TRAF4 (TNF receptor-associated factor 4)
2000-08-01 Catherine H Régnier , Catherine Tomasetto , Marie.Christine Rio AffiliationI.G.B.M.C, 1, rue Laurent FRIES, BP 163 67404 ILLKIRH, France
Identity
HGNC
LOCATION
17q11.2
IMAGE
LEGEND
TRAF4 (17q11-q12) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics.
LOCUSID
ALIAS
CART1,MLN62,RNF83
FUSION GENES
DNA/RNA
Description
5,5 kb gene; 7 exons
Transcription
2 kb cDNA; coding sequence: 1410 bp
Proteins
Description
470 amino acids; 53 kDa; contains an amino-terminal RING finger domain, a central stretch of six putative Zinc-binding domains (3 CART domains) and a carboxyl-terminal TRAF domain
Expression
epithelial cells; weak ubiquitous expression in adult tissues; stronger expression level in kidney and thymus
Localisation
cytoplasmic; nuclear when overexpressed
Function
putative signal transducer
Homology
to TRAF proteins (Tumor Necrosis Factor Receptor Associated Factor)
Implicated in
Entity name
17q11-q12 gene amplification; found in about 25% of primary breast carcinomas
Prognosis
poor clinical outcome; increase risk of relapse
Article Bibliography
| Pubmed ID | Last Year | Title | Authors |
|---|---|---|---|
| 9744859 | 1998 | Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death. | Arch RH et al |
| 8752152 | 1996 | Two distinct amplified regions at 17q11-q21 involved in human primary breast cancer. | Bièche I et al |
| 7592751 | 1995 | Presence of a new conserved domain in CART1, a novel member of the tumor necrosis factor receptor-associated protein family, which is expressed in breast carcinoma. | Régnier CH et al |
| 7490069 | 1995 | Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. | Tomasetto C et al |
Other Information
Locus ID:
NCBI: 9618
MIM: 602464
HGNC: 12034
Ensembl: ENSG00000076604
Variants:
dbSNP: 9618
ClinVar: 9618
TCGA: ENSG00000076604
COSMIC: TRAF4
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Small cell lung cancer | KEGG | ko05222 |
| Pathways in cancer | KEGG | hsa05200 |
| Small cell lung cancer | KEGG | hsa05222 |
| IL-17 signaling pathway | KEGG | ko04657 |
| IL-17 signaling pathway | KEGG | hsa04657 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38164179 | 2024 | TRAF4 regulates ubiquitination-modulated survivin turnover and confers radioresistance. | 0 |
| 38164179 | 2024 | TRAF4 regulates ubiquitination-modulated survivin turnover and confers radioresistance. | 0 |
| 36622335 | 2023 | De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation. | 2 |
| 36765039 | 2023 | TRAF4-mediated ubiquitination-dependent activation of JNK/Bcl-xL drives radioresistance. | 4 |
| 36795185 | 2023 | TRAF4 Silencing Induces Cell Apoptosis and Improves Retinoic Acid Sensitivity in Human Neuroblastoma. | 1 |
| 37006049 | 2023 | USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis. | 0 |
| 36622335 | 2023 | De Novo PACSIN1 Gene Variant Found in Childhood Lupus and a Role for PACSIN1/TRAF4 Complex in Toll-like Receptor 7 Activation. | 2 |
| 36765039 | 2023 | TRAF4-mediated ubiquitination-dependent activation of JNK/Bcl-xL drives radioresistance. | 4 |
| 36795185 | 2023 | TRAF4 Silencing Induces Cell Apoptosis and Improves Retinoic Acid Sensitivity in Human Neuroblastoma. | 1 |
| 37006049 | 2023 | USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis. | 0 |
| 34983361 | 2022 | LncRNA HCG18 upregulates TRAF4/TRAF5 to facilitate proliferation, migration and EMT of epithelial ovarian cancer by targeting miR-29a/b. | 9 |
| 35731212 | 2022 | TRAF4 Inhibits Bladder Cancer Progression by Promoting BMP/SMAD Signaling. | 6 |
| 35748027 | 2022 | Overexpression of TRAF4 promotes lung cancer growth and EGFR-dependent phosphorylation of ERK5. | 1 |
| 35864174 | 2022 | TRAF4 hyperactivates HER2 signaling and contributes to Trastuzumab resistance in HER2-positive breast cancer. | 6 |
| 35895752 | 2022 | TRAF4 Maintains Deubiquitination of Caveolin-1 to Drive Glioblastoma Stemness and Temozolomide Resistance. | 7 |
Citation
Catherine H Régnier ; Catherine Tomasetto ; Marie.Christine Rio
TRAF4 (TNF receptor-associated factor 4)
Atlas Genet Cytogenet Oncol Haematol. 2000-08-01
Online version: http://atlasgeneticsoncology.org/gene/204/traf4
