| HGNC (Hugo) |
NONO |
| HGNC Alias symb | NRB54 |
| NMT55 |
| P54NRB |
| P54 |
| PPP1R114 |
| HGNC Alias name | "Nuclear RNA-binding protein, 54-kD |
| non-Pou domain-containing octamer (ATGCAAAT) binding protein |
| protein phosphatase 1, regulatory subunit 114" |
| HGNC Previous name | "non-POU-domain-containing, octamer-binding" |
| LocusID (NCBI) |
4841 |
| Atlas_Id |
168 |
| Location |
Xq13.1 [Link to chromosome band Xq13] |
| Location_base_pair |
Starts at 71283635 and ends at 71301168 bp from pter ( according to GRCh38/hg38-Dec_2013) [Mapping NONO.png] |
| Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. |
| Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS |
| Oncogene. 1997 ; 15 (18) : 2233-2239. |
| PMID 9393982 |
| |
| Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6. |
| Dong B, Horowitz DS, Kobayashi R, Krainer AR |
| Nucleic acids research. 1993 ; 21 (17) : 4085-4092. |
| PMID 8371983 |
| |
| The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. |
| Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F |
| The Journal of biological chemistry. 1998 ; 273 (41) : 26261-26264. |
| PMID 9756848 |
| |
| NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss. |
| Yang YS, Hanke JH, Carayannopoulos L, Craft CM, Capra JD, Tucker PW |
| Molecular and cellular biology. 1993 ; 13 (9) : 5593-5603. |
| PMID 8355702 |
| |
| NonO enhances the association of many DNA-binding proteins to their targets. |
| Yang YS, Yang MC, Tucker PW, Capra JD |
| Nucleic acids research. 1997 ; 25 (12) : 2284-2292. |
| PMID 9171077 |
| |
| Nomenclature |
|---|
| HGNC (Hugo) | NONO 7871 |
| Cards |
|---|
| Atlas | NONOID168 |
| Entrez_Gene (NCBI) | NONO non-POU domain containing octamer binding |
| Aliases | MRXS34; NMT55; NRB54; P54; |
| P54NRB; PPP1R114 |
| GeneCards (Weizmann) | NONO |
| Ensembl hg19 (Hinxton) | ENSG00000147140 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000147140 [Gene_View] ENSG00000147140 [Sequence] chrX:71283635-71301168 [Contig_View] NONO [Vega] |
| ICGC DataPortal | ENSG00000147140 |
| TCGA cBioPortal | NONO |
| AceView (NCBI) | NONO |
| Genatlas (Paris) | NONO |
| SOURCE (Princeton) | NONO |
| Genetics Home Reference (NIH) | NONO |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | NONO - chrX:71283635-71301168 + Xq13.1 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | NONO - Xq13.1 [Description] (hg19-Feb_2009) |
| GoldenPath | NONO - Xq13.1 [CytoView hg19] NONO - Xq13.1 [CytoView hg38] |
| ImmunoBase | ENSG00000147140 |
| genome Data Viewer NCBI | NONO [Mapview hg19] |
| OMIM | 300084 300967 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK055406 AK291140 AK297144 AU119361 BC002364 |
| RefSeq transcript (Entrez) | NM_001145408 NM_001145409 NM_001145410 NM_007363 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | NONO |
| Alternative Splicing Gallery | ENSG00000147140 |
| Gene Expression | NONO [ NCBI-GEO ] NONO [ EBI - ARRAY_EXPRESS ]
NONO [ SEEK ] NONO [ MEM ] |
| Gene Expression Viewer (FireBrowse) | NONO [ Firebrowse - Broad ] |
| Genevisible | Expression of NONO in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 4841 |
| GTEX Portal (Tissue expression) | NONO |
| Human Protein Atlas | ENSG00000147140-NONO [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q15233 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q15233 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q15233 |
| Splice isoforms : SwissVar | Q15233 |
| PhosPhoSitePlus | Q15233 |
| Domaine pattern : Prosite (Expaxy) | RRM (PS50102) |
| Domains : Interpro (EBI) | NOPS Nucleotide-bd_a/b_plait_sf p54nrb_RRM1 RBD_domain_sf RRM_dom |
| Domain families : Pfam (Sanger) | NOPS (PF08075) RRM_1 (PF00076) |
| Domain families : Pfam (NCBI) | pfam08075 pfam00076 |
| Domain families : Smart (EMBL) | RRM (SM00360) |
| Conserved Domain (NCBI) | NONO |
| Blocks (Seattle) | NONO |
| PDB (RSDB) | 3SDE 5IFM |
| PDB Europe | 3SDE 5IFM |
| PDB (PDBSum) | 3SDE 5IFM |
| PDB (IMB) | 3SDE 5IFM |
| Structural Biology KnowledgeBase | 3SDE 5IFM |
| SCOP (Structural Classification of Proteins) | 3SDE 5IFM |
| CATH (Classification of proteins structures) | 3SDE 5IFM |
| Superfamily | Q15233 |
| Human Protein Atlas [tissue] | ENSG00000147140-NONO [tissue] |
| Peptide Atlas | Q15233 |
| HPRD | 02098 |
| IPI | IPI00304596 IPI00018152 IPI00922367 IPI00646520 IPI00645010 IPI00647641 IPI00645966 IPI00644848 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q15233 |
| IntAct (EBI) | Q15233 |
| BioGRID | NONO |
| STRING (EMBL) | NONO |
| ZODIAC | NONO |
| Ontologies - Pathways |
|---|
| QuickGO | Q15233 |
| Ontology : AmiGO | "mRNA splicing, via spliceosome transcription regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding fibrillar center activation of innate immune response nucleic acid binding chromatin binding RNA binding protein binding nucleus nucleus nucleus nucleoplasm DNA repair DNA recombination regulation of transcription, DNA-templated mRNA processing circadian rhythm RNA splicing membrane nuclear matrix nuclear speck paraspeckles regulation of circadian rhythm identical protein binding innate immune response negative regulation of transcription, DNA-templated E-box binding RNA polymerase II transcription factor complex negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway" |
| Ontology : EGO-EBI | "mRNA splicing, via spliceosome transcription regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding fibrillar center activation of innate immune response nucleic acid binding chromatin binding RNA binding protein binding nucleus nucleus nucleus nucleoplasm DNA repair DNA recombination regulation of transcription, DNA-templated mRNA processing circadian rhythm RNA splicing membrane nuclear matrix nuclear speck paraspeckles regulation of circadian rhythm identical protein binding innate immune response negative regulation of transcription, DNA-templated E-box binding RNA polymerase II transcription factor complex negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway" |
| NDEx Network | NONO |
| Atlas of Cancer Signalling Network | NONO |
| Wikipedia pathways | NONO |
| Orthology - Evolution |
|---|
| OrthoDB | 4841 |
| GeneTree (enSembl) | ENSG00000147140 |
| Phylogenetic Trees/Animal Genes : TreeFam | NONO |
| HOGENOM | Q15233 |
| Homologs : HomoloGene | NONO |
| Homology/Alignments : Family Browser (UCSC) | NONO |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | NONO/TFE3 [Xq13.1/Xp11.23] |
| Fusion : Mitelman | TFE3/NONO [Xp11.23/Xq13.1] |
| Fusion : COSMIC | NONO [Xq13.1] - TFE3 [Xp11.23] [fusion_865] |
| Fusion : TICdb | NONO [Xq13.1] - TFE3 [Xp11.23] |
| Fusion : Fusion_Hub | ABI3BP--NONO AP2A1--NONO ARNTL--NONO ASPSCR1--NONO CLASRP--NONO COPS7B--NONO FBLIM1--NONO IAH1--NONO IGHG1--NONO ITGA7--NONO LYZ--NONO MKRN2OS--NONO NONO--ABCB1 NONO--AHCY NONO--ARL6IP4 |
| NONO--EXOSC9 NONO--IQCB1 NONO--NSUN2 NONO--PTRF NONO--REV1 NONO--SFTPB NONO--SLC25A16 NONO--SLX4IP NONO--TARS2 NONO--TFE3 PALLD--NONO PRM1--NONO SORBS1--NONO SPTBN4--NONO SZT2--NONO |
| TFE3--NONO ZC3HAV1--NONO ZSCAN21--NONO |
| Fusion : Quiver | NONO |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | NONO [hg38] |
| dbVar | NONO |
| ClinVar | NONO |
| Monarch | NONO |
| 1000_Genomes | NONO |
| Exome Variant Server | NONO |
| GNOMAD Browser | ENSG00000147140 |
| Varsome Browser | NONO |
| Genomic Variants (DGV) | NONO [DGVbeta] |
| DECIPHER | NONO [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | NONO |
| Mutations |
|---|
| ICGC Data Portal | NONO |
| TCGA Data Portal | NONO |
| Broad Tumor Portal | NONO |
| OASIS Portal | NONO [ Somatic mutations - Copy number] |
| Cancer Gene: Census | NONO |
| Somatic Mutations in Cancer : COSMIC | NONO [overview] [genome browser] [tissue] [distribution] |
| Somatic Mutations in Cancer : COSMIC3D | NONO |
| Mutations and Diseases : HGMD | NONO |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search NONO |
| DgiDB (Drug Gene Interaction Database) | NONO |
| DoCM (Curated mutations) | NONO (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | NONO (select a term) |
| intoGen | NONO |
| OncoKB | NONO |
| NCG6 (London) | select NONO |
| Cancer3D | NONO(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 300084 300967 |
| Orphanet | 21643 |
| DisGeNET | NONO |
| Medgen | NONO |
| Genetic Testing Registry | NONO
|
| NextProt | Q15233 [Medical] |
| GENETests | NONO |
| Target Validation | NONO |
| Huge Navigator |
NONO [HugePedia] |
| ClinGen | NONO |
| Clinical trials, drugs, therapy |
|---|
| MyCancerGenome | NONO |
| Protein Interactions : CTD | |
| Pharm GKB Gene | PA31680 |
| Pharos | Q15233 |
| Clinical trial | NONO |
| Miscellaneous |
|---|
| canSAR (ICR) | NONO (select the gene name) |
| Harmonizome | NONO |
| DataMed Index | NONO |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 238 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| EVEX | NONO |
