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TFF1 (trefoil factor 1)

Written2000-08Catherine Tomasetto, Marie-Christine Rio
I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France

(Note : for Links provided by Atlas : click)


Alias (NCBI)pS2
HGNC (Hugo) TFF1
HGNC Alias symbD21S21
HGNC Previous nameBCEI
HGNC Previous name"breast cancer, estrogen-inducible sequence expressed in"
LocusID (NCBI) 7031
Atlas_Id 201
Location 21q22.3  [Link to chromosome band 21q22]
Location_base_pair Starts at 42362282 and ends at 42366535 bp from pter ( according to GRCh38/hg38-Dec_2013)  [Mapping TFF1.png]
Local_order belongs to the TFF cluster
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
C2CD2 (21q22.3) / TFF1 (21q22.3)TFF1 (21q22.3) / RABEP1 (17p13.2)TFF1 (21q22.3) / RALB (2q14.2)


Description 5kb gene; 3 exons
Transcription 600bp cDNA; coding sequence: 252 bp


Description 84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain
Expression epithelial cells of the stomach surface
Localisation cytoplasmic
Function in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma
Homology TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor)

Implicated in

Disease overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach)
Prognosis good prognosis factor, and marker of response to hormonal treatment in breast carcinomas


Prediction of relapse and survival in breast cancer patients by pS2 protein status.
Foekens JA, Rio MC, Seguin P, van Putten WL, Fauque J, Nap M, Klijn JG, Chambon P
Cancer research. 1990 ; 50 (13) : 3832-3837.
PMID 2354435
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.
Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC
Science (New York, N.Y.). 1996 ; 274 (5285) : 259-262.
PMID 8824193
The pS2/TFF1 trefoil factor, from basic research to clinical applications.
Ribieras S, Tomasetto C, Rio MC
Biochimica et biophysica acta. 1998 ; 1378 (1) : F61-F77.
PMID 9739760
pS2 and response to adjuvant hormone therapy in primary breast cancer.
Spyratos F, Andrieu C, Hacène K, Chambon P, Rio MC
British journal of cancer. 1994 ; 69 (2) : 394-397.
PMID 8297741
pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.
Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, Rio MC
Gastroenterology. 2000 ; 118 (1) : 70-80.
PMID 10611155


This paper should be referenced as such :
Tomasetto, C ; Rio, MC
TFF1 (TreFoil Factor 1)
Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):185-185.
Free journal version : [ pdf ]   [ DOI ]

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(17;21)(p13;q22) TFF1/RABEP1
C2CD2/TFF1 (21q22)

External links

HGNC (Hugo)TFF1   11755
Entrez_Gene (NCBI)TFF1    trefoil factor 1
AliasesBCEI; D21S21; HP1.A; HPS2; 
pNR-2; pS2
GeneCards (Weizmann)TFF1
Ensembl hg19 (Hinxton)ENSG00000160182 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000160182 [Gene_View]  ENSG00000160182 [Sequence]  chr21:42362282-42366535 [Contig_View]  TFF1 [Vega]
ICGC DataPortalENSG00000160182
TCGA cBioPortalTFF1
AceView (NCBI)TFF1
Genatlas (Paris)TFF1
SOURCE (Princeton)TFF1
Genetics Home Reference (NIH)TFF1
Genomic and cartography
GoldenPath hg38 (UCSC)TFF1  -     chr21:42362282-42366535 -  21q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TFF1  -     21q22.3   [Description]    (hg19-Feb_2009)
GoldenPathTFF1 - 21q22.3 [CytoView hg19]  TFF1 - 21q22.3 [CytoView hg38]
genome Data Viewer NCBITFF1 [Mapview hg19]  
Gene and transcription
Genbank (Entrez)BC032811 BQ083523 BU539534 M12075 X00474
RefSeq transcript (Entrez)NM_003225
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TFF1
Alternative Splicing GalleryENSG00000160182
Gene ExpressionTFF1 [ NCBI-GEO ]   TFF1 [ EBI - ARRAY_EXPRESS ]   TFF1 [ SEEK ]   TFF1 [ MEM ]
Gene Expression Viewer (FireBrowse)TFF1 [ Firebrowse - Broad ]
GenevisibleExpression of TFF1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7031
GTEX Portal (Tissue expression)TFF1
Human Protein AtlasENSG00000160182-TFF1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04155   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP04155  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP04155
Splice isoforms : SwissVarP04155
Domaine pattern : Prosite (Expaxy)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domains : Interpro (EBI)P_trefoil_chordata    P_trefoil_CS    P_trefoil_dom   
Domain families : Pfam (Sanger)Trefoil (PF00088)   
Domain families : Pfam (NCBI)pfam00088   
Domain families : Smart (EMBL)PD (SM00018)  
Conserved Domain (NCBI)TFF1
Blocks (Seattle)TFF1
PDB (RSDB)1HI7    1PS2    6V1D   
PDB Europe1HI7    1PS2    6V1D   
PDB (PDBSum)1HI7    1PS2    6V1D   
PDB (IMB)1HI7    1PS2    6V1D   
Structural Biology KnowledgeBase1HI7    1PS2    6V1D   
SCOP (Structural Classification of Proteins)1HI7    1PS2    6V1D   
CATH (Classification of proteins structures)1HI7    1PS2    6V1D   
Human Protein Atlas [tissue]ENSG00000160182-TFF1 [tissue]
Peptide AtlasP04155
Protein Interaction databases
IntAct (EBI)P04155
Ontologies - Pathways
Ontology : AmiGOprotein binding  extracellular region  extracellular space  carbohydrate metabolic process  signal transduction  growth factor activity  negative regulation of cell proliferation  response to iron ion  cell differentiation  maintenance of gastrointestinal epithelium  response to immobilization stress  response to peptide hormone  
Ontology : EGO-EBIprotein binding  extracellular region  extracellular space  carbohydrate metabolic process  signal transduction  growth factor activity  negative regulation of cell proliferation  response to iron ion  cell differentiation  maintenance of gastrointestinal epithelium  response to immobilization stress  response to peptide hormone  
REACTOMEP04155 [protein]
REACTOME PathwaysR-HSA-9018519 [pathway]   
NDEx NetworkTFF1
Atlas of Cancer Signalling NetworkTFF1
Wikipedia pathwaysTFF1
Orthology - Evolution
GeneTree (enSembl)ENSG00000160182
Phylogenetic Trees/Animal Genes : TreeFamTFF1
Homologs : HomoloGeneTFF1
Homology/Alignments : Family Browser (UCSC)TFF1
Gene fusions - Rearrangements
Fusion : MitelmanTFF1/RABEP1 [21q22.3/17p13.2]  
Fusion PortalTFF1 21q22.3 RABEP1 17p13.2 LUAD
Fusion : Fusion_HubAC096579.13--TFF1    C2CD2--TFF1    IGK@--TFF1    IGKC--TFF1    IGKV1-8--TFF1    IGKV3-11--TFF1    LYZ--TFF1    RP11-1143G9.4--TFF1    TFF1--DDX21    TFF1--RABEP1    TFF1--RALB    TFF1--TFF2    TMPRSS3--TFF1    ZNF295--TFF1   
Fusion : QuiverTFF1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTFF1 [hg38]
Exome Variant ServerTFF1
GNOMAD BrowserENSG00000160182
Varsome BrowserTFF1
Genomic Variants (DGV)TFF1 [DGVbeta]
DECIPHERTFF1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTFF1 
ICGC Data PortalTFF1 
TCGA Data PortalTFF1 
Broad Tumor PortalTFF1
OASIS PortalTFF1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTFF1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTFF1
Mutations and Diseases : HGMDTFF1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TFF1
DgiDB (Drug Gene Interaction Database)TFF1
DoCM (Curated mutations)TFF1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TFF1 (select a term)
NCG6 (London) select TFF1
Cancer3DTFF1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry TFF1
NextProtP04155 [Medical]
Target ValidationTFF1
Huge Navigator TFF1 [HugePedia]
Clinical trials, drugs, therapy
Protein Interactions : CTD
Pharm GKB GenePA36470
Clinical trialTFF1
canSAR (ICR)TFF1 (select the gene name)
DataMed IndexTFF1
PubMed170 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Feb 19 18:01:30 CET 2021

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