| Identity |
| Other names | 9030418M05Rik |
| NET-1 | |
| RP11-322N21.1 | |
| TSPAN-1 | |
| HGNC (Hugo) | TSPAN1 |
| Location | 1p34.1 |
| Location_base_pair | Starts at 46640749 and ends at 46651633 bp from pter ( according to hg19-Feb_2009) [Mapping] |
| DNA/RNA |
| Description | The TSPAN1 gene is located on chromosome 1 in a 5419 bp sequence (46418799..46424217). The gene contains 10 exons. |
| Transcription | mRNA: 1297 nucleotides in length. |
| Protein |
| Description | 241 amino acids, 26.2 kDa Protein. The 241 amino acid sequence is: 1 mqcfsfiktm milfnllifl cgaallavgi wvsidgasfl kifgplsssa mqfvnvgyfl |
| Expression | Widely expressed. |
| Localisation | Plasma Membrane |
| Function | The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. These are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. |
| Homology | Holomogy with Pan troglodytes (100%); Canis lupus familiaris (89%); Mus musculus (82%), Rattus norvegicus (82%), Gallus gallus (70%). |
| Mutations |
| Note | TSPAN1 is subject to the following misense mutations :
|
| Implicated in |
| Entity | Cervical Cancer |
| Disease | Cervical cancer is a malignant carcinoma or the cervix, typically composed of squamous cells. Most studies have found that human papillomavirus (HPV) infection is responsible for virtually all cases of cervical cancer. |
| Prognosis | Prognosis depends on the stage of the cancer. The 5 year survival rate with treatment is 80 to 90% in patients with stage I disease and 50 to 65% in patients with stage II disease. 25 to 35% of women with stage III cancer and 15% or fewer of those with stage IV cancer are alive after 5 years. Prognosis drops dramatically with tumour metastasis. Thirty-five percent of patients with invasive cervical cancer have persistent or recurrent disease after treatment. |
| Entity | Hepatocellular Carcinoma |
| Disease | Hepatocellular Carcinoma (HCC) is a malignancy of the liver. Most cases of HCC are secondary to either a hepatitis B or C infection or cirrhosis. |
| Prognosis | The prognosis of HCC is dependent on many factors, including tumour size, tumour staging, the involvement of liver vessels, the presence of extrahepatic metastases and the vascularisation of the tumor. |
| External links |
| Bibliography |
| Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas. |
| Wollscheid V, Khne-Heid R, Stein I, Jansen L, Kllner S, Schneider A, Drst M |
| International journal of cancer. Journal international du cancer. 2002 ; 99 (6) : 771-775. |
| PMID 12115476 |
| Association of NET-1 gene expression with human hepatocellular carcinoma. |
| Chen L, Wang Z, Zhan X, Li DC, Zhu YY, Zhu J |
| International journal of surgical pathology. 2007 ; 15 (4) : 346-353. |
| PMID 17913940 |
| REVIEW articles | automatic search in PubMed |
| Last year publications | automatic search in PubMed |
| Contributor(s) |
| Written | 01-2008 | David Murray, Peter Doran |
| UCD School of Medicine and Medical Sciences, UCD-Mater Clinical Research Centre, Mater Misericordiae University Hospital, Dublin 7, Ireland |
| Citation |
| This paper should be referenced as such : |
| Murray D, Doran P . TSPAN1 (tetraspanin 1). Atlas Genet Cytogenet Oncol Haematol. January 2008 . URL : http://AtlasGeneticsOncology.org/Genes/TSPAN1ID44178ch1p34.html |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Thu Jul 15 14:42:22 CEST 2010 |
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