TFF2 (TreFoil Factor 2)
2000-12-01 Catherine Tomasetto AffiliationI.G.B.M.C., BP 163, 1 rue Laurent Fries, 67404 Illkirch, France
DNA/RNA
Description
5.1 kb gene, 4 exons
Transcription
600 bp
Proteins
Description
precursor: 129 amino acids; mature peptide: 106 amino acids; 3-dimentional structure was solved; the129 amino acids TFF2 protein contains a signal peptide; the mature secreted peptide of 106 amino acids contains two TFF (TreFoil Factor) domains and one acidic C-terminal domain
Expression
under normal condition, TFF2 is expressed in mucus neck cells of the fundus, basal cells of the antral and pyloric glands and by the Brunners glands of the duodenum
Localisation
secreted in gastric fluid
Function
in repair and epithelial restitution of the gastro-intestinal mucosa
Implicated in
Entity name
TFF2 was found implicated in inflamatory bowel diseases, cancers of gastrointestinal organs such as stomach and pancreas; in constrast to TFF1 and TFF3, TFF2 expression was not found in breast carcinomas
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 8566596 | 1996 | Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats. | Babyatsky MW et al |
| 8081739 | 1993 | Pancreatic spasmolytic polypeptide: first three-dimensional structure of a member of the mammalian trefoil family of peptides. | Gajhede M et al |
| 8314841 | 1993 | The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. | Lefebvre O et al |
| 7806031 | 1995 | Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration. | Playford RJ et al |
| 3041593 | 1988 | Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. | Rio MC et al |
| 1985035 | 1991 | Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract. | Rio MC et al |
| 9070946 | 1997 | The three human trefoil genes TFF1, TFF2, and TFF3 are located within a region of 55 kb on chromosome 21q22.3. | Seib T et al |
| 1829922 | 1991 | Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma. | Theisinger B et al |
| 2737304 | 1989 | A new family of growth factor-like peptides. 'Trefoil' disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins). | Thim L et al |
| 2857575 | 1985 | The amino acid sequence of pancreatic spasmolytic polypeptide. | Thim L et al |
| 2303034 | 1990 | hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. | Tomasetto C et al |
| 1735955 | 1992 | Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma. | Welter C et al |
| 8419234 | 1993 | Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease. | Wright NA et al |
Other Information
Locus ID:
NCBI: 7032
MIM: 182590
HGNC: 11756
Ensembl: ENSG00000160181
Variants:
dbSNP: 7032
ClinVar: 7032
TCGA: ENSG00000160181
COSMIC: TFF2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160181 | ENST00000291526 | Q03403 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32897966 | 2021 | Trefoil Factor 2 (TFF2) as a Surrogate Marker for Endocervical Gastric-type Carcinoma. | 4 |
| 33515301 | 2021 | Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients. | 9 |
| 34242119 | 2021 | Circulating trefoil factors in relation to lung cancer, age and lung function: a cross-sectional study in patients referred for suspected lung cancer. | 0 |
| 34662329 | 2021 | Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. | 1 |
| 34944474 | 2021 | Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2 (TFF2) as an Illustration: Metabolic Implications and Potential Applications. | 5 |
| 32897966 | 2021 | Trefoil Factor 2 (TFF2) as a Surrogate Marker for Endocervical Gastric-type Carcinoma. | 4 |
| 33515301 | 2021 | Pyloric, pseudopyloric, and spasmolytic polypeptide-expressing metaplasias in autoimmune gastritis: a case series of 22 Japanese patients. | 9 |
| 34242119 | 2021 | Circulating trefoil factors in relation to lung cancer, age and lung function: a cross-sectional study in patients referred for suspected lung cancer. | 0 |
| 34662329 | 2021 | Parasitic helminth infections in humans modulate Trefoil Factor levels in a manner dependent on the species of parasite and age of the host. | 1 |
| 34944474 | 2021 | Diet Impact on Obesity beyond Calories and Trefoil Factor Family 2 (TFF2) as an Illustration: Metabolic Implications and Potential Applications. | 5 |
| 30877236 | 2020 | Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands. | 2 |
| 32122390 | 2020 | MUC1 is associated with TFF2 methylation in gastric cancer. | 9 |
| 30877236 | 2020 | Evidence for heightened genetic instability in precancerous spasmolytic polypeptide expressing gastric glands. | 2 |
| 32122390 | 2020 | MUC1 is associated with TFF2 methylation in gastric cancer. | 9 |
| 30324235 | 2019 | Trefoil factor family 2 protein: a potential immunohistochemical marker for aiding diagnosis of lobular endocervical glandular hyperplasia and gastric-type adenocarcinoma of the uterine cervix. | 7 |
Citation
Catherine Tomasetto
TFF2 (TreFoil Factor 2)
Atlas Genet Cytogenet Oncol Haematol. 2000-12-01
Online version: http://atlasgeneticsoncology.org/gene/264/tff2-(trefoil-factor-2)
