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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
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Don't let the Atlas imminent demise
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ZNF146 (zinc finger protein 146)

Identity

Other namesOZF
HGNC (Hugo) ZNF146
LocusID (NCBI) 7705
Location 19q13.12
Location_base_pair Starts at 36705504 and ends at 36729675 bp from pter ( according to hg19-Feb_2009)  [Mapping]

Protein

Description 33 kDa; a kruppel zinc finger protein consisting of 10 zinc finger motives, preceeded by 10 amino acids and followed by 2 amino acids
Expression in most proliferating tissues
Localisation nucleus
Function represse gene expression through a consensus motive

Implicated in

Disease tumors of the exocrine pancreas
Cytogenetics amplification of the 19q13.1 region in a subset of pancreatic tumors
  

External links

Nomenclature
HGNC (Hugo)ZNF146   12931
Cards
AtlasOZFID267
Entrez_Gene (NCBI)ZNF146  7705  zinc finger protein 146
GeneCards (Weizmann)ZNF146
Ensembl hg19 (Hinxton)ENSG00000167635 [Gene_View]  chr19:36705504-36729675 [Contig_View]  ZNF146 [Vega]
Ensembl hg38 (Hinxton)ENSG00000167635 [Gene_View]  chr19:36705504-36729675 [Contig_View]  ZNF146 [Vega]
ICGC DataPortalENSG00000167635
cBioPortalZNF146
AceView (NCBI)ZNF146
Genatlas (Paris)ZNF146
WikiGenes7705
SOURCE (Princeton)ZNF146
Genomic and cartography
GoldenPath hg19 (UCSC)ZNF146  -     chr19:36705504-36729675 +  19q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)ZNF146  -     19q13.1   [Description]    (hg38-Dec_2013)
EnsemblZNF146 - 19q13.1 [CytoView hg19]  ZNF146 - 19q13.1 [CytoView hg38]
Mapping of homologs : NCBIZNF146 [Mapview hg19]  ZNF146 [Mapview hg38]
OMIM601505   
Gene and transcription
Genbank (Entrez)AI039686 AK311486 AK313460 BC005154 BC065568
RefSeq transcript (Entrez)NM_001099638 NM_001099639 NM_007145
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838494 NW_004929415
Consensus coding sequences : CCDS (NCBI)ZNF146
Cluster EST : UnigeneHs.643436 [ NCBI ]
CGAP (NCI)Hs.643436
Alternative Splicing : Fast-db (Paris)GSHG0014857
Alternative Splicing GalleryENSG00000167635
Gene ExpressionZNF146 [ NCBI-GEO ]     ZNF146 [ SEEK ]   ZNF146 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15072 (Uniprot)
NextProtQ15072  [Medical]
With graphics : InterProQ15072
Splice isoforms : SwissVarQ15072 (Swissvar)
Domaine pattern : Prosite (Expaxy)ZINC_FINGER_C2H2_1 (PS00028)    ZINC_FINGER_C2H2_2 (PS50157)   
Domains : Interpro (EBI)Znf_C2H2    Znf_C2H2-like    Znf_C2H2/integrase_DNA-bd   
Related proteins : CluSTrQ15072
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)ZnF_C2H2 (SM00355)  
DMDM Disease mutations7705
Blocks (Seattle)Q15072
Human Protein AtlasENSG00000167635
Peptide AtlasQ15072
HPRD03296
IPIIPI00014305   
Protein Interaction databases
DIP (DOE-UCLA)Q15072
IntAct (EBI)Q15072
FunCoupENSG00000167635
BioGRIDZNF146
IntegromeDBZNF146
STRING (EMBL)ZNF146
Ontologies - Pathways
QuickGOQ15072
Ontology : AmiGODNA binding  sequence-specific DNA binding transcription factor activity  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-templated  heparin binding  zinc ion binding  
Ontology : EGO-EBIDNA binding  sequence-specific DNA binding transcription factor activity  nucleus  nucleolus  cytoplasm  regulation of transcription, DNA-templated  heparin binding  zinc ion binding  
Protein Interaction DatabaseZNF146
DoCM (Curated mutations)ZNF146
Wikipedia pathwaysZNF146
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerZNF146 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)ZNF146
dbVarZNF146
ClinVarZNF146
1000_GenomesZNF146 
Exome Variant ServerZNF146
SNP (GeneSNP Utah)ZNF146
SNP : HGBaseZNF146
Genetic variants : HAPMAPZNF146
Genomic Variants (DGV)ZNF146 [DGVbeta]
Mutations
ICGC Data PortalENSG00000167635 
Somatic Mutations in Cancer : COSMICZNF146 
CONAN: Copy Number AnalysisZNF146 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:36705504-36729675
Mutations and Diseases : HGMDZNF146
OMIM601505   
MedgenZNF146
NextProtQ15072 [Medical]
GENETestsZNF146
Disease Genetic AssociationZNF146
Huge Navigator ZNF146 [HugePedia]  ZNF146 [HugeCancerGEM]
snp3D : Map Gene to Disease7705
DGIdb (Drug Gene Interaction db)ZNF146
General knowledge
Homologs : HomoloGeneZNF146
Homology/Alignments : Family Browser (UCSC)ZNF146
Phylogenetic Trees/Animal Genes : TreeFamZNF146
Chemical/Protein Interactions : CTD7705
Chemical/Pharm GKB GenePA37518
Clinical trialZNF146
Cancer Resource (Charite)ENSG00000167635
Other databases
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
CoreMineZNF146
GoPubMedZNF146
iHOPZNF146

Bibliography

The OZF gene encodes a protein consisting essentially of zinc finger motifs.
Le Chalony C, Prospˆ©ri MT, Haluza R, Apiou F, Dutrillaux B, Goubin G
Journal of molecular biology. 1994 ; 236 (2) : 399-404.
PMID 8107129
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written10-2000Gérard.Goubin
Laboratoire d'Oncogenèse, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France

Citation

This paper should be referenced as such :
Goubin, G
ZNF146 (zinc finger protein 146)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):197-197.
Free journal version : [ pdf ]   [ DOI ]
URL : http://AtlasGeneticsOncology.org/Genes/OZFID267.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Feb 17 20:02:42 CET 2015

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