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| Description | 707-712 amino acids; 76 kDa; N-term proline/glutamine rich domain, a prolin rich region, 2 tandem RNA binding domains, and C-term. |
| Localisation | nucleus |
| Function | splicing factor required early in spliceosome formation; form a complex with the polypyrimidine tract binding protein (PTB, herein the name); involved in pre-m RNA splicing step 2 (step 1: cut after exon n, intron n is still joined to exon n+1; step 2: cut between intron n and exon n+1, join exons n and n+1); forms a heterodimer with p54nrb (nuclear RNA binbing) a protein sharing vast homologies, encoded by NONO; both form complexes with DNA topoisomerase I, which renders this enzyme much more active. |
| Homology | with the above mentioned NONE product and with other proteins with a DBHS domain (Drosophila behaviour, human splicing) which includes the tandem RNA binding domains. |
| A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. |
| Gozani O, Patton JG, Reed R |
| The EMBO journal. 1994 ; 13 (14) : 3356-3367. |
| PMID 8045264 |
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| Fusion of splicing factor genes PSF and NonO (p54nrb) to the TFE3 gene in papillary renal cell carcinoma. |
| Clark J, Lu YJ, Sidhar SK, Parker C, Gill S, Smedley D, Hamoudi R, Linehan WM, Shipley J, Cooper CS |
| Oncogene. 1997 ; 15 (18) : 2233-2239. |
| PMID 9393982 |
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| The RNA-splicing factor PSF/p54 controls DNA-topoisomerase I activity by a direct interaction. |
| Straub T, Grue P, Uhse A, Lisby M, Knudsen BR, Tange TO, Westergaard O, Boege F |
| The Journal of biological chemistry. 1998 ; 273 (41) : 26261-26264. |
| PMID 9756848 |
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