATHWAY    BIOCARTA_TCRPATHWAY    BIOCARTA_41BBPATHWAY    BIOCARTA_STRESSPATHWAY    BIOCARTA_TNFR1PATHWAY    BIOCARTA_TOLLPATHWAY    BIOCARTA_TPOPATHWAY   
Pathways : KEGGKEGG_MAPK_SIGNALING    KEGG_ERBB_SIGNALING    KEGG_WNT_SIGNALING    KEGG_FOCAL_ADHESION    KEGG_TOLL_LIKE_RECEPTOR_SIGNALING    KEGG_T_CELL_RECEPTOR_SIGNALING    KEGG_B_CELL_RECEPTOR_SIGNALING    KEGG_NEUROTROPHIN_SIGNALING    KEGG_GNRH_SIGNALING    KEGG_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION    KEGG_LEISHMANIA_INFECTION    KEGG_PATHWAYS_IN_CANCER    KEGG_COLORECTAL_CANCER    KEGG_RENAL_CELL_CARCINOMA   
REACTOMEP05412 [protein]
REACTOME PathwaysR-HSA-9018519 [pathway]   
NDEx NetworkJUN
Atlas of Cancer Signalling NetworkJUN
Wikipedia pathwaysJUN
Orthology - Evolution
OrthoDB3725
GeneTree (enSembl)ENSG00000177606
Phylogenetic Trees/Animal Genes : TreeFamJUN
Homologs : HomoloGeneJUN
Homology/Alignments : Family Browser (UCSC)JUN
Gene fusions - Rearrangements
Fusion : FusionHubADCY1--JUN    ESD--JUN    FLNC--JUN    GNAS--JUN    JUN--AP1    JUN--ATF2    JUN--DES    JUN--FOS    JUN--GMPR2    JUN--HERC2   
JUN--IGFBP7    JUN--JNK    JUN--LARP4B    JUN--MPV17    JUN--RPS20    JUN--SLAIN2    JUN--SLC25A1    JUN--TG    KRT13--JUN    MAGI1--JUN   
NSD1--JUN    PFDN5--JUN    PIGY--JUN    RCCD1--JUN    SIPA1L2--JUN    SLC25A1--JUN    TG--JUN   
Fusion : QuiverJUN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerJUN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)JUN
dbVarJUN
ClinVarJUN
MonarchJUN
1000_GenomesJUN 
Exome Variant ServerJUN
GNOMAD BrowserENSG00000177606
Varsome BrowserJUN
ACMGJUN variants
VarityP05412
Genomic Variants (DGV)JUN [DGVbeta]
DECIPHERJUN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisJUN 
Mutations
ICGC Data PortalJUN 
TCGA Data PortalJUN 
Broad Tumor PortalJUN
OASIS PortalJUN [ Somatic mutations - Copy number]
Cancer Gene: CensusJUN 
Somatic Mutations in Cancer : COSMICJUN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DJUN
Mutations and Diseases : HGMDJUN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaJUN
DgiDB (Drug Gene Interaction Database)JUN
DoCM (Curated mutations)JUN
CIViC (Clinical Interpretations of Variants in Cancer)JUN
OncoKBJUN
NCG (London)JUN
Cancer3DJUN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165160   
Orphanet
DisGeNETJUN
MedgenJUN
Genetic Testing Registry JUN
NextProtP05412 [Medical]
GENETestsJUN
Target ValidationJUN
Huge Navigator JUN [HugePedia]
ClinGenJUN
Clinical trials, drugs, therapy
MyCancerGenomeJUN
Protein Interactions : CTDJUN
Pharm GKB GenePA30006
Pharm GKB PathwaysPA162356267   PA165980050   PA165985892   
PharosP05412
Clinical trialJUN
Miscellaneous
canSAR (ICR)JUN
HarmonizomeJUN
ARCHS4JUN
DataMed IndexJUN
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXJUN
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 14:10:06 CET 2022

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