TCL1B (T-cell leukemia/lymphoma 1B)

2008-01-01   Herbert Eradat , Michael A Teitell 

Departments of Medicine (H.E.), Pathology, Laboratory Medicine (M.A.T.), David Geffen School of Medicine at UCLA, 675 Charles Young Drive South, 4-762 MacDonald Research Laboratories, Los Angeles, CA 90095-1732, USA

Identity

HGNC
LOCATION
14q32.13
LOCUSID
ALIAS
SYN-1,TML1
FUSION GENES

DNA/RNA

Description

6.5 kb TCL1B cDNA. 4 exons (181, 171, 69, 697 bp); centromere - exons 1 to 4 - telomere orientation; only the first three exons are coding. Located 15-16 kb centromeric of TCL1A.

Transcription

TCL1B transcripts detected by RT-PCR or Northern blot in fetal tissues (liver, thymus, spleen, and kidney) and in testis, placenta, peripheral blood lymphocytes, kidney, tonsil, spleen, and bone marrow.

Pseudogene

Localized to 5q12-5q13, lacks an initiating ATG and introns and has a stop codon in the middle of the ORF.

Proteins

Description

15 kDa, 128 amino acid protein; one domain with a beta-barrel topology.

Expression

Undefined

Localisation

Undefined

Function

Undefined in vivo but binds and coactivates AKT (protein kinase B) in vitro and in transfected cell lines.

Homology

30% identical to TCL1A, 60% similar to TCL1A
36% identical to MTCP1, 63% similar to MTCP1

Implicated in

Entity name
Expression in rare mature T cell leukemias carrying t(14;14)(q11;q32.1) causing a TRA/TRD -TCL1A/TCL1B translocation.
Entity name
Expression in some Burkitt lymphoma cell lines.
Disease
May be upregulated in T-cell prolymphocytic leukemia (T-PLL) with t(14;14)(q11;q32.1) and in Burkitt lymphoma .
Oncogenesis
TCL1 over expression by chromosomal rearrangement is a critical oncogenetic mechanism in T-PLL; a role for TCL1B over expression in oncogenesis is not yet shown.

Bibliography

Pubmed IDLast YearTitleAuthors
117074442002Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family.Laine J et al
107166932000Tcl1 enhances Akt kinase activity and mediates its nuclear translocation.Pekarsky Y et al
103447351999Identification of the TCL1/MTCP1-like 1 (TML1) gene from the region next to the TCL1 locus.Sugimoto J et al
160562592005The TCL1 family of oncoproteins: co-activators of transformation.Teitell MA et al

Other Information

Locus ID:

NCBI: 9623
MIM: 603769
HGNC: 11649
Ensembl: ENSG00000213231

Variants:

dbSNP: 9623
ClinVar: 9623
TCGA: ENSG00000213231
COSMIC: TCL1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000213231ENST00000340722O95988
ENSG00000213231ENST00000340722A0A024R6P4

Expression (GTEx)

0
1
2
3
4
5
6
7

Pathways

PathwaySourceExternal ID
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
202282242010Subcellular localization of activated AKT in estrogen receptor- and progesterone receptor-expressing breast cancers: potential clinical implications.20
208006032010Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.12

Citation

Herbert Eradat ; Michael A Teitell

TCL1B (T-cell leukemia/lymphoma 1B)

Atlas Genet Cytogenet Oncol Haematol. 2008-01-01

Online version: http://atlasgeneticsoncology.org/gene/354/tcl1b