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NCOA3 (Nuclear Receptor Coactivator 3)

Written2005-04Sarah L Anzick
Cancer Genetics Branch National Human Genome, Research Institute National Institutes of Health 50 South Drive, MSC 8000 Bldg. 50, Rm. 5148 Bethesda, MD 20892-8000, USA

(Note : for Links provided by Atlas : click)

Identity

Other namesACTR
AIB-1
AIB1
CAGH16
CTG26
KAT13B
RAC3
SRC-3
SRC3
TNRC14
TNRC16
TRAM-1
bHLHe42
pCIP
HGNC (Hugo) NCOA3
LocusID (NCBI) 8202
Atlas_Id 505
Location 20q13.12
Location_base_pair Starts at 46130601 and ends at 46285621 bp from pter ( according to hg19-Feb_2009)  [Mapping]
 
  AIB1 (20q12)
Fusion genes
(updated 2016)
ANTXR1 (2p13.3) / NCOA3 (20q13.12)C4orf48 (4p16.3) / NCOA3 (20q13.12)KAT6A (8p11.21) / NCOA3 (20q13.12)
NCOA3 (20q13.12) / CD36 (7q21.11)NCOA3 (20q13.12) / DUSP15 (20q11.21)NCOA3 (20q13.12) / EYA2 (20q13.12)
NCOA3 (20q13.12) / SGK2 (20q13.12)NCOA3 (20q13.12) / SLAIN1 (13q22.3)NCOA3 (20q13.12) / SPINT1 (15q15.1)
NCOA3 (20q13.12) / TXNDC5 (6p24.3)NCOA3 (20q13.12) / ZMYND8 (20q13.12)PTPRT (20q12) / NCOA3 (20q13.12)
SPINK1 (5q32) / NCOA3 (20q13.12)STAT5B (17q21.2) / NCOA3 (20q13.12)XPO6 (16p11.2) / NCOA3 (20q13.12)

DNA/RNA

 
  Genomic structure of NCOA3 with NCBI Build 35.1 genomic positions indicated. Black boxes indicate exons. The translational start (*) and stop codons (^) are also shown. UTR, untranslated region.
Description The human AIB1 gene spans approximately155 kb and has 23 exons. RNA Expression: Highly expressed in placenta, heart, pancreas, muscle, brain, liver, uterus, pituitary, mammary gland, and testis. Lower levels of expression are found in lung and kidney.
Transcription Transcription is from centromere to telomere. There are two reported transcripts: Isoform a (7935 bp) and isoform b (7923 bp). Isoform b uses an alternate in-frame splice site and lacks exon 3.
Pseudogene Chromosome 8 (AF010227)

Protein

 
  Structural features of AIB1. AIB1 contains a basic helix-loop-helix preceding a PAS (Per/Arnt/Sim) region, serine-and threonine-rich regions, and a charged cluster. There is also a glutamine-rich region that contains a polyglutamine tract. The central portion of the protein contains three LXXLL motifs (L=leucine, X=any amino acid) that are critical for interaction with ligand-bound nuclear receptors. An activation domain located C-terminal to the nuclear receptor interaction domain contains three LXXLL motifs that are important for interaction with general transcription cointegrators, CREB binding protein (CBP)/p300. A second transcriptional activation domain is responsible for interaction with histone methyltransferases, coactivator-associated arginine methyltranserase 1 (CARM1) and PRMT1.
Description A member of the p160/steroid receptor coactivator family. 1424 amino acids. 155 kDa (130 kDa encoded by isoform b).
Expression Protein expression found in testis, lung, liver, brain, mammary gland, and heart.
Localisation Mainly cytoplasmic and weakly nuclear. The protein translocates to the nucleus upon TNF activation and phosphorylation.
Function A transcriptional coactivator that interacts with nuclear hormone receptors to enhance their transcriptional activation. AIB1 interacts with other transcription factors including TP52, NfkB, and ER81. It has intrinsic histone acytyltransferase activity and recruits CREB Binding Protein (CBP)/p300 cointegrators to a multisubunit coactivator complete.

Mutations

Somatic The gene copy number and expression levels are altered in several cancer types. Overexpression has been found in breast, ovarian, endometrial, gastric, and pancreatic cancers. Amplification of AIB1 in hepatocellular carcinoma is associated with poor prognosis. Increased numbers of polyglutamine repeats correlate with higher breast cancer risk in BRCA1 and BRCA2 mutation carriers. However, the polymorphic repeat genotype does not influence postmenopausal breast cancer risk among Caucasian women in the general population.

To be noted

Overexpression of AIB1 in tamoxifen-treated patients is associated with tamoxifen resistance and worse survival. Tamoxifen behaves as estrogen in breast cancer cells that express high levels of AIB1 and HER2, resulting in de novo resistance.

An N-terminally deleted isoform (AIB1-Delta3) which lacks exon 3 was identified and found to be overexpressed in breast cancer cell lines and in tumors from breast cancer patients. Of interest, this splice variant has more potent transcriptional coactivation properties on estrogen and progesterone receptors than the full-length AIB1 protein.

Bibliography

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer.
Anzick SL, Kononen J, Walker RL, Azorsa DO, Tanner MM, Guan XY, Sauter G, Kallioniemi OP, Trent JM, Meltzer PS
Science (New York, N.Y.). 1997 ; 277 (5328) : 965-968.
PMID 9252329
 
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM
Cell. 1997 ; 90 (3) : 569-580.
PMID 9267036
 
RAC3, a steroid/nuclear receptor-associated coactivator that is related to SRC-1 and TIF2.
Li H, Gomes PJ, Chen JD
Proceedings of the National Academy of Sciences of the United States of America. 1997 ; 94 (16) : 8479-8484.
PMID 9238002
 
TRAM-1, A novel 160-kDa thyroid hormone receptor activator molecule, exhibits distinct properties from steroid receptor coactivator-1.
Takeshita A, Cardona GR, Koibuchi N, Suen CS, Chin WW
The Journal of biological chemistry. 1997 ; 272 (44) : 27629-27634.
PMID 9346901
 
The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.
Torchia J, Rose DW, Inostroza J, Kamei Y, Westin S, Glass CK, Rosenfeld MG
Nature. 1997 ; 387 (6634) : 677-684.
PMID 9192892
 
In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity.
Bautista S, Vallès H, Walker RL, Anzick S, Zeillinger R, Meltzer P, Theillet C
Clinical cancer research : an official journal of the American Association for Cancer Research. 1998 ; 4 (12) : 2925-2929.
PMID 9865902
 
The receptor-associated coactivator 3 activates transcription through CREB-binding protein recruitment and autoregulation.
Li H, Chen JD
The Journal of biological chemistry. 1998 ; 273 (10) : 5948-5954.
PMID 9488734
 
A transcriptional coactivator, steroid receptor coactivator-3, selectively augments steroid receptor transcriptional activity.
Suen CS, Berrodin TJ, Mastroeni R, Cheskis BJ, Lyttle CR, Frail DE
The Journal of biological chemistry. 1998 ; 273 (42) : 27645-27653.
PMID 9765300
 
Specific chromosomal aberrations and amplification of the AIB1 nuclear receptor coactivator gene in pancreatic carcinomas.
Ghadimi BM, Schröck E, Walker RL, Wangsa D, Jauho A, Meltzer PS, Ried T
The American journal of pathology. 1999 ; 154 (2) : 525-536.
PMID 10027410
 
Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53.
Lee SK, Kim HJ, Kim JW, Lee JW
Molecular endocrinology (Baltimore, Md.). 1999 ; 13 (11) : 1924-1933.
PMID 10551785
 
Polymorphic repeat in AIB1 does not alter breast cancer risk.
Haiman CA, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Speizer FE, Brown M, Hunter DJ
Breast cancer research : BCR. 2000 ; 2 (5) : 378-385.
PMID 11056690
 
Amplification and over-expression of the AIB1 nuclear receptor co-activator gene in primary gastric cancers.
Sakakura C, Hagiwara A, Yasuoka R, Fujita Y, Nakanishi M, Masuda K, Kimura A, Nakamura Y, Inazawa J, Abe T, Yamagishi H
International journal of cancer. Journal international du cancer. 2000 ; 89 (3) : 217-223.
PMID 10861496
 
RAC-3 is a NF-kappa B coactivator.
Werbajh S, Nojek I, Lanz R, Costas MA
FEBS letters. 2000 ; 485 (2-3) : 195-199.
PMID 11094166
 
The steroid receptor coactivator SRC-3 (p/CIP/RAC3/AIB1/ACTR/TRAM-1) is required for normal growth, puberty, female reproductive function, and mammary gland development.
Xu J, Liao L, Ning G, Yoshida-Komiya H, Deng C, O'Malley BW
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (12) : 6379-6384.
PMID 10823921
 
Gene amplification and expression of the steroid receptor coactivator SRC3 (AIB1) in sporadic breast and endometrial carcinomas.
Glaeser M, Floetotto T, Hanstein B, Beckmann MW, Niederacher D
Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et metabolisme. 2001 ; 33 (3) : 121-126.
PMID 11355743
 
Modification of BRCA1- and BRCA2-associated breast cancer risk by AIB1 genotype and reproductive history.
Rebbeck TR, Wang Y, Kantoff PW, Krithivas K, Neuhausen SL, Godwin AK, Daly MB, Narod SA, Brunet JS, Vesprini D, Garber JE, Lynch HT, Weber BL, Brown M
Cancer research. 2001 ; 61 (14) : 5420-5424.
PMID 11454686
 
An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer.
Reiter R, Wellstein A, Riegel AT
The Journal of biological chemistry. 2001 ; 276 (43) : 39736-39741.
PMID 11502741
 
Prognostic significance of c-myc and AIB1 amplification in hepatocellular carcinoma. A broad survey using high-throughput tissue microarray.
Wang Y, Wu MC, Sham JS, Zhang W, Wu WQ, Guan XY
Cancer. 2002 ; 95 (11) : 2346-2352.
PMID 12436441
 
Differentially regulated genes as putative targets of amplifications at 20q in ovarian cancers.
Watanabe T, Imoto I, Katahira T, Hirasawa A, Ishiwata I, Emi M, Takayama M, Sato A, Inazawa J
Japanese journal of cancer research : Gann. 2002 ; 93 (10) : 1114-1122.
PMID 12417041
 
Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW
Molecular and cellular biology. 2002 ; 22 (10) : 3549-3561.
PMID 11971985
 
Role of the estrogen receptor coactivator AIB1 (SRC-3) and HER-2/neu in tamoxifen resistance in breast cancer.
Osborne CK, Bardou V, Hopp TA, Chamness GC, Hilsenbeck SG, Fuqua SA, Wong J, Allred DC, Clark GM, Schiff R
Journal of the National Cancer Institute. 2003 ; 95 (5) : 353-361.
PMID 12618500
 
Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu.
Goel A, Janknecht R
The Journal of biological chemistry. 2004 ; 279 (15) : 14909-14916.
PMID 14747462
 
Overexpression of the nuclear receptor coactivator AIB1 (SRC-3) during progression of pancreatic adenocarcinoma.
Henke RT, Haddad BR, Kim SE, Rone JD, Mani A, Jessup JM, Wellstein A, Maitra A, Riegel AT
Clinical cancer research : an official journal of the American Association for Cancer Research. 2004 ; 10 (18 Pt 1) : 6134-6142.
PMID 15448000
 
Polyglutamine repeat length in the AIB1 gene modifies breast cancer susceptibility in BRCA1 carriers.
Kadouri L, Kote-Jarai Z, Easton DF, Hubert A, Hamoudi R, Glaser B, Abeliovich D, Peretz T, Eeles RA
International journal of cancer. Journal international du cancer. 2004 ; 108 (3) : 399-403.
PMID 14648706
 
Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways.
Wu RC, Qin J, Yi P, Wong J, Tsai SY, Tsai MJ, O'Malley BW
Molecular cell. 2004 ; 15 (6) : 937-949.
PMID 15383283
 

Citation

This paper should be referenced as such :
Anzick, SL
NCOA3 (nuclear receptor coactivator 3)
Atlas Genet Cytogenet Oncol Haematol. 2005;9(3):216-218.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/NCOA3ID505ch20q13.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(8;16)(p11;p13) KAT6A/CREBBP
t(10;16)(q22;p13) KAT6B/CREBBP
t(8;20)(p11;q13) KAT6A/NCOA3

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Ovarian tumours : an overview

External links

Nomenclature
HGNC (Hugo)NCOA3   7670
Cards
AtlasNCOA3ID505ch20q13
Entrez_Gene (NCBI)NCOA3  8202  nuclear receptor coactivator 3
GeneCards (Weizmann)NCOA3
Ensembl hg19 (Hinxton)ENSG00000124151 [Gene_View]  chr20:46130601-46285621 [Contig_View]  NCOA3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000124151 [Gene_View]  chr20:46130601-46285621 [Contig_View]  NCOA3 [Vega]
ICGC DataPortalENSG00000124151
TCGA cBioPortalNCOA3
AceView (NCBI)NCOA3
Genatlas (Paris)NCOA3
WikiGenes8202
SOURCE (Princeton)NCOA3
Genomic and cartography
GoldenPath hg19 (UCSC)NCOA3  -     chr20:46130601-46285621 +  20q12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NCOA3  -     20q12   [Description]    (hg38-Dec_2013)
EnsemblNCOA3 - 20q12 [CytoView hg19]  NCOA3 - 20q12 [CytoView hg38]
Mapping of homologs : NCBINCOA3 [Mapview hg19]  NCOA3 [Mapview hg38]
OMIM601937   
Gene and transcription
Genbank (Entrez)AB209863 AF010227 AF012108 AF016031 AF036892
RefSeq transcript (Entrez)NM_001174087 NM_001174088 NM_006534 NM_181659
RefSeq genomic (Entrez)NC_000020 NC_018931 NG_016810 NT_011362 NW_004929418
Consensus coding sequences : CCDS (NCBI)NCOA3
Cluster EST : UnigeneHs.592142 [ NCBI ]
CGAP (NCI)Hs.592142
Alternative Splicing GalleryENSG00000124151
Gene ExpressionNCOA3 [ NCBI-GEO ]   NCOA3 [ EBI - ARRAY_EXPRESS ]   NCOA3 [ SEEK ]   NCOA3 [ MEM ]
Gene Expression Viewer (FireBrowse)NCOA3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8202
GTEX Portal (Tissue expression)NCOA3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6Q9 (Uniprot)
NextProtQ9Y6Q9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6Q9
Splice isoforms : SwissVarQ9Y6Q9 (Swissvar)
Catalytic activity : Enzyme2.3.1.48 [ Enzyme-Expasy ]   2.3.1.482.3.1.48 [ IntEnz-EBI ]   2.3.1.48 [ BRENDA ]   2.3.1.48 [ KEGG ]   
PhosPhoSitePlusQ9Y6Q9
Domaine pattern : Prosite (Expaxy)BHLH (PS50888)    PAS (PS50112)   
Domains : Interpro (EBI)bHLH_dom    DUF1518    DUF4927    NCOA3    Nuc_rcpt_coact    Nuc_rcpt_coact_Ncoa-typ    Nuclear_rcpt_coactivator    PAS    PAS_fold    SRC-1    Src1_rcpt_coact   
Domain families : Pfam (Sanger)DUF1518 (PF07469)    DUF4927 (PF16279)    Nuc_rec_co-act (PF08815)    PAS (PF00989)    SRC-1 (PF08832)   
Domain families : Pfam (NCBI)pfam07469    pfam16279    pfam08815    pfam00989    pfam08832   
Domain families : Smart (EMBL)HLH (SM00353)  PAS (SM00091)  
DMDM Disease mutations8202
Blocks (Seattle)NCOA3
PDB (SRS)1KBH    3L3X    3L3Z   
PDB (PDBSum)1KBH    3L3X    3L3Z   
PDB (IMB)1KBH    3L3X    3L3Z   
PDB (RSDB)1KBH    3L3X    3L3Z   
Structural Biology KnowledgeBase1KBH    3L3X    3L3Z   
SCOP (Structural Classification of Proteins)1KBH    3L3X    3L3Z   
CATH (Classification of proteins structures)1KBH    3L3X    3L3Z   
SuperfamilyQ9Y6Q9
Human Protein AtlasENSG00000124151
Peptide AtlasQ9Y6Q9
HPRD03570
IPIIPI00748532   IPI00220079   IPI00220080   IPI00220081   IPI00220082   IPI00936481   IPI00956370   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6Q9
IntAct (EBI)Q9Y6Q9
FunCoupENSG00000124151
BioGRIDNCOA3
STRING (EMBL)NCOA3
ZODIACNCOA3
Ontologies - Pathways
QuickGOQ9Y6Q9
Ontology : AmiGOnuclear chromatin  transcription coactivator activity  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  transcription, DNA-templated  positive regulation of gene expression  histone acetylation  histone acetylation  ligand-dependent nuclear receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  intracellular receptor signaling pathway  nuclear hormone receptor binding  receptor transactivation  positive regulation of keratinocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  thyroid hormone receptor binding  protein dimerization activity  protein N-terminus binding  androgen receptor binding  extracellular exosome  cellular response to estradiol stimulus  regulation of RNA biosynthetic process  
Ontology : EGO-EBInuclear chromatin  transcription coactivator activity  transcription coactivator activity  transcription coactivator activity  histone acetyltransferase activity  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  transcription, DNA-templated  positive regulation of gene expression  histone acetylation  histone acetylation  ligand-dependent nuclear receptor binding  ligand-dependent nuclear receptor transcription coactivator activity  androgen receptor signaling pathway  intracellular receptor signaling pathway  nuclear hormone receptor binding  receptor transactivation  positive regulation of keratinocyte differentiation  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  thyroid hormone receptor binding  protein dimerization activity  protein N-terminus binding  androgen receptor binding  extracellular exosome  cellular response to estradiol stimulus  regulation of RNA biosynthetic process  
Pathways : KEGGThyroid hormone signaling pathway   
REACTOMEQ9Y6Q9 [protein]
REACTOME PathwaysR-HSA-1989781 PPARA activates gene expression [pathway]
REACTOME PathwaysR-HSA-5687128 MAPK6/MAPK4 signaling [pathway]
REACTOME PathwaysR-HSA-381340 Transcriptional regulation of white adipocyte differentiation [pathway]
NDEx Network
Atlas of Cancer Signalling NetworkNCOA3
Wikipedia pathwaysNCOA3
Orthology - Evolution
OrthoDB8202
GeneTree (enSembl)ENSG00000124151
Phylogenetic Trees/Animal Genes : TreeFamNCOA3
Homologs : HomoloGeneNCOA3
Homology/Alignments : Family Browser (UCSC)NCOA3
Gene fusions - Rearrangements
Fusion : MitelmanKAT6A/NCOA3 [8p11.21/20q13.12]  [t(8;20)(p11;q13)]  
Fusion : MitelmanNCOA3/DUSP15 [20q13.12/20q11.21]  [t(20;20)(q11;q13)]  
Fusion : MitelmanNCOA3/EYA2 [20q13.12/20q13.12]  [dup(20)(q13q13)]  [t(20;20)(q13;q13)]  
Fusion : MitelmanNCOA3/SGK2 [20q13.12/20q13.12]  [t(20;20)(q13;q13)]  
Fusion : MitelmanNCOA3/SPINT1 [20q13.12/15q15.1]  [t(15;20)(q15;q13)]  
Fusion : MitelmanPTPRT/NCOA3 [20q12/20q13.12]  [t(20;20)(q13;q13)]  
Fusion: TCGANCOA3 20q13.12 DUSP15 20q11.21 BLCA
Fusion: TCGANCOA3 20q13.12 EYA2 20q13.12 LUAD LUSC OV
Fusion: TCGANCOA3 20q13.12 SGK2 20q13.12 LUAD
Fusion: TCGAPTPRT 20q12 NCOA3 20q13.12 BRCA
Fusion : TICdbKAT6A [8p11.21]  -  NCOA3 [20q13.12]
Polymorphisms : SNP, variants
NCBI Variation ViewerNCOA3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NCOA3
dbVarNCOA3
ClinVarNCOA3
1000_GenomesNCOA3 
Exome Variant ServerNCOA3
ExAC (Exome Aggregation Consortium)NCOA3 (select the gene name)
Genetic variants : HAPMAP8202
Genomic Variants (DGV)NCOA3 [DGVbeta]
Mutations
ICGC Data PortalNCOA3 
TCGA Data PortalNCOA3 
Broad Tumor PortalNCOA3
OASIS PortalNCOA3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICNCOA3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NCOA3
DgiDB (Drug Gene Interaction Database)NCOA3
DoCM (Curated mutations)NCOA3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NCOA3 (select a term)
intoGenNCOA3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)20:46130601-46285621  ENSG00000124151
CONAN: Copy Number AnalysisNCOA3 
Mutations and Diseases : HGMDNCOA3
OMIM601937   
MedgenNCOA3
Genetic Testing Registry NCOA3
NextProtQ9Y6Q9 [Medical]
TSGene8202
GENETestsNCOA3
Huge Navigator NCOA3 [HugePedia]
snp3D : Map Gene to Disease8202
BioCentury BCIQNCOA3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8202
Chemical/Pharm GKB GenePA31472
Clinical trialNCOA3
Miscellaneous
canSAR (ICR)NCOA3 (select the gene name)
Probes
Litterature
PubMed306 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNCOA3
EVEXNCOA3
GoPubMedNCOA3
iHOPNCOA3
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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