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| | TMPRSS4 is a 437 amino acid single-pass type II membrane protein. It contains a Serine protease domain at the C-terminus, followed by a Scavenger receptor cysteine-rich domain (SRDR) and a Low Density Lipoprotein Receptor Class A domain. Letters H, D and S in the serine protease domain indicate the position of the three catalytic residues histidine, aspartate and serine, respectively. |
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| Description | TMPRSS4 is a 437 amino acid type II transmembrane serine protease (TTSPs) which are expressed at the cell surface and are thus ideally located to regulate cell-cell and cell-matrix interactions. |
| Expression | TMPRSS4 is highly expressed in pancreatic, colon, lung and gastric cancer tissues, and TMPRSS4 is also broadly expressed in a variety of human cancer cell lines, such as NCI-H322, Colo205 and HCT15. |
| Localisation | Membrane; Single-pass type II membrane protein. |
| Function | TMPRSS4 plays a role in invasion, metastasis, migration and adhesion, as well as in the EMT in cancer cells. Loss of E-cadherin transcript, a hallmark of EMT, was induced by TMPRSS4. It also modulates cell growth in a cell type-dependent manner. TMPRSS4 expression is upregulated in lung cancer tissues compared with normal tissues, and various cancer cell lines themselves express TMPRSS4 at various levels. |
| Homology | TMPRSS4 is a type II transmembrane serine protease (TTSPs) which contains a Serine protease domain. Human TTSPs, which consists of 17 members, were grouped into four subfamilies based on similarity in domain structure and phylogenetic analysis of the serine protease domains, namely the matriptase, corin, hepsin/TMPRSS and HAT/DESC subfamilies. |
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| Proteolytic activation of the 1918 influenza virus hemagglutinin. |
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| PMID 19158246 |
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| Role of TMPRSS4 during cancer progression. |
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| PMID 19034347 |
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| Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications. |
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| TMPRSS4 promotes invasion, migration and metastasis of human tumor cells by facilitating an epithelial-mesenchymal transition. |
| Jung H, Lee KP, Park SJ, Park JH, Jang YS, Choi SY, Jung JG, Jo K, Park DY, Yoon JH, Park JH, Lim DS, Hong GR, Choi C, Park YK, Lee JW, Hong HJ, Kim S, Park YW. |
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| IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. |
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| Biochem Biophys Res Commun. 2008 May 2;369(2):554-60. Epub 2008 Feb 21. |
| PMID 18294957 |
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| A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer. |
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| PMID 10825129 |
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| Effect of splice-site polymorphisms of the TMPRSS4, NPHP4 and ORCTL4 genes on their mRNA expression. |
| Yamada H, Shinmura K, Tsuneyoshi T, Sugimura H. |
| J Genet. 2005 Aug;84(2):131-6. |
| PMID 16131712 |
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