Atlas of Genetics and Cytogenetics in Oncology and Haematology


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JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))

Identity

Other namesc-jun
Activator Protein-1
HGNC (Hugo) JUN
LocusID (NCBI) 3725
Location 1p32.1
Location_base_pair Starts at 59246463 and ends at 59249785 bp from pter ( according to hg19-Feb_2009)  [Mapping]

DNA/RNA

Description The Jun gene maps on chromosome 1p32-p31 spanning 333799bp. The study by Hattori et al suggested that the Jun gene has no introns.
Transcription Due to 5' and 3' heterogeneities, several transcripts of Jun mRNA has been identified. The predicted molecular weight of JUN protein is 41.9 kD.

Protein

 
Description The JUN protein was originally identified as an oncoprotein encoded by a cellular insert in the genome of avian sarcoma virus 17. Following studies demonstrated that JUN is a critical component of AP-1 transcription factor that recognizes the palindromic DNA sequence TGAC/GTCA, the so-called TPA response element (TRE), in the promoter or intron region of a number of genes. JUN can stably associate with itself or Fos protein to form AP-1 complex. JUN can also interact with some activating transcription factor (ATF) members, such as ATF2, ATF3 and ATF4, to form heterodimers that bind to the cAMP-responsive element (CRE) DNA sequence, TGACGTCA. All JUN proteins from different species contain a N-terminal JNK docking domain (delta domain) adjacent to the JNK phosphorylating site Ser63/73. In the C-terminal, there is a basic domain for DNA binding, followed by a nuclear localization signal (NLS) and a leucine zipper motif for dimerization with partner proteins.
Expression Ubiquitously expressed.
Localisation Nuclear and mitochondria.
Function JUN is the most important component of AP-1 transcription factors, and its transcriptional activity is possibly attenuated by JUNB or JUND. It has been well accepted that JUN regulates cell proliferation, apoptosis and transformation. JUN promotes cell cycle transition from G1 phase to S phase by up-regulating cyclin D1 expression and antagonizing the function of p53and p21. The JUN protein is involved in both the induction and prevention of apoptosis, possibly dependent on the types and development stages of cells. JUN-dependent induction of pro-apoptotic protein FasL and Bim has been demonstrated in several experimental systems. However, evidence indicating an anti-apoptotic activity of JUN has also been provided by the fact that deficiency of Jun gene causes massive hepatocyte apoptosis. The potential oncogenic transformation of JUN has been revealed by overexpression experiments. This effect of JUN may partially through the induction of certain JUN targeting genes, such as heparin-bind epidermal growth factor-like growth factor (HB-EGF), proliferin and Jun-activated gene in chicken embryo fibroblasts (JAC).

Implicated in

Entity Inflammation
  
Entity cancer
Oncogenesis Overexpression of JUN has been observed in certain human cancer. However, no mutation, rearrangement or amplification of Jun gene has been reported.
  

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)JUN   6204
Cards
AtlasJUNID151
Entrez_Gene (NCBI)JUN  3725  jun proto-oncogene
GeneCards (Weizmann)JUN
Ensembl (Hinxton)ENSG00000177606 [Gene_View]  chr1:59246463-59249785 [Contig_View]  JUN [Vega]
ICGC DataPortalENSG00000177606
AceView (NCBI)JUN
Genatlas (Paris)JUN
WikiGenes3725
SOURCE (Princeton)NM_002228
Genomic and cartography
GoldenPath (UCSC)JUN  -  1p32.1   chr1:59246463-59249785 -  1p32-p31   [Description]    (hg19-Feb_2009)
EnsemblJUN - 1p32-p31 [CytoView]
Mapping of homologs : NCBIJUN [Mapview]
OMIM165160   
Gene and transcription
Genbank (Entrez)BC002646 BC006175 BC009874 BC068522 BG831943
RefSeq transcript (Entrez)NM_002228
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_032977 NW_001838579 NW_004929290
Consensus coding sequences : CCDS (NCBI)JUN
Cluster EST : UnigeneHs.696684 [ NCBI ]
CGAP (NCI)Hs.696684
Alternative Splicing : Fast-db (Paris)GSHG0002147
Alternative Splicing GalleryENSG00000177606
Gene ExpressionJUN [ NCBI-GEO ]     JUN [ SEEK ]   JUN [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05412 (Uniprot)
NextProtP05412  [Medical]
With graphics : InterProP05412
Splice isoforms : SwissVarP05412 (Swissvar)
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    JNK    Leuzip_Jun    TF_DNA-bd   
Related proteins : CluSTrP05412
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    Jun (PF03957)   
Domain families : Pfam (NCBI)pfam00170    pfam03957   
Domain families : Smart (EMBL)BRLZ (SM00338)  
DMDM Disease mutations3725
Blocks (Seattle)P05412
PDB (SRS)1A02    1FOS    1JNM    1JUN    1S9K    1T2K   
PDB (PDBSum)1A02    1FOS    1JNM    1JUN    1S9K    1T2K   
PDB (IMB)1A02    1FOS    1JNM    1JUN    1S9K    1T2K   
PDB (RSDB)1A02    1FOS    1JNM    1JUN    1S9K    1T2K   
Human Protein AtlasENSG00000177606
Peptide AtlasP05412
HPRD01302
IPIIPI00008965   IPI00978455   
Protein Interaction databases
DIP (DOE-UCLA)P05412
IntAct (EBI)P05412
FunCoupENSG00000177606
BioGRIDJUN
IntegromeDBJUN
STRING (EMBL)JUN
Ontologies - Pathways
QuickGOP05412
Ontology : AmiGOnuclear chromosome  RNA polymerase II distal enhancer sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II activating transcription factor binding  RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription  angiogenesis  microglial cell activation  release of cytochrome c from mitochondria  liver development  positive regulation of endothelial cell proliferation  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  outflow tract morphogenesis  DNA binding  double-stranded DNA binding  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  transcription coactivator activity  Rho GTPase activator activity  protein binding  nucleoplasm  transcription factor complex  nuclear euchromatin  cytosol  transcription from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  SMAD protein import into nucleus  aging  learning  circadian rhythm  transcription factor binding  negative regulation of cell proliferation  response to radiation  response to mechanical stimulus  transcriptional repressor complex  enzyme binding  monocyte differentiation  axon regeneration  negative regulation of protein autophosphorylation  positive regulation of Rho GTPase activity  response to lipopolysaccharide  response to cytokine  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  leading edge cell differentiation  cAMP response element binding  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  response to drug  response to hydrogen peroxide  negative regulation of DNA binding  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  negative regulation by host of viral transcription  positive regulation by host of viral transcription  transcription regulatory region DNA binding  poly(A) RNA binding  innate immune response  positive regulation of monocyte differentiation  positive regulation of DNA replication  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fibroblast proliferation  positive regulation of smooth muscle cell proliferation  regulation of sequence-specific DNA binding transcription factor activity  cellular response to potassium ion starvation  stress-activated MAPK cascade  response to cAMP  regulation of cell cycle  membrane depolarization  SMAD protein signal transduction  R-SMAD binding  cellular response to calcium ion  HMG box domain binding  
Ontology : EGO-EBInuclear chromosome  RNA polymerase II distal enhancer sequence-specific DNA binding  RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription  RNA polymerase II activating transcription factor binding  RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription  angiogenesis  microglial cell activation  release of cytochrome c from mitochondria  liver development  positive regulation of endothelial cell proliferation  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  outflow tract morphogenesis  DNA binding  double-stranded DNA binding  sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity  transcription coactivator activity  Rho GTPase activator activity  protein binding  nucleoplasm  transcription factor complex  nuclear euchromatin  cytosol  transcription from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  SMAD protein import into nucleus  aging  learning  circadian rhythm  transcription factor binding  negative regulation of cell proliferation  response to radiation  response to mechanical stimulus  transcriptional repressor complex  enzyme binding  monocyte differentiation  axon regeneration  negative regulation of protein autophosphorylation  positive regulation of Rho GTPase activity  response to lipopolysaccharide  response to cytokine  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  leading edge cell differentiation  cAMP response element binding  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  response to drug  response to hydrogen peroxide  negative regulation of DNA binding  negative regulation of neuron apoptotic process  positive regulation of neuron apoptotic process  negative regulation by host of viral transcription  positive regulation by host of viral transcription  transcription regulatory region DNA binding  poly(A) RNA binding  innate immune response  positive regulation of monocyte differentiation  positive regulation of DNA replication  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of fibroblast proliferation  positive regulation of smooth muscle cell proliferation  regulation of sequence-specific DNA binding transcription factor activity  cellular response to potassium ion starvation  stress-activated MAPK cascade  response to cAMP  regulation of cell cycle  membrane depolarization  SMAD protein signal transduction  R-SMAD binding  cellular response to calcium ion  HMG box domain binding  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]    BCR Signaling Pathway [Genes]    Signaling Pathway from G-Protein Families [Genes]    PDGF Signaling Pathway [Genes]    Agrin in Postsynaptic Differentiation [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    D4-GDI Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Hypoxia-Inducible Factor in the Cardiovascular System [Genes]    IL 6 signaling pathway [Genes]    MAPKinase Signaling Pathway [Genes]    T Cell Receptor Signaling Pathway [Genes]    Toll-Like Receptor Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Repression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]    EGF Signaling Pathway [Genes]    Signal transduction through IL1R [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    TNFR1 Signaling Pathway [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    EPO Signaling Pathway [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Insulin Signaling Pathway [Genes]    The information-processing pathway at the IFN-beta enhancer [Genes]    TSP-1 Induced Apoptosis in Microvascular Endothelial Cell [Genes]    Oxidative Stress Induced Gene Expression Via Nrf2 [Genes]    ATM Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    TNF/Stress Related Signaling [Genes]    Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    METS affect on Macrophage Differentiation [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Keratinocyte Differentiation [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    IL 2 signaling pathway [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    TPO Signaling Pathway [Genes]    IGF-1 Signaling Pathway [Genes]    Integrin Signaling Pathway [Genes]    Nerve growth factor pathway (NGF) [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Wnt signaling pathway    Osteoclast differentiation    Focal adhesion    Toll-like receptor signaling pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    TNF signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Cocaine addiction    Amphetamine addiction    Epithelial cell signaling in Helicobacter pylori infection    Salmonella infection    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Hepatitis B    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Colorectal cancer    Renal cell carcinoma    Inflammatory bowel disease (IBD)    Rheumatoid arthritis   
REACTOMEP05412 [protein]
REACTOME PathwaysREACT_120956 Cellular responses to stress [pathway]
REACTOME PathwaysREACT_6900 Immune System [pathway]
REACTOME PathwaysREACT_6782 TRAF6 Mediated Induction of proinflammatory cytokines [pathway]
Protein Interaction DatabaseJUN
Wikipedia pathwaysJUN
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)JUN
SNP (GeneSNP Utah)JUN
SNP : HGBaseJUN
Genetic variants : HAPMAPJUN
1000_GenomesJUN 
ICGC programENSG00000177606 
Cancer Gene: CensusJUN 
CONAN: Copy Number AnalysisJUN 
Somatic Mutations in Cancer : COSMICJUN 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)1:59246463-59249785
Mutations and Diseases : HGMDJUN
OMIM165160   
MedgenJUN
GENETestsJUN
Disease Genetic AssociationJUN
Huge Navigator JUN [HugePedia]  JUN [HugeCancerGEM]
Genomic VariantsJUN  JUN [DGVbeta]
Exome VariantJUN
dbVarJUN
ClinVarJUN
snp3D : Map Gene to Disease3725
General knowledge
Homologs : HomoloGeneJUN
Homology/Alignments : Family Browser (UCSC)JUN
Phylogenetic Trees/Animal Genes : TreeFamJUN
Chemical/Protein Interactions : CTD3725
Chemical/Pharm GKB GenePA30006
Clinical trialJUN
Cancer Resource (Charite)ENSG00000177606
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMineJUN
GoPubMedJUN
iHOPJUN

Bibliography

Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Hattori K, Angel P, Le Beau MM, Karin M
Proceedings of the National Academy of Sciences of the United States of America. 1988 ; 85 (23) : 9148-9152.
PMID 3194415
 
AP-1 as a regulator of cell life and death.
Shaulian E, Karin M
Nature cell biology. 2002 ; 4 (5) : E131-E136.
PMID 11988758
 
Jun, the oncoprotein.
Vogt PK
Oncogene. 2001 ; 20 (19) : 2365-2377.
PMID 11402333
 
Fortuitous convergences: the beginnings of JUN.
Vogt PK
Nature reviews. Cancer. 2002 ; 2 (6) : 465-469.
PMID 12189388
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written01-2003Fei Chen

Citation

This paper should be referenced as such :
Chen, F
JUN (v-Jun sarcoma virus 17 oncogene homolog (avian))
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):98-99.
Free online version   Free pdf version   [Bibliographic record ]
URL : http://AtlasGeneticsOncology.org/Genes/JUNID151.html

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indexed on : Sat Nov 8 16:49:59 CET 2014

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