Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

TRAF4 TNF receptor-associated factor 4

Identity

Other namesMLN62
CART1
HGNC (Hugo) TRAF4
Location 17q11-q12
Location_base_pair Starts at 27071130 and ends at 27076594 bp from pter ( according to hg19-Feb_2009)  [Mapping]
Local_order TRAF4, Lasp1(alias MLN50), c-erbB2, MLN64, MLN51
 
  TRAF4 (17q11-q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it

DNA/RNA

Description 5,5 kb gene; 7 exons
Transcription 2 kb cDNA; coding sequence: 1410 bp

Protein

Description 470 amino acids; 53 kDa; contains an amino-terminal RING finger domain, a central stretch of six putative Zinc-binding domains (3 CART domains) and a carboxyl-terminal TRAF domain
Expression epithelial cells; weak ubiquitous expression in adult tissues; stronger expression level in kidney and thymus
Localisation cytoplasmic; nuclear when overexpressed
Function putative signal transducer
Homology to TRAF proteins (Tumor Necrosis Factor Receptor Associated Factor)

Implicated in

Entity 17q11-q12 gene amplification; found in about 25% of primary breast carcinomas
Prognosis poor clinical outcome; increase risk of relapse
  

External links

Nomenclature
HGNC (Hugo)TRAF4   12034
Entrez_Gene (NCBI)TRAF4  9618  TNF receptor-associated factor 4
Cards
AtlasTRAF4ID204
GeneCards (Weizmann)TRAF4
Ensembl (Hinxton)ENSG00000076604 [Gene_View]  TRAF4 [Vega]
AceView (NCBI)TRAF4
Genatlas (Paris)TRAF4
euGene (Indiana)9618
SOURCE (Stanford)NM_004295
Gene Expression (Array Express) ENSG00000076604
Genomic and cartography
GoldenPath (UCSC)TRAF4  -     chr17:27071130-27076594 +  17q11-q12   [Description]    (hg19-Feb_2009)
EnsemblTRAF4 - 17q11-q12 [CytoView]
Mapping of homologs : NCBITRAF4 [Mapview]
OMIM602464   
Gene and transcription
Gene : Genbank (Entrez)AF082185 AK300804 AY937222 AY937223 AY937224
Reference sequence (RefSeq transcript) :SRSNM_004295
Reference transcript : EntrezNM_004295
RefSeq genomic : SRSAC_000060 AC_000149 NC_000017 NT_010799 NW_001838430 NW_926750
RefSeq genomic : EntrezAC_000060 AC_000149 NC_000017 NT_010799 NW_001838430 NW_926750
Consensus coding sequences : CCDS NCBITRAF4
Cluster EST : UnigeneHs.8375 [ SRS ] Hs.8375 [ NCBI ]
Alternative Splicing : Fast-db (Paris)7227
Protein : pattern, domain, 3D structure
Protein : UniProt/SwissProtQ9BUZ4 (SRS) Q9BUZ4 (Expasy) Q9BUZ4 (Uniprot)
With graphics : InterProQ9BUZ4
Splice isoforms : VarSplice FASTAQ9BUZ4(VarSplice FASTA)
Domaine pattern : Prosite (SRS)MATH (PS50144)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domain pattern : Prosite (Expaxy)MATH (PS50144)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)    ZF_TRAF (PS50145)   
Domains : Interpro (SRS)MATH    TNF_recpt_TRAF    TRAF-like    TRAF-type    Znf_C3HC4_RING-type    Znf_RING    Znf_RING_CS    Znf_TRAF   
Domains : Interpro (EBI)MATH    TNF_recpt_TRAF    TRAF-like    TRAF-type    Znf_C3HC4_RING-type    Znf_RING    Znf_RING_CS    Znf_TRAF   
Related proteins : CluSTrQ9BUZ4
Domain families : Pfam SRSMATH (PF00917)    zf-C3HC4 (PF00097)   
Domain families : Pfam SangerMATH (PF00917)    zf-C3HC4 (PF00097)   
Domain families : Pfam NCBIpfam00917    pfam00097   
Domain families : Smart EMBLMATH (SM00061)  RING (SM00184)  
Blocks (Seattle)Q9BUZ4
Crystal structure of protein : PDB SRS2EOD    2YUC   
Crystal structure of protein : PDBSum2EOD    2YUC   
Crystal structure of protein : IMB2EOD    2YUC   
Crystal structure of protein : PDB RSDB2EOD    2YUC   
Human Protein AtlasENSG00000076604
HPRD03915
Protein Interaction databases
DIP (DOE-UCLA)Q9BUZ4
IntAct (EBI)Q9BUZ4
FunCoupENSG00000076604
Polymorphism : SNP, mutations, diseases
Single Nucleotide Polymorphism (SNP) : dbSNP NCBITRAF4
SNP : GeneSNP UtahTRAF4
SNP : HGBaseTRAF4
Genetic variants : HAPMAPTRAF4
Somatic Mutations in Cancer : COSMICTRAF4 
Mutations and Diseases : HGMDTRAF4
Hereditary diseases : OMIM602464   
Hereditary diseases : GENETests602464   
Diseases : Genetic AssociationTRAF4
General knowledge
Homologs : HomoloGeneTRAF4
Homology/Alignments : Family Browser UCSCTRAF4
Phylogenetic Trees/Animal Genes : TreeFamTRAF4
Chemical/Protein Interactions : CTD9618
Keywords Ontology : AmiGODNA binding  protein binding  nucleus  cytoplasm  signal transduction  multicellular organismal development  respiratory gaseous exchange  zinc ion binding  respiratory tube development  regulation of apoptosis  positive regulation of protein kinase activity  positive regulation of JNK cascade  metal ion binding  WW domain binding  positive regulation of protein homodimerization activity  
Keywords Ontology : EGO-EBIDNA binding  protein binding  nucleus  cytoplasm  signal transduction  multicellular organismal development  respiratory gaseous exchange  zinc ion binding  respiratory tube development  regulation of apoptosis  positive regulation of protein kinase activity  positive regulation of JNK cascade  metal ion binding  WW domain binding  positive regulation of protein homodimerization activity  
Pathways : BIOCARTA
Pathways : KEGG
Other databases
Probes
ProbeCancer Cytogenetics (Bari)
Probes : ImagenesTRAF4 Related clones (RZPD - Berlin)
Literature
PubMed27 Pubmed reference(s) in Entrez
PubGeneTRAF4

Bibliography

Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17.
Tomasetto C, Rˆ©gnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC
Genomics. 1995 ; 28 (3) : 367-376.
PMID 7490069
 
Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma.
Rˆ©gnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC
The Journal of biological chemistry. 1995 ; 270 (43) : 25715-25721.
PMID 7592751
 
Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer.
Biˆ®che I, Tomasetto C, Rˆ©gnier CH, Moog-Lutz C, Rio MC, Lidereau R
Cancer research. 1996 ; 56 (17) : 3886-3890.
PMID 8752152
 
Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death.
Arch RH, Gedrich RW, Thompson CB
Genes & development. 1998 ; 12 (18) : 2821-2830.
PMID 9744859
 
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written08-2000Catherine H Régnier, Catherine Tomasetto, Marie.Christine Rio
I.G.B.M.C., BP163, 1 rue Laurent Fries, 67404 ILLKIRCH, France

Citation

This paper should be referenced as such :
Régnier CH, Tomasetto C, Rio MC . TRAF4 TNF receptor-associated factor 4. Atlas Genet Cytogenet Oncol Haematol. August 2000 .
URL : http://AtlasGeneticsOncology.org/Genes/TRAF4ID204.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 31 20:07:45 CEST 2010
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.