Atlas of Genetics and Cytogenetics in Oncology and Haematology

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NONO (non-POU domain containing, octamer-binding)

Written1999-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)


Other alias
LocusID (NCBI) 4841
Atlas_Id 168
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at and ends at bp from pter
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
NONO (Xq13.1) / TFE3 (Xp11.23)TFE3 (Xp11.23) / NONO (Xq13.1)


Transcription alternative splicing; 2.4 mRNA complete cds; coding sequence: CDS 129 ... 1550


Description the protein encoded by NONO is called p54nrb (nuclear RNA binbing); 471 amino acids; 54 kDa; N-term glutamine/histidine rich region, tandem RNA binding domains (amino acids 75 to 228), helix-turn-helix implicated in DNA binding, and a proline rich region in C-term; N-term and C-term allow protein-protein interactions.
Expression wide
Function binds independantly to DNA and RNA; forms a heterodimer with PSF, a protein sharing vast homologies; both form complexes with DNA topoisomerase I, which renders this enzyme much more active; NONO also enhances the binding of several DNA-binding proteins (but not all).
Homology with PSF and other proteins with a DBHS domain (Drosophila behaviour, human splicing) which includes the tandem RNA binding domains.

Implicated in

Entity inv(X)(p11.2q12) in renal cell carcinoma -->NONO/TFE3
Disease only one case of papillary renal cell carcinoma
Hybrid/Mutated Gene 5' NONO- 3' TFE3
Abnormal Protein N-term NONO and most of it except the C-term proline rich sequence fused to the DNA binding domains of TFE3 (excluding the acidic transcriptional activation domain, including the C-term helix-loop-helix, and the leucine zipper); the reciprocal transcript is found


Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.
Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS
Oncogene. 1997 ; 15 (18) : 2233-2239.
PMID 9393982
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6.
Dong B, Horowitz DS, Kobayashi R, Krainer AR
Nucleic acids research. 1993 ; 21 (17) : 4085-4092.
PMID 8371983
The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.
Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F
The Journal of biological chemistry. 1998 ; 273 (41) : 26261-26264.
PMID 9756848
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss.
Yang YS, Hanke JH, Carayannopoulos L, Craft CM, Capra JD, Tucker PW
Molecular and cellular biology. 1993 ; 13 (9) : 5593-5603.
PMID 8355702
NonO enhances the association of many DNA-binding proteins to their targets.
Yang YS, Yang MC, Tucker PW, Capra JD
Nucleic acids research. 1997 ; 25 (12) : 2284-2292.
PMID 9171077


This paper should be referenced as such :
Huret, JL
NONO (non-POU domain containing, octamer-binding)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):54-55.
Free journal version : [ pdf ]   [ DOI ]
On line version :

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 7 ]
  t(X;2)(q13;p21) NONO/ZFP36L2
t(X;X)(p11;q13) NONO/TFE3
t(X;X)(p11;q13) TFE3/NONO
t(1;9)(p34;q34) SFPQ/ABL1
t(X;2)(q13;p21) NONO/ZFP36L2
t(X;X)(p11;q13) NONO/TFE3
t(X;X)(p11;q13) TFE3/NONO

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Kidney: Renal cell carcinoma with inv(X)(p11q12) NONO/TFE3
Kidney: Renal cell carcinomas with MiT family translocation
t(X;X)(p11;q13) TFE3/NONO

External links

Genomic and cartography
Gene and transcription
RefSeq transcript (Entrez)
RefSeq genomic (Entrez)
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4841
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Protein Interaction databases
Ontologies - Pathways
Clinical trials, drugs, therapy
canSAR (ICR) (select the gene name)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Oct 18 17:45:32 CEST 2018

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