ZEB2 (zinc finger E-box binding homeobox 2)

2007-02-01  

Identity

HGNC
ZEB2
LOCATION
2q22.3
LOCUSID
9839
ALIAS
HSPC082,SIP-1,SIP1,SMADIP1,ZFHX1B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9839
MIM: 605802
HGNC: 14881
Ensembl: ENSG00000169554

Variants:

dbSNP: 9839
ClinVar: 9839
TCGA: ENSG00000169554
COSMIC: ZEB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169554ENST00000303660A0JP08
ENSG00000169554ENST00000392861E7ESP8
ENSG00000169554ENST00000409211E7EVG9
ENSG00000169554ENST00000409487O60315
ENSG00000169554ENST00000419938H7C0G0
ENSG00000169554ENST00000427902E7EUW9
ENSG00000169554ENST00000431672U3KPV5
ENSG00000169554ENST00000434448A0A0D9SG93
ENSG00000169554ENST00000435831C9JU62
ENSG00000169554ENST00000440875U3KQ51
ENSG00000169554ENST00000444559C9JUQ1
ENSG00000169554ENST00000462355U3KQ33
ENSG00000169554ENST00000465070U3KQ33
ENSG00000169554ENST00000465308A0A0D9SGG5
ENSG00000169554ENST00000470879U3KPX6
ENSG00000169554ENST00000484313A0A0D9SF71
ENSG00000169554ENST00000539609O60315
ENSG00000169554ENST00000558170O60315
ENSG00000169554ENST00000627532O60315
ENSG00000169554ENST00000629520U3KQ33
ENSG00000169554ENST00000630572A0A0D9SF74
ENSG00000169554ENST00000636026A0A1B0GW50
ENSG00000169554ENST00000636413A0A1B0GVV8
ENSG00000169554ENST00000636445A0A1B0GWA7
ENSG00000169554ENST00000636471A0A1B0GV02
ENSG00000169554ENST00000636732A0A1B0GUM8
ENSG00000169554ENST00000637045A0A1B0GVV8
ENSG00000169554ENST00000637267A0A1X7SC99
ENSG00000169554ENST00000637304A0A1B0GVV8
ENSG00000169554ENST00000637873A0A1B0GTH3
ENSG00000169554ENST00000638007A0A1B0GVV8
ENSG00000169554ENST00000638087A0A1B0GVV8
ENSG00000169554ENST00000638128A0A1B0GWI0
ENSG00000169554ENST00000639389A0A1W2PS25
ENSG00000169554ENST00000647488A0A2R8YDQ8

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382715122024The transcription factor ZEB2 drives the formation of age-associated B cells.8
382734252024Entero-toxigenic Bacteroides fragilis contributes to intestinal barrier injury and colorectal cancer progression by mediating the BFT/STAT3/ZEB2 pathway.0
383300972024Zeb2 drives the formation of CD11c(+) atypical B cells to sustain germinal centers that control persistent infection.2
383301412024Age-associated CD4(+) T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity.0
384850332024ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway.1
385258132024ABCs begin with ZEB2.0
386100092024Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT.0
382715122024The transcription factor ZEB2 drives the formation of age-associated B cells.8
382734252024Entero-toxigenic Bacteroides fragilis contributes to intestinal barrier injury and colorectal cancer progression by mediating the BFT/STAT3/ZEB2 pathway.0
383300972024Zeb2 drives the formation of CD11c(+) atypical B cells to sustain germinal centers that control persistent infection.2
383301412024Age-associated CD4(+) T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity.0
384850332024ZEB2 alleviates Hirschsprung's-associated enterocolitis by promoting the proliferation and differentiation of enteric neural precursor cells via the Notch-1/Jagged-2 pathway.1
385258132024ABCs begin with ZEB2.0
386100092024Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT.0
359867412023MIR-518a-5p Targets ZEB2 to Suppress the Migration and Invasion of Breast-cancer Cells.1

Citation

Dessen P

ZEB2 (zinc finger E-box binding homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45746/zeb2-(zinc-finger-e-box-binding-homeobox-2)