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ZNF146 (zinc finger protein 146)

Identity

Other namesOZF
HGNC (Hugo) ZNF146
LocusID (NCBI) 7705
Location 19q13.12
Location_base_pair Starts at 36705504 and ends at 36729675 bp from pter ( according to hg19-Feb_2009)  [Mapping]

Protein

Description 33 kDa; a kruppel zinc finger protein consisting of 10 zinc finger motives, preceeded by 10 amino acids and followed by 2 amino acids
Expression in most proliferating tissues
Localisation nucleus
Function represse gene expression through a consensus motive

Implicated in

Disease tumors of the exocrine pancreas
Cytogenetics amplification of the 19q13.1 region in a subset of pancreatic tumors
  

External links

Nomenclature
HGNC (Hugo)ZNF146   12931
Cards
AtlasOZFID267
Entrez_Gene (NCBI)ZNF146  7705  zinc finger protein 146
GeneCards (Weizmann)ZNF146
Ensembl (Hinxton)ENSG00000167635 [Gene_View]  chr19:36705504-36729675 [Contig_View]  ZNF146 [Vega]
AceView (NCBI)ZNF146
Genatlas (Paris)ZNF146
WikiGenes7705
SOURCE (Princeton)NM_001099638 NM_001099639 NM_007145
Genomic and cartography
GoldenPath (UCSC)ZNF146  -  19q13.12   chr19:36705504-36729675 +  19q13.1   [Description]    (hg19-Feb_2009)
EnsemblZNF146 - 19q13.1 [CytoView]
Mapping of homologs : NCBIZNF146 [Mapview]
OMIM601505   
Gene and transcription
Genbank (Entrez)AI039686 AK311486 AK313460 BC005154 BC065568
RefSeq transcript (Entrez)NM_001099638 NM_001099639 NM_007145
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838494 NW_004929415
Consensus coding sequences : CCDS (NCBI)ZNF146
Cluster EST : UnigeneHs.643436 [ NCBI ]
CGAP (NCI)Hs.643436
Alternative Splicing : Fast-db (Paris)GSHG0014857
Alternative Splicing GalleryENSG00000167635
Gene ExpressionZNF146 [ NCBI-GEO ]     ZNF146 [ SEEK ]   ZNF146 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15072 (Uniprot)
NextProtQ15072  [Medical]
With graphics : InterProQ15072
Splice isoforms : SwissVarQ15072 (Swissvar)
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Related proteins : CluSTrQ15072
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM Disease mutations7705
Blocks (Seattle)Q15072
Human Protein AtlasENSG00000167635
Peptide AtlasQ15072
HPRD03296
IPIIPI00014305   
Protein Interaction databases
DIP (DOE-UCLA)Q15072
IntAct (EBI)Q15072
FunCoupENSG00000167635
BioGRIDZNF146
InParanoidQ15072
Interologous Interaction database Q15072
IntegromeDBZNF146
STRING (EMBL)ZNF146
Ontologies - Pathways
Ontology : AmiGODNA binding  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-dependent  heparin binding  zinc ion binding  
Ontology : EGO-EBIDNA binding  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-dependent  heparin binding  zinc ion binding  
REACTOMEZNF146
Protein Interaction DatabaseZNF146
Wikipedia pathwaysZNF146
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)ZNF146
SNP (GeneSNP Utah)ZNF146
SNP : HGBaseZNF146
Genetic variants : HAPMAPZNF146
1000_GenomesZNF146 
ICGC programENSG00000167635 
Somatic Mutations in Cancer : COSMICZNF146 
CONAN: Copy Number AnalysisZNF146 
Mutations and Diseases : HGMDZNF146
OMIM601505   
GENETestsZNF146
Disease Genetic AssociationZNF146
Huge Navigator ZNF146 [HugePedia]  ZNF146 [HugeCancerGEM]
Genomic VariantsZNF146  ZNF146 [DGVbeta]
Exome VariantZNF146
dbVarZNF146
ClinVarZNF146
snp3D : Map Gene to Disease7705
General knowledge
Homologs : HomoloGeneZNF146
Homology/Alignments : Family Browser (UCSC)ZNF146
Phylogenetic Trees/Animal Genes : TreeFamZNF146
Chemical/Protein Interactions : CTD7705
Chemical/Pharm GKB GenePA37518
Clinical trialZNF146
Cancer Resource (Charite)ENSG00000167635
Other databases
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
CoreMineZNF146
iHOPZNF146

Bibliography

The OZF gene encodes a protein consisting essentially of zinc finger motifs.
Le Chalony C, Prospˆ©ri MT, Haluza R, Apiou F, Dutrillaux B, Goubin G
Journal of molecular biology. 1994 ; 236 (2) : 399-404.
PMID 8107129
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written10-2000Gérard.Goubin
Laboratoire d'Oncogenèse, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France

Citation

This paper should be referenced as such :
Goubin G . ZNF146 (zinc finger protein 146). Atlas Genet Cytogenet Oncol Haematol. October 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/OZFID267.html

The various updated versions of this paper are referenced and archived by INIST as such :
http://documents.irevues.inist.fr/bitstream/2042/37667/1/10-2000-OZFID267.pdf   [ Bibliographic record ]

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Apr 18 17:19:09 CEST 2014

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