Atlas of Genetics and Cytogenetics in Oncology and Haematology
TRAF4 (TNF receptor-associated factor 4)
| Identity |
| Other names | MLN62 |
| CART1 | |
| HGNC (Hugo) | TRAF4 |
| LocusID (NCBI) | 9618 |
| Location | 17q11-q12 |
| Location_base_pair | Starts at 27071023 and ends at 27077976 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| Local_order | TRAF4, Lasp1(alias MLN50), c-erbB2, MLN64, MLN51 |
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| TRAF4 (17q11-q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. Laboratories willing to validate the probes are welcome : contact rocchi@biologia.uniba.it | |
| DNA/RNA |
| Description | 5,5 kb gene; 7 exons |
| Transcription | 2 kb cDNA; coding sequence: 1410 bp |
| Protein |
| Description | 470 amino acids; 53 kDa; contains an amino-terminal RING finger domain, a central stretch of six putative Zinc-binding domains (3 CART domains) and a carboxyl-terminal TRAF domain |
| Expression | epithelial cells; weak ubiquitous expression in adult tissues; stronger expression level in kidney and thymus |
| Localisation | cytoplasmic; nuclear when overexpressed |
| Function | putative signal transducer |
| Homology | to TRAF proteins (Tumor Necrosis Factor Receptor Associated Factor) |
| Implicated in |
| Entity | 17q11-q12 gene amplification; found in about 25% of primary breast carcinomas |
| Prognosis | poor clinical outcome; increase risk of relapse |
| External links |
| Bibliography |
| Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |
| Tomasetto C, Rˆ©gnier C, Moog-Lutz C, Mattei MG, Chenard MP, Lidereau R, Basset P, Rio MC |
| Genomics. 1995 ; 28 (3) : 367-376. |
| PMID 7490069 |
| Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. |
| Rˆ©gnier CH, Tomasetto C, Moog-Lutz C, Chenard MP, Wendling C, Basset P, Rio MC |
| The Journal of biological chemistry. 1995 ; 270 (43) : 25715-25721. |
| PMID 7592751 |
| Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. |
| Biˆ®che I, Tomasetto C, Rˆ©gnier CH, Moog-Lutz C, Rio MC, Lidereau R |
| Cancer research. 1996 ; 56 (17) : 3886-3890. |
| PMID 8752152 |
| Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. |
| Arch RH, Gedrich RW, Thompson CB |
| Genes & development. 1998 ; 12 (18) : 2821-2830. |
| PMID 9744859 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 08-2000 | Catherine H Régnier, Catherine Tomasetto, Marie.Christine Rio |
| I.G.B.M.C., BP163, 1 rue Laurent Fries, 67404 ILLKIRCH, France |
| Citation |
| This paper should be referenced as such : |
| Régnier CH, Tomasetto C, Rio MC . TRAF4 (TNF receptor-associated factor 4). Atlas Genet Cytogenet Oncol Haematol. August 2000 . URL : http://AtlasGeneticsOncology.org/Genes/TRAF4ID204.html |
This paper is referenced by INIST as such : |
| http://documents.irevues.inist.fr/bitstream/2042/37664/1/08-2000-TRAF4ID204.pdf [ Bibliographic record ] |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Sat Apr 28 15:03:52 CEST 2012 |
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