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PRDX1 (peroxiredoxin 1)

Identity

Other namesPAGA (Proliferation Associated Gene A)
PAG
PRX1
Hs.1163
NKEFA (natural killer-enhancing factor A)
Prx-1 (peroxiredoxin 1)
HBP23 (Heme-binding protein 23 kDa)
MSP23 (macrophage 23-kD stress protein)
HGNC (Hugo) PRDX1
Location 1p34.1
Location_base_pair Starts at 45749294 and ends at 45760196 bp from pter ( according to hg18-Mar_2006)  [Mapping]
Note PAGA/NKEFA/PRDX1/peroxiredoxin 1, located in 1p34, is often confused in databases and elsewhere with PAGB/TDPX2, a pseudogene located in 9p22; PAGB is not either NKEFB/PRDX2/peroxiredoxin 2, located in 13q12; the other peroxiredoxins, PRDX3 and PRDX5, are located in 10q25-26 and in 11q13 respectively

DNA/RNA

Description 6 exons, 13 kb
Transcription 937 bp mRNA; 599 bp coding sequence
Pseudogene pseudogene in 9p22

Protein

Description 199 amino acids; 22 kDa; form dimers through a disulfide bridge
Expression widely expressed, in particular in the various cell types of the central nervous system and in red blood cells; overexpressed following induction of proliferation and oxidative stress
Localisation cytosolic
Function antioxidant, against oxidative stress; Abl SH3-binding protein; inhibitor of c-Abl tyrosine kinase activity; also binds to heme
Homology thioperoxiredoxines

Implicated in

Disease Correlations between the expression level and the stage of tumor progrssion in squamous cell carcinoma of the oral cavity; high expression in follicular thyroid tumors, but not in papillary carcinoma of the thyroid
  

External links

Nomenclature
HGNC (Hugo)PRDX1   9352
Entrez_Gene (NCBI)PRDX1  5052  peroxiredoxin 1
Cards
AtlasPAGID266
GeneCards (Weizmann)PRDX1
Ensembl (Hinxton)ENSG00000117450 [Gene_View]  PRDX1 [Vega]
AceView (NCBI)PRDX1
Genatlas (Paris)PRDX1
euGene (Indiana)5052
SOURCE (Stanford)NM_002574 NM_181696 NM_181697
Genomic and cartography
GoldenPath (UCSC)PRDX1  -  1p34.1   chr1:45749294-45760196 -  1p34.1   [Description]    (hg18-Mar_2006)
EnsemblPRDX1 - 1p34.1 [CytoView]
Mapping of homologs : NCBIPRDX1 [Mapview]
OMIM176763   
Gene and transcription
Gene : Genbank (Entrez)AB451262 AB451388 AI912389 AK131049 AK311898
Reference sequence (RefSeq transcript) :SRSNM_002574 NM_181696 NM_181697
Reference transcript : EntrezNM_002574 NM_181696 NM_181697
RefSeq genomic : SRSAC_000044 AC_000133 NC_000001 NT_032977 NW_001838578 NW_921351
RefSeq genomic : EntrezAC_000044 AC_000133 NC_000001 NT_032977 NW_001838578 NW_921351
Consensus coding sequences : CCDS NCBIPRDX1
Cluster EST : UnigeneHs.180909 [ SRS ] Hs.180909 [ NCBI ]
Alternative Splicing : Fast-db (Paris)15679
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ06830 (SRS) Q06830 (Expasy) Q06830 (Uniprot)
With graphics : InterProQ06830
Splice isoforms : VarSplice FASTAQ06830(VarSplice FASTA)
Domaine pattern : Prosite (SRS)THIOREDOXIN_2 (PS51352)   
Domain pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (SRS)AhpC-TSA    Thioredoxin_fold   
Domains : Interpro (EBI)AhpC-TSA    Thioredoxin_fold   
Related proteins : CluSTrQ06830
Domain families : Pfam SRSAhpC-TSA (PF00578)   
Domain families : Pfam SangerAhpC-TSA (PF00578)   
Domain families : Pfam NCBIpfam00578   
Blocks (Seattle)Q06830
Crystal structure of protein : PDB SRS2RII   
Crystal structure of protein : PDBSum2RII   
Crystal structure of protein : IMB2RII   
Crystal structure of protein : PDB RSDB2RII   
HPRD01458
Protein Interaction databases
DIP (DOE-UCLA)Q06830
IntAct (EBI)Q06830
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBIPRDX1
SNP : GeneSNP UtahPRDX1
SNP : HGBasePRDX1
Genetic variants : HAPMAPPRDX1
Mutations and Diseases : HGMDPRDX1
Hereditary diseases : OMIM176763   
Hereditary diseases : GENETests176763   
Diseases : Genetic AssociationPRDX1
General knowledge
Homologs : HomoloGenePRDX1
Homology/Alignments : Family Browser UCSCPRDX1
Phylogenetic Trees/Animal Genes : TreeFamPRDX1
Catalytic activity : Enzyme1.11.1.15 [ Enzyme-Expasy ]   1.11.1.15 [ Enzyme-SRS ]   1.11.1.15 [ IntEnz-EBI ]   1.11.1.15 [ BRENDA ]   1.11.1.15 [ KEGG ]   
Chemical/Protein Interactions : CTD5052
Keywords Ontology : AmiGOskeletal system development  protein binding  nucleus  cytoplasm  cell proliferation  oxidoreductase activity  melanosome  hydrogen peroxide catabolic process  cell redox homeostasis  peroxiredoxin activity  oxidation reduction  
Keywords Ontology : EGO-EBIskeletal system development  protein binding  nucleus  cytoplasm  cell proliferation  oxidoreductase activity  melanosome  hydrogen peroxide catabolic process  cell redox homeostasis  peroxiredoxin activity  oxidation reduction  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesPRDX1 Related clones (RZPD - Berlin)
Literature
PubMed57 Pubmed reference(s) in Entrez
PubGenePRDX1

Bibliography

A human cDNA corresponding to a gene overexpressed during cell proliferation encodes a product sharing homology with amoebic and bacterial proteins.
Prospˆ©ri MT, Ferbus D, Karczinski I, Goubin G
The Journal of biological chemistry. 1993 ; 268 (15) : 11050-11056.
PMID 8496166
 
Organization and chromosomal assignment of two human PAG gene loci: PAGA encoding a functional gene and PAGB a processed pseudogene.
Prospˆ©ri MT, Apiou F, Dutrillaux B, Goubin G
Genomics. 1994 ; 19 (2) : 236-241.
PMID 8188254
 
Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.
Shau H, Butterfield LH, Chiu R, Kim A
Immunogenetics. 1994 ; 40 (2) : 129-134.
PMID 8026862
 
Identification of natural killer enhancing factor as a major antioxidant in human red blood cells.
Shau H, Kim A
Biochemical and biophysical research communications. 1994 ; 199 (1) : 83-88.
PMID 8123050
 
Antioxidant function of recombinant human natural killer enhancing factor.
Sauri H, Butterfield L, Kim A, Shau H
Biochemical and biophysical research communications. 1995 ; 208 (3) : 964-969.
PMID 7702627
 
Recombinant natural killer enhancing factor augments natural killer cytotoxicity.
Sauri H, Ashjian PH, Kim AT, Shau H
Journal of leukocyte biology. 1996 ; 59 (6) : 925-931.
PMID 8691079
 
The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.
Wen ST, Van Etten RA
Genes & development. 1997 ; 11 (19) : 2456-2467.
PMID 9334312
 
Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.
Kang SW, Baines IC, Rhee SG
The Journal of biological chemistry. 1998 ; 273 (11) : 6303-6311.
PMID 9497358
 
The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress.
Prospˆ©ri MT, Ferbus D, Rouillard D, Goubin G
FEBS letters. 1998 ; 423 (1) : 39-44.
PMID 9506838
 
Expression of the antioxidant gene NKEF in the central nervous system.
Sarafian TA, Huang C, Kim A, de Vellis J, Shau H
Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid. 1998 ; 34 (1) : 39-51.
PMID 9778645
 
Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
Hirotsu S, Abe Y, Okada K, Nagahara N, Hori H, Nishino T, Hakoshima T
Proceedings of the National Academy of Sciences of the United States of America. 1999 ; 96 (22) : 12333-12338.
PMID 10535922
 
Differential expression of peroxiredoxin subtypes in human brain cell types.
Sarafian TA, Verity MA, Vinters HV, Shih CC, Shi L, Ji XD, Dong L, Shau H
Journal of neuroscience research. 1999 ; 56 (2) : 206-212.
PMID 10494109
 
Peroxiredoxin I expression in human thyroid tumors.
Yanagawa T, Ishikawa T, Ishii T, Tabuchi K, Iwasa S, Bannai S, Omura K, Suzuki H, Yoshida H
Cancer letters. 1999 ; 145 (1-2) : 127-132.
PMID 10530780
 
Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system.
Mizusawa H, Ishii T, Bannai S
Neuroscience letters. 2000 ; 283 (1) : 57-60.
PMID 10729633
 
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Yanagawa T, Iwasa S, Ishii T, Tabuchi K, Yusa H, Onizawa K, Omura K, Harada H, Suzuki H, Yoshida H
Cancer letters. 2000 ; 156 (1) : 27-35.
PMID 10840156
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written10-2000Maité P Prosperi, Didier Ferbus, Gérard.Goubin
Laboratoire d'Oncogenese, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France.
Updated12-2000Jean-Loup Huret

Citation

This paper should be referenced as such :
Prosperi MP, Ferbus D, Goubin G . PRDX1 (peroxiredoxin 1). Atlas Genet Cytogenet Oncol Haematol. October 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/PAGID266.html
Huret JL . PRDX1 (peroxiredoxin 1). Atlas Genet Cytogenet Oncol Haematol. December 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/PAGID266.html

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indexed on : Sat Jun 27 16:40:10 CEST 2009

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