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RPRM (reprimo, TP53 dependent G2 arrest mediator candidate)

Written2011-11Alejandro H Corvalan, Veronica A Torres
Laboratory of Molecular Pathology, Epidemiology, Department of Hemathology - Oncology, School of Medicine - P Universidad Catolica de Chile, 391 Marcoleta St - Santiago 8330074 Chile

(Note : for Links provided by Atlas : click)

Identity

Alias_namesreprimo
Alias_symbol (synonym)FLJ90327
REPRIMO
Other alias
HGNC (Hugo) RPRM
LocusID (NCBI) 56475
Atlas_Id 42082
Location 2q23.3  [Link to chromosome band 2q23]
Location_base_pair Starts at 154333852 and ends at 154335322 bp from pter ( according to hg19-Feb_2009)  [Mapping RPRM.png]
Fusion genes
(updated 2016)
TNS1 (2q35) / RPRM (2q23.3)

DNA/RNA

Description Reprimo gene consists of 1 exon. The gene spans 1,47 kb of genomic DNA on the chromosome 2 in the minus strand.
Transcription The mRNA is 1496 bp in length.

Protein

Description The open reading frame encodes a 109 amino acid protein with an estimated molecular weight of 11774 Da. Reprimo is a highly glycosylated protein which has two sites in amino acids 7 and 18. The protein has a potential transmembrane site covering amino acids 56 to 76.
Expression The expression of Reprimo is induced by tumor protein p53 following X-ray irradiation.
Localisation When Reprimo is ectopically expressed, it is localized in the cytoplasm.
Function Reprimo is a candidate tumor suppresor gene involved in the G2/M phase cell cycle arrest mediated by tumor protein p53. Reprimo induces cell cycle arrest by inhibiting the nuclear translocation of the Cdc2-Cyclin B1 complex.

Implicated in

Note
  
Entity Various cancers
Note The aberrant methylation of the promoter region of Reprimo is a common event that may contribute to the pathogenesis of some types of human cancer. Promoter methylation of Reprimo was found in pancreatic cancer (91%), gastric cancer (90%), gallbladder cancer (62%), lymphomas (57%), colorectal cancer (56%) and esophageal adenocarcinomas (40%). In breast cancer, leukemias and lung cancer, promoter methylation of Reprimo was found in less than 40% of tested cases.
  
  
Entity Gastric cancer
Disease Aberrant hypermethylation of Reprimo is frequently found in primary gastric cancer as well as in pair plasma samples. In plasma from asymptomatic controls, Reprimo is infrequently methylated. Therefore, plasmatic detection of Reprimo is a putative biomarker for early detection of gastric cancer.
 
The above histogram represents the percentage of positive cases for Reprimo and other genes (APC, SHP1, CDH-1, ER, SEMA3B and 3OST2) in 43 prospectively collected gastric cancer cases and 31 asymptomatic age- and gender-matched controls. Only Reprimo shows a significant difference in plasma between gastric cancer and asymptomatic controls (Bernal et al., Clin Cancer Res. 2008;14:6264-9).
  
  
Entity Pancreatic cancer
Disease Aberrant hypermethylation of Reprimo is also common in pancreatic cell lines (91%) and in pancreatic adenocarcinomas (66%). Reprimo methylation is correlated with poor prognosis in a large series of resected pancreatic cancers. This fact raises the possibility that aberrant methylation of Reprimo is an epigenetic event that may have a mechanistic role in pancreatic cancer.
  

Bibliography

Reprimo as a potential biomarker for early detection in gastric cancer.
Bernal C, Aguayo F, Villarroel C, Vargas M, Diaz I, Ossandon FJ, Santibanez E, Palma M, Aravena E, Barrientos C, Corvalan AH.
Clin Cancer Res. 2008 Oct 1;14(19):6264-9.
PMID 18829507
 
Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progression.
Hamilton JP, Sato F, Jin Z, Greenwald BD, Ito T, Mori Y, Paun BC, Kan T, Cheng Y, Wang S, Yang J, Abraham JM, Meltzer SJ.
Clin Cancer Res. 2006 Nov 15;12(22):6637-42.
PMID 17121882
 
Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase.
Ohki R, Nemoto J, Murasawa H, Oda E, Inazawa J, Tanaka N, Taniguchi T.
J Biol Chem. 2000 Jul 28;275(30):22627-30.
PMID 10930422
 
Aberrant methylation of Reprimo correlates with genetic instability and predicts poor prognosis in pancreatic ductal adenocarcinoma.
Sato N, Fukushima N, Matsubayashi H, Iacobuzio-Donahue CA, Yeo CJ, Goggins M.
Cancer. 2006 Jul 15;107(2):251-7.
PMID 16752411
 
Aberrant methylation of Reprimo in lung cancer.
Suzuki M, Shigematsu H, Takahashi T, Shivapurkar N, Sathyanarayana UG, Iizasa T, Fujisawa T, Gazdar AF.
Lung Cancer. 2005 Mar;47(3):309-14.
PMID 15713514
 
Aberrant methylation of Reprimo in human malignancies.
Takahashi T, Suzuki M, Shigematsu H, Shivapurkar N, Echebiri C, Nomura M, Stastny V, Augustus M, Wu CW, Wistuba II, Meltzer SJ, Gazdar AF.
Int J Cancer. 2005 Jul 1;115(4):503-10.
PMID 15700311
 

Citation

This paper should be referenced as such :
Corvalan, AH ; TorresVA
RPRM (reprimo, TP53 dependent G2 arrest mediator candidate)
Atlas Genet Cytogenet Oncol Haematol. 2012;16(3):223-224.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/RPRMID42082ch2q23.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)RPRM   24201
Cards
AtlasRPRMID42082ch2q23
Entrez_Gene (NCBI)RPRM  56475  reprimo, TP53 dependent G2 arrest mediator candidate
AliasesREPRIMO
GeneCards (Weizmann)RPRM
Ensembl hg19 (Hinxton)ENSG00000177519 [Gene_View]  chr2:154333852-154335322 [Contig_View]  RPRM [Vega]
Ensembl hg38 (Hinxton)ENSG00000177519 [Gene_View]  chr2:154333852-154335322 [Contig_View]  RPRM [Vega]
ICGC DataPortalENSG00000177519
TCGA cBioPortalRPRM
AceView (NCBI)RPRM
Genatlas (Paris)RPRM
WikiGenes56475
SOURCE (Princeton)RPRM
Genetics Home Reference (NIH)RPRM
Genomic and cartography
GoldenPath hg19 (UCSC)RPRM  -     chr2:154333852-154335322 -  2q24.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)RPRM  -     2q24.1   [Description]    (hg38-Dec_2013)
EnsemblRPRM - 2q24.1 [CytoView hg19]  RPRM - 2q24.1 [CytoView hg38]
Mapping of homologs : NCBIRPRM [Mapview hg19]  RPRM [Mapview hg38]
OMIM612171   
Gene and transcription
Genbank (Entrez)AA452090 AB043585 AK074808 AK311958 BC002908
RefSeq transcript (Entrez)NM_019845
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)RPRM
Cluster EST : UnigeneHs.100890 [ NCBI ]
CGAP (NCI)Hs.100890
Alternative Splicing GalleryENSG00000177519
Gene ExpressionRPRM [ NCBI-GEO ]   RPRM [ EBI - ARRAY_EXPRESS ]   RPRM [ SEEK ]   RPRM [ MEM ]
Gene Expression Viewer (FireBrowse)RPRM [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56475
GTEX Portal (Tissue expression)RPRM
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NS64   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NS64  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NS64
Splice isoforms : SwissVarQ9NS64
PhosPhoSitePlusQ9NS64
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)RPRM
DMDM Disease mutations56475
Blocks (Seattle)RPRM
SuperfamilyQ9NS64
Human Protein AtlasENSG00000177519
Peptide AtlasQ9NS64
HPRD18002
IPIIPI00022875   
Protein Interaction databases
DIP (DOE-UCLA)Q9NS64
IntAct (EBI)Q9NS64
FunCoupENSG00000177519
BioGRIDRPRM
STRING (EMBL)RPRM
ZODIACRPRM
Ontologies - Pathways
QuickGOQ9NS64
Ontology : AmiGOprotein binding  cytoplasm  cell cycle arrest  regulation of mitotic cell cycle  integral component of membrane  
Ontology : EGO-EBIprotein binding  cytoplasm  cell cycle arrest  regulation of mitotic cell cycle  integral component of membrane  
Pathways : KEGGp53 signaling pathway   
NDEx NetworkRPRM
Atlas of Cancer Signalling NetworkRPRM
Wikipedia pathwaysRPRM
Orthology - Evolution
OrthoDB56475
GeneTree (enSembl)ENSG00000177519
Phylogenetic Trees/Animal Genes : TreeFamRPRM
HOVERGENQ9NS64
HOGENOMQ9NS64
Homologs : HomoloGeneRPRM
Homology/Alignments : Family Browser (UCSC)RPRM
Gene fusions - Rearrangements
Fusion : MitelmanTNS1/RPRM [2q35/2q23.3]  [t(2;2)(q23;q35)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerRPRM [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)RPRM
dbVarRPRM
ClinVarRPRM
1000_GenomesRPRM 
Exome Variant ServerRPRM
ExAC (Exome Aggregation Consortium)RPRM (select the gene name)
Genetic variants : HAPMAP56475
Genomic Variants (DGV)RPRM [DGVbeta]
DECIPHER (Syndromes)2:154333852-154335322  ENSG00000177519
CONAN: Copy Number AnalysisRPRM 
Mutations
ICGC Data PortalRPRM 
TCGA Data PortalRPRM 
Broad Tumor PortalRPRM
OASIS PortalRPRM [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICRPRM  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDRPRM
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch RPRM
DgiDB (Drug Gene Interaction Database)RPRM
DoCM (Curated mutations)RPRM (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)RPRM (select a term)
intoGenRPRM
NCG5 (London)RPRM
Cancer3DRPRM(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612171   
Orphanet
MedgenRPRM
Genetic Testing Registry RPRM
NextProtQ9NS64 [Medical]
TSGene56475
GENETestsRPRM
Huge Navigator RPRM [HugePedia]
snp3D : Map Gene to Disease56475
BioCentury BCIQRPRM
ClinGenRPRM
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56475
Chemical/Pharm GKB GenePA134937494
Clinical trialRPRM
Miscellaneous
canSAR (ICR)RPRM (select the gene name)
Probes
Litterature
PubMed19 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineRPRM
EVEXRPRM
GoPubMedRPRM
iHOPRPRM
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:48:46 CET 2017

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