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TFF1 trefoil factor 1

Identity

Other namespS2
HGNC (Hugo) TFF1
Location 21q22.3
Location_base_pair Starts at 42655460 and ends at 42659713 bp from pter ( according to hg18-Mar_2006)  [Mapping]
Local_order belongs to the TFF cluster

DNA/RNA

Description 5kb gene; 3 exons
Transcription 600bp cDNA; coding sequence: 252 bp

Protein

Description 84 amino acids, containing a peptide signal; the 60 AA-long mature secreted peptide contains one TFF (TreFoil Factor) domain and one acidic C-terminal domain
Expression epithelial cells of the stomach surface
Localisation cytoplasmic
Function in the maintenance of mucosa integrity; unknown at the molecular level; deficient mice develop antro-pyloric adenoma
Homology TFF2/SP (spasmolytic peptide) and TFF3/ITF (intestinal trefoil factor)

Implicated in

Disease overexpressed in estradiol-dependent breast carcinomas; overexpressed in carcinoma of several other organs; loss of expression in half of gastric carcinomas (TFF1 is normally expressed in the stomach)
Prognosis good prognosis factor, and marker of response to hormonal treatment in breast carcinomas
  

External links

Nomenclature
HGNC (Hugo)TFF1   11755
Entrez_Gene (NCBI)TFF1  7031  trefoil factor 1
Cards
AtlasTFF1ID201
GeneCards (Weizmann)TFF1
Ensembl (Hinxton)ENSG00000160182 [Gene_View]  TFF1 [Vega]
AceView (NCBI)TFF1
Genatlas (Paris)TFF1
euGene (Indiana)7031
SOURCE (Stanford)NM_003225
Gene Expression (Array Express) ENSG00000160182
Genomic and cartography
GoldenPath (UCSC)TFF1  -  21q22.3   chr21:42655460-42659713 -  21q22.3   [Description]    (hg18-Mar_2006)
EnsemblTFF1 - 21q22.3 [CytoView]
Mapping of homologs : NCBITFF1 [Mapview]
OMIM113710   
Gene and transcription
Gene : Genbank (Entrez)BC032811 BQ083523 BU539534 M12075 X00474
Reference sequence (RefSeq transcript) :SRSNM_003225
Reference transcript : EntrezNM_003225
RefSeq genomic : SRSAC_000064 AC_000153 NC_000021 NT_011515 NW_001838714 NW_927384
RefSeq genomic : EntrezAC_000064 AC_000153 NC_000021 NT_011515 NW_001838714 NW_927384
Consensus coding sequences : CCDS NCBITFF1
Cluster EST : UnigeneHs.162807 [ SRS ] Hs.162807 [ NCBI ]
Alternative Splicing : Fast-db (Paris)3404
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtP04155 (SRS) P04155 (Expasy) P04155 (Uniprot)
With graphics : InterProP04155
Splice isoforms : VarSplice FASTAP04155(VarSplice FASTA)
Domaine pattern : Prosite (SRS)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domain pattern : Prosite (Expaxy)P_TREFOIL_1 (PS00025)    P_TREFOIL_2 (PS51448)   
Domains : Interpro (SRS)P_trefoil    P_trefoil_chordata    P_trefoil_CS   
Domains : Interpro (EBI)P_trefoil    P_trefoil_chordata    P_trefoil_CS   
Related proteins : CluSTrP04155
Domain families : Pfam SRSTrefoil (PF00088)   
Domain families : Pfam SangerTrefoil (PF00088)   
Domain families : Pfam NCBIpfam00088   
Domain families : Smart EMBLPD (SM00018)  
Blocks (Seattle)P04155
Crystal structure of protein : PDB SRS1HI7    1PS2   
Crystal structure of protein : PDBSum1HI7    1PS2   
Crystal structure of protein : IMB1HI7    1PS2   
Crystal structure of protein : PDB RSDB1HI7    1PS2   
HPRD00219
Protein Interaction databases
DIP (DOE-UCLA)P04155
IntAct (EBI)P04155
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITFF1
SNP : GeneSNP UtahTFF1
SNP : HGBaseTFF1
Genetic variants : HAPMAPTFF1
Somatic Mutations in Cancer : COSMICTFF1 
Mutations and Diseases : HGMDTFF1
Hereditary diseases : OMIM113710   
Hereditary diseases : GENETests113710   
Diseases : Genetic AssociationTFF1
General knowledge
Homologs : HomoloGeneTFF1
Homology/Alignments : Family Browser UCSCTFF1
Phylogenetic Trees/Animal Genes : TreeFamTFF1
Chemical/Protein Interactions : CTD7031
Keywords Ontology : AmiGOextracellular region  extracellular space  carbohydrate metabolic process  response to stress  digestion  growth factor activity  response to iron ion  maintenance of gastrointestinal epithelium  response to estradiol stimulus  response to peptide hormone stimulus  
Keywords Ontology : EGO-EBIextracellular region  extracellular space  carbohydrate metabolic process  response to stress  digestion  growth factor activity  response to iron ion  maintenance of gastrointestinal epithelium  response to estradiol stimulus  response to peptide hormone stimulus  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
Probes : ImagenesTFF1 Related clones (RZPD - Berlin)
Literature
PubMed81 Pubmed reference(s) in Entrez
PubGeneTFF1

Bibliography

Prediction of relapse and survival in breast cancer patients by pS2 protein status.
Foekens JA, Rio MC, Seguin P, van Putten WL, Fauque J, Nap M, Klijn JG, Chambon P
Cancer research. 1990 ; 50 (13) : 3832-3837.
PMID 2354435
 
The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression.
Lefebvre O, Wolf C, Kˆ©dinger M, Chenard MP, Tomasetto C, Chambon P, Rio MC
The Journal of cell biology. 1993 ; 122 (1) : 191-198.
PMID 8314841
 
pS2 and response to adjuvant hormone therapy in primary breast cancer.
Spyratos F, Andrieu C, Hacˆ®ne K, Chambon P, Rio MC
British journal of cancer. 1994 ; 69 (2) : 394-397.
PMID 8297741
 
Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein.
Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, Wendling C, Tomasetto C, Chambon P, Rio MC
Science (New York, N.Y.). 1996 ; 274 (5285) : 259-262.
PMID 8824193
 
The pS2/TFF1 trefoil factor, from basic research to clinical applications.
Ribieras S, Tomasetto C, Rio MC
Biochimica et biophysica acta. 1998 ; 1378 (1) : F61-F77.
PMID 9739760
 
pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins.
Tomasetto C, Masson R, Linares JL, Wendling C, Lefebvre O, Chenard MP, Rio MC
Gastroenterology. 2000 ; 118 (1) : 70-80.
PMID 10611155
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written08-2000Catherine Tomasetto, Marie-Christine Rio
I.G.B.M.C., BP163, 1 rue Laurent Fries, 67404 ILLKIRCH, France

Citation

This paper should be referenced as such :
Tomasetto C and Rio MC . TFF1 trefoil factor 1. Atlas Genet Cytogenet Oncol Haematol. August 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/TFF1ID201.html

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indexed on : Sat Feb 27 10:50:26 CET 2010

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