TSPAN1 (tetraspanin 1)

Identity

Other names	9030418M05Rik
	NET-1
	RP11-322N21.1
	TSPAN-1
HGNC	TSPAN1
Location	1p34.1

DNA/RNA

Description	The TSPAN1 gene is located on chromosome 1 in a 5419 bp sequence (46418799..46424217). The gene contains 10 exons.
Transcription	mRNA: 1297 nucleotides in length.

Protein

Description	241 amino acids, 26.2 kDa Protein. The 241 amino acid sequence is: 1 mqcfsfiktm milfnllifl cgaallavgi wvsidgasfl kifgplsssa mqfvnvgyfl; 61 iaagvvvfal gflgcygakt eskcalvtff filllifiae vaaavvalvy ttmaehfltl; 121 lvvpaikkdy gsqedftqvw nttmkglkcc gftnytdfed spyfkensaf ppfccndnvt; 181 ntanetctkq kahdqkvegc fnqllydirt navtvggvaa gigglelaam ivsmylycnl; 241 q
Expression	Widely expressed.
Localisation	Plasma Membrane
Function	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. These are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility.
Homology	Holomogy with Pan troglodytes (100%); Canis lupus familiaris (89%); Mus musculus (82%), Rattus norvegicus (82%), Gallus gallus (70%).

Mutations

Note	TSPAN1 is subject to the following misense mutations : Source ID rs2234266 rs2234267 rs2234268 rs1047216 Wild type nucleotide A C G A Wild type amino acid M S V K Variant nucleotide G T A G Variant amino acid V F M E Amino Acid Position 0 37 86 188

Implicated in

Entity	Cervical Cancer
Disease	Cervical cancer is a malignant carcinoma or the cervix, typically composed of squamous cells. Most studies have found that human papillomavirus (HPV) infection is responsible for virtually all cases of cervical cancer.
Prognosis	Prognosis depends on the stage of the cancer. The 5 year survival rate with treatment is 80 to 90% in patients with stage I disease and 50 to 65% in patients with stage II disease. 25 to 35% of women with stage III cancer and 15% or fewer of those with stage IV cancer are alive after 5 years. Prognosis drops dramatically with tumour metastasis. Thirty-five percent of patients with invasive cervical cancer have persistent or recurrent disease after treatment.
Entity	Hepatocellular Carcinoma
Disease	Hepatocellular Carcinoma (HCC) is a malignancy of the liver. Most cases of HCC are secondary to either a hepatitis B or C infection or cirrhosis.
Prognosis	The prognosis of HCC is dependent on many factors, including tumour size, tumour staging, the involvement of liver vessels, the presence of extrahepatic metastases and the vascularisation of the tumor.

External links

	Nomenclature
HGNC	TSPAN1   20657
Entrez_Gene	TSPAN1  10103  tetraspanin 1
	Cards
Atlas	TSPAN1ID44178ch1p34
GeneCards	TSPAN1
Ensembl	TSPAN1 [Search_View]   ENSG00000117472 [Gene_View]
Genatlas	TSPAN1
GeneLynx	TSPAN1
eGenome	TSPAN1
euGene	10103
	Genomic and cartography
GoldenPath	TSPAN1  -  1p34.1   chr1:46418799-46424217 +  1p33   [Description]    (hg18-Mar_2006)
Ensembl	TSPAN1 - 1p33 [CytoView]
NCBI	Mapview
HomoloGene	TSPAN1
	Gene and transcription
Genbank	AF054838 [ ENTREZ ]
Genbank	AF065388 [ ENTREZ ]
Genbank	AF133425 [ ENTREZ ]
Genbank	AK313774 [ ENTREZ ]
Genbank	BC000695 [ ENTREZ ]
RefSeq	NM_005727 [ SRS ]    NM_005727 [ ENTREZ ]
RefSeq	AC_000044 [ SRS ]    AC_000044 [ ENTREZ ]
RefSeq	AC_000133 [ SRS ]    AC_000133 [ ENTREZ ]
RefSeq	NC_000001 [ SRS ]    NC_000001 [ ENTREZ ]
RefSeq	NT_032977 [ SRS ]    NT_032977 [ ENTREZ ]
RefSeq	NW_001838578 [ SRS ]    NW_001838578 [ ENTREZ ]
RefSeq	NW_921351 [ SRS ]    NW_921351 [ ENTREZ ]
AceView	TSPAN1 AceView - NCBI
Unigene	Hs.38972 [ SRS ]    Hs.38972 [ NCBI ]     HS38972 [ spliceNest ]
Fast-db	15814 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	O60635 [ SRS]    O60635 [ EXPASY ]     O60635 [ INTERPRO ]     O60635 [ UNIPROT ]
Prosite	PS00421 TM4_1 [ SRS ]    PS00421 TM4_1 [ Expasy ]
Interpro	IPR000301 Transmem_4 [ SRS ]    IPR000301 Transmem_4 [ EBI ]
CluSTr	O60635
Pfam	PF00335 Tetraspannin [ SRS ]    PF00335 Tetraspannin [ Sanger ]    pfam00335 [ NCBI-CDD ]
Blocks	O60635
HPRD	18232
	Protein Interaction databases
DIP	O60635
IntAct	O60635
	Polymorphism : SNP, mutations, diseases
SNP	TSPAN1 [dbSNP-NCBI]
SNP	NM_005727 [SNP-NCI]
SNP	TSPAN1 [GeneSNPs - Utah]  TSPAN1] [HGBASE - SRS]
HAPMAP	TSPAN1 [HAPMAP]
HGMD	TSPAN1
	General knowledge
Family Browser	TSPAN1 [UCSC Family Browser]
SOURCE	NM_005727
SMD	Hs.38972
SAGE	Hs.38972
GO	membrane [Amigo]  membrane
GO	integral to membrane [Amigo]  integral to membrane
PubGene	TSPAN1
TreeFam	TSPAN1
CTD	10103 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	TSPAN1 Related clones (RZPD - Berlin)
	PubMed
PubMed	7 Pubmed reference(s) in Entrez

Bibliography

Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas.

Wollscheid V, K��hne-Heid R, Stein I, Jansen L, K��llner S, Schneider A, D��rst M

International journal of cancer. Journal international du cancer. 2002 ; 99 (6) : 771-775.

PMID 12115476

Association of NET-1 gene expression with human hepatocellular carcinoma.

Chen L, Wang Z, Zhan X, Li DC, Zhu YY, Zhu J

International journal of surgical pathology. 2007 ; 15 (4) : 346-353.

PMID 17913940

REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	01-2008	David Murray, Peter Doran
		UCD School of Medicine and Medical Sciences, UCD-Mater Clinical Research Centre, Mater Misericordiae University Hospital, Dublin 7, Ireland

Citation

This paper should be referenced as such :

Murray D, Doran P . TSPAN1 (tetraspanin 1). Atlas Genet Cytogenet Oncol Haematol. January 2008 . URL : http://AtlasGeneticsOncology.org/Genes/TSPAN1ID44178ch1p34.html

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Sep 29 18:48:05 2008