EPO (erythropoietin)

2004-05-01 Affiliation

Identity

HGNC

EPO

LOCATION

7q22.1

LOCUSID

2056

ALIAS

DBAL,ECYT5,EP,MVCD2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2056
MIM: 133170
HGNC: 3415
Ensembl: ENSG00000130427

Variants:

dbSNP: 2056
ClinVar: 2056
TCGA: ENSG00000130427
COSMIC: EPO

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000130427	ENST00000252723	P01588
ENSG00000130427	ENST00000252723	G9JKG7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Cytokine-cytokine receptor interaction	KEGG	ko04060
Jak-STAT signaling pathway	KEGG	ko04630
Hematopoietic cell lineage	KEGG	ko04640
Cytokine-cytokine receptor interaction	KEGG	hsa04060
Jak-STAT signaling pathway	KEGG	hsa04630
Hematopoietic cell lineage	KEGG	hsa04640
PI3K-Akt signaling pathway	KEGG	hsa04151
PI3K-Akt signaling pathway	KEGG	ko04151
HIF-1 signaling pathway	KEGG	hsa04066
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular response to hypoxia	REACTOME	R-HSA-2262749
Regulation of Hypoxia-inducible Factor (HIF) by oxygen	REACTOME	R-HSA-1234174
Regulation of gene expression by Hypoxia-inducible Factor	REACTOME	R-HSA-1234158

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15240563	2004	Differentiating the functional role of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2alpha target gene in Hep3B and Kelly cells.	130
12975460	2003	Erythropoietin selectively attenuates cytokine production and inflammation in cerebral ischemia by targeting neuronal apoptosis.	118
11854521	2002	Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury.	89
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
18458324	2008	Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.	62
18458324	2008	Promoter polymorphism of the erythropoietin gene in severe diabetic eye and kidney complications.	62
16645141	2006	Erythropoietin-mobilized endothelial progenitors enhance reendothelialization via Akt-endothelial nitric oxide synthase activation and prevent neointimal hyperplasia.	60
15205261	2004	Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells.	59
22388478	2012	Prevention of β-amyloid degeneration of microglia by erythropoietin depends on Wnt1, the PI 3-K/mTOR pathway, Bad, and Bcl-xL.	56
15142852	2004	Oxygen-dependent and tissue-specific regulation of erythropoietin gene expression.	54

Citation

Dessen P

EPO (erythropoietin)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/182/epo-(erythropoietin)