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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome
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Don't let the Atlas imminent demise
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Smooth muscle: Intravenous leiomyomatosis


ICD-Morpho 8890/1 Intravascular leiomyomatosis
Phylum Other:Smooth muscle:Intravenous leiomyomatosis

Clinics and Pathology

Etiology Intravenous leiomyomatosis (IVL) is a rare smooth muscle proliferation of special interest because of its quasi-malignant behavior.
Clinics IVL is a smooth muscle proliferation that arises from the uterus with vermiform extensions in some cases into the inferior vena cava and ultimately into the right heart.
Pathology The neoplastic smooth muscle of intravenous leiomyomatosis resembles that of benign uterine leiomyomata and may include the same histological variants found in the uterus. Furthermore, the neoplastic smooth cells of IVL express estrogen and progesterone receptors and tumor growth appears to respond to hormonal manipulation.
Treatment Although benign, its hemodynamic effects may require invasive extirpation.


There are only two cytogenetic reports in IVL and both exhibited a karyotype with a der(14)t(12;14)(q15;q24) and two normal copies of chromosome 12.
Fluorescence in situ hybridization revealed three copies of HMGA2 (a.k.a. HMGIC): two signals were detected on the normal chromosomes 12 at 12q15, as well as another on the der(14) in the breakpoint region, suggesting that the 12q breakpoint occurred 5' (centromeric) to HMGA2, as has been commonly observed and previously described in uterine leiomyoma with a t(12;14). Based on these findings, it has been suggested that the pathogenesis of IVL is more similar to that of typical uterine leiomyoma than it is to leiomyosarcoma.

Translocations implicated (Data extracted from papers in the Atlas)

 t(12;14)(q15;q24) HMGA2

External links

Mitelman database
t(12;14)(q15;q24) - Mitelman database (CGAP - NCBI)
arrayMapMorph ( 8890/1) - arrayMap (Zurich)


Intravenous leiomyomatosis of the uterus. A clinicopathological analysis of 16 cases with unusual histologic features.
Clement PB, Young RH, Scully RE
The American journal of surgical pathology. 1988 ; 12 (12) : 932-945.
PMID 3202247
Intravenous leiomyomatosis: molecular and cytogenetic analysis of a case.
Quade BJ, Dal Cin P, Neskey DM, Weremowicz S, Morton CC
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2002 ; 15 (3) : 351-356.
PMID 11904348
Intravenous leiomyomatosis is characterized by a der(14)t(12;14)(q15;q24).
Dal Cin P, Quade BJ, Neskey DM, Kleinman MS, Weremowicz S, Morton CC
Genes, chromosomes & cancer. 2003 ; 36 (2) : 205-206.
PMID 12508249
Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15.
Quade BJ, Weremowicz S, Neskey DM, Vanni R, Ladd C, Dal Cin P, Morton CC
Cancer research. 2003 ; 63 (6) : 1351-1358.
PMID 12649198
REVIEW articlesautomatic search in PubMed
Last year articlesautomatic search in PubMed


Written07-2003Paola Dal Cin
Cytogenetics Laboratory, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Amory 3-154, Boston, Massachusetts 02115, USA


This paper should be referenced as such :
Dal, Cin P
Smooth muscle: Intravenous leiomyomatosis
Atlas Genet Cytogenet Oncol Haematol. 2003;7(3):210-210.
Free journal version : [ pdf ]   [ DOI ]

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