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PRDX1 (peroxiredoxin 1)

Written2000-10Maité P Prosperi, Didier Ferbus, Gérard.Goubin
Laboratoire d'Oncogenese, UMR147 CNRS, Section de recherche, Institut Curie, Paris, France.
Updated2000-12Jean-Loup Huret
Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesPAGA
Alias_symbol (synonym)NKEFA
Other aliasPAGA (Proliferation Associated Gene A)
PAG
PRX1
Hs.1163
NKEFA (natural killer-enhancing factor A)
Prx-1 (peroxiredoxin 1)
HBP23 (Heme-binding protein 23 kDa)
MSP23 (macrophage 23-kD stress protein)
HGNC (Hugo) PRDX1
LocusID (NCBI) 5052
Atlas_Id 266
Location 1p34.1  [Link to chromosome band 1p34]
Location_base_pair Starts at 45511051 and ends at 45521884 bp from pter ( according to hg19-Feb_2009)  [Mapping PRDX1.png]
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
HS2ST1 (1p22.3) / PRDX1 (1p34.1)PRDX1 (1p34.1) / AKR1A1 (1p34.1)PRDX1 (1p34.1) / PRDX1 (1p34.1)
PRDX1 (1p34.1) / TNFAIP3 (6q23.3)PRDX1 (1p34.1) / WDR59 (16q23.1)SNRNP40 (1p35.2) / PRDX1 (1p34.1)
USP16 (21q21.3) / PRDX1 (1p34.1)
Note PAGA/NKEFA/PRDX1/peroxiredoxin 1, located in 1p34, is often confused in databases and elsewhere with PAGB/TDPX2, a pseudogene located in 9p22; PAGB is not either NKEFB/PRDX2/peroxiredoxin 2, located in 13q12; the other peroxiredoxins, PRDX3 and PRDX5, are located in 10q25-26 and in 11q13 respectively

DNA/RNA

Description 6 exons, 13 kb
Transcription 937 bp mRNA; 599 bp coding sequence
Pseudogene pseudogene in 9p22

Protein

Description 199 amino acids; 22 kDa; form dimers through a disulfide bridge
Expression widely expressed, in particular in the various cell types of the central nervous system and in red blood cells; overexpressed following induction of proliferation and oxidative stress
Localisation cytosolic
Function antioxidant, against oxidative stress; Abl SH3-binding protein; inhibitor of c-Abl tyrosine kinase activity; also binds to heme
Homology thioperoxiredoxines

Implicated in

Note
Disease Correlations between the expression level and the stage of tumor progrssion in squamous cell carcinoma of the oral cavity; high expression in follicular thyroid tumors, but not in papillary carcinoma of the thyroid
  

Bibliography

Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
Hirotsu S, Abe Y, Okada K, Nagahara N, Hori H, Nishino T, Hakoshima T
Proceedings of the National Academy of Sciences of the United States of America. 1999 ; 96 (22) : 12333-12338.
PMID 10535922
 
Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.
Kang SW, Baines IC, Rhee SG
The Journal of biological chemistry. 1998 ; 273 (11) : 6303-6311.
PMID 9497358
 
Peroxiredoxin I (macrophage 23 kDa stress protein) is highly and widely expressed in the rat nervous system.
Mizusawa H, Ishii T, Bannai S
Neuroscience letters. 2000 ; 283 (1) : 57-60.
PMID 10729633
 
The pag gene product, a physiological inhibitor of c-abl tyrosine kinase, is overexpressed in cells entering S phase and by contact with agents inducing oxidative stress.
Prospéri MT, Ferbus D, Rouillard D, Goubin G
FEBS letters. 1998 ; 423 (1) : 39-44.
PMID 9506838
 
Differential expression of peroxiredoxin subtypes in human brain cell types.
Sarafian TA, Verity MA, Vinters HV, Shih CC, Shi L, Ji XD, Dong L, Shau H
Journal of neuroscience research. 1999 ; 56 (2) : 206-212.
PMID 10494109
 
Recombinant natural killer enhancing factor augments natural killer cytotoxicity.
Sauri H, Ashjian PH, Kim AT, Shau H
Journal of leukocyte biology. 1996 ; 59 (6) : 925-931.
PMID 8691079
 
Antioxidant function of recombinant human natural killer enhancing factor.
Sauri H, Butterfield L, Kim A, Shau H
Biochemical and biophysical research communications. 1995 ; 208 (3) : 964-969.
PMID 7702627
 
Cloning and sequence analysis of candidate human natural killer-enhancing factor genes.
Shau H, Butterfield LH, Chiu R, Kim A
Immunogenetics. 1994 ; 40 (2) : 129-134.
PMID 8026862
 
Identification of natural killer enhancing factor as a major antioxidant in human red blood cells.
Shau H, Kim A
Biochemical and biophysical research communications. 1994 ; 199 (1) : 83-88.
PMID 8123050
 
The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3-binding protein and a physiological inhibitor of c-Abl tyrosine kinase activity.
Wen ST, Van Etten RA
Genes & development. 1997 ; 11 (19) : 2456-2467.
PMID 9334312
 
Peroxiredoxin I expression in oral cancer: a potential new tumor marker.
Yanagawa T, Iwasa S, Ishii T, Tabuchi K, Yusa H, Onizawa K, Omura K, Harada H, Suzuki H, Yoshida H
Cancer letters. 2000 ; 156 (1) : 27-35.
PMID 10840156
 

Citation

This paper should be referenced as such :
Huret, JL
PRDX1 (peroxiredoxin 1)
Atlas Genet Cytogenet Oncol Haematol. 2001;5(1):14-15.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/PAGID266.html
History of this paper:
Prosperi, MP ; Ferbus, D ; Goubin, G. PAG (proliferation associated gene A). Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):192-192.
http://documents.irevues.inist.fr/bitstream/handle/2042/37668/10-2000-PAGID266.pdf

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(X;21)(p22;q22) RUNX1/PRDX4

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(1;1)(p22;p34) HS2ST1/PRDX1
PRDX1/AKR1A1 (1p34)

External links

Nomenclature
HGNC (Hugo)PRDX1   9352
Cards
AtlasPAGID266
Entrez_Gene (NCBI)PRDX1  5052  peroxiredoxin 1
AliasesMSP23; NKEF-A; NKEFA; PAG; 
PAGA; PAGB; PRX1; PRXI; TDPX2
GeneCards (Weizmann)PRDX1
Ensembl hg19 (Hinxton)ENSG00000117450 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000117450 [Gene_View]  ENSG00000117450 [Sequence]  chr1:45511051-45521884 [Contig_View]  PRDX1 [Vega]
ICGC DataPortalENSG00000117450
TCGA cBioPortalPRDX1
AceView (NCBI)PRDX1
Genatlas (Paris)PRDX1
WikiGenes5052
SOURCE (Princeton)PRDX1
Genetics Home Reference (NIH)PRDX1
Genomic and cartography
GoldenPath hg38 (UCSC)PRDX1  -     chr1:45511051-45521884 -  1p34.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PRDX1  -     1p34.1   [Description]    (hg19-Feb_2009)
GoldenPathPRDX1 - 1p34.1 [CytoView hg19]  PRDX1 - 1p34.1 [CytoView hg38]
Genome Data Viewer NCBIPRDX1 [Mapview hg19]  
OMIM176763   277400   
Gene and transcription
Genbank (Entrez)AB451262 AB451388 AI912389 AK129949 AK131049
RefSeq transcript (Entrez)NM_001202431 NM_002574 NM_181696 NM_181697
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PRDX1
Alternative Splicing GalleryENSG00000117450
Gene ExpressionPRDX1 [ NCBI-GEO ]   PRDX1 [ EBI - ARRAY_EXPRESS ]   PRDX1 [ SEEK ]   PRDX1 [ MEM ]
Gene Expression Viewer (FireBrowse)PRDX1 [ Firebrowse - Broad ]
GenevisibleExpression of PRDX1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5052
GTEX Portal (Tissue expression)PRDX1
Human Protein AtlasENSG00000117450-PRDX1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ06830   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ06830  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ06830
Splice isoforms : SwissVarQ06830
PhosPhoSitePlusQ06830
Domaine pattern : Prosite (Expaxy)THIOREDOXIN_2 (PS51352)   
Domains : Interpro (EBI)AhpC/TSA    Peroxiredoxin_AhpC-typ    Peroxiredoxin_C    Thioredoxin-like_sf    Thioredoxin_domain   
Domain families : Pfam (Sanger)1-cysPrx_C (PF10417)    AhpC-TSA (PF00578)   
Domain families : Pfam (NCBI)pfam10417    pfam00578   
Conserved Domain (NCBI)PRDX1
DMDM Disease mutations5052
PDB (RSDB)2RII    3HY2    4XCS   
PDB Europe2RII    3HY2    4XCS   
PDB (PDBSum)2RII    3HY2    4XCS   
PDB (IMB)2RII    3HY2    4XCS   
Structural Biology KnowledgeBase2RII    3HY2    4XCS   
SCOP (Structural Classification of Proteins)2RII    3HY2    4XCS   
CATH (Classification of proteins structures)2RII    3HY2    4XCS   
SuperfamilyQ06830
Human Protein Atlas [tissue]ENSG00000117450-PRDX1 [tissue]
Peptide AtlasQ06830
HPRD01458
IPIIPI00000874   IPI00640741   IPI00641244   
Protein Interaction databases
DIP (DOE-UCLA)Q06830
IntAct (EBI)Q06830
FunCoupENSG00000117450
BioGRIDPRDX1
STRING (EMBL)PRDX1
ZODIACPRDX1
Ontologies - Pathways
QuickGOQ06830
Ontology : AmiGOskeletal system development  retina homeostasis  RNA binding  peroxidase activity  peroxidase activity  protein binding  extracellular space  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  response to oxidative stress  cell proliferation  thioredoxin peroxidase activity  thioredoxin peroxidase activity  removal of superoxide radicals  natural killer cell activation  regulation of stress-activated MAPK cascade  cellular response to stress  erythrocyte homeostasis  cellular response to oxidative stress  natural killer cell mediated cytotoxicity  melanosome  hydrogen peroxide catabolic process  hydrogen peroxide catabolic process  identical protein binding  cadherin binding  leukocyte activation  cell redox homeostasis  oxidation-reduction process  extracellular exosome  regulation of NIK/NF-kappaB signaling  
Ontology : EGO-EBIskeletal system development  retina homeostasis  RNA binding  peroxidase activity  peroxidase activity  protein binding  extracellular space  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  response to oxidative stress  cell proliferation  thioredoxin peroxidase activity  thioredoxin peroxidase activity  removal of superoxide radicals  natural killer cell activation  regulation of stress-activated MAPK cascade  cellular response to stress  erythrocyte homeostasis  cellular response to oxidative stress  natural killer cell mediated cytotoxicity  melanosome  hydrogen peroxide catabolic process  hydrogen peroxide catabolic process  identical protein binding  cadherin binding  leukocyte activation  cell redox homeostasis  oxidation-reduction process  extracellular exosome  regulation of NIK/NF-kappaB signaling  
Pathways : KEGGPeroxisome   
REACTOMEQ06830 [protein]
REACTOME PathwaysR-HSA-8862803 [pathway]   
NDEx NetworkPRDX1
Atlas of Cancer Signalling NetworkPRDX1
Wikipedia pathwaysPRDX1
Orthology - Evolution
OrthoDB5052
GeneTree (enSembl)ENSG00000117450
Phylogenetic Trees/Animal Genes : TreeFamPRDX1
HOGENOMQ06830
Homologs : HomoloGenePRDX1
Homology/Alignments : Family Browser (UCSC)PRDX1
Gene fusions - Rearrangements
Fusion : MitelmanHS2ST1/PRDX1 [1p22.3/1p34.1]  
Fusion PortalHS2ST1 1p22.3 PRDX1 1p34.1 BRCA
Fusion : Fusion_HubAKR1A1--PRDX1    ALB--PRDX1    ANAPC5--PRDX1    COASY--PRDX1    EEF2--PRDX1    EIF2B3--PRDX1    GAPDH--PRDX1    GOLIM4--PRDX1    HS2ST1--PRDX1    JA040725--PRDX1    MTATP8P1--PRDX1    MTHFR--PRDX1    MTND1P23--PRDX1    MTND2P28--PRDX1    PRDX1--AKR1A1   
PRDX1--C1QBP    PRDX1--CANX    PRDX1--CBX2    PRDX1--CTDSP2    PRDX1--DDX27    PRDX1--EEF2    PRDX1--FN1    PRDX1--GIN1    PRDX1--IRF1    PRDX1--MGA    PRDX1--MMACHC    PRDX1--NDUFB8    PRDX1--PERP    PRDX1--PRDX1    PRDX1--RFX5   
PRDX1--STT3B    PRDX1--TBC1D3P1-DHX40P1    PRDX1--TESK2    PRDX1--TMEM167B    PRDX1--TMEM98    PRDX1--TNFAIP3    PRDX1--TTF2    PRDX1--WDR59    PRDX1--ZNF555    RIOK2--PRDX1    RP5-857K21.11--PRDX1    RP5-857K21.7--PRDX1    RPL30--PRDX1    SMG1--PRDX1    SNRNP40--PRDX1   
SPRTN--PRDX1    TG--PRDX1    TPI1--PRDX1    UBC--PRDX1    UCHL5--PRDX1    USP16--PRDX1   
Fusion : QuiverPRDX1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPRDX1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PRDX1
dbVarPRDX1
ClinVarPRDX1
1000_GenomesPRDX1 
Exome Variant ServerPRDX1
GNOMAD BrowserENSG00000117450
Varsome BrowserPRDX1
Genetic variants : HAPMAP5052
Genomic Variants (DGV)PRDX1 [DGVbeta]
DECIPHERPRDX1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPRDX1 
Mutations
ICGC Data PortalPRDX1 
TCGA Data PortalPRDX1 
Broad Tumor PortalPRDX1
OASIS PortalPRDX1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPRDX1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPRDX1
Mutations and Diseases : HGMDPRDX1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutaselect PRDX1
DgiDB (Drug Gene Interaction Database)PRDX1
DoCM (Curated mutations)PRDX1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PRDX1 (select a term)
intoGenPRDX1
NCG6 (London) select PRDX1
Cancer3DPRDX1 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176763    277400   
Orphanet
DisGeNETPRDX1
MedgenPRDX1
Genetic Testing Registry PRDX1
NextProtQ06830 [Medical]
TSGene5052
GENETestsPRDX1
Open Targets GeneticsENSG00000117450  [validation]
snp3D : Map Gene to Disease5052
BioCentury BCIQPRDX1
ClinGenPRDX1
Clinical trials, drugs, therapy
Protein Interactions : CTD5052
Pharm GKB GenePA33722
Clinical trialPRDX1
Miscellaneous
canSAR (ICR)PRDX1 (select the gene name)
HarmonizomePRDX1
DataMed IndexPRDX1
Probes
Litterature
PubMed300 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePRDX1
EVEXPRDX1
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:32:06 CEST 2020
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