ZNF146 (zinc finger protein 146)

Identity

Other names	OZF
Hugo	ZNF146
Location	19q13.1

Protein

Description	33 kDa; a kruppel zinc finger protein consisting of 10 zinc finger motives, preceeded by 10 amino acids and followed by 2 amino acids
Expression	in most proliferating tissues
Localisation	nucleus
Function	represse gene expression through a consensus motive

Implicated in

Disease	tumors of the exocrine pancreas
Cytogenetics	amplification of the 19q13.1 region in a subset of pancreatic tumors

External links

	Nomenclature
Hugo	ZNF146
GDB	ZNF146
Entrez_Gene	ZNF146  7705  zinc finger protein 146
	Cards
Atlas	OZFID267
GeneCards	ZNF146
Ensembl	ZNF146 [Search_View]   ENSG00000167635 [Gene_View]
Genatlas	ZNF146
GeneLynx	ZNF146
eGenome	ZNF146
euGene	7705
	Genomic and cartography
GoldenPath	ZNF146  -  19q13.1   chr19:41397344-41421515 +  19q13.1   [Description]    (hg18-Mar_2006)
Ensembl	ZNF146 - 19q13.1 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	ZNF146
	Gene and transcription
Genbank	AI039686 [ ENTREZ ]
Genbank	BC005154 [ ENTREZ ]
Genbank	BC065568 [ ENTREZ ]
Genbank	BC110500 [ ENTREZ ]
Genbank	BC110501 [ ENTREZ ]
RefSeq	NM_001099638 [ SRS ]    NM_001099638 [ ENTREZ ]
RefSeq	NM_001099639 [ SRS ]    NM_001099639 [ ENTREZ ]
RefSeq	NM_007145 [ SRS ]    NM_007145 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NT_011109 [ SRS ]    NT_011109 [ ENTREZ ]
RefSeq	NW_927206 [ SRS ]    NW_927206 [ ENTREZ ]
AceView	ZNF146 AceView - NCBI
Unigene	Hs.643436 [ SRS ]    Hs.643436 [ NCBI ]     HS643436 [ spliceNest ]
Fast-db	11301 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q15072 [ SRS]    Q15072 [ EXPASY ]     Q15072 [ INTERPRO ]
Prosite	PS00028 ZINC_FINGER_C2H2_1 [ SRS ]    PS00028 ZINC_FINGER_C2H2_1 [ Expasy ]
Prosite	PS50157 ZINC_FINGER_C2H2_2 [ SRS ]    PS50157 ZINC_FINGER_C2H2_2 [ Expasy ]
Interpro	IPR007087 Znf_C2H2 [ SRS ]    IPR007087 Znf_C2H2 [ EBI ]
Interpro	IPR015880 Znf_C2H2-like [ SRS ]    IPR015880 Znf_C2H2-like [ EBI ]
Interpro	IPR013087 Znf_C2H2/integrase_DNA-bd [ SRS ]    IPR013087 Znf_C2H2/integrase_DNA-bd [ EBI ]
CluSTr	Q15072
Pfam	PF00096 zf-C2H2 [ SRS ]    PF00096 zf-C2H2 [ Sanger ]    pfam00096 [ NCBI-CDD ]
Smart	SM00355 ZnF_C2H2 [EMBL]
Prodom	PD000003 Znf_C2H2[INRA-Toulouse]
Prodom	Q15072 OZF_HUMAN [ Domain structure ]   Q15072 OZF_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	Q15072
HPRD	03296
	Protein Interaction databases
DIP	Q15072
IntAct	Q15072
	Polymorphism : SNP, mutations, diseases
OMIM	601505    [ map ]
GENECLINICS	601505
SNP	ZNF146 [dbSNP-NCBI]
SNP	NM_001099638 [SNP-NCI]
SNP	NM_001099639 [SNP-NCI]
SNP	NM_007145 [SNP-NCI]
SNP	ZNF146 [GeneSNPs - Utah]  ZNF146] [HGBASE - SRS]
HAPMAP	ZNF146 [HAPMAP]
HGMD	ZNF146
	General knowledge
Family Browser	ZNF146 [UCSC Family Browser]
SOURCE	NM_001099638
SOURCE	NM_001099639
SOURCE	NM_007145
SMD	Hs.643436
SAGE	Hs.643436
GO	DNA binding [Amigo]  DNA binding
GO	intracellular [Amigo]  intracellular
GO	nucleus [Amigo]  nucleus
GO	regulation of transcription, DNA-dependent [Amigo]  regulation of transcription, DNA-dependent
GO	heparin binding [Amigo]  heparin binding
GO	zinc ion binding [Amigo]  zinc ion binding
GO	metal ion binding [Amigo]  metal ion binding
PubGene	ZNF146
TreeFam	ZNF146
CTD	7705 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	ZNF146 Related clones (RZPD - Berlin)
	PubMed
PubMed	14 Pubmed reference(s) in LocusLink

Bibliography

The OZF gene encodes a protein consisting essentially of zinc finger motifs.

Le Chalony C, Prospˆ©ri MT, Haluza R, Apiou F, Dutrillaux B, Goubin G

Journal of molecular biology. 1994 ; 236 (2) : 399-404.

PMID 8107129

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	10-2000	Gérard.Goubin
		Laboratoire d'Oncogenèse, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France

Citation

This paper should be referenced as such :

Goubin G . ZNF146 (zinc finger protein 146). Atlas Genet Cytogenet Oncol Haematol. October 2000 . URL : http://AtlasGeneticsOncology.org/Genes/OZFID267.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Wed Jul 2 08:25:45 2008