TPM4 (tropomyosin)
2001-08-01 Jean-Loup Huret AffiliationGenetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France
DNA/RNA
Transcription
alternate transcripts
Proteins
Description
248 amino acids, 29 kDa. Coiled-coil structure
Function
Tropomyosins are actin-binding proteins; component of cytoskeletal microfilaments; tropomyosins mediate the effect of Ca2+ on the myosin-actin interaction In skeletal muscles, but their function in smooth muscles and other tissues is yet unknown
Homology
Other tropomyosins: TPM1 (alpha) located in 15q22, TPM2 (beta), located in 9q13, and TPM3 located in 1q25
Implicated in
Entity name
Inflammatory myofibroblastic tumors with t(2;19)(p23;p13.1)
Disease
rare soft tissue tumour found in children and young adults
Prognosis
good prognosis
Hybrid gene
5 CLTC - 3 ALK
Fusion protein
221 N-term amino acids from TPM4 fused to the 562 C-term amino acids from ALK (i.e. the entire cytoplasmic portion of ALK with the tyrosine kinase domain); homodimerization of the fusion protein.
Oncogenesis
TPM4-ALK is contitutively activated
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 11438684 | 2001 | Deciphering the design of the tropomyosin molecule. | Brown JH et al |
| 10383129 | 1999 | Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors. | Griffin CA et al |
| 10934137 | 2000 | Aberrant ALK tyrosine kinase signaling. Different cellular lineages, common oncogenic mechanisms. | Ladanyi M et al |
| 10934142 | 2000 | TPM3-ALK and TPM4-ALK oncogenes in inflammatory myofibroblastic tumors. | Lawrence B et al |
| 10986121 | 2000 | Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments. | Lehman W et al |
Other Information
Locus ID:
NCBI: 7171
MIM: 600317
HGNC: 12013
Ensembl: ENSG00000167460
Variants:
dbSNP: 7171
ClinVar: 7171
TCGA: ENSG00000167460
COSMIC: TPM4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36993958 | 2023 | Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer. | 6 |
| 37328795 | 2023 | MicroRNA-5195-3p mediated malignant biological behaviour of insulin-resistant liver cancer cells via SOX9 and TPM4. | 0 |
| 36993958 | 2023 | Integrated pan-cancer analysis and experimental verification of the roles of tropomyosin 4 in gastric cancer. | 6 |
| 37328795 | 2023 | MicroRNA-5195-3p mediated malignant biological behaviour of insulin-resistant liver cancer cells via SOX9 and TPM4. | 0 |
| 34758189 | 2022 | Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding. | 2 |
| 36344495 | 2022 | LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation. | 5 |
| 34758189 | 2022 | Rare missense variants in Tropomyosin-4 (TPM4) are associated with platelet dysfunction, cytoskeletal defects, and excessive bleeding. | 2 |
| 36344495 | 2022 | LncRNA SFTA1P promotes cervical cancer progression by interaction with PTBP1 to facilitate TPM4 mRNA degradation. | 5 |
| 33390785 | 2021 | The expression and clinical significance of TPM4 in hepatocellular carcinoma. | 11 |
| 34575979 | 2021 | The miR-133a, TPM4 and TAp63γ Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression. | 5 |
| 33390785 | 2021 | The expression and clinical significance of TPM4 in hepatocellular carcinoma. | 11 |
| 34575979 | 2021 | The miR-133a, TPM4 and TAp63γ Role in Myocyte Differentiation Microfilament Remodelling and Colon Cancer Progression. | 5 |
| 32363617 | 2020 | Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin-4 in alpha-fetoprotein-negative hepatocellular carcinoma. | 2 |
| 32432739 | 2020 | TPM4 aggravates the malignant progression of hepatocellular carcinoma through negatively regulating SUSD2. | 7 |
| 32363617 | 2020 | Differential expression and diagnostic significance of P53, MutS homologs 2, tropomyosin-4 in alpha-fetoprotein-negative hepatocellular carcinoma. | 2 |
Citation
Jean-Loup Huret
TPM4 (tropomyosin)
Atlas Genet Cytogenet Oncol Haematol. 2001-08-01
Online version: http://atlasgeneticsoncology.org/gene/359/tpm4-(tropomyosin)
