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NONO (non-POU domain containing, octamer-binding)

Written1999-01Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

HGNC (Hugo) NONO
LocusID (NCBI) 4841
Atlas_Id 168
Location Xq13.1  [Link to chromosome band Xq13]
Location_base_pair Starts at 70503042 and ends at 70521018 bp from pter ( according to hg19-Feb_2009)  [Mapping NONO.png]
Fusion genes
(updated 2016)
NONO (Xq13.1) / TFE3 (Xp11.23)TFE3 (Xp11.23) / NONO (Xq13.1)

DNA/RNA

Transcription alternative splicing; 2.4 mRNA complete cds; coding sequence: CDS 129 ... 1550

Protein

 
Description the protein encoded by NONO is called p54nrb (nuclear RNA binbing); 471 amino acids; 54 kDa; N-term glutamine/histidine rich region, tandem RNA binding domains (amino acids 75 to 228), helix-turn-helix implicated in DNA binding, and a proline rich region in C-term; N-term and C-term allow protein-protein interactions.
Expression wide
Function binds independantly to DNA and RNA; forms a heterodimer with PSF, a protein sharing vast homologies; both form complexes with DNA topoisomerase I, which renders this enzyme much more active; NONO also enhances the binding of several DNA-binding proteins (but not all).
Homology with PSF and other proteins with a DBHS domain (Drosophila behaviour, human splicing) which includes the tandem RNA binding domains.

Implicated in

Note
Entity inv(X)(p11.2q12) in renal cell carcinoma -->NonO/TFE3
Disease only one case of papillary renal cell carcinoma
Hybrid/Mutated Gene 5' NONO- 3' TFE3
 
Abnormal Protein N-term NONO and most of it except the C-term proline rich sequence fused to the DNA binding domains of TFE3 (excluding the acidic transcriptional activation domain, including the C-term helix-loop-helix, and the leucine zipper); the reciprocal transcript is found
  

Bibliography

Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma.
Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS
Oncogene. 1997 ; 15 (18) : 2233-2239.
PMID 9393982
 
Purification and cDNA cloning of HeLa cell p54nrb, a nuclear protein with two RNA recognition motifs and extensive homology to human splicing factor PSF and Drosophila NONA/BJ6.
Dong B, Horowitz DS, Kobayashi R, Krainer AR
Nucleic acids research. 1993 ; 21 (17) : 4085-4092.
PMID 8371983
 
The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction.
Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F
The Journal of biological chemistry. 1998 ; 273 (41) : 26261-26264.
PMID 9756848
 
NonO, a non-POU-domain-containing, octamer-binding protein, is the mammalian homolog of Drosophila nonAdiss.
Yang YS, Hanke JH, Carayannopoulos L, Craft CM, Capra JD, Tucker PW
Molecular and cellular biology. 1993 ; 13 (9) : 5593-5603.
PMID 8355702
 
NonO enhances the association of many DNA-binding proteins to their targets.
Yang YS, Yang MC, Tucker PW, Capra JD
Nucleic acids research. 1997 ; 25 (12) : 2284-2292.
PMID 9171077
 

Citation

This paper should be referenced as such :
Huret, JL
NONO (non-POU domain containing, octamer-binding)
Atlas Genet Cytogenet Oncol Haematol. 1999;3(2):54-55.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/NONOID168.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(1;9)(p34;q34) SFPQ/ABL1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Kidney: Renal cell carcinoma with inv(X)(p11q12) NONO/TFE3

External links

Nomenclature
HGNC (Hugo)NONO   7871
Cards
AtlasNONOID168
Entrez_Gene (NCBI)NONO  4841  non-POU domain containing, octamer-binding
AliasesMRXS34; NMT55; NRB54; P54; 
P54NRB; PPP1R114
GeneCards (Weizmann)NONO
Ensembl hg19 (Hinxton)ENSG00000147140 [Gene_View]  chrX:70503042-70521018 [Contig_View]  NONO [Vega]
Ensembl hg38 (Hinxton)ENSG00000147140 [Gene_View]  chrX:70503042-70521018 [Contig_View]  NONO [Vega]
ICGC DataPortalENSG00000147140
TCGA cBioPortalNONO
AceView (NCBI)NONO
Genatlas (Paris)NONO
WikiGenes4841
SOURCE (Princeton)NONO
Genomic and cartography
GoldenPath hg19 (UCSC)NONO  -     chrX:70503042-70521018 +  Xq13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)NONO  -     Xq13.1   [Description]    (hg38-Dec_2013)
EnsemblNONO - Xq13.1 [CytoView hg19]  NONO - Xq13.1 [CytoView hg38]
Mapping of homologs : NCBINONO [Mapview hg19]  NONO [Mapview hg38]
OMIM300084   
Gene and transcription
Genbank (Entrez)AK055406 AK291140 AK297144 AU119361 BC002364
RefSeq transcript (Entrez)NM_001145408 NM_001145409 NM_001145410 NM_007363
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_046742 NT_011651 NW_004929443
Consensus coding sequences : CCDS (NCBI)NONO
Cluster EST : UnigeneHs.700344 [ NCBI ]
CGAP (NCI)Hs.700344
Alternative Splicing GalleryENSG00000147140
Gene ExpressionNONO [ NCBI-GEO ]   NONO [ EBI - ARRAY_EXPRESS ]   NONO [ SEEK ]   NONO [ MEM ]
Gene Expression Viewer (FireBrowse)NONO [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4841
GTEX Portal (Tissue expression)NONO
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15233 (Uniprot)
NextProtQ15233  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15233
Splice isoforms : SwissVarQ15233 (Swissvar)
PhosPhoSitePlusQ15233
Domaine pattern : Prosite (Expaxy)RRM (PS50102)   
Domains : Interpro (EBI)NOPS    Nucleotide-bd_a/b_plait    RRM_dom   
Domain families : Pfam (Sanger)NOPS (PF08075)    RRM_1 (PF00076)   
Domain families : Pfam (NCBI)pfam08075    pfam00076   
Domain families : Smart (EMBL)RRM (SM00360)  
DMDM Disease mutations4841
Blocks (Seattle)NONO
PDB (SRS)3SDE   
PDB (PDBSum)3SDE   
PDB (IMB)3SDE   
PDB (RSDB)3SDE   
Structural Biology KnowledgeBase3SDE   
SCOP (Structural Classification of Proteins)3SDE   
CATH (Classification of proteins structures)3SDE   
SuperfamilyQ15233
Human Protein AtlasENSG00000147140
Peptide AtlasQ15233
HPRD02098
IPIIPI00304596   IPI00018152   IPI00922367   IPI00646520   IPI00645010   IPI00647641   IPI00645966   IPI00644848   
Protein Interaction databases
DIP (DOE-UCLA)Q15233
IntAct (EBI)Q15233
FunCoupENSG00000147140
BioGRIDNONO
STRING (EMBL)NONO
ZODIACNONO
Ontologies - Pathways
QuickGOQ15233
Ontology : AmiGOnucleotide binding  mRNA splicing, via spliceosome  transcription regulatory region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  core promoter binding  chromatin binding  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  DNA repair  DNA recombination  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  circadian rhythm  RNA splicing  membrane  nuclear matrix  nuclear speck  paraspeckles  regulation of circadian rhythm  identical protein binding  poly(A) RNA binding  negative regulation of transcription, DNA-templated  RNA polymerase II transcription factor complex  negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
Ontology : EGO-EBInucleotide binding  mRNA splicing, via spliceosome  transcription regulatory region sequence-specific DNA binding  RNA polymerase II distal enhancer sequence-specific DNA binding  core promoter binding  chromatin binding  protein binding  nucleus  nucleus  nucleoplasm  nucleolus  DNA repair  DNA recombination  transcription, DNA-templated  regulation of transcription, DNA-templated  mRNA processing  circadian rhythm  RNA splicing  membrane  nuclear matrix  nuclear speck  paraspeckles  regulation of circadian rhythm  identical protein binding  poly(A) RNA binding  negative regulation of transcription, DNA-templated  RNA polymerase II transcription factor complex  negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  
Pathways : BIOCARTARNA polymerase III transcription [Genes]   
NDEx Network
Atlas of Cancer Signalling NetworkNONO
Wikipedia pathwaysNONO
Orthology - Evolution
OrthoDB4841
GeneTree (enSembl)ENSG00000147140
Phylogenetic Trees/Animal Genes : TreeFamNONO
Homologs : HomoloGeneNONO
Homology/Alignments : Family Browser (UCSC)NONO
Gene fusions - Rearrangements
Fusion : MitelmanNONO/TFE3 [Xq13.1/Xp11.23]  
Fusion : MitelmanTFE3/NONO [Xp11.23/Xq13.1]  [t(X;X)(p11;q13)]  
Fusion : COSMICNONO [Xq13.1]  -  TFE3 [Xp11.23]  [fusion_865]  [fusion_866]  
Fusion : TICdbNONO [Xq13.1]  -  TFE3 [Xp11.23]
Polymorphisms : SNP, variants
NCBI Variation ViewerNONO [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)NONO
dbVarNONO
ClinVarNONO
1000_GenomesNONO 
Exome Variant ServerNONO
ExAC (Exome Aggregation Consortium)NONO (select the gene name)
Genetic variants : HAPMAP4841
Genomic Variants (DGV)NONO [DGVbeta]
Mutations
ICGC Data PortalNONO 
TCGA Data PortalNONO 
Broad Tumor PortalNONO
OASIS PortalNONO [ Somatic mutations - Copy number]
Cancer Gene: CensusNONO 
Somatic Mutations in Cancer : COSMICNONO 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch NONO
DgiDB (Drug Gene Interaction Database)NONO
DoCM (Curated mutations)NONO (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)NONO (select a term)
intoGenNONO
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:70503042-70521018  ENSG00000147140
CONAN: Copy Number AnalysisNONO 
Mutations and Diseases : HGMDNONO
OMIM300084   
MedgenNONO
Genetic Testing Registry NONO
NextProtQ15233 [Medical]
TSGene4841
GENETestsNONO
Huge Navigator NONO [HugePedia]
snp3D : Map Gene to Disease4841
BioCentury BCIQNONO
ClinGenNONO
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4841
Chemical/Pharm GKB GenePA31680
Clinical trialNONO
Miscellaneous
canSAR (ICR)NONO (select the gene name)
Probes
Litterature
PubMed137 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineNONO
EVEXNONO
GoPubMedNONO
iHOPNONO
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Aug 10 18:51:44 CEST 2016

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jlhuret@AtlasGeneticsOncology.org.