VEGFC (vascular endothelial growth factor C)

2003-02-01  

Identity

HGNC
LOCATION
4q34.3
LOCUSID
ALIAS
Flt4-L,LMPH1D,LMPHM4,VRP
FUSION GENES

Other Information

Locus ID:

NCBI: 7424
MIM: 601528
HGNC: 12682
Ensembl: ENSG00000150630

Variants:

dbSNP: 7424
ClinVar: 7424
TCGA: ENSG00000150630
COSMIC: VEGFC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000150630ENST00000618562P49767

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
Pathways in cancerKEGGhsa05200
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGF ligand-receptor interactionsREACTOMER-HSA-194313
VEGF binds to VEGFR leading to receptor dimerizationREACTOMER-HSA-195399
AGE-RAGE signaling pathway in diabetic complicationsKEGGko04933
AGE-RAGE signaling pathway in diabetic complicationsKEGGhsa04933

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA130232992bevacizumabChemicalPathwayassociated20124951
PA166118342afliberceptChemicalPathwayassociated20124951
PA28180FLT1GenePathwayassociated20124951
PA30086KDRGenePathwayassociated20124951
PA31783NRP1GenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
122137232002Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis.208
168161212006Functional interaction of VEGF-C and VEGF-D with neuropilin receptors.100
221798342012Interaction of tumor cells and lymphatic vessels in cancer progression.96
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
155906422005The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1.63
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
235932822013miRNA-27b targets vascular endothelial growth factor C to inhibit tumor progression and angiogenesis in colorectal cancer.59
192997062009Vascular endothelial growth factor C facilitates immune tolerance and endovascular activity of human uterine NK cells at the maternal-fetal interface.58
229675082012Collaborative interplay between FGF-2 and VEGF-C promotes lymphangiogenesis and metastasis.58
201451162010Structural determinants of growth factor binding and specificity by VEGF receptor 2.57

Citation

Dessen P

VEGFC (vascular endothelial growth factor C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/42789/vegfc-(vascular-endothelial-growth-factor-c)