| Written | 2000-08 | Catherine H Régnier, Catherine Tomasetto, Marie.Christine Rio |
| I.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France |
| Identity |
| Alias (NCBI) | MLN62 | CART1 |
| HGNC (Hugo) | TRAF4 |
| HGNC Alias symb | CART1 | MLN62 | RNF83 |
| LocusID (NCBI) | 9618 |
| Atlas_Id | 204 |
| Location | 17q11.2 [Link to chromosome band 17q11] |
| Location_base_pair | Starts at 28744011 and ends at 28750956 bp from pter ( according to hg19-Feb_2009) [Mapping TRAF4.png] |
| Local_order | TRAF4, Lasp1(alias MLN50), c-erbB2, MLN64, MLN51 |
 | |
| TRAF4 (17q11-q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. | |
| Fusion genes (updated 2017) | Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands) |
| EML2 (19q13.32) / TRAF4 (17q11.2) | NDRG2 (14q11.2) / TRAF4 (17q11.2) | TRAF4 (17q11.2) / TRAF4 (17q11.2) | |
| TRAF4 (17q11.2) / WSB1 (17q11.1) |
| DNA/RNA |
| Description | 5,5 kb gene; 7 exons |
| Transcription | 2 kb cDNA; coding sequence: 1410 bp |
| Protein |
| Description | 470 amino acids; 53 kDa; contains an amino-terminal RING finger domain, a central stretch of six putative Zinc-binding domains (3 CART domains) and a carboxyl-terminal TRAF domain |
| Expression | epithelial cells; weak ubiquitous expression in adult tissues; stronger expression level in kidney and thymus |
| Localisation | cytoplasmic; nuclear when overexpressed |
| Function | putative signal transducer |
| Homology | to TRAF proteins (Tumor Necrosis Factor Receptor Associated Factor) |
| Implicated in |
| Note | |
| Entity | 17q11-q12 gene amplification; found in about 25% of primary breast carcinomas |
| Prognosis | poor clinical outcome; increase risk of relapse |
| Bibliography |
| Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. |
| Arch RH, Gedrich RW, Thompson CB |
| Genes & development. 1998 ; 12 (18) : 2821-2830. |
| PMID 9744859 |
| Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. |
| Bièche I, Tomasetto C, Régnier CH, Moog-Lutz C, Rio MC, Lidereau R |
| Cancer research. 1996 ; 56 (17) : 3886-3890. |
| PMID 8752152 |
| Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. |
| Régnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC |
| The Journal of biological chemistry. 1995 ; 270 (43) : 25715-25721. |
| PMID 7592751 |
| Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |
| Tomasetto C, Régnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC |
| Genomics. 1995 ; 28 (3) : 367-376. |
| PMID 7490069 |
| Citation |
| This paper should be referenced as such : |
| Régnier, CH ; Tomasetto, C ; Rio, MC |
| TRAF4 (TNF receptor-associated factor 4) |
| Atlas Genet Cytogenet Oncol Haematol. 2000;4(4):186-187. |
| Free journal version : [ pdf ] [ DOI ] |
| On line version : http://AtlasGeneticsOncology.org/Genes/TRAF4ID204.html |
| Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ] |
|
Male breast cancer
TRAF4/WSB1 (17q11) |
| External links |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Jul 16 16:55:14 CEST 2020 |
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