Atlas of Genetics and Cytogenetics in Oncology and Haematology


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ZNF146 (zinc finger protein 146)

Identity

Other namesOZF
Hugo ZNF146
Location 19q13.1

Protein

Description 33 kDa; a kruppel zinc finger protein consisting of 10 zinc finger motives, preceeded by 10 amino acids and followed by 2 amino acids
Expression in most proliferating tissues
Localisation nucleus
Function represse gene expression through a consensus motive

Implicated in

Disease tumors of the exocrine pancreas
Cytogenetics amplification of the 19q13.1 region in a subset of pancreatic tumors
  

External links

Nomenclature
HugoZNF146
GDBZNF146
Entrez_GeneZNF146  7705  zinc finger protein 146
Cards
AtlasOZFID267
GeneCardsZNF146
EnsemblZNF146 [Search_View]   ENSG00000167635 [Gene_View]
GenatlasZNF146
GeneLynxZNF146
eGenomeZNF146
euGene7705
Genomic and cartography
GoldenPathZNF146  -  19q13.1   chr19:41397344-41421515 +  19q13.1   [Description]    (hg18-Mar_2006)
EnsemblZNF146 - 19q13.1 [CytoView]
NCBIMapview
OMIMDisease map [OMIM]
HomoloGeneZNF146
Gene and transcription
GenbankAI039686 [ ENTREZ ]
GenbankBC005154 [ ENTREZ ]
GenbankBC065568 [ ENTREZ ]
GenbankBC110500 [ ENTREZ ]
GenbankBC110501 [ ENTREZ ]
RefSeqNM_001099638 [ SRS ]    NM_001099638 [ ENTREZ ]
RefSeqNM_001099639 [ SRS ]    NM_001099639 [ ENTREZ ]
RefSeqNM_007145 [ SRS ]    NM_007145 [ ENTREZ ]
RefSeqAC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeqNC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeqNT_011109 [ SRS ]    NT_011109 [ ENTREZ ]
RefSeqNW_927206 [ SRS ]    NW_927206 [ ENTREZ ]
AceViewZNF146 AceView - NCBI
UnigeneHs.643436 [ SRS ]    Hs.643436 [ NCBI ]     HS643436 [ spliceNest ]
Fast-db11301 (alternative variants)
Protein : pattern, domain, 3D structure
SwissProtQ15072 [ SRS]    Q15072 [ EXPASY ]     Q15072 [ INTERPRO ]
PrositePS00028 ZINC_FINGER_C2H2_1 [ SRS ]    PS00028 ZINC_FINGER_C2H2_1 [ Expasy ]
PrositePS50157 ZINC_FINGER_C2H2_2 [ SRS ]    PS50157 ZINC_FINGER_C2H2_2 [ Expasy ]
InterproIPR007087 Znf_C2H2 [ SRS ]    IPR007087 Znf_C2H2 [ EBI ]
InterproIPR015880 Znf_C2H2-like [ SRS ]    IPR015880 Znf_C2H2-like [ EBI ]
InterproIPR013087 Znf_C2H2/integrase_DNA-bd [ SRS ]    IPR013087 Znf_C2H2/integrase_DNA-bd [ EBI ]
CluSTrQ15072
PfamPF00096 zf-C2H2 [ SRS ]    PF00096 zf-C2H2 [ Sanger ]    pfam00096 [ NCBI-CDD ]
SmartSM00355 ZnF_C2H2 [EMBL]
ProdomPD000003 Znf_C2H2[INRA-Toulouse]
ProdomQ15072 OZF_HUMAN [ Domain structure ]   Q15072 OZF_HUMAN  [ sequences sharing at least 1 domain ]
BlocksQ15072
HPRD03296
Protein Interaction databases
DIPQ15072
IntActQ15072
Polymorphism : SNP, mutations, diseases
OMIM601505    [ map ]   
GENECLINICS601505
SNPZNF146 [dbSNP-NCBI]  
SNPNM_001099638 [SNP-NCI]  
SNPNM_001099639 [SNP-NCI]  
SNPNM_007145 [SNP-NCI]  
SNPZNF146 [GeneSNPs - Utah]  ZNF146] [HGBASE - SRS]
HAPMAPZNF146 [HAPMAP]  
HGMDZNF146
General knowledge
Family BrowserZNF146 [UCSC Family Browser]
SOURCENM_001099638
SOURCENM_001099639
SOURCENM_007145
SMDHs.643436
SAGEHs.643436
GODNA binding [Amigo]  DNA binding
GOintracellular [Amigo]  intracellular
GOnucleus [Amigo]  nucleus
GOregulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GOheparin binding [Amigo]  heparin binding
GOzinc ion binding [Amigo]  zinc ion binding
GOmetal ion binding [Amigo]  metal ion binding
PubGeneZNF146
TreeFamZNF146
CTD7705 [Comparative ToxicoGenomics Database]
Other databases
Probes
ProbeZNF146 Related clones (RZPD - Berlin)
PubMed
PubMed14 Pubmed reference(s) in LocusLink

Bibliography

The OZF gene encodes a protein consisting essentially of zinc finger motifs.
Le Chalony C, Prospˆ©ri MT, Haluza R, Apiou F, Dutrillaux B, Goubin G
Journal of molecular biology. 1994 ; 236 (2) : 399-404.
PMID 8107129
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written10-2000Gérard.Goubin
Laboratoire d'Oncogenèse, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France

Citation

This paper should be referenced as such :
Goubin G . ZNF146 (zinc finger protein 146). Atlas Genet Cytogenet Oncol Haematol. October 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/OZFID267.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jul 2 08:25:45 2008


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