| A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. |
| Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A |
| The EMBO journal. 1995 ; 14 (12) : 2816-2826. |
| PMID 7796808 |
| |
| A new protein containing an SH2 domain that inhibits JAK kinases. |
| Endo TA, Masuhara M, Yokouchi M, Suzuki R, Sakamoto H, Mitsui K, Matsumoto A, Tanimura S, Ohtsubo M, Misawa H, Miyazaki T, Leonor N, Taniguchi T, Fujita T, Kanakura Y, Komiya S, Yoshimura A |
| Nature. 1997 ; 387 (6636) : 921-924. |
| PMID 9202126 |
| |
| SOCS-1/JAB/SSI-1 can bind to and suppress Tec protein-tyrosine kinase. |
| Ohya K, Kajigaya S, Yamashita Y, Miyazato A, Hatake K, Miura Y, Ikeda U, Shimada K, Ozawa K, Mano H |
| The Journal of biological chemistry. 1997 ; 272 (43) : 27178-27182. |
| PMID 9341160 |
| |
| A family of cytokine-inducible inhibitors of signalling. |
| Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ |
| Nature. 1997 ; 387 (6636) : 917-921. |
| PMID 9202125 |
| |
| Twenty proteins containing a C-terminal SOCS box form five structural classes. |
| Hilton DJ, Richardson RT, Alexander WS, Viney EM, Willson TA, Sprigg NS, Starr R, Nicholson SE, Metcalf D, Nicola NA |
| Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (1) : 114-119. |
| PMID 9419338 |
| |
| A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13. |
| Kramer JA, Adams MD, Singh GB, Doggett NA, Krawetz SA |
| Somatic cell and molecular genetics. 1998 ; 24 (2) : 131-133. |
| PMID 9919312 |
| |
| Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1. |
| Starr R, Metcalf D, Elefanty AG, Brysha M, Willson TA, Nicola NA, Hilton DJ, Alexander WS |
| Proceedings of the National Academy of Sciences of the United States of America. 1998 ; 95 (24) : 14395-14399. |
| PMID 9826711 |
| |
| SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine. |
| Alexander WS, Starr R, Fenner JE, Scott CL, Handman E, Sprigg NS, Corbin JE, Cornish AL, Darwiche R, Owczarek CM, Kay TW, Nicola NA, Hertzog PJ, Metcalf D, Hilton DJ |
| Cell. 1999 ; 98 (5) : 597-608. |
| PMID 10490099 |
| |
| SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. |
| Marine JC, Topham DJ, McKay C, Wang D, Parganas E, Stravopodis D, Yoshimura A, Ihle JN |
| Cell. 1999 ; 98 (5) : 609-616. |
| PMID 10490100 |
| |
| Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis. |
| Nagai H, Kim YS, Lee KT, Chu MY, Konishi N, Fujimoto J, Baba M, Matsubara K, Emi M |
| Journal of hepatology. 2001 ; 34 (3) : 416-421. |
| PMID 11322203 |
| |
| SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity. |
| Yoshikawa H, Matsubara K, Qian GS, Jackson P, Groopman JD, Manning JE, Harris CC, Herman JG |
| Nature genetics. 2001 ; 28 (1) : 29-35. |
| PMID 11326271 |
| |
| Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). |
| Metcalf D, Mifsud S, Di Rago L, Nicola NA, Hilton DJ, Alexander WS |
| Proceedings of the National Academy of Sciences of the United States of America. 2002 ; 99 (2) : 943-948. |
| PMID 11782537 |
| |
| TRIM8/GERP RING finger protein interacts with SOCS-1. |
| Toniato E, Chen XP, Losman J, Flati V, Donahue L, Rothman P |
| The Journal of biological chemistry. 2002 ; 277 (40) : 37315-37322. |
| PMID 12163497 |
| |
| Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors. |
| Zardo G, Tiirikainen MI, Hong C, Misra A, Feuerstein BG, Volik S, Collins CC, Lamborn KR, Bollen A, Pinkel D, Albertson DG, Costello JF |
| Nature genetics. 2002 ; 32 (3) : 453-458. |
| PMID 12355068 |
| |
| Persistence of lesions in suppressor of cytokine signaling-1-deficient mice infected with Leishmania major. |
| Bullen DV, Baldwin TM, Curtis JM, Alexander WS, Handman E |
| Journal of immunology (Baltimore, Md. : 1950). 2003 ; 170 (8) : 4267-4272. |
| PMID 12682261 |
| |
| SOCS1 methylation in patients with newly diagnosed acute myeloid leukemia. |
| Chen CY, Tsay W, Tang JL, Shen HL, Lin SW, Huang SY, Yao M, Chen YC, Shen MC, Wang CH, Tien HF |
| Genes, chromosomes & cancer. 2003 ; 37 (3) : 300-305. |
| PMID 12759928 |
| |
| Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. |
| Fukushima N, Sato N, Sahin F, Su GH, Hruban RH, Goggins M |
| British journal of cancer. 2003 ; 89 (2) : 338-343. |
| PMID 12865927 |
| |
| SOCS-1, a negative regulator of cytokine signaling, is frequently silenced by methylation in multiple myeloma. |
| Galm O, Yoshikawa H, Esteller M, Osieka R, Herman JG |
| Blood. 2003 ; 101 (7) : 2784-2788. |
| PMID 12456503 |
| |
| Regulation of cytokine receptor signaling by SOCS1. |
| Ilangumaran S, Rottapel R |
| Immunological reviews. 2003 ; 192 : 196-211. |
| PMID 12670405 |
| |
| Epigenetic alteration of the SOCS1 gene in chronic myeloid leukaemia. |
| Liu TC, Lin SF, Chang JG, Yang MY, Hung SY, Chang CS |
| British journal of haematology. 2003 ; 123 (4) : 654-661. |
| PMID 14616969 |
| |
| Hypermethylation associated with inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human hepatoblastomas. |
| Nagai H, Naka T, Terada Y, Komazaki T, Yabe A, Jin E, Kawanami O, Kishimoto T, Konishi N, Nakamura M, Kobayashi Y, Emi M |
| Journal of human genetics. 2003 ; 48 (2) : 65-69. |
| PMID 12601549 |
| |
| Methylation-mediated silencing of SOCS-1 gene in hepatocellular carcinoma derived from cirrhosis. |
| Okochi O, Hibi K, Sakai M, Inoue S, Takeda S, Kaneko T, Nakao A |
| Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 ; 9 (14) : 5295-5298. |
| PMID 14614012 |
| |
| The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury. |
| Yasukawa H, Yajima T, Duplain H, Iwatate M, Kido M, Hoshijima M, Weitzman MD, Nakamura T, Woodard S, Xiong D, Yoshimura A, Chien KR, Knowlton KU |
| The Journal of clinical investigation. 2003 ; 111 (4) : 469-478. |
| PMID 12588885 |
| |
| Aberrant methylation of SOCS-1 was observed in younger colorectal cancer patients. |
| Fujitake S, Hibi K, Okochi O, Kodera Y, Ito K, Akiyama S, Nakao A |
| Journal of gastroenterology. 2004 ; 39 (2) : 120-124. |
| PMID 15074307 |
| |
| Hypermethylation-associated inactivation of the SOCS-1 gene, a JAK/STAT inhibitor, in human pancreatic cancers. |
| Komazaki T, Nagai H, Emi M, Terada Y, Yabe A, Jin E, Kawanami O, Konishi N, Moriyama Y, Naka T, Kishimoto T |
| Japanese journal of clinical oncology. 2004 ; 34 (4) : 191-194. |
| PMID 15121754 |
| |
| Methylation status of suppressor of cytokine signaling-1 gene in hepatocellular carcinoma. |
| Miyoshi H, Fujie H, Moriya K, Shintani Y, Tsutsumi T, Makuuchi M, Kimura S, Koike K |
| Journal of gastroenterology. 2004 ; 39 (6) : 563-569. |
| PMID 15235874 |
| |
| Epigenetic inactivation of SOCS-1 by CpG island hypermethylation in human gastric carcinoma. |
| Oshimo Y, Kuraoka K, Nakayama H, Kitadai Y, Yoshida K, Chayama K, Yasui W |
| International journal of cancer. Journal international du cancer. 2004 ; 112 (6) : 1003-1009. |
| PMID 15386345 |
| |
| SOCS-1 localizes to the microtubule organizing complex-associated 20S proteasome. |
| Vuong BQ, Arenzana TL, Showalter BM, Losman J, Chen XP, Mostecki J, Banks AS, Limnander A, Fernandez N, Rothman PB |
| Molecular and cellular biology. 2004 ; 24 (20) : 9092-9101. |
| PMID 15456882 |
| |
| SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis. |
| Yoshida T, Ogata H, Kamio M, Joo A, Shiraishi H, Tokunaga Y, Sata M, Nagai H, Yoshimura A |
| The Journal of experimental medicine. 2004 ; 199 (12) : 1701-1707. |
| PMID 15197228 |
| |
| Hypermethylation of the suppressor of cytokine signalling-1 (SOCS-1) in myelodysplastic syndrome. |
| Brakensiek K, Lˆ§nger F, Schlegelberger B, Kreipe H, Lehmann U |
| British journal of haematology. 2005 ; 130 (2) : 209-217. |
| PMID 16029449 |
| |
| Aberrant methylation of the negative regulators RASSFIA, SHP-1 and SOCS-1 in myelodysplastic syndromes and acute myeloid leukaemia. |
| Johan MF, Bowen DT, Frew ME, Goodeve AC, Reilly JT |
| British journal of haematology. 2005 ; 129 (1) : 60-65. |
| PMID 15801956 |
| |
| SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. |
| Evel-Kabler K, Song XT, Aldrich M, Huang XF, Chen SY |
| The Journal of clinical investigation. 2006 ; 116 (1) : 90-100. |
| PMID 16357940 |
| |
| IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice. |
| Hanada T, Kobayashi T, Chinen T, Saeki K, Takaki H, Koga K, Minoda Y, Sanada T, Yoshioka T, Mimata H, Kato S, Yoshimura A |
| The Journal of experimental medicine. 2006 ; 203 (6) : 1391-1397. |
| PMID 16717119 |
| |
| SOCS1 inhibits tumor necrosis factor-induced activation of ASK1-JNK inflammatory signaling by mediating ASK1 degradation. |
| He Y, Zhang W, Zhang R, Zhang H, Min W |
| The Journal of biological chemistry. 2006 ; 281 (9) : 5559-5566. |
| PMID 16407264 |
| |
| Biallelic deletion within 16p13.13 including SOCS-1 in Karpas1106P mediastinal B-cell lymphoma line is associated with delayed degradation of JAK2 protein. |
| Melzner I, Weniger MA, Bucur AJ, Brˆºderlein S, Dorsch K, Hasel C, Leithˆ§user F, Ritz O, Dyer MJ, Barth TF, Mˆller P |
| International journal of cancer. Journal international du cancer. 2006 ; 118 (8) : 1941-1944. |
| PMID 16287070 |
| |
| Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulation. |
| Weniger MA, Melzner I, Menz CK, Wegener S, Bucur AJ, Dorsch K, Mattfeldt T, Barth TF, Mˆller P |
| Oncogene. 2006 ; 25 (18) : 2679-2684. |
| PMID 16532038 |
| |
| Clinical implications of SOCS1 methylation in myelodysplastic syndrome. |
| Wu SJ, Yao M, Chou WC, Tang JL, Chen CY, Ko BS, Huang SY, Tsay W, Chen YC, Shen MC, Wang CH, Yeh YC, Tien HF |
| British journal of haematology. 2006 ; 135 (3) : 317-323. |
| PMID 16978223 |
| |
| The SOCS-1 gene methylation in chronic myeloid leukemia patients. |
| Hatirnaz O, Ure U, Ar C, Akyerli C, Soysal T, FerhanoŸülu B, Ozˆßelik T, Ozbek U |
| American journal of hematology. 2007 ; 82 (8) : 729-730. |
| PMID 17315216 |
| |
