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PAX5 (paired box gene 5)

Written2004-01Sabine Strehl
Children's Cancer Research Institute, Kinderspitalgasse 6, A-1090 Vienna, Austria
Updated2005-08Sabine Strehl
Children's Cancer Research Institute, Kinderspitalgasse 6, A-1090 Vienna, Austria

(Note : for Links provided by Atlas : click)

Identity

Other namesALL3
BSAP
HGNC (Hugo) PAX5
LocusID (NCBI) 5079
Atlas_Id 62
Location 9p13.2
Location_base_pair Starts at 36833272 and ends at 37034476 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Fusion genes
(updated 2016)
ELN (7q11.23) / PAX5 (9p13.2)ETV6 (12p13.2) / PAX5 (9p13.2)FOXP1 (3p13) / PAX5 (9p13.2)
IGH (14q32.33) / PAX5 (9p13.2)IGHG1 (14q32.33) / PAX5 (9p13.2)JAK2 (9p24.1) / PAX5 (9p13.2)
MBNL1 (3q25.1) / PAX5 (9p13.2)PAX5 (9p13.2) / ASXL1 (20q11.21)PAX5 (9p13.2) / AUTCACNA2D4S2 ()
PAX5 (9p13.2) / AUTS2 (7q11.22)PAX5 (9p13.2) / BRD1 (22q13.33)PAX5 (9p13.2) / DACH1 (13q21.33)
PAX5 (9p13.2) / DACH2 (Xq21.2)PAX5 (9p13.2) / ELN (7q11.23)PAX5 (9p13.2) / ESRRB (14q24.3)
PAX5 (9p13.2) / ETV6 (12p13.2)PAX5 (9p13.2) / FOXP1 (3p13)PAX5 (9p13.2) / GOLGA6A (15q24.1)
PAX5 (9p13.2) / HIPK1 (1p13.2)PAX5 (9p13.2) / IGH (14q32.33)PAX5 (9p13.2) / JAK2 (9p24.1)
PAX5 (9p13.2) / KANK1 (9p24.3)PAX5 (9p13.2) / KIF3B (20q11.21)PAX5 (9p13.2) / LOC392027 ()
PAX5 (9p13.2) / MLLT3 (9p21.3)PAX5 (9p13.2) / NCOR1 (17p12)PAX5 (9p13.2) / NOL4L (20q11.21)
PAX5 (9p13.2) / NOL4L20q11.21 ()PAX5 (9p13.2) / PAX5 (9p13.2)PAX5 (9p13.2) / PML (15q24.1)
PAX5 (9p13.2) / POM121 (7q11.23)PAX5 (9p13.2) / SLCO1B3 (12p12.2)PAX5 (9p13.2) / TAOK1 (17q11.2)
PAX5 (9p13.2) / TMEM14B (6p24.2)PAX5 (9p13.2) / TMEM9B (11p15.4)PAX5 (9p13.2) / ZCCHC7 (9p13.2)
PAX5 (9p13.2) / ZNF521 (18q11.2)PLAC1 (Xq26.3) / PAX5 (9p13.2)PML (15q24.1) / PAX5 (9p13.2)
ZCCHC7 (9p13.2) / PAX5 (9p13.2)ZNF521 (18q11.2) / PAX5 (9p13.2)

DNA/RNA

Description The PAX5 coding region extends over a genomic interval of approximately 200 kb and comprises 10 exons.
Transcription Two alternative transcripts have been identified, originating from alternative promotor usage, containing exon 1A or 1B; full length mRNA is 3650 bp; transcription is from centromere to telomere.

Protein

 
Description 391 amino acids, 42 kDa, PAX5 belongs to the paired box family of transcription factors, contains a paired box (DNA binding) domain, a truncated homeo domain homology region, and a transactivation domain.
Expression B lymphocytes, the developing CNS, and adult testis.
Localisation Nuclear.
Function Involved in a multitude of developmental processes, PAX5 expression is not only continuously required for B cell lineage commitment during early B cell development but also for B lineage maintenance, involved in the regulation of the CD19 gene, a B-lymphoid-specific target gene.

Implicated in

Note
Entity t(9;14)(p13;q23) lymphoproliferative disorders
Hybrid/Mutated Gene PAX5 - IGH juxtaposition
  
Entity dic(9;12)(p13;p13) acute lymphoblastic leukemia
Hybrid/Mutated Gene PAX5 - ETV6
  

Breakpoints

 

Bibliography

A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation.
Barberis A, Widenhorn K, Vitelli L, Busslinger M
Genes & development. 1990 ; 4 (5) : 849-859.
PMID 2116362
 
t(9;14)(p13;q32) denotes a subset of low-grade non-Hodgkin's lymphoma with plasmacytoid differentiation.
Offit K, Parsa NZ, Filippa D, Jhanwar SC, Chaganti RS
Blood. 1992 ; 80 (10) : 2594-2599.
PMID 1384792
 
Deregulation of PAX-5 by translocation of the Emu enhancer of the IgH locus adjacent to two alternative PAX-5 promoters in a diffuse large-cell lymphoma.
Busslinger M, Klix N, Pfeffer P, Graninger PG, Kozmik Z
Proceedings of the National Academy of Sciences of the United States of America. 1996 ; 93 (12) : 6129-6134.
PMID 8650231
 
The t(9;14)(p13;q32) chromosomal translocation associated with lymphoplasmacytoid lymphoma involves the PAX-5 gene.
Iida S, Rao PH, Nallasivam P, Hibshoosh H, Butler M, Louie DC, Dyomin V, Ohno H, Chaganti RS, Dalla-Favera R
Blood. 1996 ; 88 (11) : 4110-4117.
PMID 8943844
 
Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.
Nutt SL, Urbanek P, Rolink A, Busslinger M
Genes & development. 1997 ; 11 (4) : 476-491.
PMID 9042861
 
Expression of the PAX5/BSAP transcription factor in haematological tumour cells and further molecular characterization of the t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
Hamada T, Yonetani N, Ueda C, Maesako Y, Akasaka H, Akasaka T, Ohno H, Kawakami K, Amakawa R, Okuma M
British journal of haematology. 1998 ; 102 (3) : 691-700.
PMID 9722295
 
Commitment to the B-lymphoid lineage depends on the transcription factor Pax5.
Nutt SL, Heavey B, Rolink AG, Busslinger M
Nature. 1999 ; 401 (6753) : 556-562.
PMID 10524622
 
The t(9;14)(p13;q32) translocation in B-cell non-Hodgkin's lymphoma.
Ohno H, Ueda C, Akasaka T
Leukemia & lymphoma. 2000 ; 36 (5-6) : 435-445.
PMID 10784387
 
The paired box domain gene PAX5 is fused to ETV6/TEL in an acute lymphoblastic leukemia case.
Cazzaniga G, Daniotti M, Tosi S, Giudici G, Aloisi A, Pogliani E, Kearney L, Biondi A
Cancer research. 2001 ; 61 (12) : 4666-4670.
PMID 11406533
 
Reversion of B cell commitment upon loss of Pax5 expression.
Mikkola I, Heavey B, Horcher M, Busslinger M
Science (New York, N.Y.). 2002 ; 297 (5578) : 110-113.
PMID 12098702
 
Transcriptional control of B-cell development.
Schebesta M, Heavey B, Busslinger M
Current opinion in immunology. 2002 ; 14 (2) : 216-223.
PMID 11869895
 
Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1.
Souabni A, Cobaleda C, Schebesta M, Busslinger M
Immunity. 2002 ; 17 (6) : 781-793.
PMID 12479824
 
Pax5 is required for recombination of transcribed, acetylated, 5' IgH V gene segments.
Hesslein DG, Pflugh DL, Chowdhury D, Bothwell AL, Sen R, Schatz DG
Genes & development. 2003 ; 17 (1) : 37-42.
PMID 12514097
 
PAX5/ETV6 fusion defines cytogenetic entity dic(9;12)(p13;p13).
Strehl S, Konig M, Dworzak MN, Kalwak K, Haas OA
Leukemia : official journal of the Leukemia Society of America, Leukemia Research Fund, U.K. 2003 ; 17 (6) : 1121-1123.
PMID 12764378
 
Transcriptional control of early B cell development.
Busslinger M
Annual review of immunology. 2004 ; 22 : 55-79.
PMID 15032574
 
Pax5 induces V-to-DJ rearrangements and locus contraction of the immunoglobulin heavy-chain gene.
Fuxa M, Skok J, Souabni A, Salvagiotto G, Roldan E, Busslinger M
Genes & development. 2004 ; 18 (4) : 411-422.
PMID 15004008
 
PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia.
Tiacci E, Pileri S, Orleth A, Pacini R, Tabarrini A, Frenguelli F, Liso A, Diverio D, Lo-Coco F, Falini B
Cancer research. 2004 ; 64 (20) : 7399-7404.
PMID 15492262
 
PAX5/IGH rearrangement is a recurrent finding in a subset of aggressive B-NHL with complex chromosomal rearrangements.
Poppe B, De Paepe P, Michaux L, Dastugue N, Bastard C, Herens C, Moreau E, Cavazzini F, Yigit N, Van Limbergen H, De Paepe A, Praet M, De Wolf-Peeters C, Wlodarska I, Speleman F
Genes, chromosomes & cancer. 2005 ; 44 (2) : 218-223.
PMID 15942942
 

Citation

This paper should be referenced as such :
Strehl, S
PAX5 (paired box gene 5)
Atlas Genet Cytogenet Oncol Haematol. 2005;9(4):313-314.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/PAX5ID62.html
History of this paper:
Strehl, S. PAX5 (paired box gene 5). Atlas Genet Cytogenet Oncol Haematol. 2004;8(2):61-62.
http://documents.irevues.inist.fr/bitstream/handle/2042/38062/01-2004-PAX5ID62.pdf


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 29 ]
  Classification of B-cell non-Hodgkin lymphomas (NHL)
dic(3;9)(p14;p13) PAX5/FOXP1
dic(7;9)(p11-12;p12-13) PAX5/LOC392027
dic(9;12)(p13;p13) PAX5/ETV6
dic(9;12)(p13;p12) PAX5/SLCO1B3
dic(9;16)(p13;q11) PAX5/?
dic(9;17)(p13;q11) PAX5/TAOK1
dic(9;18)(p13;q11) PAX5/ZNF521
dic(9;20)(p11-13;q11) PAX5/Various
Hodgkin lymphoma
Lymphoplasmacytic lymphoma
t(1;9)(p13;p12) PAX5/HIPK1
t(2;9)(p11;p13) PAX5/?
t(5;9)(q14.1;p24) SSBP2/JAK2
t(6;14)(p22;q32) IGH/ID4
t(7;9)(q11;p12) PAX5/POM121
t(7;9)(q11;p13) PAX5/ELN
t(7;9)(q11.2;p13.2) PAX5/AUTS2
t(8;9)(q24;p13) ?/MYC
t(9;9)(p13;p24) PAX5/JAK2;del(9)(p13p24) PAX5/JAK2;inv(9)(p13p24) PAX5/JAK2
t(9;13)(p12;q21) PAX5/DACH1
t(9;14)(p13;q32) PAX5/IGH
t(9;15)(p13;q24) PAX5/PML
t(9;15)(p13;q24) PAX5/GOLGA6A
t(9;17)(p13;p12) PAX5/NCOR1
t(9;22)(p13;q13) PAX5/BRD1
T-cell/histiocyte-rich large B cell lymphoma
t(X;9)(q21;p13) PAX5/DACH2
Waldenstrom's macroglobulinemia (WM)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Nervous system: Medulloblastoma

External links

Nomenclature
HGNC (Hugo)PAX5   8619
Cards
AtlasPAX5ID62
Entrez_Gene (NCBI)PAX5  5079  paired box 5
GeneCards (Weizmann)PAX5
Ensembl hg19 (Hinxton)ENSG00000196092 [Gene_View]  chr9:36833272-37034476 [Contig_View]  PAX5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000196092 [Gene_View]  chr9:36833272-37034476 [Contig_View]  PAX5 [Vega]
ICGC DataPortalENSG00000196092
TCGA cBioPortalPAX5
AceView (NCBI)PAX5
Genatlas (Paris)PAX5
WikiGenes5079
SOURCE (Princeton)PAX5
Genomic and cartography
GoldenPath hg19 (UCSC)PAX5  -     chr9:36833272-37034476 -  9p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PAX5  -     9p13.2   [Description]    (hg38-Dec_2013)
EnsemblPAX5 - 9p13.2 [CytoView hg19]  PAX5 - 9p13.2 [CytoView hg38]
Mapping of homologs : NCBIPAX5 [Mapview hg19]  PAX5 [Mapview hg38]
OMIM167414   615545   
Gene and transcription
Genbank (Entrez)AF080573 AY463952 AY463953 AY463954 AY463955
RefSeq transcript (Entrez)NM_001280547 NM_001280548 NM_001280549 NM_001280550 NM_001280551 NM_001280552 NM_001280553 NM_001280554 NM_001280555 NM_001280556 NM_016734
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_033894 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)PAX5
Cluster EST : UnigeneHs.654464 [ NCBI ]
CGAP (NCI)Hs.654464
Alternative Splicing GalleryENSG00000196092
Gene ExpressionPAX5 [ NCBI-GEO ]   PAX5 [ EBI - ARRAY_EXPRESS ]   PAX5 [ SEEK ]   PAX5 [ MEM ]
Gene Expression Viewer (FireBrowse)PAX5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5079
GTEX Portal (Tissue expression)PAX5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02548 (Uniprot)
NextProtQ02548  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02548
Splice isoforms : SwissVarQ02548 (Swissvar)
PhosPhoSitePlusQ02548
Domaine pattern : Prosite (Expaxy)PAIRED_1 (PS00034)    PAIRED_2 (PS51057)   
Domains : Interpro (EBI)Homeodomain-like    Paired_dom    Pax2_C    WHTH_DNA-bd_dom   
Domain families : Pfam (Sanger)PAX (PF00292)    Pax2_C (PF12403)   
Domain families : Pfam (NCBI)pfam00292    pfam12403   
Domain families : Smart (EMBL)PAX (SM00351)  
DMDM Disease mutations5079
Blocks (Seattle)PAX5
PDB (SRS)1K78    1MDM   
PDB (PDBSum)1K78    1MDM   
PDB (IMB)1K78    1MDM   
PDB (RSDB)1K78    1MDM   
Structural Biology KnowledgeBase1K78    1MDM   
SCOP (Structural Classification of Proteins)1K78    1MDM   
CATH (Classification of proteins structures)1K78    1MDM   
SuperfamilyQ02548
Human Protein AtlasENSG00000196092
Peptide AtlasQ02548
HPRD01334
IPIIPI00026209   IPI00815658   IPI00929199   IPI00554620   IPI00437171   IPI00973553   IPI00437172   IPI00437169   IPI00437168   IPI00929668   IPI00941332   IPI00985158   IPI00980894   IPI00977401   IPI00929705   IPI00929236   IPI00973580   
Protein Interaction databases
DIP (DOE-UCLA)Q02548
IntAct (EBI)Q02548
FunCoupENSG00000196092
BioGRIDPAX5
STRING (EMBL)PAX5
ZODIACPAX5
Ontologies - Pathways
QuickGOQ02548
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  protein binding  nucleus  transcription from RNA polymerase II promoter  humoral immune response  multicellular organism development  spermatogenesis  aging  organ morphogenesis  lateral ventricle development  cerebral cortex development  adult behavior  skeletal muscle cell differentiation  positive regulation of transcription from RNA polymerase II promoter  embryonic cranial skeleton morphogenesis  negative regulation of histone H3-K9 methylation  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  protein binding  nucleus  transcription from RNA polymerase II promoter  humoral immune response  multicellular organism development  spermatogenesis  aging  organ morphogenesis  lateral ventricle development  cerebral cortex development  adult behavior  skeletal muscle cell differentiation  positive regulation of transcription from RNA polymerase II promoter  embryonic cranial skeleton morphogenesis  negative regulation of histone H3-K9 methylation  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx Network
Atlas of Cancer Signalling NetworkPAX5
Wikipedia pathwaysPAX5
Orthology - Evolution
OrthoDB5079
GeneTree (enSembl)ENSG00000196092
Phylogenetic Trees/Animal Genes : TreeFamPAX5
Homologs : HomoloGenePAX5
Homology/Alignments : Family Browser (UCSC)PAX5
Gene fusions - Rearrangements
Fusion : MitelmanIGH/PAX5 [14q32.33/9p13.2]  [t(2;9;14)(p12;p13;q32)]  [t(9;14)(p13;q32)]  
Fusion : MitelmanPAX5/ASXL1 [9p13.2/20q11.21]  [dic(9;20)(p13;q11)]  
Fusion : MitelmanPAX5/AUTS2 [9p13.2/7q11.22]  [t(7;9)(q11;p13)]  
Fusion : MitelmanPAX5/BRD1 [9p13.2/22q13.33]  [t(9;22)(p13;q13)]  
Fusion : MitelmanPAX5/DACH1 [9p13.2/13q21.33]  [t(9;13)(p12;q21)]  
Fusion : MitelmanPAX5/DACH2 [9p13.2/Xq21.2]  [t(X;9)(q21;p13)]  
Fusion : MitelmanPAX5/ELN [9p13.2/7q11.23]  [t(7;9)(q11;p13)]  
Fusion : MitelmanPAX5/ETV6 [9p13.2/12p13.2]  [dic(9;12)(p13;p13)]  [t(9;12)(p13;p13)]  
Fusion : MitelmanPAX5/FOXP1 [9p13.2/3p13]  [t(3;9)(p13;p13)]  
Fusion : MitelmanPAX5/GOLGA6A [9p13.2/15q24.1]  [t(9;15)(p13;q24)]  
Fusion : MitelmanPAX5/HIPK1 [9p13.2/1p13.2]  [t(1;9)(p13;p12)]  
Fusion : MitelmanPAX5/JAK2 [9p13.2/9p24.1]  [del(9)(p13)]  [del(9)(p13p24)]  
[del(9)(p24)]  [inv(9)(p13p24)]  [t(9;9)(p13;p24)]  
Fusion : MitelmanPAX5/KIF3B [9p13.2/20q11.21]  [dic(9;20)(p13;q11)]  
Fusion : MitelmanPAX5/LOC392027 [9p13.2/-]  [dic(7;9)(p12;p13)]  
Fusion : MitelmanPAX5/NOL4L [9p13.2/20q11.21]  [dic(9;20)(p13;q11)]  
Fusion : MitelmanPAX5/PML [9p13.2/15q24.1]  [t(9;15)(p13;q22)]  
Fusion : MitelmanPAX5/POM121 [9p13.2/7q11.23]  [t(7;9)(q11;p12)]  
Fusion : MitelmanPAX5/SLCO1B3 [9p13.2/12p12.2]  [dic(9;12)(p13;p12)]  
Fusion : MitelmanPAX5/TAOK1 [9p13.2/17q11.2]  [t(9;17)(p13;q11)]  
Fusion : MitelmanPAX5/TMEM9B [9p13.2/11p15.4]  [t(9;11)(p13;p15)]  
Fusion : MitelmanPAX5/ZNF521 [9p13.2/18q11.2]  [t(9;18)(p13;q11)]  
Fusion : COSMICPAX5 [9p13.2]  -  JAK2 [9p24.1]  [fusion_1071]  [fusion_1072]  
Fusion: TCGAPAX5 9p13.2 TMEM9B 11p15.4 BRCA
Fusion : TICdbPAX5 [9p13.2]  -  AUTS2 [7q11.22]
Fusion : TICdbPAX5 [9p13.2]  -  BRD1 [22q13.33]
Fusion : TICdbPAX5 [9p13.2]  -  C20orf112 [20q11.21]
Fusion : TICdbPAX5 [9p13.2]  -  DACH1 [13q21.33]
Fusion : TICdbPAX5 [9p13.2]  -  ELN [7q11.23]
Fusion : TICdbPAX5 [9p13.2]  -  ETV6 [12p13.2]
Fusion : TICdbPAX5 [9p13.2]  -  FOXP1 [3p13]
Fusion : TICdbPAX5 [9p13.2]  -  HIPK1 [1p13.2]
Fusion : TICdbPAX5 [9p13.2]  -  JAK2 [9p24.1]
Fusion : TICdbPAX5 [9p13.2]  -  PML [15q24.1]
Fusion : TICdbPAX5 [9p13.2]  -  POM121 [7q11.23]
Fusion : TICdbPAX5 [9p13.2]  -  SLCO1B3 [12p12.2]
Fusion : TICdbPAX5 [9p13.2]  -  ZNF521 [18q11.2]
Polymorphisms : SNP, variants
NCBI Variation ViewerPAX5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAX5
dbVarPAX5
ClinVarPAX5
1000_GenomesPAX5 
Exome Variant ServerPAX5
ExAC (Exome Aggregation Consortium)PAX5 (select the gene name)
Genetic variants : HAPMAP5079
Genomic Variants (DGV)PAX5 [DGVbeta]
Mutations
ICGC Data PortalPAX5 
TCGA Data PortalPAX5 
Broad Tumor PortalPAX5
OASIS PortalPAX5 [ Somatic mutations - Copy number]
Cancer Gene: CensusPAX5 
Somatic Mutations in Cancer : COSMICPAX5 
intOGen PortalPAX5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAX5
DgiDB (Drug Gene Interaction Database)PAX5
DoCM (Curated mutations)PAX5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAX5 (select a term)
intoGenPAX5
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:36833272-37034476  ENSG00000196092
CONAN: Copy Number AnalysisPAX5 
Mutations and Diseases : HGMDPAX5
OMIM167414    615545   
MedgenPAX5
Genetic Testing Registry PAX5
NextProtQ02548 [Medical]
TSGene5079
GENETestsPAX5
Huge Navigator PAX5 [HugePedia]
snp3D : Map Gene to Disease5079
BioCentury BCIQPAX5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5079
Chemical/Pharm GKB GenePA32959
Clinical trialPAX5
Miscellaneous
canSAR (ICR)PAX5 (select the gene name)
Probes
Litterature
PubMed124 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAX5
EVEXPAX5
GoPubMedPAX5
iHOPPAX5
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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