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MIR183 (microRNA 183)

Written2011-11Juanjuan Zhu, Xiaofei Zheng
Beijing Institute of Radiation Medicine, Beijing 100850, PR China

(Note : for Links provided by Atlas : click)


Alias (NCBI)MIRN183
HGNC (Hugo) MIR183
HGNC Alias symbhsa-mir-183
HGNC Previous nameMIRN183
LocusID (NCBI) 406959
Atlas_Id 50539
Location 7q32.2  [Link to chromosome band 7q32]
Location_base_pair Starts at 129774905 and ends at 129775014 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping MIR183.png]
Local_order Based on Mapviewer (Master Map: Genes on sequence), genes flanking miR-183 oriented from centromere to telomere on 7q32.2 are:
- MIR182 (7q32.2): microRNA 182
- MIRN183 (7q32.2): microRNA 183
- MIRN96 (7q32.2): microRNA 96
- UBE2H (7q32.2): ubiquitin-conjugating enzyme E2H
- ZC3HC1 (7q32.2): zinc finger, C3HC-type containing 1.
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)


  Figure1. A. Stem-loop structure of miR-183. B. Genomic localization of miR-183 (MIRN183), miR-96 (MIRN96) and miR-182 (MIRN182) on chromosomal band 7q32.2 (modified from Ensembl).
Description miR-183 is located in an intergenic region. miR-182, miR-183 and miR-96 are clustered genes, containing identical seed sequences and both map to the 7 chromosome. The positions of these cluster microRNAs are:
- hsa-mir-183 7: 129414745-129414854 [-]
- has-mir-96 7: 129414532-129414609 [-]
- has-mir-182 7: 129410223-129410332 [-].
Transcription In general, the microRNA genes are transcribed by RNA polymerase II, whereas RNA polymerase III is also responsible for transcription of some other microRNAs.
Pre-microRNA 183 (precursor microRNA)
- Accession: MI0000273.
- Length: 110 bp.
- Sequence:
Mature miR-183
- Accession: MIMAT0000261.
- Length: 22 nucleotides.
- Sequence: 27-uauggcacugguagaauucacu-48.
Pseudogene No pseudogenes were reported for mir-183 and 182.


Note MicroRNAs are not translated into amino acids.

Implicated in

Entity Various cancers
Oncogenesis The transcription factor EGR1 is a tumor suppressor gene that is downregulated in many types of cancer. Clinically, loss the function of EGR1 translates to increased tumor transformation and subsequent patient morbidity and mortality. In synovial sarcoma, the SS18-SSX fusion protein represses EGR1 expression through a direct association with the EGR1 promoter. However, the mechanism through which EGR1 becomes downregulated in other tumor types is unclear. Researcher reported that EGR1 is regulated by miR-183 in multiple tumor types including synovial sarcoma, rhabdomyosarcoma (RMS), and colon cancer. Using an integrative network analysis, researchers identified that miR-183 is significantly overexpressed in these tumor types as well as in corresponding tumor cell lines. Bioinformatic analyses implied that miR-183 could target EGR1 mRNA and this specific interaction was validated in vitro. miR-183 knockdown in synovial sarcoma, RMS, and colon cancer cell lines revealed deregulation of a miRNA network composed of miR-183-EGR1-PTEN in these tumors. Integrated miRNA- and mRNA-based genomic analyses indicated that miR-183 is an important contributor to cell migration in these tumor types and this result was functionally validated to be occurring via an EGR1-based mechanism. In conclusion, these findings have significant implications in the mechanisms underlying EGR1 regulation in cancers. miR-183 has a potential oncogenic role through the regulation of 2 tumor suppressor genes, EGR1 and PTEN, and the deregulation of this fundamental miRNA regulatory network may be significant to many tumor types.
Entity Breast cancer
Note In breast cancer, miR183 is dysregulated. Its expression correlates with estrogen receptor and HER2/neu receptor expression. Overexpression of miR183 would inhibit migration of breast cancer cells. Specifically, the VIL2-coding protein ezrin was confirmed as a target of miR183 and downregulation of this protein was confirmed by immunocytochemistry. Consequently, miRNA183 may present an attractive target for therapeutic intervention in breast tumor.
Entity Lung cancer
Note Lung cancer is the leading cause of cancer death. In the present study, researchers have addressed the significant role of miRNA in mediating tumor metastasis, through a screen with miRNA array, researchers found that miR183 was reversely correlated with the metastatic potential of lung cancer cells. In addition, ectopic overexpression of miR183 in highly metastatic cells could inhibit cell migration and invasion. Consistent with its cellular function, miR183 regulated the expression of many migration and invasion-related genes, including ezrin, which has a role in controlling actin cytoskeleton, cell adhesion and motility.
Entity Hepatocellular carcinoma (HCC)
Note miR-183 can inhibit apoptosis in human HCC cells by repressing the PDCD4 expression, and miR-183 may play an important role in HCC development.
Entity Development
Note MicroRNAs (miRNAs) constitute a class of small non-coding endogenous RNAs that downregulate gene expression by mapping to 3' untranslated region (UTR) of target messenger RNAs. They have been found to regulate developmental and physiological processes in several organs and tissues. Based on previous background, researchers have performed systematic in situ hybridizations to analyze the temporal and spatial distribution of three miRNAs (miR-96, miR-182 and miR-183) that are likely to arise from a single precursor RNA during the development and the maturation of the cochlea. Strikingly, the expression of miR-96, miR-182 and miR-183 was highly dynamic during the development of the cochlea, from the patterning to the differentiation of the main cochlear structures.


Evolution of the "autophagamiR"
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PMID 22024754
Molecular basis of differential target regulation by miR-96 and miR-182: the Glypican-3 as a model.
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Nucleic Acids Res. 2011 Oct 18. [Epub ahead of print]
PMID 22009679
A cluster of specified microRNAs in peripheral blood as biomarkers for metastatic non-small-cell lung cancer by stem-loop RT-PCR.
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PMID 20739942
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J Mol Neurosci. 2010 Jan;40(1-2):47-55. Epub 2009 Aug 27.
PMID 19711202
The miR-183-96-182 cluster is overexpressed in prostate tissue and regulates zinc homeostasis in prostate cells.
Mihelich BL, Khramtsova EA, Arva N, Vaishnav A, Johnson DN, Giangreco AA, Martens-Uzunova E, Bagasra O, Kajdacsy-Balla A, Nonn L.
J Biol Chem. 2011 Nov 1. [Epub ahead of print]
PMID 22045813
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PMID 20028871
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PMID 22042419
MicroRNA expression in induced sputum of smokers and patients with chronic obstructive pulmonary disease.
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Am J Respir Crit Care Med. 2011 Apr 1;183(7):898-906. Epub 2010 Oct 29.
PMID 21037022
MicroRNA miR-183 functions as an oncogene by targeting the transcription factor EGR1 and promoting tumor cell migration.
Sarver AL, Li L, Subramanian S.
Cancer Res. 2010 Dec 1;70(23):9570-80. Epub 2010 Nov 30.
PMID 21118966
Genetic variants and abnormal processing of pre-miR-182, a circadian clock modulator, in major depression patients with late insomnia.
Saus E, Soria V, Escaramis G, Vivarelli F, Crespo JM, Kagerbauer B, Menchon JM, Urretavizcaya M, Gratacos M, Estivill X.
Hum Mol Genet. 2010 Oct 15;19(20):4017-25. Epub 2010 Jul 23.
PMID 20656788
Diagnostic and prognostic implications of microRNA profiling in prostate carcinoma.
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Int J Cancer. 2010 Mar 1;126(5):1166-76.
PMID 19676045
High-Resolution Profiling and Analysis of Viral and Host Small RNAs during Human Cytomegalovirus Infection.
Stark TJ, Arnold JD, Spector DH, Yeo GW.
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[Expressions of 6 microRNAs in prostate cancer].
Yin Y, Li M, Li H, Jiang Y, Cao LY, Zhang HF, Xu XC.
Zhonghua Nan Ke Xue. 2010 Jul;16(7):599-605.
PMID 20873592
Sponge transgenic mouse model reveals important roles for the microRNA-183 (miR-183)/96/182 cluster in postmitotic photoreceptors of the retina.
Zhu Q, Sun W, Okano K, Chen Y, Zhang N, Maeda T, Palczewski K.
J Biol Chem. 2011 Sep 9;286(36):31749-60. Epub 2011 Jul 15.
PMID 21768104
Overexpression of members of the microRNA-183 family is a risk factor for lung cancer: a case control study.
Zhu W, Liu X, He J, Chen D, Hunag Y, Zhang YK.
BMC Cancer. 2011 Sep 15;11:393.
PMID 21920043


This paper should be referenced as such :
Zhu, J ; Zheng, X
MIR183 (microRNA 183)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(4):275-277.
Free journal version : [ pdf ]   [ DOI ]

External links

HGNC (Hugo)MIR183   31554
Entrez_Gene (NCBI)MIR183    microRNA 183
AliasesMIRN183; miR-183; miRNA183
GeneCards (Weizmann)MIR183
Ensembl hg19 (Hinxton)ENSG00000207691 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000207691 [Gene_View]  ENSG00000207691 [Sequence]  chr7:129774905-129775014 [Contig_View]  MIR183 [Vega]
ICGC DataPortalENSG00000207691
TCGA cBioPortalMIR183
AceView (NCBI)MIR183
Genatlas (Paris)MIR183
SOURCE (Princeton)MIR183
Genetics Home Reference (NIH)MIR183
Genomic and cartography
GoldenPath hg38 (UCSC)MIR183  -     chr7:129774905-129775014 -  7q32.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MIR183  -     7q32.2   [Description]    (hg19-Feb_2009)
GoldenPathMIR183 - 7q32.2 [CytoView hg19]  MIR183 - 7q32.2 [CytoView hg38]
Genome Data Viewer NCBIMIR183 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AY194163 LM608347
RefSeq transcript (Entrez)
Consensus coding sequences : CCDS (NCBI)MIR183
Gene ExpressionMIR183 [ NCBI-GEO ]   MIR183 [ EBI - ARRAY_EXPRESS ]   MIR183 [ SEEK ]   MIR183 [ MEM ]
Gene Expression Viewer (FireBrowse)MIR183 [ Firebrowse - Broad ]
GenevisibleExpression of MIR183 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)406959
GTEX Portal (Tissue expression)MIR183
Human Protein AtlasENSG00000207691-MIR183 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)MIR183
Human Protein Atlas [tissue]ENSG00000207691-MIR183 [tissue]
Protein Interaction databases
Ontologies - Pathways
PubMed141 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Oct 8 21:22:22 CEST 2021

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