| Description | 2349 amino acids, 267 kDa. The protein contains extensive coilecoiled domains and an acidic globular C-terminus, and is phosphorylated. |
| Expression | widespread, if not ubiquitous; highest in testis, thymus, spleen and brain, lower levels in heart, liver and kidney. |
| Localisation | nucleoplasmic side of the nucleopore and discrete foci in the nuclear interior, binds to the nucleoporin Nup98. |
| Function | still controversial, part of a filamentous intranuclear network, role in nuclear protein and/or polyA+RNA export. |
| Homology | yeast Mlp1 and Mlp2, drosophila Bx34 , xenopus Tpr. |
| Note | |
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| Entity | gastric cancers with TPR- MET hybrid gene |
| Disease | the TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions |
| Hybrid/Mutated Gene | 5' TPR- 3'MET 5 kb mRNA |
| Abnormal Protein | 65 kDa, The fusion protein contains the constitutive promoter and first 424 coding nucleotides (142 amino acids) of Tpr, and the the tyrosine kinase domain of the c-met protooncogene. |
| Oncogenesis | transgenic expression of TPR-MET oncogene leads to development of mammary hyperplasia and tumors. |
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| Entity | humanpapillary thyroid carcinomas with TPR- NTRK1 hybrid gene |
| Hybrid/Mutated Gene | TRK-T1 (TPR-NTRK1): 598 nucleotides of the TPR gene 5' end are fused to 1148 bp of the TRK proto-oncogene which contain the TRK tyrosine kinase domain. TRK-T2 : 3073 nucleotides of Tpr 5' end fused to 1412 nucleotides of TRK . There is another hybrid gene between TPR and NTRK1 named TRK-T4. Arise by paracentric inversions on chromosome 1. |
| Abnormal Protein | 55 kDa for the TRK-T1 fusion protein. |
| Oncogenesis | TRK-T1 induces neoplastic transformation of thyroid epithelium in transgenic mice expressing the hybrid gene. |
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| Entity | rat induced tumors (adenocarcinomas and fibroblastomas). with Tpr-raf |
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| Functional analysis of Tpr: identification of nuclear pore complex association and nuclear localization domains and a role in mRNA export. |
| Bangs P, Burke B, Powers C, Craig R, Purohit A, Doxsey S |
| The Journal of cell biology. 1998 ; 143 (7) : 1801-1812. |
| PMID 9864356 |
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| Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export. |
| Frosst P, Guan T, Subauste C, Hahn K, Gerace L |
| The Journal of cell biology. 2002 ; 156 (4) : 617-630. |
| PMID 11839768 |
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| Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. |
| Gonzatti-Haces M, Seth A, Park M, Copeland T, Oroszlan S, Vande Woude GF |
| Proceedings of the National Academy of Sciences of the United States of America. 1988 ; 85 (1) : 21-25. |
| PMID 3277171 |
| |
| Chromosome 1 rearrangements involving the genes TPR and NTRK1 produce structurally different thyroid-specific TRK oncogenes. |
| Greco A, Miranda C, Pagliardini S, Fusetti L, Bongarzone I, Pierotti MA |
| Genes, chromosomes & cancer. 1997 ; 19 (2) : 112-123. |
| PMID 9172002 |
| |
| Rat c-raf oncogene activation by a rearrangement that produces a fused protein. |
| Ishikawa F, Takaku F, Nagao M, Sugimura T |
| Molecular and cellular biology. 1987 ; 7 (3) : 1226-1232. |
| PMID 3550433 |
| |
| The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. |
| Soman NR, Correa P, Ruiz BA, Wogan GN |
| Proceedings of the National Academy of Sciences of the United States of America. 1991 ; 88 (11) : 4892-4896. |
| PMID 2052572 |
| |
| Frequency of TPR-MET rearrangement in patients with gastric carcinoma and in first-degree relatives. |
| Yu J, Miehlke S, Ebert MP, Hoffmann J, Breidert M, Alpen B, Starzynska T, Stolte Prof M, Malfertheiner P, Bayerdörffer E |
| Cancer. 2000 ; 88 (8) : 1801-1806. |
| PMID 10760755 |
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