DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1)

2007-04-01  

Identity

HGNC
DNAJB1
LOCATION
19p13.12
LOCUSID
3337
ALIAS
HSPF1,Hdj1,Hsp40,RSPH16B,Sis1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3337
MIM: 604572
HGNC: 5270
Ensembl: ENSG00000132002

Variants:

dbSNP: 3337
ClinVar: 3337
TCGA: ENSG00000132002
COSMIC: DNAJB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132002ENST00000254322P25685
ENSG00000132002ENST00000254322Q6FHS4
ENSG00000132002ENST00000396969P25685
ENSG00000132002ENST00000594099M0QZD0
ENSG00000132002ENST00000595139M0QXK0
ENSG00000132002ENST00000595992M0QYT3
ENSG00000132002ENST00000596075M0R128
ENSG00000132002ENST00000596853M0QYT3
ENSG00000132002ENST00000598235M0R080
ENSG00000132002ENST00000598692A0A1B0GX60
ENSG00000132002ENST00000601533M0R1D6

Expression (GTEx)

0
50
100
150
200
250
300
350
400
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568
Regulation of HSF1-mediated heat shock responseREACTOMER-HSA-3371453

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
351676232022DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.5
351676232022DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling.5
336924542021Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.15
347277502021DNAJB11 predicts a poor prognosis and is associated with immune infiltration in thyroid carcinoma: a bioinformatics analysis.3
336924542021Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.15
347277502021DNAJB11 predicts a poor prognosis and is associated with immune infiltration in thyroid carcinoma: a bioinformatics analysis.3
316767852020DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.44
320843852020Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins.38
321982032020Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function.22
331777182020HSP40 proteins use class-specific regulation to drive HSP70 functional diversity.74
316767852020DNAJB1-PRKACA fusions occur in oncocytic pancreatic and biliary neoplasms and are not specific for fibrolamellar hepatocellular carcinoma.44
320843852020Knocking out C9ORF72 Exacerbates Axonal Trafficking Defects Associated with Hexanucleotide Repeat Expansion and Reduces Levels of Heat Shock Proteins.38
321982032020Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function.22
331777182020HSP40 proteins use class-specific regulation to drive HSP70 functional diversity.74
310278802019Hsp70- and Hsp90-Mediated Regulation of the Conformation of p53 DNA Binding Domain and p53 Cancer Variants.47

Citation

Dessen P

DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-04-01

Online version: http://atlasgeneticsoncology.org/gene/46862/dnajb1-(dnaj-heat-shock-protein-family-(hsp40)-member-b1)