TFF1

Identity

Other names	pS2
Hugo	TFF1
Location	21q22.3
Local_order	belongs to the TFF cluster

DNA/RNA

Description	5kb gene; 3 exons
Transcription	600bp cDNA; coding sequence: 252 bp

Protein

Description	84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain
Expression	epithelial cells of the stomach surface
Localisation	cytoplasmic
Function	in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma
Homology	TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor)

Implicated in

Disease	overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach)
Prognosis	good prognosis factor, and marker of response to hormonal treatment in breast carcinomas

External links

	Nomenclature
Hugo	TFF1
GDB	TFF1
Entrez_Gene	TFF1  7031  trefoil factor 1
	Cards
Atlas	TFF1ID201
GeneCards	TFF1
Ensembl	TFF1 [Search_View]   ENSG00000160182 [Gene_View]
Genatlas	TFF1
GeneLynx	TFF1
eGenome	TFF1
euGene	7031
	Genomic and cartography
GoldenPath	TFF1  -  21q22.3   chr21:42655462-42659713 -  21q22.3   [Description]    (hg18-Mar_2006)
Ensembl	TFF1 - 21q22.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	TFF1
	Gene and transcription
Genbank	BC032811 [ ENTREZ ]
Genbank	BQ083523 [ ENTREZ ]
Genbank	BU539534 [ ENTREZ ]
Genbank	M12075 [ ENTREZ ]
Genbank	X00474 [ ENTREZ ]
RefSeq	NM_003225 [ SRS ]    NM_003225 [ ENTREZ ]
RefSeq	AC_000064 [ SRS ]    AC_000064 [ ENTREZ ]
RefSeq	AC_000153 [ SRS ]    AC_000153 [ ENTREZ ]
RefSeq	NC_000021 [ SRS ]    NC_000021 [ ENTREZ ]
RefSeq	NT_030188 [ SRS ]    NT_030188 [ ENTREZ ]
RefSeq	NW_001838714 [ SRS ]    NW_001838714 [ ENTREZ ]
RefSeq	NW_927384 [ SRS ]    NW_927384 [ ENTREZ ]
AceView	TFF1 AceView - NCBI
Unigene	Hs.162807 [ SRS ]    Hs.162807 [ NCBI ]     HS162807 [ spliceNest ]
Fast-db	3404 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P04155 [ SRS]    P04155 [ EXPASY ]     P04155 [ INTERPRO ]
Prosite	PS00025 P_TREFOIL [ SRS ]    PS00025 P_TREFOIL [ Expasy ]
Interpro	IPR000519 P_trefoil [ SRS ]    IPR000519 P_trefoil [ EBI ]
CluSTr	P04155
Pfam	PF00088 Trefoil [ SRS ]    PF00088 Trefoil [ Sanger ]    pfam00088 [ NCBI-CDD ]
Smart	SM00018 PD [EMBL]
Blocks	P04155
PDB	TFF1 [ SRS ]    TFF1 [ PdbSum ],   TFF1 [ IMB ]   TFF1 [ RSDB ]
HPRD	00219
	Protein Interaction databases
DIP	P04155
IntAct	P04155
	Polymorphism : SNP, mutations, diseases
OMIM	113710    [ map ]
GENECLINICS	113710
SNP	TFF1 [dbSNP-NCBI]
SNP	NM_003225 [SNP-NCI]
SNP	TFF1 [GeneSNPs - Utah]  TFF1] [HGBASE - SRS]
HAPMAP	TFF1 [HAPMAP]
HGMD	TFF1
	General knowledge
Family Browser	TFF1 [UCSC Family Browser]
SOURCE	NM_003225
SMD	Hs.162807
SAGE	Hs.162807
GO	extracellular region [Amigo]  extracellular region
GO	carbohydrate metabolic process [Amigo]  carbohydrate metabolic process
GO	digestion [Amigo]  digestion
GO	growth factor activity [Amigo]  growth factor activity
PubGene	TFF1
TreeFam	TFF1
CTD	7031 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TFF1 Related clones (RZPD - Berlin)
	PubMed
PubMed	62 Pubmed reference(s) in LocusLink

Bibliography

Prediction of relapse and survival in breast cancer patients by pS2 protein status.

Foekens JA, Rio MC, Seguin P, van Putten WL, Fauque J, Nap M, Klijn JG, Chambon P

Cancer research. 1990 ; 50 (13) : 3832-3837.

PMID 2354435

The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.

Lefebvre O, Wolf C, Kˆ©dinger M, Chenard MP, Tomasetto C, Chambon P, Rio MC

The Journal of cell biology. 1993 ; 122 (1) : 191-198.

PMID 8314841

pS2 and response to adjuvant hormone therapy in primary breast cancer.

Spyratos F, Andrieu C, Hacˆ®ne K, Chambon P, Rio MC

British journal of cancer. 1994 ; 69 (2) : 394-397.

PMID 8297741

Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.

Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC

Science (New York, N.Y.). 1996 ; 274 (5285) : 259-262.

PMID 8824193

The pS2/TFF1 trefoil factor, from basic research to clinical applications.

Ribieras S, Tomasetto C, Rio MC

Biochimica et biophysica acta. 1998 ; 1378 (1) : F61-F77.

PMID 9739760

pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.

Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, Rio MC

Gastroenterology. 2000 ; 118 (1) : 70-80.

PMID 10611155

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	08-2000	Catherine Tomasetto, Marie-Christine Rio
		I.G.B.M.C., BP163, 1 rue Laurent Fries, 67404 ILLKIRCH, France

Citation

This paper should be referenced as such :

Tomasetto C and Rio MC . TFF1. Atlas Genet Cytogenet Oncol Haematol. August 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TFF1ID201.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Jul 14 17:51:04 2008