Atlas of Genetics and Cytogenetics in Oncology and Haematology

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TNN (tenascin N)

Written2008-02Martin Degen, Ruth Chiquet-Ehrismann
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland

(Note : for Links provided by Atlas : click)


Other aliasTN-W
LocusID (NCBI) 63923
Atlas_Id 44209
Location 1q25.1  [Link to chromosome band 1q25]
Location_base_pair Starts at 175067858 and ends at 175148066 bp from pter ( according to hg19-Feb_2009)  [Mapping TNN.png]
Local_order tail to tail configuration next to the tenascin-R gene(TNR)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
TNN (1q25.1) / UBE2D1 (10q21.1)


  The distribution of the 19 exons is shown in the upper part, whereas the lengths of exons and introns are indicated in the lower part.
Description The tenascin-W gene consists of 19 exons spanning 80.21 kb of genomic DNA.
Transcription 5005 bp mRNA transcribed in centromeric to telomeric orientation on the forward strand; 3885 bp open reading frame.
The transcript starts with a non-coding exon followed by exon 2, which contains the start codon (ATG) for translation initiation. Exon 1 is located 9448 bp upstream of exon 2.


  Schematic representation of human tenascin-W is shown.
Description Tenascin-W is built up of different structural motifs arranged in a linear order, namely amino-terminal heptad repeats, 3.5 EGF-like repeats, 9 FN III domains, and a carboxyl-terminal fibrinogen globe.
The primary sequence encodes a protein of 1294 amino acids. Amino acids 1-16 represent the secretion signal, amino acids 150-254 constitute the EGF-like repeats, and amino acids 255-1054 account for the FNIII domains. FN III domain number 3 was subject to duplication as indicated by the dark boxes in the schematic representation. Tenascin-W is known to form hexameric structures called hexabrachions.
SDS-Page analysis revealed a molecular weight of 160kDa per subunit under reducing conditions.
So far, there is no evidence for alternative splicing.
Expression Initially, tenascin-W was identified in zebrafish where it was expressed in migrating cells of sclerotomal and neural crest origin. More recently, tenascin-W was characterized in mouse and chicken during embryogenesis as well as in the adult organism. These studies revealed that tenascin-W, similar to tenascin-C, shows tight regulation during development and in the adult. Immunohistochemistry showed prominent expression in the developing and adult metanephric kidney, developing and adult periosteum around ribs, and transient expression in smooth muscles of the developing gut, often but not always overlapping with tenascin-C expression. Furthermore, tenascin-W is highly expressed in the tumor stroma in different solid tumors.
Tenascin-W is most likely produced and secreted by mesenchymal cells such as fibroblasts and osteoblasts.
Known stimuli that induce tenascin-W expression include so far tumor necrosis factor alpha (TNFα) and bone morphogenetic protein 2 (BMP2).
Localisation Extracellular matrix.
Function Adhesion: Tenascin-W is an adhesive substratum for some cells (osteoblasts, fibroblasts), while others cannot attach and spread on tenascin-W.
Migration: Tenascin-W stimulates the migratory behavior of cells.
Homology Tenascin-W belongs to the tenascin family, which is a highly conserved family of large oligomeric extracellular matrix proteins. Vertebrate genomes harbor four tenascin genes, which have been termed tenascin-C, tenascin-XB (TNXB), tenascin-R, and tenascin-W.
Human tenascin-W shows high sequence conservation with mouse tenascin-W.

Implicated in

Entity Breast cancer
Oncogenesis Tenascin-W is highly expressed in a large fraction of breast cancer patients whereas it is not detectable in normal human mammary tissue. Expression in tumors correlated with tumor grade. There is statistically significant higher mean expression of tenascin-W in low-grade tumors (Grade1/Grade2) compared to high-grade tumors (Grade3).
Tenascin-W is produced in the stromal compartment, most likely by cancer-associated fibroblasts, which are part of a tumor permissive microenvironment that facilitates tumor cell migration. In vitro, presence of tenascin-W stimulated breast cancer cell migration.
Benign tumors as well as carcinomas do express tenascin-W.
Furthermore, tenascin-W is elevated in sera of breast cancer patients compared to that of healthy volunteers.
Tenascin-W is postulated to be a marker for conversion of the normal physiological stroma to an activated stroma in breast cancer.
Entity Colorectal cancer
Oncogenesis Tenascin-W is highly expressed in colorectal cancer patients whereas it is not detectable in the normal colon mucosa. Furthermore, mean tenascin-W level in sera of colorectal cancer patients is statistically increased compared to that in sera of healthy volunteers. Follow-up studies of colorectal cancer patients revealed that 4 out of 5 patients who developed tumor recurrence after treatment showed high tenascin-W levels in their sera. Thus, tenascin-W might have prognostic value as a serum tumor marker.


Tenascin-W, a new marker of cancer stroma, is elevated in sera of colon and breast cancer patients.
Degen M, Brellier F, Schenk S, Driscoll R, Zaman K, Stupp R, Tornillo L, Terracciano L, Chiquet-Ehrismann R, Rüegg C, Seelentag W.
Int J Cancer in press.
Avian tenascin-W: expression in smooth muscle and bone, and effects on calvarial cell spreading and adhesion in vitro.
Meloty-Kapella C, Degen M, Chiquet-Ehrismann R, Tucker RP.
Dev Dyn. 2006 Jun;235(6):1532-42.
PMID 16534782
Tenascin-W is found in malignant mammry tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF alpha induced expression in vitro.
Scherberich A, Tucker RP, Degen M, Brown-Luedi M, Andres AC, Chiquet-Ehrismann R.
Oncogene. 2005 Feb 24;24(9):1525-32.
PMID 15592496
Phylogenetic analysis of the tenascin gene family: evidence of origin early in the chordate lineage.
Tucker RP, Drabikowski K, Hess JF, Ferralli J, Chiquet-Ehrismann R, Adams JC.
BMC Evol Biol. 2006 Aug 7;6:60.
PMID 16893461
Zebrafish tenascin-W, a new member of the tenascin family.
Weber P, Montag D, Schachner M.
J Neurobiol. 1998 Apr;35(1):1-16.
PMID 9552162


This paper should be referenced as such :
Degen, M ; Chiquet-Ehrismann, R
TNN (tenascin N)
Atlas Genet Cytogenet Oncol Haematol. 2008;12(6):449-451.
Free journal version : [ pdf ]   [ DOI ]
On line version :

External links

HGNC (Hugo)TNN   22942
Entrez_Gene (NCBI)TNN  63923  tenascin N
GeneCards (Weizmann)TNN
Ensembl hg19 (Hinxton)ENSG00000120332 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120332 [Gene_View]  ENSG00000120332 [Sequence]  chr1:175067858-175148066 [Contig_View]  TNN [Vega]
ICGC DataPortalENSG00000120332
TCGA cBioPortalTNN
Genatlas (Paris)TNN
SOURCE (Princeton)TNN
Genetics Home Reference (NIH)TNN
Genomic and cartography
GoldenPath hg38 (UCSC)TNN  -     chr1:175067858-175148066 +  1q25.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)TNN  -     1q25.1   [Description]    (hg19-Feb_2009)
GoldenPathTNN - 1q25.1 [CytoView hg19]  TNN - 1q25.1 [CytoView hg38]
Mapping of homologs : NCBITNN [Mapview hg19]  TNN [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK127044 AK127654 AL049689 BC136619 BC144305
RefSeq transcript (Entrez)NM_022093
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)TNN
Cluster EST : UnigeneHs.156369 [ NCBI ]
CGAP (NCI)Hs.156369
Alternative Splicing GalleryENSG00000120332
Gene ExpressionTNN [ NCBI-GEO ]   TNN [ EBI - ARRAY_EXPRESS ]   TNN [ SEEK ]   TNN [ MEM ]
Gene Expression Viewer (FireBrowse)TNN [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)63923
GTEX Portal (Tissue expression)TNN
Human Protein AtlasENSG00000120332-TNN [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UQP3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UQP3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UQP3
Splice isoforms : SwissVarQ9UQP3
Domaine pattern : Prosite (Expaxy)EGF_1 (PS00022)    EGF_2 (PS01186)    FIBRINOGEN_C_1 (PS00514)    FIBRINOGEN_C_2 (PS51406)    FN3 (PS50853)   
Domains : Interpro (EBI)EGF-like_CS    EGF-like_dom    Fibrinogen-like_C    Fibrinogen_a/b/g_C_dom    Fibrinogen_CS    FN3_dom    FN3_sf    Ig-like_fold   
Domain families : Pfam (Sanger)Fibrinogen_C (PF00147)    fn3 (PF00041)   
Domain families : Pfam (NCBI)pfam00147    pfam00041   
Domain families : Smart (EMBL)EGF (SM00181)  FBG (SM00186)  FN3 (SM00060)  
Conserved Domain (NCBI)TNN
DMDM Disease mutations63923
Blocks (Seattle)TNN
Human Protein Atlas [tissue]ENSG00000120332-TNN [tissue]
Peptide AtlasQ9UQP3
IPIIPI00010814   IPI00922500   
Protein Interaction databases
IntAct (EBI)Q9UQP3
Ontologies - Pathways
Ontology : AmiGOosteoblast development  molecular_function  integrin binding  cellular_component  cell-matrix adhesion  axonogenesis  cell surface  extracellular matrix  negative regulation of osteoblast proliferation  identical protein binding  neuronal cell body  negative regulation of osteoblast differentiation  dendrite self-avoidance  CA3 pyramidal cell dendrite  negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation  hippocampal mossy fiber expansion  negative regulation of neuron migration  
Ontology : EGO-EBIosteoblast development  molecular_function  integrin binding  cellular_component  cell-matrix adhesion  axonogenesis  cell surface  extracellular matrix  negative regulation of osteoblast proliferation  identical protein binding  neuronal cell body  negative regulation of osteoblast differentiation  dendrite self-avoidance  CA3 pyramidal cell dendrite  negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation  hippocampal mossy fiber expansion  negative regulation of neuron migration  
Pathways : KEGGPI3K-Akt signaling pathway    Focal adhesion    ECM-receptor interaction    MicroRNAs in cancer   
NDEx NetworkTNN
Atlas of Cancer Signalling NetworkTNN
Wikipedia pathwaysTNN
Orthology - Evolution
GeneTree (enSembl)ENSG00000120332
Phylogenetic Trees/Animal Genes : TreeFamTNN
Homologs : HomoloGeneTNN
Homology/Alignments : Family Browser (UCSC)TNN
Gene fusions - Rearrangements
Fusion : FusionGDB38930   
Fusion : Fusion_HubMALAT1--TNN    TNN--IFI44    TNN--UBE2D1   
Fusion : QuiverTNN
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerTNN [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)TNN
Exome Variant ServerTNN
ExAC (Exome Aggregation Consortium)ENSG00000120332
GNOMAD BrowserENSG00000120332
Varsome BrowserTNN
Genetic variants : HAPMAP63923
Genomic Variants (DGV)TNN [DGVbeta]
DECIPHERTNN [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisTNN 
ICGC Data PortalTNN 
TCGA Data PortalTNN 
Broad Tumor PortalTNN
OASIS PortalTNN [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICTNN  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DTNN
Mutations and Diseases : HGMDTNN
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch TNN
DgiDB (Drug Gene Interaction Database)TNN
DoCM (Curated mutations)TNN (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)TNN (select a term)
NCG5 (London)TNN
Cancer3DTNN(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Genetic Testing Registry TNN
NextProtQ9UQP3 [Medical]
Target ValidationTNN
Huge Navigator TNN [HugePedia]
snp3D : Map Gene to Disease63923
BioCentury BCIQTNN
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD63923
Chemical/Pharm GKB GenePA134973710
Clinical trialTNN
canSAR (ICR)TNN (select the gene name)
DataMed IndexTNN
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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