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| | TGFBI contains a secretory signal peptide (SP) at the N-terminus, followed by a cysteine-rich domain (CRD), four internal homologous domains (FAS), and a C-terminal RGD motif. |
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| Description | TGFBI is a 683 amino acid extracellular matrix protein, 68 kDa. Contains an N-terminal secretory signal peptide, a cysteine-rich domain, four internal homologous repeats (fasciclin-like FAS domains), and a C-terminal RGD motif. |
| Expression | TGFBI is normally found in thymus, bone marrow, spleen, brain, heart, skeleton muscle, lung, kidney, liver, pancreas, and prostate. |
| Localisation | TGFBI is an extracellular matrix protein. It localizes in the extracellular matrix. |
| Function | Binds to type I, II, IV, VI collagens and fibronectin. The RGD motif may serve as a ligand recognition sequence for integrins. The protein may be involved in cell-matrix interactions, cell adhesion, migration and differentiation. The protein may be involved in endochondrial bone formation in cartilage. The roles of TGFBI in malignant progression are controversial. Some studies suggested that TGFBI suppresses the progression of ovarian, lung cancer and neuroblastomas, while other reports identify TGFBI as an overexpressed gene in colon, pancreatic, and liver cancer. |
| Homology | TGFBI contains four FAS1 domains. Proteins cantaining the FAS domain include Arabidopsis fasciclin-like arabinogalactan proteins, bacterial immunogenic protein MPT70, human extracellular matrix protein periostin, and mammalian stabilin proteins. |
| The extracellular matrix protein TGFBI induces microtubule stabilization and sensitizes ovarian cancers to paclitaxel. |
| Ahmed AA, Mills AD, Ibrahim AE, Temple J, Blenkiron C, Vias M, Massie CE, Iyer NG, McGeoch A, Crawford R, Nicke B, Downward J, Swanton C, Bell SD, Earl HM, Laskey RA, Caldas C, Brenton JD. |
| Cancer Cell. 2007 Dec;12(6):514-27. |
| PMID 18068629 |
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| Keratoepithelin suppresses the progression of experimental human neuroblastomas. |
| Becker J, Erdlenbruch B, Noskova I, Schramm A, Aumailley M, Schorderet DF, Schweigerer L. |
| Cancer Res. 2006 May 15;66(10):5314-21. |
| PMID 16707457 |
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| The transforming growth factor-beta-inducible matrix protein (beta)ig-h3 interacts with fibronectin. |
| Billings PC, Whitbeck JC, Adams CS, Abrams WR, Cohen AJ, Engelsberg BN, Howard PS, Rosenbloom J. |
| J Biol Chem. 2002 Aug 2;277(31):28003-9. Epub 2002 May 28. |
| PMID 12034705 |
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| Expression patterns of betaig-h3 in chondrocyte differentiation during endochondral ossification. |
| Han MS, Kim JE, Shin HI, Kim IS. |
| Exp Mol Med. 2008 Aug 31;40(4):453-60. |
| PMID 18779658 |
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| Characterization of a cartilage-derived 66-kDa protein (RGD-CAP/beta ig-h3) that binds to collagen. |
| Hashimoto K, Noshiro M, Ohno S, Kawamoto T, Satakeda H, Akagawa Y, Nakashima K, Okimura A, Ishida H, Okamoto T, Pan H, Shen M, Yan W, Kato Y. |
| Biochim Biophys Acta. 1997 Mar 1;1355(3):303-14. |
| PMID 9061001 |
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| TGFbeta-induced protein mediates lymphatic endothelial cell adhesion to the extracellular matrix under low oxygen conditions. |
| Irigoyen M, Anso E, Salvo E, de las Herrerias JD, Martinez-Irujo JJ, Rouzaut A. |
| Cell Mol Life Sci. 2008 Jul;65(14):2244-55. |
| PMID 18560760 |
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| TGFBI gene mutations in corneal dystrophies. |
| Kannabiran C, Klintworth GK. |
| Hum Mutat. 2006 Jul;27(7):615-25. Review |
| PMID 16683255 |
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| Transforming growth factor-beta-induced gene product, as a novel ligand of integrin alphaMbeta2, promotes monocytes adhesion, migration and chemotaxis. |
| Kim HJ, Kim IS. |
| Int J Biochem Cell Biol. 2008;40(5):991-1004. Epub 2007 Nov 13. |
| PMID 18083624 |
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| Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. |
| Ma C, Rong Y, Radiloff DR, Datto MB, Centeno B, Bao S, Cheng AW, Lin F, Jiang S, Yeatman TJ, Wang XF. |
| Genes Dev. 2008 Feb 1;22(3):308-21. |
| PMID 18245446 |
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| Beta ig-h3 interacts directly with biglycan and decorin, promotes collagen VI aggregation, and participates in ternary complexing with these macromolecules. |
| Reinboth B, Thomas J, Hanssen E, Gibson MA. |
| J Biol Chem. 2006 Mar 24;281(12):7816-24. Epub 2006 Jan 24. |
| PMID 16434404 |
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| Induction and expression of betaig-h3 in pancreatic cancer cells. |
| Schneider D, Kleeff J, Berberat PO, Zhu Z, Korc M, Friess H, Buchler MW. |
| Biochim Biophys Acta. 2002 Oct 9;1588(1):1-6. |
| PMID 12379307 |
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| cDNA cloning and sequence analysis of beta ig-h3, a novel gene induced in a human adenocarcinoma cell line after treatment with transforming growth factor-beta. |
| Skonier J, Neubauer M, Madisen L, Bennett K, Plowman GD, Purchio AF. |
| DNA Cell Biol. 1992 Sep;11(7):511-22. |
| PMID 1388724 |
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| Loss of Betaig-h3 protein is frequent in primary lung carcinoma and related to tumorigenic phenotype in lung cancer cells. |
| Zhao Y, El-Gabry M, Hei TK. |
| Mol Carcinog. 2006 Feb;45(2):84-92. |
| PMID 16329146 |
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