MLF1 (myelodysplasia/myeloid leukemia factor 1)

1997-12-01   Jean-Loup Huret  

Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France

Identity

HGNC
MLF1
LOCATION
3q25.32
LOCUSID
4291
ALIAS
-
FUSION GENES
Show Gene Fusions

DNA/RNA

Transcription

alternate splicing: 1.4 and 2.4 kb

Proteins

Description

267 amino acids; 31 KDa; do not contain known functional motifs

Expression

MLF1 transcripts widely expressed (gonads, muscle, heart, kidney, colon)

Localisation

cytoplasmic localisation

Homology

none is known, apart from MLF2 (40% homology)

Implicated in

Entity name
t(3;5)(q25;q34)/AML or MDS--> NPM1 - MLF1
Disease
AML, MDS, BC-CML; trilineage involvement
Prognosis
very poor
Cytogenetics
location of breakpoints difficult to ascertain
Hybrid gene
5 NPM1-3 MLF1 on der(5)
Fusion protein
nuclear protein

Article Bibliography

Pubmed IDLast YearTitleAuthors
85702041996The t(3;5)(q25.1;q34) of myelodysplastic syndrome and acute myeloid leukemia produces a novel fusion gene, NPM-MLF1.Yoneda-Kato N et al

Other Information

Locus ID:

NCBI: 4291
MIM: 601402
HGNC: 7125
Ensembl: ENSG00000178053

Variants:

dbSNP: 4291
ClinVar: 4291
TCGA: ENSG00000178053
COSMIC: MLF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178053ENST00000355893P58340
ENSG00000178053ENST00000355893A0A0S2Z4U8
ENSG00000178053ENST00000359117P58340
ENSG00000178053ENST00000359117A0A140VKD2
ENSG00000178053ENST00000392822P58340
ENSG00000178053ENST00000466246A0A0S2Z4A4
ENSG00000178053ENST00000469452P58340
ENSG00000178053ENST00000471745P58340
ENSG00000178053ENST00000477042P58340
ENSG00000178053ENST00000478894P58340
ENSG00000178053ENST00000482628P58340
ENSG00000178053ENST00000482628A0A140VKD2
ENSG00000178053ENST00000484955P58340
ENSG00000178053ENST00000484955A0A140VKD2
ENSG00000178053ENST00000487838F8VXT4
ENSG00000178053ENST00000491767C9JNE5
ENSG00000178053ENST00000495452F8WEY0
ENSG00000178053ENST00000498592C9K0D4
ENSG00000178053ENST00000618075P58340
ENSG00000178053ENST00000619577A0A499FJ64
ENSG00000178053ENST00000650750A0A494C127
ENSG00000178053ENST00000650753A0A494C175
ENSG00000178053ENST00000651874P58340
ENSG00000178053ENST00000651874A0A140VKD2
ENSG00000178053ENST00000651984A0A494C1P6
ENSG00000178053ENST00000652045A0A494C1S3

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202

References

Pubmed IDYearTitleCitations
374869652023Epigenetic deregulation of MLF1 drives intrahepatic cholangiocarcinoma progression through EGFR/AKT and Wnt/β-catenin signaling.3
374869652023Epigenetic deregulation of MLF1 drives intrahepatic cholangiocarcinoma progression through EGFR/AKT and Wnt/β-catenin signaling.3
327034002020CRL4(DCAF8) and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs).4
327034002020CRL4(DCAF8) and USP11 oppositely regulate the stability of myeloid leukemia factors (MLFs).4
316753752019NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.5
316753752019NPM and NPM-MLF1 interact with chromatin remodeling complexes and influence their recruitment to specific genes.5
278401552017Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.8
279840432017Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression.6
281376432017MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.3
285451282017Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.50
278401552017Modulation of mutant Huntingtin aggregates and toxicity by human myeloid leukemia factors.8
279840432017Myeloid Leukemia Factor Acts in a Chaperone Complex to Regulate Transcription Factor Stability and Gene Expression.6
281376432017MLF1 is a proapoptotic antagonist of HOP complex-mediated survival.3
285451282017Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma.50
232714362013Subcellular localization of full-length human myeloid leukemia factor 1 (MLF1) is independent of 14-3-3 proteins.2

Citation

Jean-Loup Huret

MLF1 (myelodysplasia/myeloid leukemia factor 1)

Atlas Genet Cytogenet Oncol Haematol. 1997-12-01

Online version: http://atlasgeneticsoncology.org/gene/18/js/lib/meetings/gene-fusions-explorer/