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JUN (V-Jun sarcoma virus 17 oncogene homolog (avian))

Written2003-01Fei Chen
Health Effects Laboratory Division, NIOSH, 1095 Willowdale Rd, Morgantown, WV 26505, USA

(Note : for Links provided by Atlas : click)

Identity

Alias (NCBI)c-jun
Activator Protein-1
HGNC (Hugo) JUN
HGNC Alias symbc-Jun
AP-1
HGNC Previous namev-jun avian sarcoma virus 17 oncogene homolog
 jun oncogene
LocusID (NCBI) 3725
Atlas_Id 151
Location 1p32.1  [Link to chromosome band 1p32]
Location_base_pair Starts at 58780791 and ends at 58784047 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping JUN.png]
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADCY1 (7p12.3)::JUN (1p32.1)JUN (1p32.1)::GMPR2 (14q12)JUN (1p32.1)::LARP4B (10p15.3)
JUN (1p32.1)::MPV17 (2p23.3)JUN (1p32.1)::SLC25A1 (22q11.21)MAGI1 (3p14.1)::JUN (1p32.1)
PIGY (4q22.1)::JUN (1p32.1)SLC25A1 (22q11.21)::JUN (1p32.1)

DNA/RNA

Description The Jun gene maps on chromosome 1p32-p31 spanning 333799bp. The study by Hattori et al suggested that the Jun gene has no introns.
Transcription Due to 5' and 3' heterogeneities, several transcripts of Jun mRNA has been identified. The predicted molecular weight of JUN protein is 41.9 kD.

Protein

 
Description The JUN protein was originally identified as an oncoprotein encoded by a cellular insert in the genome of avian sarcoma virus 17. Following studies demonstrated that JUN is a critical component of AP-1 transcription factor that recognizes the palindromic DNA sequence TGAC/GTCA, the so-called TPA response element (TRE), in the promoter or intron region of a number of genes. JUN can stably associate with itself or Fos protein to form AP-1 complex. JUN can also interact with some activating transcription factor (ATF) members, such as ATF2, ATF3 and ATF4, to form heterodimers that bind to the cAMP-responsive element (CRE) DNA sequence, TGACGTCA. All JUN proteins from different species contain a N-terminal JNK docking domain (delta domain) adjacent to the JNK phosphorylating site Ser63/73. In the C-terminal, there is a basic domain for DNA binding, followed by a nuclear localization signal (NLS) and a leucine zipper motif for dimerization with partner proteins.
Expression Ubiquitously expressed.
Localisation Nuclear and mitochondria.
Function JUN is the most important component of AP-1 transcription factors, and its transcriptional activity is possibly attenuated by JUNB or JUND. It has been well accepted that JUN regulates cell proliferation, apoptosis and transformation. JUN promotes cell cycle transition from G1 phase to S phase by up-regulating cyclin D1 expression and antagonizing the function of p53and p21. The JUN protein is involved in both the induction and prevention of apoptosis, possibly dependent on the types and development stages of cells. JUN-dependent induction of pro-apoptotic protein FasL and Bim has been demonstrated in several experimental systems. However, evidence indicating an anti-apoptotic activity of JUN has also been provided by the fact that deficiency of Jun gene causes massive hepatocyte apoptosis. The potential oncogenic transformation of JUN has been revealed by overexpression experiments. This effect of JUN may partially through the induction of certain JUN targeting genes, such as heparin-bind epidermal growth factor-like growth factor (HB-EGF), proliferin and Jun-activated gene in chicken embryo fibroblasts (JAC).

Implicated in

Note
  
Entity Inflammation
  
  
Entity cancer
Oncogenesis Overexpression of JUN has been observed in certain human cancer. However, no mutation, rearrangement or amplification of Jun gene has been reported.
  

Bibliography

Structure and chromosomal localization of the functional intronless human JUN protooncogene.
Hattori K, Angel P, Le Beau MM, Karin M
Proceedings of the National Academy of Sciences of the United States of America. 1988 ; 85 (23) : 9148-9152.
PMID 3194415
 
AP-1 as a regulator of cell life and death.
Shaulian E, Karin M
Nature cell biology. 2002 ; 4 (5) : E131-E136.
PMID 11988758
 
Fortuitous convergences: the beginnings of JUN.
Vogt PK
Nature reviews. Cancer. 2002 ; 2 (6) : 465-469.
PMID 12189388
 

Citation

This paper should be referenced as such :
Chen, F
JUN (v-Jun sarcoma virus 17 oncogene homolog (avian))
Atlas Genet Cytogenet Oncol Haematol. 2003;7(2):98-99.
Free journal version : [ pdf ]   [ DOI ]


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(1;5)(p32;q31) without TAL1 rearrangement
t(2;11)(p21;q24) MIR125B1::?
t(5;7)(q35;q21) TLX3::CDK6
t(9;13)(p12;q21) PAX5::DACH1
t(10;16)(q22;p13) KAT6B::CREBBP


External links

 

Nomenclature
HGNC (Hugo)JUN   6204
Cards
AtlasJUNID151
Entrez_Gene (NCBI)JUN    Jun proto-oncogene, AP-1 transcription factor subunit
AliasesAP-1; AP1; c-Jun; cJUN; 
p39
GeneCards (Weizmann)JUN
Ensembl hg19 (Hinxton)ENSG00000177606 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177606 [Gene_View]  ENSG00000177606 [Sequence]  chr1:58780791-58784047 [Contig_View]  JUN [Vega]
ICGC DataPortalENSG00000177606
TCGA cBioPortalJUN
AceView (NCBI)JUN
Genatlas (Paris)JUN
SOURCE (Princeton)JUN
Genetics Home Reference (NIH)JUN
Genomic and cartography
GoldenPath hg38 (UCSC)JUN  -     chr1:58780791-58784047 -  1p32.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)JUN  -     1p32.1   [Description]    (hg19-Feb_2009)
GoldenPathJUN - 1p32.1 [CytoView hg19]  JUN - 1p32.1 [CytoView hg38]
ImmunoBaseENSG00000177606
Genome Data Viewer NCBIJUN [Mapview hg19]  
OMIM165160   
Gene and transcription
Genbank (Entrez)AK307137 BC002646 BC006175 BC009874 BC068522
RefSeq transcript (Entrez)NM_002228
Consensus coding sequences : CCDS (NCBI)JUN
Gene ExpressionJUN [ NCBI-GEO ]   JUN [ EBI - ARRAY_EXPRESS ]   JUN [ SEEK ]   JUN [ MEM ]
Gene Expression Viewer (FireBrowse)JUN [ Firebrowse - Broad ]
GenevisibleExpression of JUN in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)3725
GTEX Portal (Tissue expression)JUN
Human Protein AtlasENSG00000177606-JUN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP05412   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP05412  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP05412
PhosPhoSitePlusP05412
Domaine pattern : Prosite (Expaxy)BZIP (PS50217)    BZIP_BASIC (PS00036)   
Domains : Interpro (EBI)bZIP    C_Jun/v-Jun    JNK    Leuzip_Jun    TF_DNA-bd_sf   
Domain families : Pfam (Sanger)bZIP_1 (PF00170)    Jun (PF03957)   
Domain families : Pfam (NCBI)pfam00170    pfam03957   
Domain families : Smart (EMBL)BRLZ (SM00338)  
Conserved Domain (NCBI)JUN
PDB (RSDB)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
PDB Europe1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
PDB (PDBSum)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
PDB (IMB)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
Structural Biology KnowledgeBase1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
SCOP (Structural Classification of Proteins)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
CATH (Classification of proteins structures)1A02    1FOS    1JNM    1JUN    1S9K    1T2K    5FV8    5T01   
SuperfamilyP05412
AlphaFold pdb e-kbP05412   
Human Protein Atlas [tissue]ENSG00000177606-JUN [tissue]
HPRD01302
Protein Interaction databases
DIP (DOE-UCLA)P05412
IntAct (EBI)P05412
Complex Portal (EBI)P05412 CPX-480 AP-1 transcription factor complex FOS-JUN-NFATC2
P05412 CPX-490 AP-1 transcription factor complex JUN dimer
P05412 CPX-490 AP-1 transcription factor complex JUN dimer
P05412 CPX-486 AP-1 transcription factor complex FOS-JUN
BioGRIDJUN
STRING (EMBL)JUN
ZODIACJUN
Ontologies - Pathways
QuickGOP05412
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  nuclear chromosome  chromatin  euchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  release of cytochrome c from mitochondria  DNA binding  DNA-binding transcription factor activity  RNA binding  GTPase activator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytosol  plasma membrane  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transforming growth factor beta receptor signaling pathway  Ras protein signal transduction  aging  learning  circadian rhythm  transcription factor binding  transcription factor binding  response to radiation  response to mechanical stimulus  enzyme binding  ubiquitin protein ligase binding  response to lipopolysaccharide  response to cytokine  cellular response to reactive oxygen species  cAMP response element binding  transcription factor AP-1 complex  transcription factor AP-1 complex  Fc-epsilon receptor signaling pathway  regulation of cell population proliferation  response to drug  response to hydrogen peroxide  identical protein binding  positive regulation of apoptotic process  negative regulation of DNA binding  positive regulation of neuron apoptotic process  negative regulation by host of viral transcription  positive regulation by host of viral transcription  ubiquitin-like protein ligase binding  protein-containing complex binding  positive regulation of monocyte differentiation  positive regulation of DNA replication  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  regulation of catalytic activity  regulation of DNA-binding transcription factor activity  cellular response to potassium ion starvation  response to cAMP  regulation of cell cycle  membrane depolarization  SMAD protein signal transduction  RNA polymerase II-specific DNA-binding transcription factor binding  R-SMAD binding  cellular response to cadmium ion  HMG box domain binding  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of vascular associated smooth muscle cell proliferation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  sequence-specific double-stranded DNA binding  positive regulation of DNA-templated transcription, initiation  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  nuclear chromosome  chromatin  euchromatin  transcription cis-regulatory region binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription repressor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  angiogenesis  release of cytochrome c from mitochondria  DNA binding  DNA-binding transcription factor activity  RNA binding  GTPase activator activity  protein binding  nucleus  nucleoplasm  nucleoplasm  transcription regulator complex  cytosol  plasma membrane  regulation of transcription by RNA polymerase II  transcription by RNA polymerase II  transforming growth factor beta receptor signaling pathway  Ras protein signal transduction  aging  learning  circadian rhythm  transcription factor binding  transcription factor binding  response to radiation  response to mechanical stimulus  enzyme binding  ubiquitin protein ligase binding  response to lipopolysaccharide  response to cytokine  cellular response to reactive oxygen species  cAMP response element binding  transcription factor AP-1 complex  transcription factor AP-1 complex  Fc-epsilon receptor signaling pathway  regulation of cell population proliferation  response to drug  response to hydrogen peroxide  identical protein binding  positive regulation of apoptotic process  negative regulation of DNA binding  positive regulation of neuron apoptotic process  negative regulation by host of viral transcription  positive regulation by host of viral transcription  ubiquitin-like protein ligase binding  protein-containing complex binding  positive regulation of monocyte differentiation  positive regulation of DNA replication  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription by RNA polymerase II  regulation of catalytic activity  regulation of DNA-binding transcription factor activity  cellular response to potassium ion starvation  response to cAMP  regulation of cell cycle  membrane depolarization  SMAD protein signal transduction  RNA polymerase II-specific DNA-binding transcription factor binding  R-SMAD binding  cellular response to cadmium ion  HMG box domain binding  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of pri-miRNA transcription by RNA polymerase II  positive regulation of vascular associated smooth muscle cell proliferation  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress  sequence-specific double-stranded DNA binding  positive regulation of DNA-templated transcription, initiation  
Pathways : BIOCARTAThe 4-1BB-dependent immune response [Genes]    BCR Signaling Pathway [Genes]    Signaling Pathway from G-Protein Families [Genes]    PDGF Signaling Pathway [Genes]    Agrin in Postsynaptic Differentiation [Genes]    Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy [Genes]    D4-GDI Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Hypoxia-Inducible Factor in the Cardiovascular System [Genes]    IL 6 signaling pathway [Genes]    MAPKinase Signaling Pathway [Genes]    T Cell Receptor Signaling Pathway [Genes]    Toll-Like Receptor Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Repression of Pain Sensation by the Transcriptional Regulator DREAM [Genes]    EGF Signaling Pathway [Genes]    Signal transduction through IL1R [Genes]    Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    TNFR1 Signaling Pathway [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    EPO Signaling Pathway [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Insulin Signaling Pathway [Genes]    The information-processing pathway at the IFN-beta enhancer [Genes]    TSP-1 Induced Apoptosis in Microvascular Endothelial Cell [Genes]    Oxidative Stress Induced Gene Expression Via Nrf2 [Genes]    ATM Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    TNF/Stress Related Signaling [Genes]    Pertussis toxin-insensitive CCR5 Signaling in Macrophage [Genes]    METS affect on Macrophage Differentiation [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Keratinocyte Differentiation [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    IL 2 signaling pathway [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    TPO Signaling Pathway [Genes]    IGF-1 Signaling Pathway [Genes]    Integrin Signaling Pathway [Genes]    Nerve growth factor pathway (NGF) [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Wnt signaling pathway    Osteoclast differentiation    Focal adhesion    Toll-like receptor signaling pathway    T cell receptor signaling pathway    B cell receptor signaling pathway    TNF signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Cocaine addiction    Amphetamine addiction    Epithelial cell signaling in Helicobacter pylori infection    Salmonella infection    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Hepatitis B    Influenza A    HTLV-I infection    Herpes simplex infection    Epstein-Barr virus infection    Pathways in cancer    Viral carcinogenesis    Colorectal cancer    Renal cell carcinoma    Inflammatory bowel disease (IBD)    Rheumatoid arthritis   
REACTOMEP05412 [protein]
REACTOME PathwaysR-HSA-9018519 [pathway]   
NDEx NetworkJUN
Atlas of Cancer Signalling NetworkJUN
Wikipedia pathwaysJUN
Orthology - Evolution
OrthoDB3725
GeneTree (enSembl)ENSG00000177606
Phylogenetic Trees/Animal Genes : TreeFamJUN
Homologs : HomoloGeneJUN
Homology/Alignments : Family Browser (UCSC)JUN
Gene fusions - Rearrangements
Fusion : QuiverJUN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerJUN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)JUN
dbVarJUN
ClinVarJUN
MonarchJUN
1000_GenomesJUN 
Exome Variant ServerJUN
GNOMAD BrowserENSG00000177606
Varsome BrowserJUN
ACMGJUN variants
VarityP05412
Genomic Variants (DGV)JUN [DGVbeta]
DECIPHERJUN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisJUN 
Mutations
ICGC Data PortalJUN 
TCGA Data PortalJUN 
Broad Tumor PortalJUN
OASIS PortalJUN [ Somatic mutations - Copy number]
Cancer Gene: CensusJUN 
Somatic Mutations in Cancer : COSMICJUN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DJUN
Mutations and Diseases : HGMDJUN
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaJUN
DgiDB (Drug Gene Interaction Database)JUN
DoCM (Curated mutations)JUN
CIViC (Clinical Interpretations of Variants in Cancer)JUN
OncoKBJUN
NCG (London)JUN
Cancer3DJUN
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM165160   
Orphanet
DisGeNETJUN
MedgenJUN
Genetic Testing Registry JUN
NextProtP05412 [Medical]
GENETestsJUN
Target ValidationJUN
Huge Navigator JUN [HugePedia]
ClinGenJUN
Clinical trials, drugs, therapy
MyCancerGenomeJUN
Protein Interactions : CTDJUN
Pharm GKB GenePA30006
Pharm GKB PathwaysPA162356267   PA165980050   PA165985892   
PharosP05412
Clinical trialJUN
Miscellaneous
canSAR (ICR)JUN
HarmonizomeJUN
DataMed IndexJUN
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXJUN
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:20:43 CEST 2021

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