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TCL1B (T-cell leukemia/lymphoma 1B)

Written2008-01Herbert Eradat, Michael A Teitell
Departments of Medicine (H.E.), Pathology, Laboratory Medicine (M.A.T.), David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4-762 MacDonald Research Laboratories, Los Angeles, CA 90095-1732, USA

(Note : for Links provided by Atlas : click)

Identity

Other namesTML1
HGNC (Hugo) TCL1B
LocusID (NCBI) 9623
Atlas_Id 354
Location 14q32.13  [Link to chromosome band 14q32]
Location_base_pair Starts at 96152754 and ends at 96158980 bp from pter ( according to hg19-Feb_2009)  [Mapping TCL1B.png]
Local_order centromere - TCL6 (TNG1 and TNG2) - TCL1B - TCL1A - telomere
Fusion genes
(updated 2016)
TCL6 (14q32.13) / TCL1B (14q32.13)

DNA/RNA

Description 6.5 kb TCL1B cDNA. 4 exons (181, 171, 69, 697 bp); centromere - exons 1 to 4 - telomere orientation; only the first three exons are coding. Located 15-16 kb centromeric of TCL1A.
Transcription TCL1B transcripts detected by RT-PCR or Northern blot in fetal tissues (liver, thymus, spleen, and kidney) and in testis, placenta, peripheral blood lymphocytes, kidney, tonsil, spleen, and bone marrow.
Pseudogene Localized to 5q12-5q13, lacks an initiating ATG and introns and has a stop codon in the middle of the ORF.

Protein

Description 15 kDa, 128 amino acid protein; one domain with a beta-barrel topology.
Expression Undefined
Localisation Undefined
Function Undefined in vivo but binds and coactivates AKT (protein kinase B) in vitro and in transfected cell lines.
Homology 30% identical to TCL1A, 60% similar to TCL1A
36% identical to MTCP1, 63% similar to MTCP1

Implicated in

Note
Entity Expression in rare mature T cell leukemias carrying t(14;14)(q11;q32.1) causing a TCRalpha/delta-TCL1A/TCL1B translocation.
Expression in some Burkitt lymphoma cell lines.
Disease May be upregulated in T-cell prolymphocytic leukemia (T-PLL) with t(14;14)(q11;q32.1) and in Burkitt lymphoma .
Oncogenesis TCL1 over expression by chromosomal rearrangement is a critical oncogenetic mechanism in T-PLL; a role for TCL1B over expression in oncogenesis is not yet shown.
  

Bibliography

Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.
Laine J, Künstle G, Obata T, Noguchi M
The Journal of biological chemistry. 2002 ; 277 (5) : 3743-3751.
PMID 11707444
 
Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.
Pekarsky Y, Koval A, Hallas C, Bichi R, Tresini M, Malstrom S, Russo G, Tsichlis P, Croce CM
Proceedings of the National Academy of Sciences of the United States of America. 2000 ; 97 (7) : 3028-3033.
PMID 10716693
 
Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus.
Sugimoto J, Hatakeyama T, Narducci MG, Russo G, Isobe M
Cancer research. 1999 ; 59 (10) : 2313-2317.
PMID 10344735
 
The TCL1 family of oncoproteins: co-activators of transformation.
Teitell MA
Nature reviews. Cancer. 2005 ; 5 (8) : 640-648.
PMID 16056259
 

Citation

This paper should be referenced as such :
Eradat, H ; Teitell, MA
TCL1B (T-cell leukemia/lymphoma 1B)
Atlas Genet Cytogenet Oncol Haematol. 2008;12(5):389-390.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/TCL1BID354ch14q32.html


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(7;14)(q35;q32.1) TRB/TCL1A;inv(14)(q11q32.1) TRA-TRD/TCL1A;t(14;14)(q11;q32.1) TRA-TRD/TCL1A
T-lineage acute lymphoblastic leukemia (T-ALL)

External links

Nomenclature
HGNC (Hugo)TCL1B   11649
Cards
AtlasTCL1BID354ch14q32
Entrez_Gene (NCBI)TCL1B  9623  T-cell leukemia/lymphoma 1B
AliasesSYN-1; TML1
GeneCards (Weizmann)TCL1B
Ensembl hg19 (Hinxton)ENSG00000213231 [Gene_View]  chr14:96152754-96158980 [Contig_View]  TCL1B [Vega]
Ensembl hg38 (Hinxton)ENSG00000213231 [Gene_View]  chr14:96152754-96158980 [Contig_View]  TCL1B [Vega]
ICGC DataPortalENSG00000213231
TCGA cBioPortalTCL1B
AceView (NCBI)TCL1B
Genatlas (Paris)TCL1B
WikiGenes9623
SOURCE (Princeton)TCL1B
Genomic and cartography
GoldenPath hg19 (UCSC)TCL1B  -     chr14:96152754-96158980 +  14q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TCL1B  -     14q32.1   [Description]    (hg38-Dec_2013)
EnsemblTCL1B - 14q32.1 [CytoView hg19]  TCL1B - 14q32.1 [CytoView hg38]
Mapping of homologs : NCBITCL1B [Mapview hg19]  TCL1B [Mapview hg38]
OMIM603769   
Gene and transcription
Genbank (Entrez)AB018563 AF110466 AF137027 AI250350 BC041616
RefSeq transcript (Entrez)NM_004918 NM_199206
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)TCL1B
Cluster EST : UnigeneHs.632346 [ NCBI ]
CGAP (NCI)Hs.632346
Alternative Splicing GalleryENSG00000213231
Gene ExpressionTCL1B [ NCBI-GEO ]   TCL1B [ EBI - ARRAY_EXPRESS ]   TCL1B [ SEEK ]   TCL1B [ MEM ]
Gene Expression Viewer (FireBrowse)TCL1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9623
GTEX Portal (Tissue expression)TCL1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95988 (Uniprot)
NextProtO95988  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95988
Splice isoforms : SwissVarO95988 (Swissvar)
PhosPhoSitePlusO95988
Domains : Interpro (EBI)TCL1_MTCP1   
Domain families : Pfam (Sanger)TCL1_MTCP1 (PF01840)   
Domain families : Pfam (NCBI)pfam01840   
Domain structure : Prodom (Prabi Lyon)TCL1_MTCP1 (PD015575)   
DMDM Disease mutations9623
Blocks (Seattle)TCL1B
SuperfamilyO95988
Human Protein AtlasENSG00000213231
Peptide AtlasO95988
HPRD04795
IPIIPI00001504   IPI00385245   
Protein Interaction databases
DIP (DOE-UCLA)O95988
IntAct (EBI)O95988
FunCoupENSG00000213231
BioGRIDTCL1B
STRING (EMBL)TCL1B
ZODIACTCL1B
Ontologies - Pathways
QuickGOO95988
Ontology : AmiGO
Ontology : EGO-EBI
Pathways : KEGGPI3K-Akt signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkTCL1B
Wikipedia pathwaysTCL1B
Orthology - Evolution
OrthoDB9623
GeneTree (enSembl)ENSG00000213231
Phylogenetic Trees/Animal Genes : TreeFamTCL1B
Homologs : HomoloGeneTCL1B
Homology/Alignments : Family Browser (UCSC)TCL1B
Gene fusions - Rearrangements
Fusion Cancer (Beijing)TCL6 [14q32.13]  -  TCL1B [14q32.13]  [FUSC000261]
Polymorphisms : SNP, variants
NCBI Variation ViewerTCL1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TCL1B
dbVarTCL1B
ClinVarTCL1B
1000_GenomesTCL1B 
Exome Variant ServerTCL1B
ExAC (Exome Aggregation Consortium)TCL1B (select the gene name)
Genetic variants : HAPMAP9623
Genomic Variants (DGV)TCL1B [DGVbeta]
Mutations
ICGC Data PortalTCL1B 
TCGA Data PortalTCL1B 
Broad Tumor PortalTCL1B
OASIS PortalTCL1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTCL1B 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TCL1B
DgiDB (Drug Gene Interaction Database)TCL1B
DoCM (Curated mutations)TCL1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TCL1B (select a term)
intoGenTCL1B
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:96152754-96158980  ENSG00000213231
CONAN: Copy Number AnalysisTCL1B 
Mutations and Diseases : HGMDTCL1B
OMIM603769   
MedgenTCL1B
Genetic Testing Registry TCL1B
NextProtO95988 [Medical]
TSGene9623
GENETestsTCL1B
Huge Navigator TCL1B [HugePedia]
snp3D : Map Gene to Disease9623
BioCentury BCIQTCL1B
ClinGenTCL1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9623
Chemical/Pharm GKB GenePA36401
Clinical trialTCL1B
Miscellaneous
canSAR (ICR)TCL1B (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTCL1B
EVEXTCL1B
GoPubMedTCL1B
iHOPTCL1B
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Aug 10 18:45:37 CEST 2016

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