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TMSB10 (thymosin beta 10)

Written2010-03Xueshan Qiu
Department of Pathology, the First Affiliated Hospital, College of Basic Medical Sciences of China Medical University, Shenyang, China

(Note : for Links provided by Atlas : click)

Identity

Alias_symbol (synonym)TB10
HGNC (Hugo) TMSB10
LocusID (NCBI) 9168
Atlas_Id 42595
Location 2p11.2  [Link to chromosome band 2p11]
Location_base_pair Starts at 85132763 and ends at 85133799 bp from pter ( according to hg19-Feb_2009)  [Mapping TMSB10.png]
Fusion genes
(updated 2016)
ACTG1 (17q25.3) / TMSB10 (2p11.2)AHDC1 (1p36.11) / TMSB10 (2p11.2)ICAM1 (19p13.2) / TMSB10 (2p11.2)
NCDN (1p34.3) / TMSB10 (2p11.2)RAB36 (22q11.22) / TMSB10 (2p11.2)TMSB10 (2p11.2) / AGAP1 (2q37.2)
TMSB10 (2p11.2) / BAIAP2 (17q25.3)TMSB10 (2p11.2) / CD63 (12q13.2)TMSB10 (2p11.2) / RPL4 (15q22.31)
TMSB10 (2p11.2) / RPS16 (19q13.2)TMSB10 (2p11.2) / TMSB10 (2p11.2)TMSB10 (2p11.2) / WAC (10p12.1)
ZC3H18 (16q24.2) / TMSB10 (2p11.2)
Note TMSB10 is a member of the beta-thymosin family, which is an actin-sequestering protein involved in cell motility. TMSB10 may be correlated with tumor cells proliferation, apoptosis, metastasis and angiogenesis.

DNA/RNA

 
Description The cDNA sequence for human TMSB10 is 482 nucleotides long comprising 3 exons. The open reading frame of the coding region is 135 bp.

Protein

 
Description Protein length (NP_066926.1): 44 amino acids.
(madkpdmgeiasfdkaklkktetqekntlptketieqekrseis)
Molecular weight: 4.9 kDa.
TMSB10 is a small G-actin binding protein, and it induces depolymerization of intracellular F-actin pools by sequestering actin monomers.
Expression TMSB10 is found in human, rat, mouse, cat, and rabbit. TMSB10 is one of the most abundant beta-thymosins.
Localisation TMSB10 is expressed in cytoplasm.
Function Overview: TMSB10 is a highly conserved small acid protein. It is present in many tissues and cell types. It can sequester actin monomers and bind to G-actin in a 1:1 complex.

Actin monomer sequestering protein: TMSB10 is one of G-actin binding proteins, being expressed in all mammalian species. It can sequester monomeric actin and inhibit actin polymerization. It participates in the regulation of cancer cell motility.

Development: The expression of TMSB10 is associated with the development of several tissues. It is involved in the development of the oral cavity and its annexes. TMSB10 plays an important role in early neuroembryogenesis. It is present in the developing nervous, and has a specific physiological function during cerebellum development. TMSB10 is only present at very low levels in a very small subpopulation of glia in the adult cerebellum. In young animals, most of the TMSB10 is localized in granule cells, Golgi neurons and Purkinje cells. In old animals, TMSB10 signal is detected faintly in a few Purkinje cells.

Apoptosis: TMSB10 regulates apoptosis. For example, upregulation of TMSB10 in M. bovis-infected macrophages is linked with increased cell death due to apoptosis. TMSB10 can disrupt F-actin stress fibers, markedly decrease ovarian cancer cells growth, and a high rate of apoptosis. TMSB10 plays a significant role in cell apoptosis possibly by acting as an actin-mediated tumor suppressor, perhaps functions as a neoapoptotic influence during embryogenesis, and may mediate some of the pro-apoptotic anticancer actions of retinoids.

Angiogenesis: TMSB10 may be an effective inhibitor of angiogenesis by inhibiting endothelial migration, tube formation, VEGF, VEGFR-1 and integrin alphaV expression in HCAECs. TMSB10 is not only a cytoskeletal regulator, it also acts as a potent inhibitor of angiogenesis and tumor growth by interaction with Ras.

Cancers: Elevated expression of TMSB10 is associated with invasion and metastasis of several kinds of tumors. It may be considered a potential tool for the diagnosis of several human neoplasias. TMSB10 is detected mainly in the malignant tissue, particularly in the cancerous cells, whereas the normal cell population around the lesions showed very weak staining. Also, the intensity of staining in the cancerous cells is proportionally increased with the increasing grade of the lesions.

Homology Homolog to thymosin beta 4 and thymosin beta 15.

Implicated in

Note
Entity Pancreatic cancer
Note TSMB10 is expressed in human pancreatic carcinoma, but not in non-neoplastic pancreatic tissue, suggesting a role for TMSB10 in the carcinogenesis of pancreatic carcinoma. It is a promising marker and a novel therapeutic target for pancreatic cancer. Exogenous TMSB10 causes the phosphorylation of JNK and increases the secretion of cytokines interleukin (IL)-7 and IL-8 in BxPC-3 pancreatic cancer cells.
  
Entity Non-small cell lung cancer
Note TMSB10 might induce microvascular and lymphatic vessel formation by up-regulating vascular endothelial growth factor and vascular endothelial growth factor-C in lung cancer tissues, thus promoting the distant and lymph node metastases and being implicated in the progression of non-small cell lung cancer.
  
Entity Breast cancer
Note TMSB10 plays a key role in sequestration of G-actin as well as in breast cancer cell motility.
  
Entity Ovarian cancer
Note TMSB10 inhibits angiogenesis and tumor growth by interfering Ras signal transduction and expression of VEGF.
  
Entity Thyroid neoplasias
Note TMSB10 overexpression is a general event of thyroid cell neoplastic transformation. An increased expression of TMSB10 mRNA in thyroid carcinomas is found. The evaluation of TMSB10 gene expression may be considered a promising means of human thyroid hyperproliferative diagnosis. By decreasing TMSB10 expression, the thyroid cancer cells growth in soft agar is inhibited.
  
Entity Renal cell carcinoma
Note The TMSB10 gene is deregulated in renal cell carcinoma and it may be a new molecular marker for renal-cell carcinoma.
  
Entity Cutaneous melanoma
Note TMSB10 can be considered as a new progression marker for human cutaneous melanoma.
  

Bibliography

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PMID 12882358
 
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PMID 18789485
 
Upregulation of thymosin beta-10 by Mycobacterium bovis infection of bovine macrophages is associated with apoptosis.
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Infect Immun. 2002 Apr;70(4):2121-7.
PMID 11895978
 
Retinoic acid regulates thymosin beta 10 levels in rat neuroblastoma cells.
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PMID 1846397
 
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PMID 2169566
 
Thymosin beta-10 accelerates apoptosis.
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PMID 8589757
 
C-terminal truncation of thymosin beta10 by an intracellular protease and its influence on the interaction with G-actin studied by ultrafiltration.
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PMID 9305728
 
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PMID 11731086
 
Thymosin {beta}(10) inhibits angiogenesis and tumor growth by interfering with Ras function.
Lee SH, Son MJ, Oh SH, Rho SB, Park K, Kim YJ, Park MS, Lee JH.
Cancer Res. 2005 Jan 1;65(1):137-48.
PMID 15665289
 
Overexpression of the thymosin beta-10 gene in human ovarian cancer cells disrupts F-actin stress fiber and leads to apoptosis.
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PMID 11709704
 
Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.
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PMID 19194824
 
Cloning and characterization of a testis-specific thymosin beta 10 cDNA. Expression in post-meiotic male germ cells.
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PMID 14975205
 
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PMID 1988550
 
Localization of thymosin beta10 in breast cancer cells: relationship to actin cytoskeletal remodeling and cell motility.
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PMID 16786322
 
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PMID 3365256
 
Thymosin beta10 inhibits cell migration and capillary-like tube formation of human coronary artery endothelial cells.
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PMID 16496302
 
Small actin-binding proteins: the beta-thymosin family.
Nachmias VT.
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PMID 8448031
 
Thymosin beta(4) and beta(10) levels in pre-term newborn oral cavity and foetal salivary glands evidence a switch of secretion during foetal development.
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PMID 12029440
 
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Citation

This paper should be referenced as such :
Qiu, X
TMSB10 (thymosin beta 10)
Atlas Genet Cytogenet Oncol Haematol. 2010;14(12):1166-1169.
Free journal version : [ pdf ]   [ DOI ]
On line version : http://AtlasGeneticsOncology.org/Genes/TMSB10ID42595ch2p11.html


External links

Nomenclature
HGNC (Hugo)TMSB10   11879
Cards
AtlasTMSB10ID42595ch2p11
Entrez_Gene (NCBI)TMSB10  9168  thymosin beta 10
AliasesMIG12; TB10
GeneCards (Weizmann)TMSB10
Ensembl hg19 (Hinxton)ENSG00000034510 [Gene_View]  chr2:85132763-85133799 [Contig_View]  TMSB10 [Vega]
Ensembl hg38 (Hinxton)ENSG00000034510 [Gene_View]  chr2:85132763-85133799 [Contig_View]  TMSB10 [Vega]
ICGC DataPortalENSG00000034510
TCGA cBioPortalTMSB10
AceView (NCBI)TMSB10
Genatlas (Paris)TMSB10
WikiGenes9168
SOURCE (Princeton)TMSB10
Genetics Home Reference (NIH)TMSB10
Genomic and cartography
GoldenPath hg19 (UCSC)TMSB10  -     chr2:85132763-85133799 +  2p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)TMSB10  -     2p11.2   [Description]    (hg38-Dec_2013)
EnsemblTMSB10 - 2p11.2 [CytoView hg19]  TMSB10 - 2p11.2 [CytoView hg38]
Mapping of homologs : NCBITMSB10 [Mapview hg19]  TMSB10 [Mapview hg38]
OMIM188399   
Gene and transcription
Genbank (Entrez)AK130949 AK311952 AY453400 BC016025 BC016731
RefSeq transcript (Entrez)NM_021103
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TMSB10
Cluster EST : UnigeneHs.446574 [ NCBI ]
CGAP (NCI)Hs.446574
Alternative Splicing GalleryENSG00000034510
Gene ExpressionTMSB10 [ NCBI-GEO ]   TMSB10 [ EBI - ARRAY_EXPRESS ]   TMSB10 [ SEEK ]   TMSB10 [ MEM ]
Gene Expression Viewer (FireBrowse)TMSB10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9168
GTEX Portal (Tissue expression)TMSB10
Protein : pattern, domain, 3D structure
UniProt/SwissProtP63313   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP63313  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP63313
Splice isoforms : SwissVarP63313
PhosPhoSitePlusP63313
Domaine pattern : Prosite (Expaxy)THYMOSIN_B4 (PS00500)   
Domains : Interpro (EBI)Beta-thymosin   
Domain families : Pfam (Sanger)Thymosin (PF01290)   
Domain families : Pfam (NCBI)pfam01290   
Domain families : Smart (EMBL)THY (SM00152)  
Domain structure : Prodom (Prabi Lyon)Thymosin_b4 (PD005116)   
Conserved Domain (NCBI)TMSB10
DMDM Disease mutations9168
Blocks (Seattle)TMSB10
SuperfamilyP63313
Human Protein AtlasENSG00000034510
Peptide AtlasP63313
HPRD01779
IPIIPI00220827   
Protein Interaction databases
DIP (DOE-UCLA)P63313
IntAct (EBI)P63313
FunCoupENSG00000034510
BioGRIDTMSB10
STRING (EMBL)TMSB10
ZODIACTMSB10
Ontologies - Pathways
QuickGOP63313
Ontology : AmiGOactin monomer binding  protein binding  cytoplasm  actin filament organization  actin cytoskeleton organization  filamentous actin  sequestering of actin monomers  
Ontology : EGO-EBIactin monomer binding  protein binding  cytoplasm  actin filament organization  actin cytoskeleton organization  filamentous actin  sequestering of actin monomers  
NDEx NetworkTMSB10
Atlas of Cancer Signalling NetworkTMSB10
Wikipedia pathwaysTMSB10
Orthology - Evolution
OrthoDB9168
GeneTree (enSembl)ENSG00000034510
Phylogenetic Trees/Animal Genes : TreeFamTMSB10
HOVERGENP63313
HOGENOMP63313
Homologs : HomoloGeneTMSB10
Homology/Alignments : Family Browser (UCSC)TMSB10
Gene fusions - Rearrangements
Fusion : MitelmanTMSB10/CD63 [2p11.2/12q13.2]  
Fusion : MitelmanTMSB10/RPS16 [2p11.2/19q13.2]  [t(2;19)(p11;q13)]  
Fusion: TCGATMSB10 2p11.2 CD63 12q13.2 PRAD
Fusion Cancer (Beijing)TMSB10 [2p11.2]  -  AGAP1 [2q37.2]  [FUSC000396]  [FUSC000396]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTMSB10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TMSB10
dbVarTMSB10
ClinVarTMSB10
1000_GenomesTMSB10 
Exome Variant ServerTMSB10
ExAC (Exome Aggregation Consortium)TMSB10 (select the gene name)
Genetic variants : HAPMAP9168
Genomic Variants (DGV)TMSB10 [DGVbeta]
DECIPHER (Syndromes)2:85132763-85133799  ENSG00000034510
CONAN: Copy Number AnalysisTMSB10 
Mutations
ICGC Data PortalTMSB10 
TCGA Data PortalTMSB10 
Broad Tumor PortalTMSB10
OASIS PortalTMSB10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTMSB10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDTMSB10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TMSB10
DgiDB (Drug Gene Interaction Database)TMSB10
DoCM (Curated mutations)TMSB10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TMSB10 (select a term)
intoGenTMSB10
NCG5 (London)TMSB10
Cancer3DTMSB10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM188399   
Orphanet
MedgenTMSB10
Genetic Testing Registry TMSB10
NextProtP63313 [Medical]
TSGene9168
GENETestsTMSB10
Huge Navigator TMSB10 [HugePedia]
snp3D : Map Gene to Disease9168
BioCentury BCIQTMSB10
ClinGenTMSB10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9168
Chemical/Pharm GKB GenePA36580
Clinical trialTMSB10
Miscellaneous
canSAR (ICR)TMSB10 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineTMSB10
EVEXTMSB10
GoPubMedTMSB10
iHOPTMSB10
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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