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TCL1B (T-cell leukemia/lymphoma 1B)

Written2008-01Herbert Eradat, Michael A Teitell
Departments of Medicine (H.E.), Pathology, Laboratory Medicine (M.A.T.), David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4-762 MacDonald Research Laboratories, Los Angeles, CA 90095-1732, USA

(Note : for Links provided by Atlas : click)


Alias (NCBI)TML1
HGNC Alias symbTML1
HGNC Previous nameT-cell leukemia/lymphoma 1B
LocusID (NCBI) 9623
Atlas_Id 354
Location 14q32.13  [Link to chromosome band 14q32]
Location_base_pair Starts at 95686426 and ends at 95692628 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TCL1B.png]
Local_order centromere - TCL6 (TNG1 and TNG2) - TCL1B - TCL1A - telomere
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TCL6 (14q32.13) / TCL1B (14q32.13)


Description 6.5 kb TCL1B cDNA. 4 exons (181, 171, 69, 697 bp); centromere - exons 1 to 4 - telomere orientation; only the first three exons are coding. Located 15-16 kb centromeric of TCL1A.
Transcription TCL1B transcripts detected by RT-PCR or Northern blot in fetal tissues (liver, thymus, spleen, and kidney) and in testis, placenta, peripheral blood lymphocytes, kidney, tonsil, spleen, and bone marrow.
Pseudogene Localized to 5q12-5q13, lacks an initiating ATG and introns and has a stop codon in the middle of the ORF.


Description 15 kDa, 128 amino acid protein; one domain with a beta-barrel topology.
Expression Undefined
Localisation Undefined
Function Undefined in vivo but binds and coactivates AKT (protein kinase B) in vitro and in transfected cell lines.
Homology 30% identical to TCL1A, 60% similar to TCL1A
36% identical to MTCP1, 63% similar to MTCP1

Implicated in

Entity Expression in rare mature T cell leukemias carrying t(14;14)(q11;q32.1) causing a TRA/TRD -TCL1A/TCL1B translocation.
Entity Expression in some Burkitt lymphoma cell lines.
Disease May be upregulated in T-cell prolymphocytic leukemia (T-PLL) with t(14;14)(q11;q32.1) and in Burkitt lymphoma .
Oncogenesis TCL1 over expression by chromosomal rearrangement is a critical oncogenetic mechanism in T-PLL; a role for TCL1B over expression in oncogenesis is not yet shown.


Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.
Laine J, Künstle G, Obata T, Noguchi M
The Journal of biological chemistry. 2002 ; 277 (5) : 3743-3751.
PMID 11707444
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.
Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, Russo G, Tsichlis P, Croce CM
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3028-3033.
PMID 10716693
Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus.
Sugimoto J, Hatakeyama T, Narducci MG, Russo G, Isobe M
Cancer research. 1999 ; 59 (10) : 2313-2317.
PMID 10344735
The TCL1 family of oncoproteins: co-activators of transformation.
Teitell MA
Nature reviews. Cancer. 2005 ; 5 (8) : 640-648.
PMID 16056259


This paper should be referenced as such :
Eradat, H ; Teitell, MA
TCL1B (T-cell leukemia/lymphoma 1B)
Atlas Genet Cytogenet Oncol Haematol. 2008;12(5):389-390.
Free journal version : [ pdf ]   [ DOI ]

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(7;14)(q35;q32.1) TRB/TCL1A::inv(14)(q11q32.1) TRA-TRD/TCL1A::t(14;14)(q11;q32.1) TRA-TRD/TCL1A
T-lineage acute lymphoblastic leukemia (T-ALL)

External links

HGNC (Hugo)TCL1B   11649
Entrez_Gene (NCBI)TCL1B    TCL1 family AKT coactivator B
AliasesSYN-1; TML1
GeneCards (Weizmann)TCL1B
Ensembl hg19 (Hinxton)ENSG00000213231 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000213231 [Gene_View]  ENSG00000213231 [Sequence]  chr14:95686426-95692628 [Contig_View]  TCL1B [Vega]
ICGC DataPortalENSG00000213231
TCGA cBioPortalTCL1B
Genatlas (Paris)TCL1B
SOURCE (Princeton)TCL1B
Genetics Home Reference (NIH)TCL1B
Genomic and cartography
GoldenPath hg38 (UCSC)TCL1B  -     chr14:95686426-95692628 +  14q32.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TCL1B  -     14q32.13   [Description]    (hg19-Feb_2009)
GoldenPathTCL1B - 14q32.13 [CytoView hg19]  TCL1B - 14q32.13 [CytoView hg38]
genome Data Viewer NCBITCL1B [Mapview hg19]  
Gene and transcription
Genbank (Entrez)AB018563 AF110466 AF137027 AI250350 BC041616
RefSeq transcript (Entrez)NM_004918 NM_199206
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TCL1B
Alternative Splicing GalleryENSG00000213231
Gene ExpressionTCL1B [ NCBI-GEO ]   TCL1B [ EBI - ARRAY_EXPRESS ]   TCL1B [ SEEK ]   TCL1B [ MEM ]
Gene Expression Viewer (FireBrowse)TCL1B [ Firebrowse - Broad ]
GenevisibleExpression of TCL1B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9623
GTEX Portal (Tissue expression)TCL1B
Human Protein AtlasENSG00000213231-TCL1B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95988   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95988  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95988
Splice isoforms : SwissVarO95988
Domains : Interpro (EBI)TCL1_MTCP1    TCL1_MTCP1_sf   
Domain families : Pfam (Sanger)TCL1_MTCP1 (PF01840)   
Domain families : Pfam (NCBI)pfam01840   
Conserved Domain (NCBI)TCL1B
Blocks (Seattle)TCL1B
Human Protein Atlas [tissue]ENSG00000213231-TCL1B [tissue]
Peptide AtlasO95988
IPIIPI00001504   IPI00385245   
Protein Interaction databases
IntAct (EBI)O95988
Ontologies - Pathways
Ontology : AmiGOprotein kinase binding  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation  protein serine/threonine kinase activator activity  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  
Ontology : EGO-EBIprotein kinase binding  protein-containing complex  positive regulation of peptidyl-serine phosphorylation  positive regulation of peptidyl-serine phosphorylation  protein serine/threonine kinase activator activity  protein serine/threonine kinase activator activity  positive regulation of protein serine/threonine kinase activity  
Pathways : KEGGPI3K-Akt signaling pathway   
NDEx NetworkTCL1B
Atlas of Cancer Signalling NetworkTCL1B
Wikipedia pathwaysTCL1B
Orthology - Evolution
GeneTree (enSembl)ENSG00000213231
Phylogenetic Trees/Animal Genes : TreeFamTCL1B
Homologs : HomoloGeneTCL1B
Homology/Alignments : Family Browser (UCSC)TCL1B
Gene fusions - Rearrangements
Fusion Cancer (Beijing)TCL6 [14q32.13]  -  TCL1B [14q32.13]  [FUSC000261]
Fusion : Fusion_HubRP11-164H13.1--TCL1B    TCL1B--SAFB    TCL6--TCL1B   
Fusion : QuiverTCL1B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTCL1B [hg38]
Exome Variant ServerTCL1B
GNOMAD BrowserENSG00000213231
Varsome BrowserTCL1B
Genomic Variants (DGV)TCL1B [DGVbeta]
DECIPHERTCL1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTCL1B 
ICGC Data PortalTCL1B 
TCGA Data PortalTCL1B 
Broad Tumor PortalTCL1B
OASIS PortalTCL1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCL1B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTCL1B
Mutations and Diseases : HGMDTCL1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCL1B
DgiDB (Drug Gene Interaction Database)TCL1B
DoCM (Curated mutations)TCL1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCL1B (select a term)
NCG6 (London) select TCL1B
Cancer3DTCL1B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry TCL1B
NextProtO95988 [Medical]
Target ValidationTCL1B
Huge Navigator TCL1B [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA36401
Clinical trialTCL1B
canSAR (ICR)TCL1B (select the gene name)
DataMed IndexTCL1B
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 19 18:01:20 CET 2021

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