REG-IV (regenerating gene type IV)

Identity

HGNC	REG4
Location	1p12
Location_base_pair	Starts at 120138231 and ends at 120155726 bp from pter ( according to hg18-Mar_2006).

DNA/RNA

Description

the gene spans 17 kb; 1191 bp cDNA; 6 exons; ORF: 474 bp

Protein

Description	158 amino acids, 18 kDa.
Expression	gastrointestinal tract: stomach, small intestine, colon, and pancreas. High expression inCrohn's disease and in ulcerative colitis.
Function	supposed to be involved in cell regeneration and/ or survival
Homology	with other members of the REG family, of which are PSP/REG-I alpha and PAP

Mutations

Somatic

strongly expressed in colorectal tumors as compared to normal colon tissue.

External links

	Nomenclature
HGNC	REG4   22977
Entrez_Gene	REG4  83998  regenerating islet-derived family, member 4
	Cards
Atlas	REGIVID485
GeneCards	REG4
Ensembl	ENSG00000134193 [Gene_View]  REG4 [Vega]
Genatlas	REG4
	Genomic and cartography
GoldenPath	REG4  -  1p12   chr1:120138231-120155726 -  1p13.1-p12   [Description]    (hg18-Mar_2006)
Ensembl	REG4 - 1p13.1-p12 [CytoView]
NCBI	Mapview
OMIM	609846 Disease map [OMIM]
HomoloGene	REG4
	Gene and transcription
Genbank	AF254415 [ ENTREZ ]
Genbank	AF345934 [ ENTREZ ]
Genbank	AK057107 [ ENTREZ ]
Genbank	AY007243 [ ENTREZ ]
Genbank	AY126670 [ ENTREZ ]
RefSeq	NM_032044 [ SRS ]    NM_032044 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_019273 [ SRS ]    NT_019273 [ ENTREZ ]
RefSeq	NW_001838594 [ SRS ]    NW_001838594 [ ENTREZ ]
RefSeq	NW_922462 [ SRS ]    NW_922462 [ ENTREZ ]
CCDS	REG4 CCDS - NCBI
AceView	REG4 AceView - NCBI
Unigene	Hs.660883 [ SRS ]    Hs.660883 [ NCBI ]
Fast-db	17178 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	Q5T3X5 [ SRS]    Q5T3X5 [ EXPASY ]     Q5T3X5 [ INTERPRO ]     Q5T3X5 [ UNIPROT ] Q5T3X5 [ VarSplice FASTA ]
Prosite	PS50041 C_TYPE_LECTIN_2 [ SRS ]    PS50041 C_TYPE_LECTIN_2 [ Expasy ]
Interpro	IPR001304 C-type_lectin [ SRS ]    IPR001304 C-type_lectin [ EBI ]
Interpro	IPR016186 C-type_lectin-like [ SRS ]    IPR016186 C-type_lectin-like [ EBI ]
Interpro	IPR003990 Pancreatis_ac [ SRS ]    IPR003990 Pancreatis_ac [ EBI ]
CluSTr	Q5T3X5
Pfam	PF00059 Lectin_C [ SRS ]    PF00059 Lectin_C [ Sanger ]    pfam00059 [ NCBI-CDD ]
Smart	SM00034 CLECT [EMBL]
Blocks	Q5T3X5
HPRD	17964
	Protein Interaction databases
DIP	Q5T3X5
IntAct	Q5T3X5
	Polymorphism : SNP, mutations, diseases
OMIM	609846    [ map ]
GENETests	609846
SNP	REG4 [dbSNP-NCBI]
SNP	NM_032044 [SNP-NCI]
SNP	REG4 [GeneSNPs - Utah]  REG4] [HGBASE - SRS]
HAPMAP	REG4 [HAPMAP]
HGMD	REG4
Genetic Association	REG4
CDC HuGE	REG4
	General knowledge
Family Browser	REG4 [UCSC Family Browser]
SOURCE	NM_032044
SMD	Hs.660883
SAGE	Hs.660883
GO	binding [Amigo]  binding
GO	sugar binding [Amigo]  sugar binding
GO	extracellular region [Amigo]  extracellular region
PubGene	REG4
TreeFam	REG4
CTD	83998 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	REG4 Related clones (RZPD - Berlin)
	PubMed
PubMed	15 Pubmed reference(s) in Entrez

Bibliography

Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV.

Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK

Biochimica et biophysica acta. 2001 ; 1518 (3) : 287-293.

PMID 11311942

Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas.

Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T

International journal of cancer. Journal international du cancer. 2003 ; 103 (2) : 185-193.

PMID 12455032

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-2003	Jean-Loup Huret, Sylvie Senon

Citation

This paper should be referenced as such :

Huret JL, Senon S . REG-IV (regenerating gene type IV). Atlas Genet Cytogenet Oncol Haematol. August 2003 . URL : http://AtlasGeneticsOncology.org/Genes/REGIVID485.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 13:28:46 2008