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SMAD2 (mothers against decapentaplegic homolog 2 (Drosophila))

Written2004-07Raphael Saffroy, Antoinette Lemoine, Brigitte Debuire
Service de Biochimie et Biologie moleculaire, Hopital Paul Brousse, Faculte de Medecine Paris Sud, 94 800 Villejuif, France

(Note : for Links provided by Atlas : click)

Identity

Alias_namesMADH2
MAD, mothers against decapentaplegic homolog 2 (Drosophila)
SMAD, mothers against DPP homolog 2 (Drosophila)
Alias_symbol (synonym)MADR2
JV18-1
HGNC (Hugo) SMAD2
LocusID (NCBI) 4087
Atlas_Id 370
Location 18q21.1  [Link to chromosome band 18q21]
Location_base_pair Starts at 45359466 and ends at 45457517 bp from pter ( according to hg19-Feb_2009)  [Mapping SMAD2.png]
 
  Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics
Fusion genes
(updated 2016)
BCAP31 (Xq28) / SMAD2 (18q21.1)CTIF (18q21.1) / SMAD2 (18q21.1)SMAD2 (18q21.1) / C10orf90 (10q26.2)
SMAD2 (18q21.1) / CD226 (18q22.2)SMAD2 (18q21.1) / PGAM1 (10q24.1)SMAD2 (18q21.1) / PPP6R3 (11q13.2)
SMAD2 (18q21.1) / ZBTB7C (18q21.1)

DNA/RNA

Description The gene encompasses 90 kb of DNA; 12 exons.
Transcription 2285 nucleotides mRNA. Alternative splicing was described.

Protein

Description 467 amino acids; 52 kDa protein. A short 438 amino acids isoform was also described. Smad2 belongs to the Darfwin proteins family which are composed of two conserved amino- and carboxyl-terminal domains known as MH1 and MH2, respectively.
Expression High expression levels in skeletal muscle, heart and placenta.
Function Smad2 is an intracellular mediator of TGF-beta family and activin type 1 receptor. Smad2 mediate TGF-beta signaling to regulate cell growth and differentiation. Smad2 is released from cytoplasmic retention by TGF-beta receptor-mediated phosphorylation. The phosphorylated Smad2 then forms a heterodimeric complex with Smad4, and this complex translocates from cytoplasm into nucleus. By interacting with DNA-binding proteins, Smad complexes then positively or negatively regulate the transcription of target genes.
Homology With the other members of the Darfwin/Smad family.

Implicated in

Note
Disease Colorectal cancers
Oncogenesis Smad2 was proposed to be a tumor suppressor gene that may function to disrupt TGF-beta signaling. Inactivating mutations in Smad2 have been found in various cancer including colorectal carcinomas. The majority of tumor-derived mutations cluster in the carboxy-terminal MH2 domain, and some of these have been shown to disrupt TGF-beta signaling by blocking receptor-dependent phosphorylation or by preventing heterodimeric interactions between Smads. A mutation at position 133 in the amino-terminal MH1 domain has also been associated with colorectal carcinoma. Nevertheless, loss of Smad2 activation and/or expression was related to occur in less than 10% of colorectal cancers.
  

To be noted

Smad2 gene has also been found alterated in lung carcinomas, cervical carcinomas and hepatocellular carcinomas.

Bibliography

A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway.
Baker JC, Harland RM
Genes & development. 1996 ; 10 (15) : 1880-1889.
PMID 8756346
 
MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.
Eppert K, Scherer SW, Ozcelik H, Pirone R, Hoodless P, Kim H, Tsui LC, Bapat B, Gallinger S, Andrulis IL, Thomsen GH, Wrana JL, Attisano L
Cell. 1996 ; 86 (4) : 543-552.
PMID 8752209
 
Identification and characterization of constitutively active Smad2 mutants: evaluation of formation of Smad complex and subcellular distribution.
Funaba M, Mathews LS
Molecular endocrinology (Baltimore, Md.). 2000 ; 14 (10) : 1583-1591.
PMID 11043574
 
MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.
Macías-Silva M, Abdollah S, Hoodless PA, Pirone R, Attisano L, Wrana JL
Cell. 1996 ; 87 (7) : 1215-1224.
PMID 8980228
 
Loss of expression, and mutations of Smad 2 and Smad 4 in human cervical cancer.
Maliekal TT, Antony ML, Nair A, Paulmurugan R, Karunagaran D
Oncogene. 2003 ; 22 (31) : 4889-4897.
PMID 12894231
 
Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway.
Nakao A, Röijer E, Imamura T, Souchelnytskyi S, Stenman G, Heldin CH, ten Dijke P
The Journal of biological chemistry. 1997 ; 272 (5) : 2896-2900.
PMID 9006934
 
Evidence that Smad2 is a tumor suppressor implicated in the control of cellular invasion.
Prunier C, Mazars A, Noë V, Bruyneel E, Mareel M, Gespach C, Atfi A
The Journal of biological chemistry. 1999 ; 274 (33) : 22919-22922.
PMID 10438456
 
Mad-related genes in the human.
Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B
Nature genetics. 1996 ; 13 (3) : 347-349.
PMID 8673135
 
Mutation analysis of SMAD2, SMAD3, and SMAD4 genes in hereditary non-polyposis colorectal.
Roth S, Johansson M, Loukola A, Peltomäki P, Järvinen H, Mecklin JP, Aaltonen LA
Journal of medical genetics. 2000 ; 37 (4) : 298-300.
PMID 10819637
 
Somatic alterations of the SMAD-2 gene in human colorectal cancers.
Takagi Y, Koumura H, Futamura M, Aoki S, Ymaguchi K, Kida H, Tanemura H, Shimokawa K, Saji S
British journal of cancer. 1998 ; 78 (9) : 1152-1155.
PMID 9820171
 
Mutation analysis of the Smad2 gene in human colon cancers using genomic DNA and intron primers.
Takenoshita S, Tani M, Mogi A, Nagashima M, Nagamachi Y, Bennett WP, Hagiwara K, Harris CC, Yokota J
Carcinogenesis. 1998 ; 19 (5) : 803-807.
PMID 9635866
 
Somatic in vivo alterations of the JV18-1 gene at 18q21 in human lung cancers.
Uchida K, Nagatake M, Osada H, Yatabe Y, Kondo M, Mitsudomi T, Masuda A, Takahashi T, Takahashi T
Cancer research. 1996 ; 56 (24) : 5583-5585.
PMID 8971158
 
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo.
Waldrip WR, Bikoff EK, Hoodless PA, Wrana JL, Robertson EJ
Cell. 1998 ; 92 (6) : 797-808.
PMID 9529255
 
Structural basis of Smad2 recognition by the Smad anchor for receptor activation.
Wu G, Chen YG, Ozdamar B, Gyuricza CA, Chong PA, Wrana JL, Massagué J, Shi Y
Science (New York, N.Y.). 2000 ; 287 (5450) : 92-97.
PMID 10615055
 
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-beta signaling.
Wu JW, Hu M, Chai J, Seoane J, Huse M, Li C, Rigotti DJ, Kyin S, Muir TW, Fairman R, Massagué J, Shi Y
Molecular cell. 2001 ; 8 (6) : 1277-1289.
PMID 11779503
 
Loss of Smad signaling in human colorectal cancer is associated with advanced disease and poor prognosis.
Xie W, Rimm DL, Lin Y, Shih WJ, Reiss M
Cancer journal (Sudbury, Mass.). 2003 ; 9 (4) : 302-312.
PMID 12967141
 
Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway.
Xu J, Attisano L
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (9) : 4820-4825.
PMID 10781087
 
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus.
Xu L, Kang Y, Cöl S, Massagué J
Molecular cell. 2002 ; 10 (2) : 271-282.
PMID 12191473
 
Smad2 and Smad4 gene mutations in hepatocellular carcinoma.
Yakicier MC, Irmak MB, Romano A, Kew M, Ozturk M
Oncogene. 1999 ; 18 (34) : 4879-4883.
PMID 10490821
 

Citation

This paper should be referenced as such :
Saffroy, R ; Lemoine, A ; Debuire, B
SMAD2 (mothers against decapentaplegic homolog 2 (Drosophila))
Atlas Genet Cytogenet Oncol Haematol. 2004;8(3):241-242.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/SMAD2ID370.html


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  Colon: Colorectal adenocarcinoma
Head and Neck: Epidermoid carcinoma
Liver: Hepatocellular carcinoma
Squamous cell cancer


External links

Nomenclature
HGNC (Hugo)SMAD2   6768
Cards
AtlasSMAD2ID370
Entrez_Gene (NCBI)SMAD2  4087  SMAD family member 2
AliasesJV18; JV18-1; MADH2; MADR2; 
hMAD-2; hSMAD2
GeneCards (Weizmann)SMAD2
Ensembl hg19 (Hinxton)ENSG00000175387 [Gene_View]  chr18:45359466-45457517 [Contig_View]  SMAD2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000175387 [Gene_View]  chr18:45359466-45457517 [Contig_View]  SMAD2 [Vega]
ICGC DataPortalENSG00000175387
TCGA cBioPortalSMAD2
AceView (NCBI)SMAD2
Genatlas (Paris)SMAD2
WikiGenes4087
SOURCE (Princeton)SMAD2
Genetics Home Reference (NIH)SMAD2
Genomic and cartography
GoldenPath hg19 (UCSC)SMAD2  -     chr18:45359466-45457517 -  18q21   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)SMAD2  -     18q21   [Description]    (hg38-Dec_2013)
EnsemblSMAD2 - 18q21 [CytoView hg19]  SMAD2 - 18q21 [CytoView hg38]
Mapping of homologs : NCBISMAD2 [Mapview hg19]  SMAD2 [Mapview hg38]
OMIM601366   
Gene and transcription
Genbank (Entrez)AA081871 AA418737 AF027964 AI087928 AI453799
RefSeq transcript (Entrez)NM_001003652 NM_001135937 NM_005901
RefSeq genomic (Entrez)NC_000018 NC_018929 NG_029946 NT_010966 NW_004929410
Consensus coding sequences : CCDS (NCBI)SMAD2
Cluster EST : UnigeneHs.741342 [ NCBI ]
CGAP (NCI)Hs.741342
Alternative Splicing GalleryENSG00000175387
Gene ExpressionSMAD2 [ NCBI-GEO ]   SMAD2 [ EBI - ARRAY_EXPRESS ]   SMAD2 [ SEEK ]   SMAD2 [ MEM ]
Gene Expression Viewer (FireBrowse)SMAD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4087
GTEX Portal (Tissue expression)SMAD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15796   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15796  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15796
Splice isoforms : SwissVarQ15796
PhosPhoSitePlusQ15796
Domaine pattern : Prosite (Expaxy)MH1 (PS51075)    MH2 (PS51076)   
Domains : Interpro (EBI)Dwarfin    MAD_homology1_Dwarfin-type    MAD_homology_MH1    SMAD_dom-like    SMAD_dom_Dwarfin-type    SMAD_FHA_domain   
Domain families : Pfam (Sanger)MH1 (PF03165)    MH2 (PF03166)   
Domain families : Pfam (NCBI)pfam03165    pfam03166   
Domain families : Smart (EMBL)DWA (SM00523)  DWB (SM00524)  
Conserved Domain (NCBI)SMAD2
DMDM Disease mutations4087
Blocks (Seattle)SMAD2
PDB (SRS)1DEV    1KHX    1U7V    2LB3   
PDB (PDBSum)1DEV    1KHX    1U7V    2LB3   
PDB (IMB)1DEV    1KHX    1U7V    2LB3   
PDB (RSDB)1DEV    1KHX    1U7V    2LB3   
Structural Biology KnowledgeBase1DEV    1KHX    1U7V    2LB3   
SCOP (Structural Classification of Proteins)1DEV    1KHX    1U7V    2LB3   
CATH (Classification of proteins structures)1DEV    1KHX    1U7V    2LB3   
SuperfamilyQ15796
Human Protein AtlasENSG00000175387
Peptide AtlasQ15796
HPRD03221
IPIIPI00019548   IPI00220364   IPI00922465   IPI00385246   
Protein Interaction databases
DIP (DOE-UCLA)Q15796
IntAct (EBI)Q15796
FunCoupENSG00000175387
BioGRIDSMAD2
STRING (EMBL)SMAD2
ZODIACSMAD2
Ontologies - Pathways
QuickGOQ15796
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  ureteric bud development  in utero embryonic development  endoderm formation  mesoderm formation  DNA binding  chromatin binding  double-stranded DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transforming growth factor beta receptor binding  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  cytosol  transcription from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  common-partner SMAD protein phosphorylation  SMAD protein complex assembly  zygotic specification of dorsal/ventral axis  gastrulation  transcription factor binding  negative regulation of cell proliferation  response to glucose  post-embryonic development  anterior/posterior pattern specification  positive regulation of epithelial to mesenchymal transition  regulation of transforming growth factor beta receptor signaling pathway  phosphatase binding  signal transduction involved in regulation of gene expression  insulin secretion  lung development  negative regulation of transforming growth factor beta receptor signaling pathway  positive regulation of BMP signaling pathway  transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity  pancreas development  primary miRNA processing  ubiquitin protein ligase binding  activin responsive factor complex  activin receptor signaling pathway  activating transcription factor binding  type I transforming growth factor beta receptor binding  somatic stem cell population maintenance  organ growth  enhancer binding  intracellular signal transduction  nodal signaling pathway  protein homodimerization activity  cell fate commitment  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  metal ion binding  protein heterodimerization activity  paraxial mesoderm morphogenesis  embryonic foregut morphogenesis  embryonic cranial skeleton morphogenesis  regulation of binding  palate development  pericardium development  SMAD protein signal transduction  co-SMAD binding  I-SMAD binding  R-SMAD binding  response to cholesterol  SMAD protein complex  SMAD2-SMAD3 protein complex  positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  RNA polymerase II core promoter proximal region sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding  ureteric bud development  in utero embryonic development  endoderm formation  mesoderm formation  DNA binding  chromatin binding  double-stranded DNA binding  transcription factor activity, sequence-specific DNA binding  transcription factor activity, sequence-specific DNA binding  transforming growth factor beta receptor binding  protein binding  nucleus  nucleoplasm  transcription factor complex  cytoplasm  cytosol  transcription from RNA polymerase II promoter  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  transforming growth factor beta receptor signaling pathway  common-partner SMAD protein phosphorylation  SMAD protein complex assembly  zygotic specification of dorsal/ventral axis  gastrulation  transcription factor binding  negative regulation of cell proliferation  response to glucose  post-embryonic development  anterior/posterior pattern specification  positive regulation of epithelial to mesenchymal transition  regulation of transforming growth factor beta receptor signaling pathway  phosphatase binding  signal transduction involved in regulation of gene expression  insulin secretion  lung development  negative regulation of transforming growth factor beta receptor signaling pathway  positive regulation of BMP signaling pathway  transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity  pancreas development  primary miRNA processing  ubiquitin protein ligase binding  activin responsive factor complex  activin receptor signaling pathway  activating transcription factor binding  type I transforming growth factor beta receptor binding  somatic stem cell population maintenance  organ growth  enhancer binding  intracellular signal transduction  nodal signaling pathway  protein homodimerization activity  cell fate commitment  negative regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  SMAD binding  metal ion binding  protein heterodimerization activity  paraxial mesoderm morphogenesis  embryonic foregut morphogenesis  embryonic cranial skeleton morphogenesis  regulation of binding  palate development  pericardium development  SMAD protein signal transduction  co-SMAD binding  I-SMAD binding  R-SMAD binding  response to cholesterol  SMAD protein complex  SMAD2-SMAD3 protein complex  positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  
Pathways : BIOCARTATGF beta signaling pathway [Genes]   
Pathways : KEGGFoxO signaling pathway    Cell cycle    Endocytosis    TGF-beta signaling pathway    Hippo signaling pathway    Adherens junction    Chagas disease (American trypanosomiasis)    HTLV-I infection    Pathways in cancer    Proteoglycans in cancer    Colorectal cancer    Pancreatic cancer    Inflammatory bowel disease (IBD)   
REACTOMEQ15796 [protein]
REACTOME PathwaysR-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer [pathway]
REACTOME PathwaysR-HSA-1502540 Signaling by Activin [pathway]
REACTOME PathwaysR-HSA-3315487 SMAD2/3 MH2 Domain Mutants in Cancer [pathway]
REACTOME PathwaysR-HSA-2173788 Downregulation of TGF-beta receptor signaling [pathway]
REACTOME PathwaysR-HSA-3656532 TGFBR1 KD Mutants in Cancer [pathway]
REACTOME PathwaysR-HSA-2173789 TGF-beta receptor signaling activates SMADs [pathway]
REACTOME PathwaysR-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity [pathway]
REACTOME PathwaysR-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [pathway]
REACTOME PathwaysR-HSA-3311021 SMAD4 MH2 Domain Mutants in Cancer [pathway]
REACTOME PathwaysR-HSA-1181150 Signaling by NODAL [pathway]
NDEx NetworkSMAD2
Atlas of Cancer Signalling NetworkSMAD2
Wikipedia pathwaysSMAD2
Orthology - Evolution
OrthoDB4087
GeneTree (enSembl)ENSG00000175387
Phylogenetic Trees/Animal Genes : TreeFamSMAD2
HOVERGENQ15796
HOGENOMQ15796
Homologs : HomoloGeneSMAD2
Homology/Alignments : Family Browser (UCSC)SMAD2
Gene fusions - Rearrangements
Fusion : MitelmanCTIF/SMAD2 [18q21.1/18q21.1]  [t(18;18)(q21;q21)]  
Fusion : MitelmanSMAD2/C10orf90 [18q21.1/10q26.2]  [t(10;18)(q26;q21)]  
Fusion : MitelmanSMAD2/CD226 [18q21.1/18q22.2]  [t(18;18)(q21;q22)]  
Fusion : MitelmanSMAD2/ZBTB7C [18q21.1/18q21.1]  [t(18;18)(q21;q21)]  
Fusion: TCGACTIF 18q21.1 SMAD2 18q21.1 BRCA
Fusion: TCGASMAD2 18q21.1 C10orf90 10q26.2 LUAD
Fusion: TCGASMAD2 18q21.1 CD226 18q22.2 LUSC
Fusion: TCGASMAD2 18q21.1 ZBTB7C 18q21.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerSMAD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)SMAD2
dbVarSMAD2
ClinVarSMAD2
1000_GenomesSMAD2 
Exome Variant ServerSMAD2
ExAC (Exome Aggregation Consortium)SMAD2 (select the gene name)
Genetic variants : HAPMAP4087
Genomic Variants (DGV)SMAD2 [DGVbeta]
DECIPHER (Syndromes)18:45359466-45457517  ENSG00000175387
CONAN: Copy Number AnalysisSMAD2 
Mutations
ICGC Data PortalSMAD2 
TCGA Data PortalSMAD2 
Broad Tumor PortalSMAD2
OASIS PortalSMAD2 [ Somatic mutations - Copy number]
Cancer Gene: CensusSMAD2 
Somatic Mutations in Cancer : COSMICSMAD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDSMAD2
intOGen PortalSMAD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch SMAD2
DgiDB (Drug Gene Interaction Database)SMAD2
DoCM (Curated mutations)SMAD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)SMAD2 (select a term)
intoGenSMAD2
NCG5 (London)SMAD2
Cancer3DSMAD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601366   
Orphanet
MedgenSMAD2
Genetic Testing Registry SMAD2
NextProtQ15796 [Medical]
TSGene4087
GENETestsSMAD2
Huge Navigator SMAD2 [HugePedia]
snp3D : Map Gene to Disease4087
BioCentury BCIQSMAD2
ClinGenSMAD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4087
Chemical/Pharm GKB GenePA134959722
Clinical trialSMAD2
Miscellaneous
canSAR (ICR)SMAD2 (select the gene name)
Other databasehttp://cancergenome.broadinstitute.org/index.php?tgene=SMAD2
Probes
Litterature
PubMed449 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineSMAD2
EVEXSMAD2
GoPubMedSMAD2
iHOPSMAD2
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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