| Identity |
| Other names | TML1 |
| HGNC (Hugo) | TCL1B |
| Location | 14q32.13 |
| Location_base_pair | Starts at 96152763 and ends at 96158966 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| Local_order | centromere - TCL6 (TNG1 and TNG2) - TCL1B - TCL1A - telomere |
| DNA/RNA |
| Description | 6.5 kb TCL1B cDNA. 4 exons (181, 171, 69, 697 bp); centromere - exons 1 to 4 - telomere orientation; only the first three exons are coding. Located 15-16 kb centromeric of TCL1A. |
| Transcription | TCL1B transcripts detected by RT-PCR or Northern blot in fetal tissues (liver, thymus, spleen, and kidney) and in testis, placenta, peripheral blood lymphocytes, kidney, tonsil, spleen, and bone marrow. |
| Pseudogene | Localized to 5q12-5q13, lacks an initiating ATG and introns and has a stop codon in the middle of the ORF. |
| Protein |
| Description | 15 kDa, 128 amino acid protein; one domain with a beta-barrel topology. |
| Expression | Undefined |
| Localisation | Undefined |
| Function | Undefined in vivo but binds and coactivates AKT (protein kinase B) in vitro and in transfected cell lines. |
| Homology | 30% identical to TCL1A, 60% similar to TCL1A 36% identical to MTCP1, 63% similar to MTCP1 |
| Implicated in |
| Entity | Expression in rare mature T cell leukemias carrying t(14;14)(q11;q32.1) causing a TCRalpha/delta-TCL1A/TCL1B translocation. Expression in some Burkitt lymphoma cell lines. |
| Disease | May be upregulated in T-cell prolymphocytic leukemia (T-PLL) with t(14;14)(q11;q32.1) and in Burkitt lymphoma . |
| Oncogenesis | TCL1 over expression by chromosomal rearrangement is a critical oncogenetic mechanism in T-PLL; a role for TCL1B over expression in oncogenesis is not yet shown. |
| External links |
| Bibliography |
| Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes. |
| Pekarsky Y, Hallas C, Isobe M, Russo G, Croce CM |
| Proceedings of the National Academy of Sciences of the United States of America. 1999 ; 96 (6) : 2949-2951. |
| PMID 10077617 |
| Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus. |
| Sugimoto J, Hatakeyama T, Narducci MG, Russo G, Isobe M |
| Cancer research. 1999 ; 59 (10) : 2313-2317. |
| PMID 10344735 |
| The protooncogene TCL1 is an Akt kinase coactivator. |
| Laine J, Kˆºnstle G, Obata T, Sha M, Noguchi M |
| Molecular cell. 2000 ; 6 (2) : 395-407. |
| PMID 10983986 |
| Tcl1 enhances Akt kinase activity and mediates its nuclear translocation. |
| Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, Russo G, Tsichlis P, Croce CM |
| Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3028-3033. |
| PMID 10716693 |
| Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family. |
| Laine J, Kˆºnstle G, Obata T, Noguchi M |
| The Journal of biological chemistry. 2002 ; 277 (5) : 3743-3751. |
| PMID 11707444 |
| The TCL1 family of oncoproteins: co-activators of transformation. |
| Teitell MA |
| Nature reviews. Cancer. 2005 ; 5 (8) : 640-648. |
| PMID 16056259 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 01-2008 | Herbert Eradat, Michael A Teitell |
| Departments of Medicine (H.E.) and Pathology and Laboratory Medicine (M.A.T.), David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4-762 MacDonald Research Laboratories, Los Angeles, CA 90095-1732, USA |
| Citation |
| This paper should be referenced as such : |
| Eradat H, Teitell MA . TCL1B (T-cell leukemia/lymphoma 1B). Atlas Genet Cytogenet Oncol Haematol. January 2008 . URL : http://AtlasGeneticsOncology.org/Genes/TCL1BID354ch14q32.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Jul 15 14:43:05 CEST 2010 |
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