ZNF146 (zinc finger protein 146)

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ZNF146 (zinc finger protein 146)

Identity

Other names	OZF
HGNC (Hugo)	ZNF146
Location	19q13.1
Location_base_pair	Starts at 41397344 and ends at 41421515 bp from pter ( according to hg18-Mar_2006) [Mapping]

Protein

Description	33 kDa; a kruppel zinc finger protein consisting of 10 zinc finger motives, preceeded by 10 amino acids and followed by 2 amino acids
Expression	in most proliferating tissues
Localisation	nucleus
Function	represse gene expression through a consensus motive

Implicated in

Disease	tumors of the exocrine pancreas
Cytogenetics	amplification of the 19q13.1 region in a subset of pancreatic tumors

External links

	Nomenclature
HGNC (Hugo)	ZNF146 12931
Entrez_Gene (NCBI)	ZNF146 7705 zinc finger protein 146
	Cards
Atlas	OZFID267
GeneCards (Weizmann)	ZNF146
Ensembl (Hinxton)	ENSG00000167635 [Gene_View] ZNF146 [Vega]
AceView (NCBI)	ZNF146
Genatlas (Paris)	ZNF146
euGene (Indiana)	7705
SOURCE (Stanford)	NM_001099638 NM_001099639 NM_007145
Gene Expression (Array Express)	ENSG00000167635
	Genomic and cartography
GoldenPath (UCSC)	ZNF146 - 19q13.1 chr19:41397344-41421515 + 19q13.1 [Description] (hg18-Mar_2006)
Ensembl	ZNF146 - 19q13.1 [CytoView]
Mapping of homologs : NCBI	ZNF146 [Mapview]
OMIM	601505
	Gene and transcription
Gene : Genbank (Entrez)	AI039686 AK311486 AK313460 BC005154 BC065568
Reference sequence (RefSeq transcript) :SRS	NM_001099638 NM_001099639 NM_007145
Reference transcript : Entrez	NM_001099638 NM_001099639 NM_007145
RefSeq genomic : SRS	AC_000062 AC_000151 NC_000019 NT_011109 NW_001838494 NW_927206
RefSeq genomic : Entrez	AC_000062 AC_000151 NC_000019 NT_011109 NW_001838494 NW_927206
Consensus coding sequences : CCDS NCBI	ZNF146
Cluster EST : Unigene	Hs.643436 [ SRS ] Hs.643436 [ NCBI ]
Alternative Splicing : Fast-db (Paris)	11301
	Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProt	Q15072 (SRS) Q15072 (Expasy) Q15072 (Uniprot)
With graphics : InterPro	Q15072
Splice isoforms : VarSplice FASTA	Q15072(VarSplice FASTA)
Domaine pattern : Prosite (SRS)	ZINC_FINGER_C2H2_1 (PS00028) ZINC_FINGER_C2H2_2 (PS50157)
Domain pattern : Prosite (Expaxy)	ZINC_FINGER_C2H2_1 (PS00028) ZINC_FINGER_C2H2_2 (PS50157)
Domains : Interpro (SRS)	Znf_C2H2 Znf_C2H2-like Znf_C2H2/integrase_DNA-bd
Domains : Interpro (EBI)	Znf_C2H2 Znf_C2H2-like Znf_C2H2/integrase_DNA-bd
Related proteins : CluSTr	Q15072
Domain families : Pfam SRS	zf-C2H2 (PF00096)
Domain families : Pfam Sanger	zf-C2H2 (PF00096)
Domain families : Pfam NCBI	pfam00096
Domain families : Smart EMBL	ZnF_C2H2 (SM00355)
Blocks (Seattle)	Q15072
Crystal structure of protein : PDB SRS
Crystal structure of protein : PDBSum
Crystal structure of protein : IMB
Crystal structure of protein : PDB RSDB
HPRD	03296
	Protein Interaction databases
DIP (DOE-UCLA)	Q15072
IntAct (EBI)	Q15072
	Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBI	ZNF146
SNP : GeneSNP Utah	ZNF146
SNP : HGBase	ZNF146
Genetic variants : HAPMAP	ZNF146
Somatic Mutations in Cancer : COSMIC	ZNF146
Mutations and Diseases : HGMD	ZNF146
Hereditary diseases : OMIM	601505
Hereditary diseases : GENETests	601505
Diseases : Genetic Association	ZNF146
	General knowledge
Homologs : HomoloGene	ZNF146
Homology/Alignments : Family Browser UCSC	ZNF146
Phylogenetic Trees/Animal Genes : TreeFam	ZNF146
Chemical/Protein Interactions : CTD	7705
Keywords Ontology : AmiGO	DNA binding intracellular nucleus nucleolus cytoplasm regulation of transcription, DNA-dependent heparin binding zinc ion binding metal ion binding
Keywords Ontology : EGO-EBI	DNA binding intracellular nucleus nucleolus cytoplasm regulation of transcription, DNA-dependent heparin binding zinc ion binding metal ion binding
Pathways : BIOCARTA
Pathways : KEGG
	Other databases
	Probes
Probes : Imagenes	ZNF146 Related clones (RZPD - Berlin)
	Literature
PubMed	15 Pubmed reference(s) in Entrez
PubGene	ZNF146

Bibliography

The OZF gene encodes a protein consisting essentially of zinc finger motifs.

Le Chalony C, Prospˆ©ri MT, Haluza R, Apiou F, Dutrillaux B, Goubin G

Journal of molecular biology. 1994 ; 236 (2) : 399-404.

PMID 8107129

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	10-2000	Gérard.Goubin
		Laboratoire d'Oncogenèse, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France

Citation
This paper should be referenced as such :
Goubin G . ZNF146 (zinc finger protein 146). Atlas Genet Cytogenet Oncol Haematol. October 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/OZFID267.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 27 10:47:31 CET 2010

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