| Written | 08-2018 | Jean-Loup Huret, Philippe Dessen |
| Identity |
| Atlas_Id | 100019 |
| Phylum | Digestive organs: Liver:: |
| WHO/OMS Classification | Digestive organs |
| Note | Non-annotated chromosomal abnormality. Preliminary data : if you are an author who wish to write a full paper/card on this translocation, go to How to contribute |
| Clinics and Pathology |
| Disease | Liver: Adenocarcinoma |
| Genes involved and Proteins |
| Gene Name | DNAJB1 |
| Location | 19p13.12 |
| Gene Name | PRKACA |
| Location | 19p13.12 |
| Bibliography |
| Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma |
| Honeyman JN, Simon EP, Robine N, Chiaroni-Clarke R, Darcy DG, Lim II, Gleason CE, Murphy JM, Rosenberg BR, Teegan L, Takacs CN, Botero S, Belote R, Germer S, Emde AK, Vacic V, Bhanot U, LaQuaglia MP, Simon SM |
| Science 2014 Feb 28;343(6174):1010-4 |
| PMID 24578576 |
| The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients |
| Darcy DG, Chiaroni-Clarke R, Murphy JM, Honeyman JN, Bhanot U, LaQuaglia MP, Simon SM |
| Oncotarget 2015 Jan 20;6(2):755-70 |
| PMID 25605237 |
| Translocations implicated (Data extracted from papers in the Atlas) |
| del(19)(p13p13) DNAJB1/PRKACA | |
| External links |
| Mitelman database | del(19)(p13p13) [Fusion] del(19)(p13p13) [Cytogenetics Case] |
| COSMIC | [ DNAJB1 ] [ PRKACA ] |
| Disease database | del(19)(p13p13) DNAJB1/PRKACA |
| REVIEW articles | automatic search in PubMed |
| Last year articles | automatic search in PubMed |
| © Atlas of Genetics and Cytogenetics in Oncology and Haematology | indexed on : Mon Jul 13 11:02:39 CEST 2020 |
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