NONO (non-POU domain containing, octamer-binding)

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NONO (non-POU domain containing, octamer-binding)

Written	1999-01	Jean-Loup Huret
		Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_names	"non-POU-domain-containing, octamer-binding"
Alias_symbol (synonym)	NRB54
	NMT55
	P54NRB
	P54
	PPP1R114
Other alias
HGNC (Hugo)	NONO
LocusID (NCBI)	4841
Atlas_Id	168
Location	Xq13.1 [Link to chromosome band Xq13]
Location_base_pair	Starts at 71283635 and ends at 71301168 bp from pter ( according to hg19-Feb_2009) [Mapping NONO.png]

Fusion genes
(updated 2017)

Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

NONO (Xq13.1) / TFE3 (Xp11.23)

TFE3 (Xp11.23) / NONO (Xq13.1)

DNA/RNA

Transcription

alternative splicing; 2.4 mRNA complete cds; coding sequence: CDS 129 ... 1550

Protein



Description	the protein encoded by NONO is called p54nrb (nuclear RNA binbing); 471 amino acids; 54 kDa; N-term glutamine/histidine rich region, tandem RNA binding domains (amino acids 75 to 228), helix-turn-helix implicated in DNA binding, and a proline rich region in C-term; N-term and C-term allow protein-protein interactions.
Expression	wide
Function	binds independantly to DNA and RNA; forms a heterodimer with PSF, a protein sharing vast homologies; both form complexes with DNA topoisomerase I, which renders this enzyme much more active; NONO also enhances the binding of several DNA-binding proteins (but not all).
Homology	with PSF and other proteins with a DBHS domain (Drosophila behaviour, human splicing) which includes the tandem RNA binding domains.

Implicated in

Note

Entity	inv(X)(p11.2q12) in renal cell carcinoma -->NONO/TFE3
Disease	only one case of papillary renal cell carcinoma
Hybrid/Mutated Gene	5' NONO- 3' TFE3


Abnormal Protein	N-term NONO and most of it except the C-term proline rich sequence fused to the DNA binding domains of TFE3 (excluding the acidic transcriptional activation domain, including the C-term helix-loop-helix, and the leucine zipper); the reciprocal transcript is found

Bibliography

Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.

Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS

Oncogene. 1997 ; 15 (18) : 2233-2239.

PMID 9393982

Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6.

Dong B, Horowitz DS, Kobayashi R, Krainer AR

Nucleic acids research. 1993 ; 21 (17) : 4085-4092.

PMID 8371983

The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.

Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F

The Journal of biological chemistry. 1998 ; 273 (41) : 26261-26264.

PMID 9756848

NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss.

Yang YS, Hanke JH, Carayannopoulos L, Craft CM, Capra JD, Tucker PW

Molecular and cellular biology. 1993 ; 13 (9) : 5593-5603.

PMID 8355702

NonO enhances the association of many DNA-binding proteins to their targets.

Yang YS, Yang MC, Tucker PW, Capra JD

Nucleic acids research. 1997 ; 25 (12) : 2284-2292.

PMID 9171077

Citation

This paper should be referenced as such :

Huret, JL

NONO (non-POU domain containing, octamer-binding)

Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):54-55.

Free journal version : [ pdf ] [ DOI ]

On line version : http://AtlasGeneticsOncology.org/Genes/NONOID168.html

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]

t(1;9)(p34;q34) SFPQ/ABL1
t(X;2)(q13;p21) NONO/ZFP36L2
t(X;X)(p11;q13) NONO/TFE3
t(X;X)(p11;q13) TFE3/NONO

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]

Kidney: Renal cell carcinoma with inv(X)(p11q12) NONO/TFE3
Kidney: Renal cell carcinomas with MiT family translocation
t(X;X)(p11;q13) TFE3/NONO

External links

	Nomenclature
HGNC (Hugo)	NONO 7871
	Cards
Atlas	NONOID168
Entrez_Gene (NCBI)	NONO 4841 non-POU domain containing octamer binding
Aliases	MRXS34; NMT55; NRB54; P54;
	P54NRB; PPP1R114
GeneCards (Weizmann)	NONO
Ensembl hg19 (Hinxton)	ENSG00000147140 [Gene_View]
Ensembl hg38 (Hinxton)	ENSG00000147140 [Gene_View] ENSG00000147140 [Sequence] chrX:71283635-71301168 [Contig_View] NONO [Vega]
ICGC DataPortal	ENSG00000147140
TCGA cBioPortal	NONO
AceView (NCBI)	NONO
Genatlas (Paris)	NONO
WikiGenes	4841
SOURCE (Princeton)	NONO
Genetics Home Reference (NIH)	NONO
	Genomic and cartography
GoldenPath hg38 (UCSC)	NONO - chrX:71283635-71301168 + Xq13.1 [Description] (hg38-Dec_2013)
GoldenPath hg19 (UCSC)	NONO - Xq13.1 [Description] (hg19-Feb_2009)
GoldenPath	NONO - Xq13.1 [CytoView hg19] NONO - Xq13.1 [CytoView hg38]
Genome Data Viewer NCBI	NONO [Mapview hg19]
OMIM	300084 300967
	Gene and transcription
Genbank (Entrez)	AK055406 AK291140 AK297144 AU119361 BC002364
RefSeq transcript (Entrez)	NM_001145408 NM_001145409 NM_001145410 NM_007363
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)	NONO
Alternative Splicing Gallery	ENSG00000147140
Gene Expression	NONO [ NCBI-GEO ] NONO [ EBI - ARRAY_EXPRESS ] NONO [ SEEK ] NONO [ MEM ]
Gene Expression Viewer (FireBrowse)	NONO [ Firebrowse - Broad ]
Genevisible	Expression of NONO in : [tissues] [cell-lines] [cancer] [perturbations]
BioGPS (Tissue expression)	4841
GTEX Portal (Tissue expression)	NONO
Human Protein Atlas	ENSG00000147140-NONO [pathology] [cell] [tissue]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q15233 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction]
NextProt	Q15233 [Sequence] [Exons] [Medical] [Publications]
With graphics : InterPro	Q15233
Splice isoforms : SwissVar	Q15233
PhosPhoSitePlus	Q15233
Domaine pattern : Prosite (Expaxy)	RRM (PS50102)
Domains : Interpro (EBI)	NOPS Nucleotide-bd_a/b_plait_sf p54nrb_RRM1 RBD_domain_sf RRM_dom
Domain families : Pfam (Sanger)	NOPS (PF08075) RRM_1 (PF00076)
Domain families : Pfam (NCBI)	pfam08075 pfam00076
Domain families : Smart (EMBL)	RRM (SM00360)
Conserved Domain (NCBI)	NONO
DMDM Disease mutations	4841
PDB (RSDB)	3SDE 5IFM
PDB Europe	3SDE 5IFM
PDB (PDBSum)	3SDE 5IFM
PDB (IMB)	3SDE 5IFM
Structural Biology KnowledgeBase	3SDE 5IFM
SCOP (Structural Classification of Proteins)	3SDE 5IFM
CATH (Classification of proteins structures)	3SDE 5IFM
Superfamily	Q15233
Human Protein Atlas [tissue]	ENSG00000147140-NONO [tissue]
Peptide Atlas	Q15233
HPRD	02098
IPI	IPI00304596 IPI00018152 IPI00922367 IPI00646520 IPI00645010 IPI00647641 IPI00645966 IPI00644848
	Protein Interaction databases
DIP (DOE-UCLA)	Q15233
IntAct (EBI)	Q15233
FunCoup	ENSG00000147140
BioGRID	NONO
STRING (EMBL)	NONO
ZODIAC	NONO
	Ontologies - Pathways
QuickGO	Q15233
Ontology : AmiGO	"mRNA splicing, via spliceosome transcription regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding fibrillar center activation of innate immune response nucleic acid binding chromatin binding RNA binding protein binding nucleus nucleus nucleus nucleoplasm DNA repair DNA recombination regulation of transcription, DNA-templated mRNA processing circadian rhythm RNA splicing membrane nuclear matrix nuclear speck paraspeckles regulation of circadian rhythm identical protein binding innate immune response negative regulation of transcription, DNA-templated E-box binding RNA polymerase II transcription factor complex negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway"
Ontology : EGO-EBI	"mRNA splicing, via spliceosome transcription regulatory region sequence-specific DNA binding RNA polymerase II proximal promoter sequence-specific DNA binding fibrillar center activation of innate immune response nucleic acid binding chromatin binding RNA binding protein binding nucleus nucleus nucleus nucleoplasm DNA repair DNA recombination regulation of transcription, DNA-templated mRNA processing circadian rhythm RNA splicing membrane nuclear matrix nuclear speck paraspeckles regulation of circadian rhythm identical protein binding innate immune response negative regulation of transcription, DNA-templated E-box binding RNA polymerase II transcription factor complex negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway"
NDEx Network	NONO
Atlas of Cancer Signalling Network	NONO
Wikipedia pathways	NONO
	Orthology - Evolution
OrthoDB	4841
GeneTree (enSembl)	ENSG00000147140
Phylogenetic Trees/Animal Genes : TreeFam	NONO
HOGENOM	Q15233
Homologs : HomoloGene	NONO
Homology/Alignments : Family Browser (UCSC)	NONO
	Gene fusions - Rearrangements
Fusion : Mitelman	NONO/TFE3 [Xq13.1/Xp11.23]
Fusion : Mitelman	TFE3/NONO [Xp11.23/Xq13.1]
Fusion : COSMIC	NONO [TFE3] - 865 []
Fusion : TICdb	NONO [Xq13.1] - TFE3 [Xp11.23]
Fusion : Fusion_Hub	ABI3BP--NONO AP2A1--NONO ARNTL--NONO ASPSCR1--NONO CLASRP--NONO COPS7B--NONO FBLIM1--NONO IAH1--NONO IGHG1--NONO ITGA7--NONO LYZ--NONO MKRN2OS--NONO NONO--ABCB1 NONO--AHCY NONO--ARL6IP4
	NONO--EXOSC9 NONO--IQCB1 NONO--NSUN2 NONO--PTRF NONO--REV1 NONO--SFTPB NONO--SLC25A16 NONO--SLX4IP NONO--TARS2 NONO--TFE3 PALLD--NONO PRM1--NONO SORBS1--NONO SPTBN4--NONO SZT2--NONO
	TFE3--NONO ZC3HAV1--NONO ZSCAN21--NONO
Fusion : Quiver	NONO
	Polymorphisms : SNP and Copy number variants
NCBI Variation Viewer	NONO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)	NONO
dbVar	NONO
ClinVar	NONO
1000_Genomes	NONO
Exome Variant Server	NONO
GNOMAD Browser	ENSG00000147140
Varsome Browser	NONO
Genetic variants : HAPMAP	4841
Genomic Variants (DGV)	NONO [DGVbeta]
DECIPHER	NONO [patients] [syndromes] [variants] [genes]
CONAN: Copy Number Analysis	NONO
	Mutations
ICGC Data Portal	NONO
TCGA Data Portal	NONO
Broad Tumor Portal	NONO
OASIS Portal	NONO [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMIC	NONO [overview] [genome browser] [tissue] [distribution]
Somatic Mutations in Cancer : COSMIC3D	NONO
Mutations and Diseases : HGMD	NONO
LOVD (Leiden Open Variation Database)	Whole genome datasets
LOVD (Leiden Open Variation Database)	LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)	LOVD 3.0 shared installation
BioMuta	select NONO
DgiDB (Drug Gene Interaction Database)	NONO
DoCM (Curated mutations)	NONO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)	NONO (select a term)
intoGen	NONO
NCG6 (London)	select NONO
Cancer3D	NONO (select the gene name)
Impact of mutations	[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
	Diseases
OMIM	300084 300967
Orphanet	21643
DisGeNET	NONO
Medgen	NONO
Genetic Testing Registry	NONO
NextProt	Q15233 [Medical]
TSGene	4841
GENETests	NONO
Open Targets Genetics	ENSG00000147140 [validation]
snp3D : Map Gene to Disease	4841
BioCentury BCIQ	NONO
ClinGen	NONO
	Clinical trials, drugs, therapy
Protein Interactions : CTD	4841
Pharm GKB Gene	PA31680
Clinical trial	NONO
	Miscellaneous
canSAR (ICR)	NONO (select the gene name)
Harmonizome	NONO
DataMed Index	NONO
	Probes
	Litterature
PubMed	238 Pubmed reference(s) in Entrez
GeneRIFs	Gene References Into Functions (Entrez)
CoreMine	NONO
EVEX	NONO

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

indexed on : Sat Jul 11 20:31:33 CEST 2020

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.