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| Description | The JUN protein was originally identified as an oncoprotein encoded by a cellular insert in the genome of avian sarcoma virus 17. Following studies demonstrated that JUN is a critical component of AP-1 transcription factor that recognizes the palindromic DNA sequence TGAC/GTCA, the so-called TPA response element (TRE), in the promoter or intron region of a number of genes. JUN can stably associate with itself or Fos protein to form AP-1 complex. JUN can also interact with some activating transcription factor (ATF) members, such as ATF2, ATF3 and ATF4, to form heterodimers that bind to the cAMP-responsive element (CRE) DNA sequence, TGACGTCA. All JUN proteins from different species contain a N-terminal JNK docking domain (delta domain) adjacent to the JNK phosphorylating site Ser63/73. In the C-terminal, there is a basic domain for DNA binding, followed by a nuclear localization signal (NLS) and a leucine zipper motif for dimerization with partner proteins. |
| Expression | Ubiquitously expressed. |
| Localisation | Nuclear and mitochondria. |
| Function | JUN is the most important component of AP-1 transcription factors, and its transcriptional activity is possibly attenuated by JUNB or JUND. It has been well accepted that JUN regulates cell proliferation, apoptosis and transformation. JUN promotes cell cycle transition from G1 phase to S phase by up-regulating cyclin D1 expression and antagonizing the function of p53and p21. The JUN protein is involved in both the induction and prevention of apoptosis, possibly dependent on the types and development stages of cells. JUN-dependent induction of pro-apoptotic protein FasL and Bim has been demonstrated in several experimental systems. However, evidence indicating an anti-apoptotic activity of JUN has also been provided by the fact that deficiency of Jun gene causes massive hepatocyte apoptosis. The potential oncogenic transformation of JUN has been revealed by overexpression experiments. This effect of JUN may partially through the induction of certain JUN targeting genes, such as heparin-bind epidermal growth factor-like growth factor (HB-EGF), proliferin and Jun-activated gene in chicken embryo fibroblasts (JAC). |
| Structure and chromosomal localization of the functional intronless human JUN protooncogene. |
| Hattori K, Angel P, Le Beau MM, Karin M |
| Proceedings of the National Academy of Sciences of the United States of America. 1988 ; 85 (23) : 9148-9152. |
| PMID 3194415 |
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| AP-1 as a regulator of cell life and death. |
| Shaulian E, Karin M |
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| PMID 11988758 |
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| Jun, the oncoprotein. |
| Vogt PK |
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| PMID 11402333 |
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| Fortuitous convergences: the beginnings of JUN. |
| Vogt PK |
| Nature reviews. Cancer. 2002 ; 2 (6) : 465-469. |
| PMID 12189388 |
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