FASLG (Fas ligand)

2005-02-01  

Identity

HGNC
LOCATION
1q24.3
LOCUSID
ALIAS
ALPS1B,APT1LG1,APTL,CD178,CD95-L,CD95L,FASL,TNFSF6,TNLG1A
FUSION GENES

Other Information

Locus ID:

NCBI: 356
MIM: 134638
HGNC: 11936
Ensembl: ENSG00000117560

Variants:

dbSNP: 356
ClinVar: 356
TCGA: ENSG00000117560
COSMIC: FASLG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000117560ENST00000340030P48023
ENSG00000117560ENST00000367721P48023
ENSG00000117560ENST00000367721Q53ZZ1

Expression (GTEx)

0
1
2
3
4
5
6

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Cytokine-cytokine receptor interactionKEGGko04060
ApoptosisKEGGko04210
Natural killer cell mediated cytotoxicityKEGGko04650
Type I diabetes mellitusKEGGko04940
Autoimmune thyroid diseaseKEGGko05320
Allograft rejectionKEGGko05330
Graft-versus-host diseaseKEGGko05332
MAPK signaling pathwayKEGGhsa04010
Cytokine-cytokine receptor interactionKEGGhsa04060
ApoptosisKEGGhsa04210
Natural killer cell mediated cytotoxicityKEGGhsa04650
Type I diabetes mellitusKEGGhsa04940
Pathways in cancerKEGGhsa05200
Autoimmune thyroid diseaseKEGGhsa05320
Allograft rejectionKEGGhsa05330
Graft-versus-host diseaseKEGGhsa05332
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
African trypanosomiasisKEGGko05143
African trypanosomiasisKEGGhsa05143
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Hepatitis BKEGGhsa05161
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
Ras signaling pathwayKEGGhsa04014
FoxO signaling pathwayKEGGhsa04068
DiseaseREACTOMER-HSA-1643685
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
TNFR2 non-canonical NF-kB pathwayREACTOMER-HSA-5668541
TNFs bind their physiological receptorsREACTOMER-HSA-5669034
Signal TransductionREACTOMER-HSA-162582
Death Receptor SignallingREACTOMER-HSA-73887
FasL/ CD95L signalingREACTOMER-HSA-75157
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Caspase activation via extrinsic apoptotic signalling pathwayREACTOMER-HSA-5357769
Ligand-dependent caspase activationREACTOMER-HSA-140534
Dimerization of procaspase-8REACTOMER-HSA-69416
Regulation by c-FLIPREACTOMER-HSA-3371378
Regulated NecrosisREACTOMER-HSA-5218859
RIPK1-mediated regulated necrosisREACTOMER-HSA-5213460
Regulation of necroptotic cell deathREACTOMER-HSA-5675482
CASP8 activity is inhibitedREACTOMER-HSA-5218900
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Neurodegenerative DiseasesREACTOMER-HSA-8863678
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease modelsREACTOMER-HSA-8862803
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378373852024CD95L concatemers highlight different stoichiometries of CD95-mediated apoptotic and nonapoptotic pathways.0
383632162024Synthesis of N-Glycosylated Soluble Fas Ligand.0
378373852024CD95L concatemers highlight different stoichiometries of CD95-mediated apoptotic and nonapoptotic pathways.0
383632162024Synthesis of N-Glycosylated Soluble Fas Ligand.0
374316142023The complex web of FasL: cell type-specific roles in affecting and controlling acute graft-vs-host disease.0
374316142023The complex web of FasL: cell type-specific roles in affecting and controlling acute graft-vs-host disease.0
338794032022Cord blood soluble Fas ligand linked to allergic rhinitis and lung function in seven-year-old children.0
343661982022Fas -670 A/G polymorphism predicts prognosis of hepatocellular carcinoma after curative resection in Chinese Han population.0
347536942022Differential cancer risk and survival in Indian oral cancer patients with genic region FAS and FASL polymorphisms.0
352402892022Cleaved CD95L perturbs in vitro macrophages responses to Toxoplasma gondii.0
358706952022miR-24-3p down-regulates the expression of the apoptotic factors FasL and BIM in human natural killer cells.2
359881042022The role of FASL, BCL-2 and BAX polymorphisms in brazilian patients with prostate cancer and benign prostatic hyperplasia.4
361244962022Fas cell surface death receptor/Fas ligand genetic variants in gastric cancer patients: A case-control study.0
366714662022Plasma Levels of sFas-sFasL and FASL Gene Expression Are Associated with Tuberculosis.2
338794032022Cord blood soluble Fas ligand linked to allergic rhinitis and lung function in seven-year-old children.0

Citation

Dessen P

FASLG (Fas ligand)

Atlas Genet Cytogenet Oncol Haematol. 2005-02-01

Online version: http://atlasgeneticsoncology.org/gene/396/faslg-(fas-ligand)