| Description | Amino acids: 1445. Molecular weight: 162058 Daltons. The PTPRG gene belongs to the receptor class 5 subfamily of the protein-tyrosine phosphatase family. |
| Expression | PTPRG is expressed in several tissues. |
| Localisation | Membrane. Single-pass type I membrane protein. |
| Function | Involved in regulating signaling through ligand-controlled protein tyrosine dephosphorylation. The protein contains an extracellular carbonic anhydrase-like and fibronectin type III-like domain, a single transmembrane domain, and a cytoplasmic region with 2 tandem catalytic tyrosine phosphatase domains. Y2H, animal models. |
| Homology | PTPRG shares a PTP domain, involved in dephosphorylating phosphorylated tyrosine residues, with the other receptor-like protein tyrosine phosphatases. The PTPRG gene is conserved in vertebrates. The human and mouse (1442-amino acid) sequences share 95% identity at the amino acid level. |
| Nomenclature | | Hugo | PTPRG |
| GDB | PTPRG |
| Entrez_Gene | PTPRG 5793 protein tyrosine phosphatase, receptor type, G |
| Cards |
|---|
| Atlas | PTPRGID41930ch3p21 |
| GeneCards | PTPRG |
| Ensembl | PTPRG [Search_View] ENSG00000144724 [Gene_View] |
| Genatlas | PTPRG |
| GeneLynx | PTPRG |
| eGenome | PTPRG |
| euGene | 5793 |
| Genomic and cartography |
|---|
| GoldenPath | PTPRG - 3p14.2 chr3:61522285-62254737 + 3p21-p14 [Description] (hg18-Mar_2006) |
| Ensembl | PTPRG - 3p21-p14 [CytoView] |
| NCBI | Mapview |
| OMIM | Disease map [OMIM] |
| HomoloGene | PTPRG |
| Gene and transcription | | Genbank | AB209871 [ ENTREZ ] |
| Genbank | AI872451 [ ENTREZ ] |
| Genbank | BC036018 [ ENTREZ ] |
| Genbank | BC047734 [ ENTREZ ] |
| Genbank | BC048961 [ ENTREZ ] |
| RefSeq | NM_002841 [ SRS ] NM_002841 [ ENTREZ ] |
| RefSeq | AC_000046 [ SRS ] AC_000046 [ ENTREZ ] |
| RefSeq | NC_000003 [ SRS ] NC_000003 [ ENTREZ ] |
| RefSeq | NT_022517 [ SRS ] NT_022517 [ ENTREZ ] |
| RefSeq | NW_921651 [ SRS ] NW_921651 [ ENTREZ ] |
| AceView | PTPRG AceView - NCBI |
| Unigene | Hs.654488 [ SRS ] Hs.654488 [ NCBI ]
HS654488 [ spliceNest ] |
| Fast-db | 9193 (alternative variants) |
| Protein : pattern, domain, 3D structure |
|---|
| SwissProt | P23470 [ SRS] P23470 [ EXPASY ] P23470 [ INTERPRO ] |
| Prosite | PS51144 ALPHA_CA_2 [ SRS ] PS51144 ALPHA_CA_2 [ Expasy ] |
| Prosite | PS50853 FN3 [ SRS ] PS50853 FN3 [ Expasy ] |
| Prosite | PS00383 TYR_PHOSPHATASE_1 [ SRS ] PS00383 TYR_PHOSPHATASE_1 [ Expasy ] |
| Prosite | PS50056 TYR_PHOSPHATASE_2 [ SRS ] PS50056 TYR_PHOSPHATASE_2 [ Expasy ] |
| Prosite | PS50055 TYR_PHOSPHATASE_PTP [ SRS ] PS50055 TYR_PHOSPHATASE_PTP [ Expasy ] |
| Interpro | IPR001148 Euk_COanhd [ SRS ] IPR001148 Euk_COanhd [ EBI ] |
| Interpro | IPR008957 Fibronectin_typ-III-like_fold [ SRS ] IPR008957 Fibronectin_typ-III-like_fold [ EBI ] |
| Interpro | IPR003961 FN_III [ SRS ] IPR003961 FN_III [ EBI ] |
| Interpro | IPR000387 Tyr_Pase [ SRS ] IPR000387 Tyr_Pase [ EBI ] |
| Interpro | IPR000242 Tyr_Pase_rcpt/non-rcpt [ SRS ] IPR000242 Tyr_Pase_rcpt/non-rcpt [ EBI ] |
| CluSTr | P23470 |
| Pfam | PF00194 Carb_anhydrase [ SRS ] PF00194 Carb_anhydrase [ Sanger ] pfam00194 [ NCBI-CDD ] |
| Pfam | PF00041 fn3 [ SRS ] PF00041 fn3 [ Sanger ] pfam00041 [ NCBI-CDD ] |
| Pfam | PF00102 Y_phosphatase [ SRS ] PF00102 Y_phosphatase [ Sanger ] pfam00102 [ NCBI-CDD ] |
| Smart | SM00060 FN3 [EMBL] |
| Smart | SM00194 PTPc [EMBL] |
| Prodom | PD000865 Euk_COanhd[INRA-Toulouse] |
| Prodom | P23470 PTPRG_HUMAN [ Domain structure ] P23470 PTPRG_HUMAN [ sequences sharing at least 1 domain ] |
| Blocks | P23470 |
| PDB | 2H4V [ SRS ] 2H4V [ PdbSum ], 2H4V [ IMB ] 2H4V [ RSDB ] |
| PDB | 2HY3 [ SRS ] 2HY3 [ PdbSum ], 2HY3 [ IMB ] 2HY3 [ RSDB ] |
| PDB | 2NLK [ SRS ] 2NLK [ PdbSum ], 2NLK [ IMB ] 2NLK [ RSDB ] |
| PDB | 2PBN [ SRS ] 2PBN [ PdbSum ], 2PBN [ IMB ] 2PBN [ RSDB ] |
| HPRD | 01478 |
| Protein Interaction databases |
|---|
| DIP | P23470 |
| IntAct | P23470 |
| Polymorphism : SNP, mutations, diseases |
|---|
| OMIM | 176886 [ map ] |
| GENECLINICS | 176886 |
| SNP | PTPRG [dbSNP-NCBI] |
| SNP | NM_002841 [SNP-NCI] |
| SNP | PTPRG [GeneSNPs - Utah] PTPRG] [HGBASE - SRS] |
| HAPMAP | PTPRG [HAPMAP] |
| COSMIC | PTPRG [Somatic mutation (COSMIC-CGP-Sanger)] |
| HGMD | PTPRG |
| General knowledge |
|---|
| Family Browser | PTPRG [UCSC Family Browser] |
| SOURCE | NM_002841 |
| SMD | Hs.654488 |
| SAGE | Hs.654488 |
| Enzyme | 3.1.3.48
[ Enzyme-SRS ] 3.1.3.48
[ Brenda-SRS ] 3.1.3.48
[ KEGG ] 3.1.3.48
[ WIT ] |
| GO | carbonate dehydratase activity [Amigo] carbonate dehydratase activity |
| GO | transmembrane receptor protein tyrosine phosphatase activity [Amigo] transmembrane receptor protein tyrosine phosphatase activity |
| GO | integral to plasma membrane [Amigo] integral to plasma membrane |
| GO | protein amino acid dephosphorylation [Amigo] protein amino acid dephosphorylation |
| GO | one-carbon compound metabolic process [Amigo] one-carbon compound metabolic process |
| GO | transmembrane receptor protein tyrosine kinase signaling pathway [Amigo] transmembrane receptor protein tyrosine kinase signaling pathway |
| GO | zinc ion binding [Amigo] zinc ion binding |
| GO | membrane [Amigo] membrane |
| GO | hydrolase activity [Amigo] hydrolase activity |
| PubGene | PTPRG |
| TreeFam | PTPRG |
| CTD | 5793 [Comparative ToxicoGenomics Database] |
| Other databases |
|---|
| Probes |
|---|
| Probe | PTPRG Related clones (RZPD - Berlin) |
| PubMed |
|---|
| PubMed | 15 Pubmed reference(s) in LocusLink |
| Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21. |
| LaForgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A |
| Proceedings of the National Academy of Sciences of the United States of America. 1991 ; 88 (11) : 5036-5040. |
| PMID 1711217 |
| |
| Mutational analysis of the tyrosine phosphatome in colorectal cancers. |
| Wang Z, Shen D, Parsons DW, Bardelli A, Sager J, Szabo S, Ptak J, Silliman N, Peters BA, van der Heijden MS, Parmigiani G, Yan H, Wang TL, Riggins G, Powell SM, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE |
| Science (New York, N.Y.). 2004 ; 304 (5674) : 1164-1166. |
| PMID 15155950 |
| |
| Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. |
| van Doorn R, Zoutman WH, Dijkman R, de Menezes RX, Commandeur S, Mulder AA, van der Velden PA, Vermeer MH, Willemze R, Yan PS, Huang TH, Tensen CP |
| Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2005 ; 23 (17) : 3886-3896. |
| PMID 15897551 |
| |
| Silencing of Peroxiredoxin 2 and aberrant methylation of 33 CpG islands in putative promoter regions in human malignant melanomas. |
| Furuta J, Nobeyama Y, Umebayashi Y, Otsuka F, Kikuchi K, Ushijima T |
| Cancer research. 2006 ; 66 (12) : 6080-6086. |
| PMID 16778180 |
| |
| Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. |
| Wu CW, Kao HL, Li AF, Chi CW, Lin WC |
| Cancer letters. 2006 ; 242 (1) : 95-103. |
| PMID 16338072 |
| |