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ADGRL2 (adhesion G protein-coupled receptor L2 )

Written2003-11Jim Heighway
Roy Castle International Centre for Lung Cancer Research, Liverpool, UK

(Note : for Links provided by Atlas : click)

Identity

Other aliasLPHN2 (latrophilin 2)
LPHH1
LEC1
KIAA0786
LocusID (NCBI) 23266
Atlas_Id 313
Location 1p31.1  [Link to chromosome band 1p31]
Location_base_pair Starts at and ends at bp from pter
Local_order --ELTD1---LPHH1----FLJ23033----PRKACB--
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ADGRL2 (1p31.1) / ADGRL2 (1p31.1)ADGRL2 (1p31.1) / AK5 (1p31.1)ADGRL2 (1p31.1) / FLNA (Xq28)
ADGRL2 (1p31.1) / MIR548N (2q31.2)BCL6 (3q27.3) / ADGRL2 (1p31.1)STAT6 (12q13.3) / ADGRL2 (1p31.1)

DNA/RNA

 
  Representation of the genomic structure of LPHH1. Black blocks represent core exons which are present in the majority of gene transcripts. The yellow blocks represent alternatively spliced coding exons which may be incorporated variably in transcripts derived from different cell types/tissues or as a consequence of differing cellular states. The red boxes represent the presence of multiple, in some cases tissue-specific, leader exons that have been identified for this gene, an observation consistent with the existence of multiple dispersed promoter elements. The most variably spliced region of the coding sequence was the carboxy-terminal domain D.
Description LPHH1 consists of 19 commonly used coding exons. A further seven exons have been identified which may be alternatively spliced into the core backbone with variable frequencies and tissue specificities. At least a number of these additional exons are highly conserved in mammalian species. The core exons (ATG, exon 1 to stop, exon 19) span a region of about 154kb. However, the 5'end of the gene is not precisely defined with transcripts in different tissues apparently initiating from specific locations over an extensive region. The most distant leader exon identified (foetal lung) lies approximately 390kb from exon 1 which makes the total size of the gene at least 550kb.
Transcription Expression has been observed by RT-PCR in all normal tissues and lines tested with the clear exception of lymphocytes and lymphoblastoid cells. Strongest expression was observed in foetal lung, normal adult lung and thyroid. Alternative splicing to some degree in at least one domain (minimally the carboxy-terminal domain D) was seen in each tissue and line examined with human brain showing a characteristic pattern and additional variability in the other three coding sequence domains.
Pseudogene No known pseudogene.

Protein

 
  Alternative splicing in domain D dramatically alters the structure of the carboxy-terminus of the encoded protein, latrophilin 2. Variable splicing in this region occurs in all tissues and cell lines tested.
Description LPHH1 encodes a putative seven-span transmembrane receptor with atypically large extra membrane N (predicted to be extra-cellular) and C termini. In addition to the seven hydrophobic membrane spanning domains, a putative lectin-like region is present near the N-terminus.
Expression Protein likely to be ubiquitously expressed in adherent cells but that has not so far been confirmed. Human brain-specific alternative splices alter the structure of the extra-membrane, intra-cellular loop between TM domains 5 and 6, a region thought to be critical for G-protein/receptor interactions.
Localisation Likely to be plasma membrane.
Function Likely role in coupling cell adhesion to cell signalling.
Homology Latrophilin 2 is part of a small sub-family of 7TMs which includes latrophilins 1 and 3. Latrophilin 1 is the receptor for Black Widow spider toxin: -latrotoxin.

Mutations

Note None reported.

Implicated in

Note
  
Entity Breast carcinoma
Note Analysis of breast cancer cell lines has demonstrated dramatic differences in transcript levels between certain lines. In one case, strong expression was allelically imbalanced.
  
  
Entity Lung carcinoma
Note strong expression in normal lung was reduced in 55% (35/64) of matched primary non-small cell lung carcinomas (NSCLC). Over-representation was not scored in any tumour, nor in any lung cancer cell line tested and transcript was undetectable by RT-PCR in one line (1/15) and very low in a further two. Loss of heterozygosity was scored in 8/16 informative NSCLC lesions. Primary and SCLC lines showed a characteristic pattern of alternative splicing.
  

Bibliography

A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.
Hayflick JS
Journal of receptor and signal transduction research. 2000 ; 20 (2-3) : 119-131.
PMID 10994649
 
Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines.
White GR, Varley JM, Heighway J
Biochimica et biophysica acta. 2000 ; 1491 (1-3) : 75-92.
PMID 10760572
 

Citation

This paper should be referenced as such :
Heighway, J
LPHN2 (latrophilin 2)
Atlas Genet Cytogenet Oncol Haematol. 2004;8(1):10-11.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/LPHH1ID313.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  ADGRL2/AK5 (1p31)


External links

Nomenclature
Cards
AtlasLPHH1ID313.txt
Aliases
Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)23266
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
Miscellaneous
canSAR (ICR) (select the gene name)
Probes
Litterature
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed


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indexed on : Thu Oct 18 17:41:40 CEST 2018

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