| Entity | rare cases of ALK+ anaplasic large cell lymphoma (ALCL) with t(1;2)(q25;p23) |
| Disease | ALCL presents as an aggressive lymphoma with systemic signs |
| Prognosis | nonetheless, have a favourable prognosis |
| Hybrid/Mutated Gene | 5' CLTC - 3' ALK |
| Abnormal Protein | 104 kDa ; 221 N-term amino acids from TPM3 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein. |
| Oncogenesis | TPM3-ALK is contitutively activated |
| | |
| Entity | cases of Inflammatory myofibroblastic tumors with t(1;2)(q25;p23) |
| Disease | rare soft tissue tumour found in children and young adults |
| Prognosis | good prognosis |
| Hybrid/Mutated Gene | 5' CLTC - 3' ALK |
| Abnormal Protein | 104 kDa ; 221 N-term amino acids from TPM3 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein. |
| Oncogenesis | TPM3-ALK is contitutively activated |
| | |
| Entity | papillary thyroid carcinoma |
| Disease | represents about 60% of thyroid cancers; small, undetectable, chromosome 1q inversions have shown to produce a TPM3-NTRK1 hybrid gene in a very few cases of papillary thyroid carcinoma. |
| Prognosis | prognosis of papillary thyroid carcinoma is excellent |
| Hybrid/Mutated Gene | 5' TPM3 - 3' NTRK1 |
| Abnormal Protein | 221 N-term amino acids from PM3 fused to the C-term of NTRK1, including its tyrosine kinase domain |
| | |
| A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. |
| Martin-Zanca D, Hughes SH, Barbacid M |
| Nature. 1986 ; 319 (6056) : 743-748. |
| PMID 2869410 |
| |
| A sequence analysis of the genomic regions involved in the rearrangements between TPM3 and NTRK1 genes producing TRK oncogenes in papillary thyroid carcinomas. |
| Butti MG, Bongarzone I, Ferraresi G, Mondellini P, Borrello MG, Pierotti MA |
| Genomics. 1995 ; 28 (1) : 15-24. |
| PMID 7590742 |
| |
| A new fusion gene TPM3-ALK in anaplastic large cell lymphoma created by a (1;2)(q25;p23) translocation. |
| Lamant L, Dastugue N, Pulford K, Delsol G, Mariamˆ© B |
| Blood. 1999 ; 93 (9) : 3088-3095. |
| PMID 10216106 |
| |
| Complex variant translocation t(1;2) with TPM3-ALK fusion due to cryptic ALK gene rearrangement in anaplastic large-cell lymphoma. |
| Siebert R, Gesk S, Harder L, Steinemann D, Grote W, Schlegelberger B, Tiemann M, Wlodarska I, Schemmel V |
| Blood. 1999 ; 94 (10) : 3614-3617. |
| PMID 10610119 |
| |
| Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. |
| Griffin CA, Hawkins AL, Dvorak C, Henkle C, Ellingham T, Perlman EJ |
| Cancer research. 1999 ; 59 (12) : 2776-2780. |
| PMID 10383129 |
| |
| Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. |
| Lehman W, Hatch V, Korman V, Rosol M, Thomas L, Maytum R, Geeves MA, Van Eyk JE, Tobacman LS, Craig R |
| Journal of molecular biology. 2000 ; 302 (3) : 593-606. |
| PMID 10986121 |
| |
| Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. |
| Ladanyi M |
| The American journal of pathology. 2000 ; 157 (2) : 341-345. |
| PMID 10934137 |
| |
| TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. |
| Lawrence B, Perez-Atayde A, Hibbard MK, Rubin BP, Dal Cin P, Pinkus JL, Pinkus GS, Xiao S, Yi ES, Fletcher CD, Fletcher JA |
| The American journal of pathology. 2000 ; 157 (2) : 377-384. |
| PMID 10934142 |
| |
| Deciphering the design of the tropomyosin molecule. |
| Brown JH, Kim KH, Jun G, Greenfield NJ, Dominguez R, Volkmann N, Hitchcock-DeGregori SE, Cohen C |
| Proceedings of the National Academy of Sciences of the United States of America. 2001 ; 98 (15) : 8496-8501. |
| PMID 11438684 |
| |
