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STARD3 (START domain containing 3)

Identity

Other namesMLN64
CAB1
HGNC (Hugo) STARD3
LocusID (NCBI) 10948
Location 17q12-21
Location_base_pair Starts at 37793333 and ends at 37820454 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order from centromere to telomere are: TRAF4 (alias MLN62/CART1), Lasp1 (alias MLN50), c-erbB2, and MLN64

DNA/RNA

Transcription cDNA: 2.1 kb; coding sequence: 1335 bp

Protein

Description 445 amino acids; 50 kDa; contains four putative transmembrane domains at its N-terminal part; posseses a StAR Homology Domain at its C-terminal part
Homology with StAR (Steroidogenic Acute Regulatory protein)

Implicated in

Entity breast carcinomas
Disease 17q11-q21 amplification is found in about 25% of primary breast carcinomas
Prognosis poor clinical outcome; increase risk of relapse
  

External links

Nomenclature
HGNC (Hugo)STARD3   17579
Entrez_Gene (NCBI)STARD3  10948  StAR-related lipid transfer (START) domain containing 3
Cards
AtlasMLN64ID202
GeneCards (Weizmann)STARD3
Ensembl (Hinxton)ENSG00000131748 [Gene_View]  chr17:37793333-37820454 [Contig_View]  STARD3 [Vega]
AceView (NCBI)STARD3
Genatlas (Paris)STARD3
euGene (Indiana)10948
SOURCE (Stanford)NM_001165937 NM_001165938 NM_006804
Genomic and cartography
GoldenPath (UCSC)STARD3  -     chr17:37793333-37820454 +  17q11-q12   [Description]    (hg19-Feb_2009)
EnsemblSTARD3 - 17q11-q12 [CytoView]
Mapping of homologs : NCBISTARD3 [Mapview]
OMIM607048   
Gene and transcription
Genbank (Entrez)AB209772 AK123364 AK225069 AK300176 AK300842
RefSeq transcript (SRS)NM_001165937 NM_001165938 NM_006804
RefSeq transcript (Entrez)NM_001165937 NM_001165938 NM_006804
RefSeq genomic (SRS)AC_000149 NC_000017 NG_008892 NT_010783 NW_001838435
RefSeq genomic (Entrez)AC_000149 NC_000017 NG_008892 NT_010783 NW_001838435
Consensus coding sequences : CCDS (NCBI)STARD3
Cluster EST : UnigeneHs.728838 [ SRS ] Hs.728838 [ NCBI ]
Alternative Splicing : Fast-db (Paris)9555
Alternative Splicing GalleryENSG00000131748
Gene ExpressionSTARD3 [ NCBI-GEO ]   STARD3 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14849 (SRS) Q14849 (Uniprot)
With graphics : InterProQ14849
Splice isoforms : SwissVarQ14849(Swissvar)
Domaine pattern : Prosite (SRS)MENTAL (PS51439)    START (PS50848)   
Domaine pattern : Prosite (Expaxy)MENTAL (PS51439)    START (PS50848)   
Domains : Interpro (SRS)MENTAL    StAR    START-like_dom    START_lipid-bd   
Domains : Interpro (EBI)MENTAL    StAR    START-like_dom    START_lipid-bd   
Related proteins : CluSTrQ14849
Domain families : Pfam (SRS)MENTAL (PF10457)    START (PF01852)   
Domain families : Pfam (Sanger)MENTAL (PF10457)    START (PF01852)   
Domain families : Pfam (NCBI)pfam10457    pfam01852   
Domain families : Smart (EMBL)START (SM00234)  
Blocks (Seattle)Q14849
PDB (SRS)1EM2    2I92   
PDB (PDBSum)1EM2    2I92   
PDB (IMB)1EM2    2I92   
PDB (RSDB)1EM2    2I92   
Human Protein AtlasENSG00000131748
HPRD06132
IPIIPI00000865   IPI00797338   IPI00791954   IPI00791237   
Protein Interaction databases
DIP (DOE-UCLA)Q14849
IntAct (EBI)Q14849
FunCoupENSG00000131748
REACTOMESTARD3
BioGRIDSTARD3
InParanoidQ14849
Interologous Interaction database Q14849
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)STARD3
SNP (GeneSNP Utah)STARD3
SNP : HGBaseSTARD3
Genetic variants : HAPMAPSTARD3
Somatic Mutations in Cancer : COSMICSTARD3 
CONAN: Copy Number AnalysisSTARD3 
Mutations and Diseases : HGMDSTARD3
OMIM607048   
GENETests607048   
Disease Genetic AssociationSTARD3
Huge Navigator STARD3 [HugePedia]  STARD3 [HugeCancerGEM]
Genomic VariantsSTARD3
snp3D : Map Gene to Disease10948
General knowledge
Homologs : HomoloGeneSTARD3
Homology/Alignments : Family Browser (UCSC)STARD3
Phylogenetic Trees/Animal Genes : TreeFamSTARD3
Chemical/Protein Interactions : CTD10948
Chemical/Pharm GKB GenePA134981867
Clinical trialSTARD3
Cancer Resource (Charite)ENSG00000131748
Ontology : AmiGOcytoplasm  endosome  lipid metabolic process  steroid biosynthetic process  transport  mitochondrial transport  lipid transport  steroid metabolic process  cholesterol metabolic process  lipid binding  cholesterol binding  membrane  integral to membrane  cholesterol transporter activity  late endosome membrane  
Ontology : EGO-EBIcytoplasm  endosome  lipid metabolic process  steroid biosynthetic process  transport  mitochondrial transport  lipid transport  steroid metabolic process  cholesterol metabolic process  lipid binding  cholesterol binding  membrane  integral to membrane  cholesterol transporter activity  late endosome membrane  
Other databases
Probes
Probes : ImagenesSTARD3 Related clones (RZPD - Berlin)
Litterature
PubMed33 Pubmed reference(s) in Entrez
PubGeneSTARD3
iHOPSTARD3

Bibliography

Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
Tomasetto C, Rˆ©gnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC
Genomics. 1995 ; 28 (3) : 367-376.
PMID 7490069
 
Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer.
Biˆ®che I, Tomasetto C, Rˆ©gnier CH, Moog-Lutz C, Rio MC, Lidereau R
Cancer research. 1996 ; 56 (17) : 3886-3890.
PMID 8752152
 
Isolation of a candidate gene, CAB1, for cholesterol transport to mitochondria from the c-ERBB-2 amplicon by a modified cDNA selection method.
Akiyama N, Sasaki H, Ishizuka T, Kishi T, Sakamoto H, Onda M, Hirai H, Yazaki Y, Sugimura T, Terada M
Cancer research. 1997 ; 57 (16) : 3548-3553.
PMID 9270027
 
MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas.
Moog-Lutz C, Tomasetto C, Rˆ©gnier CH, Wendling C, Lutz Y, Muller D, Chenard MP, Basset P, Rio MC
International journal of cancer. Journal international du cancer. 1997 ; 71 (2) : 183-191.
PMID 9139840
 
MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis.
Watari H, Arakane F, Moog-Lutz C, Kallen CB, Tomasetto C, Gerton GL, Rio MC, Baker ME, Strauss JF 3rd
Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (16) : 8462-8467.
PMID 9237999
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written03-2000Marie-Christine Rio

Citation

This paper should be referenced as such :
Rio MC . STARD3 (START domain containing 3). Atlas Genet Cytogenet Oncol Haematol. March 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/MLN64ID202.html

This paper is referenced by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37607/1/03-2000-MLN64ID202.pdf   [ Bibliographic record ]

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indexed on : Sat Apr 28 15:10:04 CEST 2012
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